The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008] See more...

Aliases for FRAT2 Gene

Aliases for FRAT2 Gene

  • FRAT Regulator Of WNT Signaling Pathway 2 2 3 5
  • Frequently Rearranged In Advanced T-Cell Lymphomas 2 2 3 4
  • FRAT2, WNT Signaling Pathway Regulator 2 3
  • GSK-3-Binding Protein FRAT2 3 4
  • FRAT-2 3 4
  • GSK-3 Binding Protein FRAT2 2

External Ids for FRAT2 Gene

Previous GeneCards Identifiers for FRAT2 Gene

  • GC10M097985
  • GC10M098325
  • GC10M099223
  • GC10M098756
  • GC10M099082
  • GC10M092717

Summaries for FRAT2 Gene

Entrez Gene Summary for FRAT2 Gene

  • The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for FRAT2 Gene

FRAT2 (FRAT Regulator Of WNT Signaling Pathway 2) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and Gastric cancer. An important paralog of this gene is FRAT1.

UniProtKB/Swiss-Prot Summary for FRAT2 Gene

  • Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

Gene Wiki entry for FRAT2 Gene

Additional gene information for FRAT2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FRAT2 Gene

Genomics for FRAT2 Gene

GeneHancer (GH) Regulatory Elements for FRAT2 Gene

Promoters and enhancers for FRAT2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J097405 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 38.7 -72.8 -72790 3.7 ZNF217 CTCF ZSCAN5C SIN3A TCF12 USF1 TEAD4 TARDBP REST KLF4 piR-48759-035 FRAT2 RRP12 FRAT1 ARHGAP19 EXOSC1 ZDHHC16 UBTD1 MMS19 ENSG00000249967
GH10J097353 Enhancer 0.5 FANTOM5 dbSUPER 8 -19.4 -19438 0.2 CTCF RRP12 ARHGAP19 PI4K2A SLIT1 SLIT1-AS1 ENSG00000249967 HOGA1 C10orf62 FRAT1 FRAT2
GH10J097412 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 1.5 -79.3 -79338 3.1 ZBTB11 RFX1 JUN MYC TAF9B RBM25 NFRKB MBD2 WT1 MAFF lnc-EXOSC1-2 RRP12 EXOSC1 ZDHHC16 MMS19 UBTD1 PGAM1 LCOR ZFYVE27 ARHGAP19
GH10J097326 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 +2.0 2019 11.9 EP300 FOXK2 ZNF217 ZSCAN5C SIN3A TCF12 NRF1 MYC POLR2G SP1 ENSG00000225850 EXOSC1 R3HCC1L NPM1P26 MARVELD1 LOXL4 RPL13AP5 TM9SF3 SLIT1 ARHGAP19
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FRAT2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FRAT2

Top Transcription factor binding sites by QIAGEN in the FRAT2 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT3
  • Zic1

Genomic Locations for FRAT2 Gene

Genomic Locations for FRAT2 Gene
chr10:97,332,497-97,334,729
(GRCh38/hg38)
Size:
2,233 bases
Orientation:
Minus strand
chr10:99,092,254-99,094,458
(GRCh37/hg19)
Size:
2,205 bases
Orientation:
Minus strand

Genomic View for FRAT2 Gene

Genes around FRAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRAT2 Gene

Proteins for FRAT2 Gene

  • Protein details for FRAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O75474-FRAT2_HUMAN
    Recommended name:
    GSK-3-binding protein FRAT2
    Protein Accession:
    O75474
    Secondary Accessions:
    • Q5JTI0
    • Q8WUL9
    • Q9BYG2

    Protein attributes for FRAT2 Gene

    Size:
    233 amino acids
    Molecular mass:
    24051 Da
    Quaternary structure:
    • Binds GSK-3 and prevents GSK-3-dependent phosphorylation.

neXtProt entry for FRAT2 Gene

Post-translational modifications for FRAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRAT2 Gene

Domains & Families for FRAT2 Gene

Gene Families for FRAT2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FRAT2 Gene

Blocks:
  • Glycogen synthase kinase-3 binding protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FRAT2 Gene

GenScript: Design optimal peptide antigens:
  • Frequently rearranged in advanced T-cell lymphomas 2 (FRAT2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

