The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008] See more...

Aliases for FRK Gene

Aliases for FRK Gene

  • Fyn Related Src Family Tyrosine Kinase 2 3 5
  • Nuclear Tyrosine Protein Kinase RAK 3 4
  • PTK5 Protein Tyrosine Kinase 5 2 3
  • Tyrosine-Protein Kinase FRK 3 4
  • Protein-Tyrosine Kinase 5 3 4
  • Fyn-Related Kinase 2 3
  • EC 2.7.10.2 4 52
  • PTK5 3 4
  • RAK 3 4
  • Fyn-Related Src Family Tyrosine Kinase 2
  • FYN-Related Kinase 4
  • EC 2.7.10 52
  • GTK 3

External Ids for FRK Gene

Previous HGNC Symbols for FRK Gene

  • PTK5

Previous GeneCards Identifiers for FRK Gene

  • GC06M116098
  • GC06M116285
  • GC06M116308
  • GC06M116369
  • GC06M113842

Summaries for FRK Gene

Entrez Gene Summary for FRK Gene

  • The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for FRK Gene

FRK (Fyn Related Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FRK include Alk-Negative Anaplastic Large Cell Lymphoma and Liver Benign Neoplasm. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FYN.

UniProtKB/Swiss-Prot Summary for FRK Gene

  • Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Gene Wiki entry for FRK Gene

Additional gene information for FRK Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FRK Gene

Genomics for FRK Gene

GeneHancer (GH) Regulatory Elements for FRK Gene

Promoters and enhancers for FRK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J116098 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.1 78 4.7 EP300 CTCF SIN3A NRF1 TCF12 POLR2G USF1 PHF8 ZFX ZNF639 NT5DC1 FRK KPNA5 DSE COL10A1 TSPYL4 lnc-FRK-3
GH06J116058 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 519.6 +41.1 41114 5.2 CTCF POLR2G EP300 POLR2A ZBTB25 RCOR1 TGIF2 TRIM22 TEAD1 U2AF2 FRK ZUP1 NT5DC1 piR-31292-180 piR-32291-010
GH06J116015 Enhancer 1 Ensembl ENCODE 28.9 +83.1 83128 5.2 TCF12 NCOR1 EP300 KDM6A FOXA1 RELA TRIM22 BCL11A FOXA2 SAP130 FRK NT5DC1 CALHM6 lnc-COL10A1-1 piR-52680-303
GH06J116034 Enhancer 0.8 Ensembl 32.1 +65.3 65327 3.2 TCF12 FOXA2 ZNF316 MAFF FOSL2 MAFK CEBPB PBX2 NFE2 TAL1 ENSG00000287933 lnc-COL10A1-1 FRK NT5DC1 TPI1P3 lnc-NT5DC1-5
GH06J116071 Enhancer 1.1 Ensembl ENCODE 19.7 +27.7 27727 4.4 EP300 FOS TCF7 FOXA1 TOE1 ZNF662 ZBTB7A SMARCC2 MYC TEAD1 FRK NT5DC1 COL10A1 lnc-FRK-3 piR-31292-180
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FRK on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FRK

Top Transcription factor binding sites by QIAGEN in the FRK gene promoter:
  • FOXL1
  • HFH-1
  • YY1

Genomic Locations for FRK Gene

Genomic Locations for FRK Gene
chr6:115,931,149-116,100,728
(GRCh38/hg38)
Size:
169,580 bases
Orientation:
Minus strand
chr6:116,252,312-116,381,921
(GRCh37/hg19)
Size:
129,610 bases
Orientation:
Minus strand

Genomic View for FRK Gene

Genes around FRK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRK Gene

Proteins for FRK Gene

  • Protein details for FRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42685-FRK_HUMAN
    Recommended name:
    Tyrosine-protein kinase FRK
    Protein Accession:
    P42685
    Secondary Accessions:
    • B4DY49
    • Q13128
    • Q9NTR5

    Protein attributes for FRK Gene

    Size:
    505 amino acids
    Molecular mass:
    58254 Da
    Quaternary structure:
    • Interacts (via the SH3-domain) with PTEN. Interacts with RB1.

