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Aliases for FRK Gene

Aliases for FRK Gene

  • Fyn Related Src Family Tyrosine Kinase 2 3 5
  • Nuclear Tyrosine Protein Kinase RAK 3 4
  • PTK5 Protein Tyrosine Kinase 5 2 3
  • Protein-Tyrosine Kinase 5 3 4
  • Fyn-Related Kinase 2 3
  • EC 2.7.10.2 4 56
  • PTK5 3 4
  • RAK 3 4
  • Fyn-Related Src Family Tyrosine Kinase 2
  • Tyrosine-Protein Kinase FRK 3
  • FYN-Related Kinase 4
  • EC 2.7.10 56
  • GTK 3

External Ids for FRK Gene

Previous HGNC Symbols for FRK Gene

  • PTK5

Previous GeneCards Identifiers for FRK Gene

  • GC06M116098
  • GC06M116285
  • GC06M116308
  • GC06M116369
  • GC06M113842

Summaries for FRK Gene

Entrez Gene Summary for FRK Gene

  • The protein encoded by this gene belongs to the TYR family of protein kinases. This tyrosine kinase is a nuclear protein and may function during G1 and S phase of the cell cycle and suppress growth. [provided by RefSeq, Jul 2008]

GeneCards Summary for FRK Gene

FRK (Fyn Related Src Family Tyrosine Kinase) is a Protein Coding gene. Among its related pathways are Innate Immune System. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FYN.

UniProtKB/Swiss-Prot for FRK Gene

  • Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on Tyr-336, which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Gene Wiki entry for FRK Gene

Additional gene information for FRK Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRK Gene

Genomics for FRK Gene

GeneHancer (GH) Regulatory Elements for FRK Gene

Promoters and enhancers for FRK Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06I116098 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 550.8 +0.1 78 4.7 HDGF PKNOX1 ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B NT5DC1 FRK KPNA5 COL10A1 TSPYL4 GC06M116078
GH06I116058 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 569.5 +40.2 40164 3.3 ATF1 FOXA2 ARID4B SIN3A DMAP1 YY1 SLC30A9 TCF12 ZNF766 ATF7 FRK NT5DC1 GC06M116052 GC06M116078
GH06I116015 Enhancer 0.9 Ensembl ENCODE 28.9 +84.0 83971 3.3 SOX13 PKNOX1 TFAP4 FOXA2 SAP130 EBF1 ZNF644 ETS1 RELA NFATC1 FRK NT5DC1 CALHM6 TPI1P3 PIR54414
GH06I116010 Enhancer 1.1 Ensembl ENCODE 17.9 +88.3 88306 3 FOXA2 SMAD1 ARID4B IRF4 YY1 ZNF143 ATF7 FOS RUNX3 RXRA FRK TPI1P3 PIR54414
GH06I116008 Enhancer 0.9 Ensembl ENCODE 17.8 +91.8 91802 1.6 MEIS2 ZNF687 PKNOX1 HLF TRIM22 CEBPG FEZF1 SP1 ZNF664 ATF3 FRK TPI1P3 PIR54414
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FRK on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FRK gene promoter:

Genomic Locations for FRK Gene

Genomic Locations for FRK Gene
chr6:115,931,149-116,100,728
(GRCh38/hg38)
Size:
169,580 bases
Orientation:
Minus strand
chr6:116,252,312-116,381,921
(GRCh37/hg19)

Genomic View for FRK Gene

Genes around FRK on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRK Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRK Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRK Gene

Proteins for FRK Gene

  • Protein details for FRK Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P42685-FRK_HUMAN
    Recommended name:
    Tyrosine-protein kinase FRK
    Protein Accession:
    P42685
    Secondary Accessions:
    • B4DY49
    • Q13128
    • Q9NTR5

    Protein attributes for FRK Gene

    Size:
    505 amino acids
    Molecular mass:
    58254 Da
    Quaternary structure:
    • Interacts (via the SH3-domain) with PTEN. Interacts with RB1.

    Alternative splice isoforms for FRK Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FRK Gene

Selected DME Specific Peptides for FRK Gene

P42685:
  • RDLAARN
  • KWTAPEA
  • IKSDVWSFGILL
  • FLIRESE
  • GQFGEVW
  • WEIDRNSI
  • GYIPSNYVA
  • AARNVLV
  • KSDVWSFG
  • PIYIITE

Post-translational modifications for FRK Gene

No Post-translational modifications

Domains & Families for FRK Gene

Gene Families for FRK Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • Enzymes
  • FDA approved drug targets
  • Plasma proteins
  • Predicted intracellular proteins

Suggested Antigen Peptide Sequences for FRK Gene

Graphical View of Domain Structure for InterPro Entry

P42685

UniProtKB/Swiss-Prot:

FRK_HUMAN :
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Family:
  • Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
genes like me logo Genes that share domains with FRK: view

Function for FRK Gene

Molecular function for FRK Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.
UniProtKB/Swiss-Prot Function:
Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on Tyr-336, which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor.

