Aliases for FRAT1 Gene
External Ids for FRAT1 Gene
Previous GeneCards Identifiers for FRAT1 Gene
The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]
GeneCards Summary for FRAT1 Gene
FRAT1 (FRAT Regulator Of WNT Signaling Pathway 1) is a Protein Coding gene. Diseases associated with FRAT1 include T-Cell Lymphoma, Subcutaneous Panniculitis-Like and Hepatocellular Carcinoma. Among its related pathways are Signaling by Wnt and Gastric cancer. An important paralog of this gene is FRAT2.
UniProtKB/Swiss-Prot Summary for FRAT1 Gene
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.