O75474

UniProtKB/Swiss-Prot:

FRAT2_HUMAN :
  • Belongs to the GSK-3-binding protein family.
Family:
  • Belongs to the GSK-3-binding protein family.
genes like me logo Genes that share domains with FRAT2: view

Function for FRAT2 Gene

Molecular function for FRAT2 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

Phenotypes From GWAS Catalog for FRAT2 Gene

Gene Ontology (GO) - Molecular Function for FRAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FRAT2: view
genes like me logo Genes that share phenotypes with FRAT2: view

Animal Models for FRAT2 Gene

MGI Knock Outs for FRAT2:

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRAT2 Gene

Localization for FRAT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRAT2 gene
Compartment Confidence
cytosol 4
nucleus 3
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FRAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005737 cytoplasm IBA 21873635
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FRAT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FRAT2 Gene

Pathways & Interactions for FRAT2 Gene

genes like me logo Genes that share pathways with FRAT2: view

SIGNOR curated interactions for FRAT2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for FRAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development NAS 9635432
GO:0008283 cell proliferation NAS 9635432
GO:0016055 Wnt signaling pathway IEA --
GO:1904886 beta-catenin destruction complex disassembly TAS --
genes like me logo Genes that share ontologies with FRAT2: view

Drugs & Compounds for FRAT2 Gene

No Compound Related Data Available

Transcripts for FRAT2 Gene

mRNA/cDNA for FRAT2 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FRAT2 Gene

No ASD Table

Relevant External Links for FRAT2 Gene

GeneLoc Exon Structure for
FRAT2

Expression for FRAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FRAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRAT2 Gene

This gene is overexpressed in Whole Blood (x26.6).

Protein differential expression in normal tissues from HIPED for FRAT2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FRAT2 Gene



Protein tissue co-expression partners for FRAT2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FRAT2

SOURCE GeneReport for Unigene cluster for FRAT2 Gene:

Hs.140720

Evidence on tissue expression from TISSUES for FRAT2 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with FRAT2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRAT2 Gene

Orthologs for FRAT2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FRAT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRAT2 31 30
  • 98.86 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FRAT2 31 30
  • 83.33 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Frat2 17 31 30
  • 79.94 (n)
rat
(Rattus norvegicus)
Mammalia Frat2 30
  • 78.41 (n)
Species where no ortholog for FRAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FRAT2 Gene

ENSEMBL:
Gene Tree for FRAT2 (if available)
TreeFam:
Gene Tree for FRAT2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FRAT2: view image

Paralogs for FRAT2 Gene

Paralogs for FRAT2 Gene

(1) SIMAP similar genes for FRAT2 Gene using alignment to 1 proteins:

  • FRAT2_HUMAN
genes like me logo Genes that share paralogs with FRAT2: view

Variants for FRAT2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FRAT2 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
769784 Benign: not provided 97,334,326(-) C/T MISSENSE_VARIANT
783577 Benign: not provided 97,334,207(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for FRAT2 Gene

Structural Variations from Database of Genomic Variants (DGV) for FRAT2 Gene

Variant ID Type Subtype PubMed ID
dgv169n67 CNV gain 20364138
esv29863 CNV loss 19812545
nsv1110852 OTHER inversion 24896259
nsv831952 CNV loss 17160897

Variation tolerance for FRAT2 Gene

Gene Damage Index Score: 5.38; 71.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FRAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRAT2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRAT2 Gene

Disorders for FRAT2 Gene

Additional Disease Information for FRAT2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FRAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRAT2 Gene

Publications for FRAT2 Gene

  1. Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway. (PMID: 11237732) Saitoh T … Katoh M (Biochemical and biophysical research communications 2001) 2 3 4 54
  2. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. (PMID: 9635432) Yost C … Kimelman D (Cell 1998) 2 3 4 54
  3. Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. (PMID: 20613673) Lee DY … Kim JG (Menopause (New York, N.Y.) 2010) 3 41 54
  4. FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. (PMID: 15522877) Stoothoff WH … Johnson GV (The Journal of biological chemistry 2005) 3 23 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for FRAT2 Gene

Sources for FRAT2 Gene