Enzyme Numbers (IUBMB) for FRK Gene

Phenotypes From GWAS Catalog for FRK Gene

Gene Ontology (GO) - Molecular Function for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004672 protein kinase activity IEA --
GO:0004713 protein tyrosine kinase activity EXP 19345329
GO:0004715 non-membrane spanning protein tyrosine kinase activity IBA,TAS --
GO:0005102 receptor binding IBA --
genes like me logo Genes that share ontologies with FRK: view
genes like me logo Genes that share phenotypes with FRK: view

Animal Models for FRK Gene

MGI Knock Outs for FRK:

miRNA for FRK Gene

miRTarBase miRNAs that target FRK

Clone Products

  • Addgene plasmids for FRK

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRK Gene

Localization for FRK Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRK Gene

Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRK gene
Compartment Confidence
extracellular 5
nucleus 5
cytosol 5
lysosome 4
plasma membrane 3
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005622 intracellular TAS 7510261
GO:0005634 nucleus TAS,IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with FRK: view

Pathways & Interactions for FRK Gene

genes like me logo Genes that share pathways with FRK: view

Pathways by source for FRK Gene

Gene Ontology (GO) - Biological Process for FRK Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IDA 12837246
GO:0006468 protein phosphorylation TAS 7696183
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway IBA --
GO:0008285 negative regulation of cell proliferation TAS 7664264
GO:0016310 phosphorylation IEA --
genes like me logo Genes that share ontologies with FRK: view

No data available for SIGNOR curated interactions for FRK Gene

Drugs & Compounds for FRK Gene

(6) Drugs for FRK Gene - From: DrugBank, DGIdb, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
regorafenib Approved Pharma Target, inhibitor Inhibitor of VEGFR/PDGFR/FGFR/mutant kit/RET/Raf-1, Kinase Inhibitors, Vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR) inhibitors 0
Dasatinib Approved, Investigational Pharma Target Kinase Inhibitors, SRC/BCR-ABL tyrosine kinase inhibitors 295
Sprycel Approved June 2006 Pharma 0
Stivarga Approved February 2013/ Approved September 2012 Pharma 0
ATP Investigational Nutra Agonist 0

(1) Additional Compounds for FRK Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
ADP
  • Adenosindiphosphorsaeure
  • Adenosine 5'-pyrophosphate
  • Adenosine diphosphate
  • Adenosine pyrophosphate
  • Adenosine-5'-diphosphate
Full agonist, Agonist 58-64-0
genes like me logo Genes that share compounds with FRK: view

Transcripts for FRK Gene

mRNA/cDNA for FRK Gene

(9) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(14) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRK Gene

Fyn-related kinase:
Representative Sequences:

Clone Products

  • Addgene plasmids for FRK

Alternative Splicing Database (ASD) splice patterns (SP) for FRK Gene

No ASD Table

Relevant External Links for FRK Gene

GeneLoc Exon Structure for
FRK
ECgene alternative splicing isoforms for
FRK

Expression for FRK Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRK Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRK Gene

This gene is overexpressed in Artery - Tibial (x4.2) and Artery - Coronary (x4.0).

Protein differential expression in normal tissues from HIPED for FRK Gene

This gene is overexpressed in Urine (31.9), Monocytes (23.7), and Lung (9.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FRK Gene



Protein tissue co-expression partners for FRK Gene

NURSA nuclear receptor signaling pathways regulating expression of FRK Gene:

FRK

SOURCE GeneReport for Unigene cluster for FRK Gene:

Hs.89426

mRNA Expression by UniProt/SwissProt for FRK Gene:

P42685-FRK_HUMAN
Tissue specificity: Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon.

Evidence on tissue expression from TISSUES for FRK Gene

  • Liver(4.3)
  • Kidney(2)
genes like me logo Genes that share expression patterns with FRK: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FRK Gene

Orthologs for FRK Gene

This gene was present in the common ancestor of animals.

