The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008] See more...

Aliases for FRAT1 Gene

Aliases for FRAT1 Gene

  • FRAT Regulator Of WNT Signaling Pathway 1 2 3 5
  • Frequently Rearranged In Advanced T-Cell Lymphomas 1 2 3 4
  • FRAT1, WNT Signaling Pathway Regulator 2 3
  • Proto-Oncogene FRAT1 3 4
  • FRAT-1 3 4
  • Frequently Rearranged In Advanced T-Cell Lymphomas 2

External Ids for FRAT1 Gene

Previous GeneCards Identifiers for FRAT1 Gene

  • GC10P097972
  • GC10P098312
  • GC10P099210
  • GC10P098743
  • GC10P099069
  • GC10P092704

Summaries for FRAT1 Gene

Entrez Gene Summary for FRAT1 Gene

  • The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]

GeneCards Summary for FRAT1 Gene

FRAT1 (FRAT Regulator Of WNT Signaling Pathway 1) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Wnt Signaling Pathway Netpath. An important paralog of this gene is FRAT2.

UniProtKB/Swiss-Prot Summary for FRAT1 Gene

  • Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.

Gene Wiki entry for FRAT1 Gene

Additional gene information for FRAT1 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FRAT1 Gene

Genomics for FRAT1 Gene

GeneHancer (GH) Regulatory Elements for FRAT1 Gene

Promoters and enhancers for FRAT1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J097318 Promoter/Enhancer 1.9 Ensembl ENCODE CraniofacialAtlas dbSUPER 750.6 +0.7 736 4.4 FOXK2 SIN3A SP1 ZBTB40 SREBF1 ZBTB6 RBPJ SMARCE1 POLR2A ATF1 FRAT1 lnc-PGAM1-4 RPL13AP5 MMS19 ARHGAP19 NPM1P26 MORN4 SLIT1 EXOSC1 ENSG00000230928
GH10J097405 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.3 +88.3 88254 3.7 CTCF RBPJ CTBP1 USF2 NR2F1 NR2F6 CREB1 MYC CC2D1A L3MBTL2 piR-48759-035 FRAT2 RRP12 FRAT1 ARHGAP19 MARVELD1 ZDHHC16 EXOSC1 MMS19 UBTD1
GH10J097569 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 5.1 +254.0 253956 6.5 SIN3A CTCF FOXA1 ZNF217 MYC RAD21 MAX MNT MTA3 NFIB ANKRD2 MORN4 PI4K2A HOGA1 FRAT1 SLIT1 UBTD1 RRP12 piR-54671 L13712-002
GH10J096862 Enhancer 1.1 Ensembl ENCODE 5.1 -454.9 -454883 4.4 SIN3A ZNF24 LCORL MLX RBPJ SMARCE1 NR2F6 ATF1 ZNF217 CREB1 MMS19 LCOR MIR607 ZNF518A FRAT1 RF00017-759 lnc-FRAT1-7
GH10J096889 Enhancer 0.9 Ensembl ENCODE 5.3 -429.0 -429030 2.5 CREB1 MIXL1 HLF TFE3 PPARG ZNF384 CEBPA GATAD2A RXRB FOXA2 LCOR MIR607 PIK3AP1 FRAT1 lnc-FRAT1-7 RF00017-759
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FRAT1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FRAT1 gene promoter:
  • Bach2
  • Cart-1
  • E47
  • FOXJ2
  • FOXJ2 (long isoform)
  • Hand1
  • HNF-4alpha1
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • POU3F2 (N-Oct-5b)

Genomic Locations for FRAT1 Gene

Genomic Locations for FRAT1 Gene
chr10:97,319,265-97,321,915
(GRCh38/hg38)
Size:
2,651 bases
Orientation:
Plus strand
chr10:99,079,022-99,081,672
(GRCh37/hg19)
Size:
2,651 bases
Orientation:
Plus strand

Genomic View for FRAT1 Gene

Genes around FRAT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FRAT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FRAT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FRAT1 Gene

Proteins for FRAT1 Gene

  • Protein details for FRAT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92837-FRAT1_HUMAN
    Recommended name:
    Proto-oncogene FRAT1
    Protein Accession:
    Q92837
    Secondary Accessions:
    • Q5JTI1
    • Q8NE74
    • Q8TDW9

    Protein attributes for FRAT1 Gene

    Size:
    279 amino acids
    Molecular mass:
    29093 Da
    Quaternary structure:
    • Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation.

    Three dimensional structures from OCA and Proteopedia for FRAT1 Gene

neXtProt entry for FRAT1 Gene

Post-translational modifications for FRAT1 Gene

Other Protein References for FRAT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FRAT1 Gene

Domains & Families for FRAT1 Gene

Gene Families for FRAT1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FRAT1 Gene

Suggested Antigen Peptide Sequences for FRAT1 Gene

GenScript: Design optimal peptide antigens:
  • Frequently rearranged in advanced T-cell lymphomas, isoform CRA_a (D3DR49_HUMAN)
  • Frequently rearranged in advanced T-cell lymphomas 1 (FRAT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q92837

UniProtKB/Swiss-Prot:

FRAT1_HUMAN :
  • Belongs to the GSK-3-binding protein family.
Family:
  • Belongs to the GSK-3-binding protein family.
genes like me logo Genes that share domains with FRAT1: view

Function for FRAT1 Gene

Molecular function for FRAT1 Gene

UniProtKB/Swiss-Prot Function:
Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.