    Alternative splice isoforms for FRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRK Gene

Selected DME Specific Peptides for FRK Gene

P42685:
  • RDLAARN
  • KWTAPEA
  • IKSDVWSFGILL
  • FLIRESE
  • GQFGEVW
  • WEIDRNSI
  • GYIPSNYVA
  • AARNVLV
  • KSDVWSFG
  • PIYIITE

Post-translational modifications for FRK Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for FRK Gene

Gene Families for FRK Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FRK Gene

Blocks:
  • Tyrosine protein kinase, active site
  • SH3 domain signature
  • SH2 domain signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FRK Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ59784, highly similar to Tyrosine-protein kinase FRK (EC 2.7.10.2) (B4DY49_HUMAN)
  • Protein-tyrosine kinase 5 (FRK_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P42685

UniProtKB/Swiss-Prot:

FRK_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with FRK: view

Function for FRK Gene

Molecular function for FRK Gene

UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-[protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.2; Evidence=. ;.

Enzyme Numbers (IUBMB) for FRK Gene

Phenotypes From GWAS Catalog for FRK Gene

Gene Ontology (GO) - Molecular Function for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity EXP 19345329
GO:0004715 non-membrane spanning protein tyrosine kinase activity TAS,IBA 21873635
GO:0005102 signaling receptor binding IBA 21873635
genes like me logo Genes that share ontologies with FRK: view
genes like me logo Genes that share phenotypes with FRK: view

Animal Models for FRK Gene

MGI Knock Outs for FRK:
  • Frk Frk<tm1Liu>

Animal Model Products

miRNA for FRK Gene

miRTarBase miRNAs that target FRK

Clone Products

  • Addgene plasmids for FRK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRK Gene

Localization for FRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRK Gene

Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRK gene
Compartment Confidence
nucleus 5
cytosol 5
plasma membrane 4
extracellular 4
lysosome 4
cytoskeleton 2
mitochondrion 2
endoplasmic reticulum 1
endosome 1
golgi apparatus 1
peroxisome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Cytosol (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular TAS 7510261
GO:0005634 nucleus TAS 7696183
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FRK: view

Pathways & Interactions for FRK Gene

PathCards logo

SuperPathways for FRK Gene

genes like me logo Genes that share pathways with FRK: view

Pathways by source for FRK Gene

Gene Ontology (GO) - Biological Process for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 12837246
GO:0006468 protein phosphorylation TAS 7696183
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA 21873635
GO:0008285 negative regulation of cell proliferation TAS 7664264
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with FRK: view

No data available for SIGNOR curated interactions for FRK Gene

Drugs & Compounds for FRK Gene

(6) Drugs for FRK Gene - From: DrugBank, DGIdb, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
regorafenib Approved Pharma Target, inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Dasatinib Approved, Investigational Pharma Target Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 319
fostamatinib Approved, Investigational Pharma Target, inhibitor Kinase Inhibitors 0
Zanubrutinib Approved, Investigational Pharma Target, inhibitor 29
ATP Investigational Nutra Agonist, Activator, Full agonist, Antagonist, Pore Blocker, Potentiation 0

(1) Additional Compounds for FRK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
Full agonist, Agonist, Partial agonist, Antagonist, Gating inhibitor 58-64-0
genes like me logo Genes that share compounds with FRK: view

Transcripts for FRK Gene

mRNA/cDNA for FRK Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

  • Addgene plasmids for FRK

Alternative Splicing Database (ASD) splice patterns (SP) for FRK Gene

No ASD Table

Relevant External Links for FRK Gene

GeneLoc Exon Structure for
FRK

Expression for FRK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRK Gene

This gene is overexpressed in Artery - Tibial (x4.2) and Artery - Coronary (x4.0).

Protein differential expression in normal tissues from HIPED for FRK Gene

This gene is overexpressed in Urine (31.9), Monocytes (23.7), and Lung (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FRK Gene



Protein tissue co-expression partners for FRK Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FRK

SOURCE GeneReport for Unigene cluster for FRK Gene:

Hs.89426

mRNA Expression by UniProt/SwissProt for FRK Gene:

P42685-FRK_HUMAN
Tissue specificity: Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.

Evidence on tissue expression from TISSUES for FRK Gene

  • Liver(4.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with FRK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FRK Gene

Orthologs for FRK Gene

This gene was present in the common ancestor of animals.