Orthologs for FRK Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRK 33 34
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia FRK 33 34
  • 87.63 (n)
mouse
(Mus musculus)
Mammalia Frk 33 16 34
  • 87.04 (n)
rat
(Rattus norvegicus)
Mammalia Frk 33
  • 85.38 (n)
oppossum
(Monodelphis domestica)
Mammalia FRK 34
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FRK 33 34
  • 82.59 (n)
chicken
(Gallus gallus)
Aves FRK 33 34
  • 71.31 (n)
lizard
(Anolis carolinensis)
Reptilia FRK 34
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia frk 33
  • 66.6 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC567549 33
  • 63.44 (n)
fynrk 34
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.9440 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006270 33
  • 59.87 (n)
fruit fly
(Drosophila melanogaster)
Insecta Src42A 33 34
  • 59.36 (n)
Src64B 35
  • 48 (a)
worm
(Caenorhabditis elegans)
Secernentea src-2 33 34
  • 58.78 (n)
src-1 35
  • 44 (a)
R151.4 35
  • 38 (a)
T14E8.1a 35
  • 38 (a)
T14E8.1b 35
  • 38 (a)
C24G6.2a 35
  • 36 (a)
C24G6.2b 35
  • 36 (a)
T21G5.1 35
  • 36 (a)
C25A8.5 35
  • 33 (a)
C35E7.10a 35
  • 33 (a)
C55C3.4 35
  • 33 (a)
Y69E1A.3 35
  • 33 (a)
F23C8.7 35
  • 32 (a)
F59A3.8 35
  • 32 (a)
R11E3.1 35
  • 32 (a)
F57B9.8 35
  • 31 (a)
W01B6.5 35
  • 29 (a)
kin-26 35
  • 28 (a)
T25B9.4 35
  • 28 (a)
kin-24 35
  • 26 (a)
ZK593.9 35
  • 26 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3054 34
  • 49 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14575 33
Species where no ortholog for FRK was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FRK Gene

ENSEMBL:
Gene Tree for FRK (if available)
TreeFam:
Gene Tree for FRK (if available)

Paralogs for FRK Gene

Paralogs for FRK Gene

genes like me logo Genes that share paralogs with FRK: view

Variants for FRK Gene

Sequence variations from dbSNP and Humsavar for FRK Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000012783 -- 116,090,746(-) CCCCC/CCCCCC genic_upstream_transcript_variant, intron_variant
rs1000018695 -- 116,061,982(-) AAAGAAAGAAA/AAAGAAA genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000027326 -- 116,023,457(-) C/T intron_variant
rs1000100882 -- 116,022,183(-) C/A intron_variant
rs1000110943 -- 116,053,629(-) G/A/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FRK Gene

Variant ID Type Subtype PubMed ID
nsv981177 CNV duplication 23825009
nsv958343 CNV deletion 24416366
nsv523972 CNV gain 19592680
nsv1152770 CNV deletion 26484159
nsv1142641 CNV deletion 24896259
nsv1132007 CNV deletion 24896259
nsv1116557 OTHER inversion 24896259
nsv1029998 CNV loss 25217958
esv3610466 CNV loss 21293372
esv3610465 CNV loss 21293372
esv3418241 CNV duplication 20981092
esv3370056 CNV duplication 20981092
esv2732603 CNV deletion 23290073
esv2528433 CNV insertion 19546169
esv1334759 CNV insertion 17803354
esv1229647 CNV deletion 17803354

Variation tolerance for FRK Gene

Residual Variation Intolerance Score: 66.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.90; 91.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FRK Gene

Human Gene Mutation Database (HGMD)
FRK
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRK

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRK Gene

Disorders for FRK Gene

Additional Disease Information for FRK

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FRK Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRK Gene

Publications for FRK Gene

  1. Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene. (PMID: 7510261) Lee J … Scadden DT (Gene 1994) 2 3 4 22 58
  2. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 44 58
  3. Biological, clinical and population relevance of 95 loci for blood lipids. (PMID: 20686565) Teslovich TM … Kathiresan S (Nature 2010) 3 44 58
  4. RAKing in AKT: a tumor suppressor function for the intracellular tyrosine kinase FRK. (PMID: 19652529) Brauer PM … Tyner AL (Cell cycle (Georgetown, Tex.) 2009) 4 22 58
  5. Rak functions as a tumor suppressor by regulating PTEN protein stability and function. (PMID: 19345329) Yim EK … Lin SY (Cancer cell 2009) 3 4 58

Products for FRK Gene

Sources for FRK Gene

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