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Aliases for FRMD8 Gene

Aliases for FRMD8 Gene

  • FERM Domain Containing 8 2 3 5
  • FERM Domain-Containing Protein 8 3
  • FKSG44 3

External Ids for FRMD8 Gene

Previous GeneCards Identifiers for FRMD8 Gene

  • GC11P064911
  • GC11P065154
  • GC11P061480

Summaries for FRMD8 Gene

GeneCards Summary for FRMD8 Gene

FRMD8 (FERM Domain Containing 8) is a Protein Coding gene. An important paralog of this gene is KRIT1.

Additional gene information for FRMD8 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRMD8 Gene

Genomics for FRMD8 Gene

GeneHancer (GH) Regulatory Elements for FRMD8 Gene

Promoters and enhancers for FRMD8 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11I065377 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 568.6 -4.1 -4088 10.3 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF263 SP3 FRMD8 SLC25A45 SF1 PCNX3 POLA2 MUS81 NEAT1 SART1 EIF1AD RELA
GH11I065470 Promoter/Enhancer 2.9 VISTA FANTOM5 Ensembl ENCODE dbSUPER 88.9 +103.5 103514 40 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 LOC105369346 SF1 PCNX3 POLA2 ZFPL1 EIF1AD SART1 MUS81 LOC105369352 KAT5
GH11I065414 Promoter/Enhancer 2.4 FANTOM5 Ensembl ENCODE dbSUPER 50.9 +37.6 37611 18.8 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 ZNF213 NEAT1 ENSG00000277599 GC11P065529 ENSG00000278144 ENSG00000278050 SF1 ZFPL1 EIF1AD POLA2 PCNX3
GH11I065851 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 44.4 +470.9 470914 12.2 CLOCK MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 MUS81 CFL1 EIF1AD POLA2 PCNX3 SART1 ENSG00000258297 ZFPL1 RBM14 RBM4
GH11I066000 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 36.3 +615.7 615713 3 CLOCK ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 EIF1AD BANF1 ENSG00000258297 ZFPL1 PCNX3 POLA2 SART1 RBM14 RBM4 SF3B2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FRMD8 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FRMD8 gene promoter:

Genomic Locations for FRMD8 Gene

Genomic Locations for FRMD8 Gene
26,956 bases
Plus strand

Genomic View for FRMD8 Gene

Genes around FRMD8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRMD8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRMD8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRMD8 Gene

Proteins for FRMD8 Gene

  • Protein details for FRMD8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    FERM domain-containing protein 8
    Protein Accession:
    Secondary Accessions:
    • B4E2P1
    • Q86V56
    • Q8NCB5

    Protein attributes for FRMD8 Gene

    464 amino acids
    Molecular mass:
    51218 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FRMD8 Gene


neXtProt entry for FRMD8 Gene

Post-translational modifications for FRMD8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FRMD8 Gene

Domains & Families for FRMD8 Gene

Gene Families for FRMD8 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FRMD8 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FRMD8: view

No data available for UniProtKB/Swiss-Prot for FRMD8 Gene

Function for FRMD8 Gene

Phenotypes From GWAS Catalog for FRMD8 Gene

Gene Ontology (GO) - Molecular Function for FRMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FRMD8: view
genes like me logo Genes that share phenotypes with FRMD8: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FRMD8 Gene

Localization for FRMD8 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRMD8 gene
Compartment Confidence
cytosol 3
cytoskeleton 2
nucleus 2
plasma membrane 1
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FRMD8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with FRMD8: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FRMD8 Gene

Pathways & Interactions for FRMD8 Gene

SuperPathways for FRMD8 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FRMD8 Gene


No data available for Pathways by source and SIGNOR curated interactions for FRMD8 Gene

Drugs & Compounds for FRMD8 Gene

No Compound Related Data Available

Transcripts for FRMD8 Gene

Unigene Clusters for FRMD8 Gene

FERM domain containing 8:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRMD8 Gene

No ASD Table

Relevant External Links for FRMD8 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRMD8 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRMD8 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FRMD8 Gene

This gene is overexpressed in Serum (31.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FRMD8 Gene

Protein tissue co-expression partners for FRMD8 Gene

NURSA nuclear receptor signaling pathways regulating expression of FRMD8 Gene:


SOURCE GeneReport for Unigene cluster for FRMD8 Gene:


Evidence on tissue expression from TISSUES for FRMD8 Gene

  • Liver(4.5)
  • Intestine(4.4)
  • Nervous system(2.9)
  • Heart(2.1)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with FRMD8: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRMD8 Gene

Orthologs for FRMD8 Gene

This gene was present in the common ancestor of animals.

Orthologs for FRMD8 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FRMD8 33
  • 99.35 (n)
(Bos Taurus)
Mammalia FRMD8 33 34
  • 88.46 (n)
(Canis familiaris)
Mammalia FRMD8 33 34
  • 87.04 (n)
(Mus musculus)
Mammalia Frmd8 33 16 34
  • 84.59 (n)
(Rattus norvegicus)
Mammalia Frmd8 33
  • 84.48 (n)
(Monodelphis domestica)
Mammalia FRMD8 34
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia FRMD8 34
  • 67 (a)
(Anolis carolinensis)
Reptilia FRMD8 34
  • 63 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia frmd8 33
  • 60.46 (n)
African clawed frog
(Xenopus laevis)
Amphibia MGC53754 33
(Danio rerio)
Actinopterygii frmd8 33 34
  • 59.46 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002678 33
  • 49.96 (n)
fruit fly
(Drosophila melanogaster)
Insecta Bili 33 34
  • 49.25 (n)
(Caenorhabditis elegans)
Secernentea frm-10 34
  • 16 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 33 (a)
Species where no ortholog for FRMD8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRMD8 Gene

Gene Tree for FRMD8 (if available)
Gene Tree for FRMD8 (if available)

Paralogs for FRMD8 Gene

Paralogs for FRMD8 Gene

(1) SIMAP similar genes for FRMD8 Gene using alignment to 6 proteins: Pseudogenes for FRMD8 Gene

genes like me logo Genes that share paralogs with FRMD8: view

Variants for FRMD8 Gene

Sequence variations from dbSNP and Humsavar for FRMD8 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000253045 -- 65,413,554(+) T/C downstream_transcript_variant
rs1000262445 -- 65,402,303(+) G/A intron_variant
rs1000277690 -- 65,399,242(+) G/A intron_variant
rs1000415190 -- 65,385,800(+) AT/ upstream_transcript_variant
rs1000639810 -- 65,409,262(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FRMD8 Gene

Variant ID Type Subtype PubMed ID
esv2422285 CNV deletion 17116639
nsv1122634 CNV deletion 24896259
nsv1145541 CNV deletion 24896259
nsv526181 CNV gain 19592680
nsv951016 CNV deletion 24416366

Variation tolerance for FRMD8 Gene

Residual Variation Intolerance Score: 66.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.81; 47.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FRMD8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRMD8 Gene

Disorders for FRMD8 Gene

Additional Disease Information for FRMD8

No disorders were found for FRMD8 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRMD8 Gene

Publications for FRMD8 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. (PMID: 24927181) Navarini AA … Barker JN (Nature communications 2014) 3 58

Products for FRMD8 Gene

Sources for FRMD8 Gene