Phenotypes From GWAS Catalog for FRAT1 Gene

Gene Ontology (GO) - Molecular Function for FRAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 10481074
genes like me logo Genes that share ontologies with FRAT1: view
genes like me logo Genes that share phenotypes with FRAT1: view

Animal Models for FRAT1 Gene

MGI Knock Outs for FRAT1:

Animal Model Products

CRISPR Products

miRNA for FRAT1 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FRAT1 Gene

Localization for FRAT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FRAT1 Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FRAT1 gene
Compartment Confidence
cytosol 4
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FRAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 12556519
GO:0005829 cytosol TAS --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FRAT1: view

Pathways & Interactions for FRAT1 Gene

genes like me logo Genes that share pathways with FRAT1: view

SIGNOR curated interactions for FRAT1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FRAT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016055 Wnt signaling pathway IEA --
GO:0060070 canonical Wnt signaling pathway IGI 12556519
GO:0090263 positive regulation of canonical Wnt signaling pathway IGI 12556519
GO:1904886 beta-catenin destruction complex disassembly TAS --
genes like me logo Genes that share ontologies with FRAT1: view

Drugs & Compounds for FRAT1 Gene

(1) Additional Compounds for FRAT1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FRAT1: view

Transcripts for FRAT1 Gene

mRNA/cDNA for FRAT1 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(44) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FRAT1 Gene

No ASD Table

Relevant External Links for FRAT1 Gene

GeneLoc Exon Structure for
FRAT1
ECgene alternative splicing isoforms for
FRAT1

Expression for FRAT1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FRAT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FRAT1 Gene

This gene is overexpressed in Whole Blood (x22.9).

Protein differential expression in normal tissues from HIPED for FRAT1 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FRAT1 Gene



Protein tissue co-expression partners for FRAT1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FRAT1 Gene:

FRAT1

SOURCE GeneReport for Unigene cluster for FRAT1 Gene:

Hs.126057

Evidence on tissue expression from TISSUES for FRAT1 Gene

  • Lung(4.2)
genes like me logo Genes that share expression patterns with FRAT1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FRAT1 Gene

Orthologs for FRAT1 Gene

This gene was present in the common ancestor of mammals.

Orthologs for FRAT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FRAT1 33 32
  • 99.64 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FRAT1 33 32
  • 86.47 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FRAT1 32
  • 85.42 (n)
mouse
(Mus musculus)
Mammalia Frat1 17 32
  • 82.35 (n)
Peg12 33
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Peg12 32
  • 78.92 (n)
Species where no ortholog for FRAT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for FRAT1 Gene

ENSEMBL:
Gene Tree for FRAT1 (if available)
TreeFam:
Gene Tree for FRAT1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FRAT1: view image

Paralogs for FRAT1 Gene

Paralogs for FRAT1 Gene

(1) SIMAP similar genes for FRAT1 Gene using alignment to 2 proteins:

  • FRAT1_HUMAN
  • D3DR49_HUMAN
genes like me logo Genes that share paralogs with FRAT1: view

Variants for FRAT1 Gene

Sequence variations from dbSNP and Humsavar for FRAT1 Gene

SNP ID Clin Chr 10 pos Variation AA Info Type
rs1000145657 -- 97,321,957(+) T/C downstream_transcript_variant
rs1000157063 -- 97,321,646(+) A/G 3_prime_UTR_variant
rs1001935435 -- 97,320,796(+) C/A 3_prime_UTR_variant
rs1002458847 -- 97,317,679(+) C/T upstream_transcript_variant
rs1002617535 -- 97,317,936(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FRAT1 Gene

Variant ID Type Subtype PubMed ID
dgv169n67 CNV gain 20364138
nsv1110852 OTHER inversion 24896259
nsv831952 CNV loss 17160897

Variation tolerance for FRAT1 Gene

Gene Damage Index Score: 0.54; 11.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FRAT1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FRAT1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FRAT1 Gene

Disorders for FRAT1 Gene

Additional Disease Information for FRAT1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FRAT1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FRAT1 Gene

Publications for FRAT1 Gene

  1. Activation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas. (PMID: 9034327) Jonkers J … Berns A (The EMBO journal 1997) 2 3 4 23 56
  2. Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin. (PMID: 12556519) Hino S … Kikuchi A (The Journal of biological chemistry 2003) 3 4 23 56
  3. Molecular cloning and expression of proto-oncogene FRAT1 in human cancer. (PMID: 11894125) Saitoh T … Katoh M (International journal of oncology 2002) 3 4 23 56
  4. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A … Goate A (American journal of human genetics 2006) 3 43 56
  5. FRAT1, a substrate-specific regulator of glycogen synthase kinase-3 activity, is a cellular substrate of protein kinase A. (PMID: 16982607) Hagen T … Reith AD (The Journal of biological chemistry 2006) 3 23 56

Products for FRAT1 Gene

Sources for FRAT1 Gene