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Aliases for FRAT2 Gene

Aliases for FRAT2 Gene

  • FRAT2, WNT Signaling Pathway Regulator 2 3 5
  • Frequently Rearranged In Advanced T-Cell Lymphomas 2 2 3 4
  • FRAT-2 3 4
  • GSK-3-Binding Protein FRAT2 3
  • GSK-3 Binding Protein FRAT2 2

External Ids for FRAT2 Gene

Previous GeneCards Identifiers for FRAT2 Gene

  • GC10M097985
  • GC10M098325
  • GC10M099223
  • GC10M098756
  • GC10M099082
  • GC10M092717

Summaries for FRAT2 Gene

Entrez Gene Summary for FRAT2 Gene

  • The protein encoded by this intronless gene belongs to the GSK-3-binding protein family. Studies show that this protein plays a role as a positive regulator of the WNT signaling pathway. It may be upregulated in tumor progression. [provided by RefSeq, Jul 2008]

GeneCards Summary for FRAT2 Gene

FRAT2 (FRAT2, WNT Signaling Pathway Regulator) is a Protein Coding gene. Among its related pathways are Signaling by Wnt and Gastric cancer. An important paralog of this gene is FRAT1.

UniProtKB/Swiss-Prot for FRAT2 Gene

  • Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

Gene Wiki entry for FRAT2 Gene

Additional gene information for FRAT2 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FRAT2 Gene

Genomics for FRAT2 Gene

GeneHancer (GH) Regulatory Elements for FRAT2 Gene

Promoters and enhancers for FRAT2 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J097331 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 650.7 +1.1 1059 4.9 HDGF CLOCK FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B FRAT2 LOC105378448 EXOSC1 NPM1P26 R3HCC1L RPL13AP5 ENSG00000230928 LOXL4 LCOR TM9SF3
GH10J097405 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 38.7 -72.8 -72779 3.8 HDGF MLX ARID4B SIN3A ZNF2 ZNF143 DEK MXD4 REST ZNF592 FRAT2 RRP12 FRAT1 ARHGAP19 ZDHHC16 EXOSC1 MMS19 UBTD1 ENSG00000249967 HOGA1
GH10J097353 Enhancer 0.8 FANTOM5 Ensembl dbSUPER 8 -19.5 -19492 1.6 CTCF RRP12 ARHGAP19 PI4K2A SLIT1 SLIT1-AS1 ENSG00000249967 HOGA1 C10orf62 FRAT1 FRAT2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FRAT2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FRAT2 gene promoter:
  • HNF-4alpha1
  • Zic1
  • STAT1beta
  • STAT1alpha
  • STAT1
  • STAT3
  • COUP
  • COUP-TF1

Genomic Locations for FRAT2 Gene

Genomic Locations for FRAT2 Gene
2,213 bases
Minus strand
2,205 bases
Minus strand

Genomic View for FRAT2 Gene

Genes around FRAT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRAT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRAT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRAT2 Gene

Proteins for FRAT2 Gene

  • Protein details for FRAT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    GSK-3-binding protein FRAT2
    Protein Accession:
    Secondary Accessions:
    • Q5JTI0
    • Q8WUL9
    • Q9BYG2

    Protein attributes for FRAT2 Gene

    233 amino acids
    Molecular mass:
    24051 Da
    Quaternary structure:
    • Binds GSK-3 and prevents GSK-3-dependent phosphorylation.

neXtProt entry for FRAT2 Gene

Post-translational modifications for FRAT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FRAT2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRAT2 Gene

Domains & Families for FRAT2 Gene

Gene Families for FRAT2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FRAT2 Gene

Suggested Antigen Peptide Sequences for FRAT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the GSK-3-binding protein family.
  • Belongs to the GSK-3-binding protein family.
genes like me logo Genes that share domains with FRAT2: view

Function for FRAT2 Gene

Molecular function for FRAT2 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3.

