Aliases for FRK Gene
External Ids for FRK Gene
Previous HGNC Symbols for FRK Gene
Previous GeneCards Identifiers for FRK Gene
The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]
GeneCards Summary for FRK Gene
FRK (Fyn Related Src Family Tyrosine Kinase) is a Protein Coding gene. Diseases associated with FRK include Alk-Negative Anaplastic Large Cell Lymphoma and Liver Benign Neoplasm. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FYN.
UniProtKB/Swiss-Prot Summary for FRK Gene
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.