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FPR3 (Formyl Peptide Receptor 3) is a Protein Coding gene. Diseases associated with FPR3 include Rubeosis Iridis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR2.
The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0004875 | complement receptor activity | IBA | 21873635 |
GO:0004930 | G protein-coupled receptor activity | IBA | 21873635 |
GO:0004982 | N-formyl peptide receptor activity | TAS,IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005886 | plasma membrane | TAS | -- |
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | TAS,IEA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Peptide ligand-binding receptors |
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2 | Signaling by GPCR | ||
3 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
4 | Staphylococcus aureus infection | ||
5 | fMLP Pathway |
fMLP Pathway
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GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0002430 | complement receptor mediated signaling pathway | IBA | 21873635 |
GO:0006935 | chemotaxis | IEA | -- |
GO:0006954 | inflammatory response | IBA | 21873635 |
GO:0007165 | signal transduction | TAS | 8198572 |
GO:0007186 | G protein-coupled receptor signaling pathway | TAS | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
WKYMVM | Pharma | Agonist, Full agonist | Selective FPR2 and FPR3 receptor agonist | 0 | ||
FPR A14 | Pharma | FPR agonist | 0 | |||
MMK 1 | Pharma | Potent and selective FPR2 agonist | 0 | |||
N-Formyl-Met-Leu-Phe | Pharma | Endogenous FPR1 agonist | 0 | |||
annexin I-(2-26) | Pharma | Agonist, Full agonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
Compound | Action | Cas Number |
---|---|---|
FPR A14 | FPR agonist | 329691-12-5 |
MMK 1 | Potent and selective FPR2 agonist | 271246-66-3 |
N-Formyl-Met-Leu-Phe | Endogenous FPR1 agonist | 59880-97-6 |
WKYMVM | Selective FPR2 and FPR3 receptor agonist | 187986-11-4 |
Compound | Action | Cas Number |
---|---|---|
Ac9-25 | 284040-76-2 | |
Boc-MLF | 67247-12-5 | |
Cyclosporin H | Selective and competitive formyl peptide receptor antagonist | 83602-39-5 |
FPR A14 | 329691-12-5 | |
MMK 1 | 271246-66-3 | |
N-Formyl-Met-Leu-Phe | 59880-97-6 | |
PBP 10 | 794466-43-6 | |
WKYMVM | 187986-11-4 | |
WRW4 | 878557-55-2 |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FPR3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fpr-rs4 31 |
|
OneToMany | |
Fpr-rs3 31 |
|
OneToMany | |||
Fpr-rs6 31 |
|
OneToMany | |||
Fpr-rs7 31 |
|
OneToMany | |||
Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
-- 31 |
|
ManyToMany | |||
Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
Zebrafish (Danio rerio) |
Actinopterygii | BX649278.1 31 |
|
ManyToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv1067e212 | CNV | gain | 25503493 |
dgv143e55 | CNV | gain | 17911159 |
dgv3625n100 | CNV | gain | 25217958 |
dgv3626n100 | CNV | gain | 25217958 |
dgv425n27 | CNV | gain | 19166990 |
dgv6523n54 | CNV | gain | 21841781 |
esv2758767 | CNV | gain+loss | 17122850 |
esv3644680 | CNV | gain | 21293372 |
nsv1140251 | OTHER | inversion | 24896259 |
nsv458733 | CNV | gain | 19166990 |
nsv470151 | CNV | gain | 18288195 |
nsv524403 | CNV | gain | 19592680 |
nsv579997 | CNV | gain | 21841781 |
nsv580001 | CNV | gain | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
rubeosis iridis |
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