Phenotypes From GWAS Catalog for FRAT2 Gene

Gene Ontology (GO) - Molecular Function for FRAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with FRAT2: view
genes like me logo Genes that share phenotypes with FRAT2: view

Animal Models for FRAT2 Gene

MGI Knock Outs for FRAT2:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRAT2 Gene

Localization for FRAT2 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRAT2 gene
Compartment Confidence
cytosol 5
nucleus 3
mitochondrion 2
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FRAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FRAT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for FRAT2 Gene

Pathways & Interactions for FRAT2 Gene

genes like me logo Genes that share pathways with FRAT2: view

Gene Ontology (GO) - Biological Process for FRAT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development NAS 9635432
GO:0008283 cell proliferation NAS 9635432
GO:0016055 Wnt signaling pathway IEA --
GO:1904886 beta-catenin destruction complex disassembly TAS --
genes like me logo Genes that share ontologies with FRAT2: view

No data available for SIGNOR curated interactions for FRAT2 Gene

Drugs & Compounds for FRAT2 Gene

No Compound Related Data Available

Transcripts for FRAT2 Gene

mRNA/cDNA for FRAT2 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(70) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FRAT2 Gene

Frequently rearranged in advanced T-cell lymphomas 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRAT2 Gene

No ASD Table

Relevant External Links for FRAT2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FRAT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRAT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRAT2 Gene

This gene is overexpressed in Whole Blood (x26.6).

Protein differential expression in normal tissues from HIPED for FRAT2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FRAT2 Gene

Protein tissue co-expression partners for FRAT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FRAT2 Gene:


SOURCE GeneReport for Unigene cluster for FRAT2 Gene:


Evidence on tissue expression from TISSUES for FRAT2 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with FRAT2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRAT2 Gene

Orthologs for FRAT2 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FRAT2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FRAT2 34 33
  • 98.86 (n)
(Bos Taurus)
Mammalia FRAT2 34 33
  • 83.33 (n)
(Mus musculus)
Mammalia Frat2 16 34 33
  • 79.94 (n)
(Rattus norvegicus)
Mammalia Frat2 33
  • 78.41 (n)
Species where no ortholog for FRAT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FRAT2 Gene

Gene Tree for FRAT2 (if available)
Gene Tree for FRAT2 (if available)
Evolutionary constrained regions (ECRs) for FRAT2: view image

Paralogs for FRAT2 Gene

Paralogs for FRAT2 Gene

(1) SIMAP similar genes for FRAT2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FRAT2: view

Variants for FRAT2 Gene

Sequence variations from dbSNP and Humsavar for FRAT2 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000163584 -- 97,335,157(-) G/A upstream_transcript_variant
rs1002266811 -- 97,332,808(-) C/G/T 3_prime_UTR_variant
rs1002299431 -- 97,332,514(-) A/G 3_prime_UTR_variant
rs1002726820 -- 97,334,336(-) C/A coding_sequence_variant, synonymous_variant
rs1003082835 -- 97,334,144(-) C/G coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for FRAT2 Gene

Variant ID Type Subtype PubMed ID
dgv169n67 CNV gain 20364138
esv29863 CNV loss 19812545
nsv1110852 OTHER inversion 24896259
nsv831952 CNV loss 17160897

Variation tolerance for FRAT2 Gene

Gene Damage Index Score: 5.38; 71.05% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FRAT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRAT2 Gene

Disorders for FRAT2 Gene

Additional Disease Information for FRAT2

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FRAT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRAT2 Gene

Publications for FRAT2 Gene

  1. Molecular cloning and characterization of FRAT2, encoding a positive regulator of the WNT signaling pathway. (PMID: 11237732) Saitoh T … Katoh M (Biochemical and biophysical research communications 2001) 2 3 4 58
  2. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. (PMID: 9635432) Yost C … Kimelman D (Cell 1998) 2 3 4 58
  3. Association between polymorphisms in Wnt signaling pathway genes and bone mineral density in postmenopausal Korean women. (PMID: 20613673) Lee DY … Kim JG (Menopause (New York, N.Y.) 2010) 3 44 58
  4. FRAT-2 preferentially increases glycogen synthase kinase 3 beta-mediated phosphorylation of primed sites, which results in enhanced tau phosphorylation. (PMID: 15522877) Stoothoff WH … Johnson GV (The Journal of biological chemistry 2005) 3 22 58
  5. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 58

Products for FRAT2 Gene

Sources for FRAT2 Gene

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