Orthologs for FRK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRK 31 30
  • 99.8 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FRK 31 30
  • 87.63 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Frk 17 31 30
  • 87.04 (n)
rat
(Rattus norvegicus)
Mammalia Frk 30
  • 85.38 (n)
oppossum
(Monodelphis domestica)
Mammalia FRK 31
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRK 31 30
  • 82.59 (n)
OneToOne
chicken
(Gallus gallus)
Aves FRK 31 30
  • 71.31 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FRK 31
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frk 30
  • 66.6 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC567549 30
  • 63.44 (n)
fynrk 31
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9440 30
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006270 30
  • 59.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta Src42A 31 30
  • 59.36 (n)
OneToOne
Src64B 32
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea src-2 31 30
  • 58.78 (n)
OneToOne
src-1 32
  • 44 (a)
T14E8.1b 32
  • 38 (a)
T14E8.1a 32
  • 38 (a)
R151.4 32
  • 38 (a)
C24G6.2b 32
  • 36 (a)
T21G5.1 32
  • 36 (a)
C24G6.2a 32
  • 36 (a)
C55C3.4 32
  • 33 (a)
C25A8.5 32
  • 33 (a)
C35E7.10a 32
  • 33 (a)
Y69E1A.3 32
  • 33 (a)
R11E3.1 32
  • 32 (a)
F59A3.8 32
  • 32 (a)
F23C8.7 32
  • 32 (a)
F57B9.8 32
  • 31 (a)
W01B6.5 32
  • 29 (a)
kin-26 32
  • 28 (a)
T25B9.4 32
  • 28 (a)
ZK593.9 32
  • 26 (a)
kin-24 32
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3054 31
  • 49 (a)
OneToOne
Cin.14575 30
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14575 30
Species where no ortholog for FRK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRK Gene

ENSEMBL:
Gene Tree for FRK (if available)
TreeFam:
Gene Tree for FRK (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FRK: view image

Paralogs for FRK Gene

genes like me logo Genes that share paralogs with FRK: view

Variants for FRK Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FRK Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs34064900 - p.Ser133Leu
rs34704018 - p.Ile100Val
rs3756772 - p.Gly122Arg

Additional dbSNP identifiers (rs#s) for FRK Gene

Structural Variations from Database of Genomic Variants (DGV) for FRK Gene

Variant ID Type Subtype PubMed ID
esv1229647 CNV deletion 17803354
esv1334759 CNV insertion 17803354
esv2528433 CNV insertion 19546169
esv2732603 CNV deletion 23290073
esv3370056 CNV duplication 20981092
esv3418241 CNV duplication 20981092
esv3610465 CNV loss 21293372
esv3610466 CNV loss 21293372
nsv1029998 CNV loss 25217958
nsv1116557 OTHER inversion 24896259
nsv1132007 CNV deletion 24896259
nsv1142641 CNV deletion 24896259
nsv1152770 CNV deletion 26484159
nsv523972 CNV gain 19592680
nsv958343 CNV deletion 24416366
nsv981177 CNV duplication 23825009

Variation tolerance for FRK Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.90; 91.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FRK Gene

Human Gene Mutation Database (HGMD)
FRK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRK

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRK Gene

Disorders for FRK Gene

MalaCards: The human disease database

(3) MalaCards diseases for FRK Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
alk-negative anaplastic large cell lymphoma
  • alk- alcl
liver benign neoplasm
  • epithelial hepatic and intrahepatic bile duct neoplasm
lung sarcoma
  • pulmonary sarcoma
- elite association - COSMIC cancer census association via MalaCards
Search FRK in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FRK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FRK: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FRK Gene

Publications for FRK Gene

  1. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene. (PMID: 7510261) Lee J … Scadden DT (Gene 1994) 2 3 4 23 54
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41 54
  3. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 41 54
  4. Rak functions as a tumor suppressor by regulating PTEN protein stability and function. (PMID: 19345329) Yim EK … Lin SY (Cancer cell 2009) 3 4 54
  5. RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. (PMID: 19652529) Brauer PM … Tyner AL (Cell cycle (Georgetown, Tex.) 2009) 4 23 54

Products for FRK Gene

  • Boster Bio Antibodies for FRK
  • Boster Bio ELISA Kits for FRK

Sources for FRK Gene