Aliases for FPR3 Gene

Aliases for FPR3 Gene

  • Formyl Peptide Receptor 3 2 3 5
  • Formyl Peptide Receptor-Like 2 2 3 4
  • FPRH1 2 3 4
  • N-Formyl Peptide Receptor 3 3 4
  • FMLP-Related Receptor II 3 4
  • FMLP-R-II 3 4
  • RMLP-R-I 2 3
  • FMLPY 2 3
  • FPRL2 3 4
  • FML2_HUMAN 3
  • FPRH2 3
  • FPR3 5

External Ids for FPR3 Gene

Previous HGNC Symbols for FPR3 Gene

  • FPRL2

Previous GeneCards Identifiers for FPR3 Gene

  • GC19P056992
  • GC19P052298
  • GC19P048629

Summaries for FPR3 Gene

GeneCards Summary for FPR3 Gene

FPR3 (Formyl Peptide Receptor 3) is a Protein Coding gene. Diseases associated with FPR3 include Rubeosis Iridis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot Summary for FPR3 Gene

  • Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Tocris Summary for FPR3 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.

Gene Wiki entry for FPR3 Gene

Additional gene information for FPR3 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FPR3 Gene

Genomics for FPR3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FPR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051798 Promoter/Enhancer 2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 610.9 +4.5 4469 3 RFX1 LEF1 IKZF1 JUND MTA2 MTA1 NR2C1 ZNF24 ZNF740 SP1 FPR3 ZNF808 ZNF841 SIGLEC14 ZNF649 SIGLEC8 FPR1 ZNF350 SIGLEC6 FPR2
GH19J051796 Promoter/Enhancer 1.5 FANTOM5 Ensembl dbSUPER 642.6 +1.1 1144 1.4 LEF1 IKZF1 JUND DDX20 MTA2 PKNOX1 MTA1 BRD9 ZNF24 DPF2 FPR3 SIGLEC6 SIGLEC14 ZNF350 SIGLEC10 FPR1 SIGLEC12 FPR2
GH19J051795 Promoter/Enhancer 0.8 EPDnew dbSUPER 600.7 0.0 -18 0.1 PKNOX1 GATA3 ZNF384 ADNP MEIS2 ZNF184 FPR3 FPR1 lnc-FPR3-1 FPR2
GH19J051792 Enhancer 0.6 dbSUPER 638.9 -1.8 -1762 1.6 PKNOX1 CBX3 HDAC2 BCOR TAL1 ATF3 TCF12 ZEB2 MEIS2 ZMYM3 FPR3 KLK8 lnc-FPR3-1 FPR1 FPR2
GH19J051803 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.5 +10.9 10942 5.6 CREB1 GATAD2A TFE3 LEF1 SOX13 IKZF1 FOXA1 MTA2 PKNOX1 RXRB FPR1 piR-37044 SIGLEC14 FPR3 SIGLEC8 RPL7P51 SIGLEC5 ZNF577 ENSG00000269483 ZNF766
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FPR3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FPR3

Top Transcription factor binding sites by QIAGEN in the FPR3 gene promoter:
  • ATF

Genomic Locations for FPR3 Gene

Genomic Locations for FPR3 Gene
chr19:51,795,157-51,826,207
(GRCh38/hg38)
Size:
31,051 bases
Orientation:
Plus strand
chr19:52,298,411-52,329,442
(GRCh37/hg19)
Size:
31,032 bases
Orientation:
Plus strand

Genomic View for FPR3 Gene

Genes around FPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR3 Gene

Proteins for FPR3 Gene

  • Protein details for FPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25089-FPR3_HUMAN
    Recommended name:
    N-formyl peptide receptor 3
    Protein Accession:
    P25089

    Protein attributes for FPR3 Gene

    Size:
    353 amino acids
    Molecular mass:
    39965 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FPR3 Gene

Post-translational modifications for FPR3 Gene

  • Glycosylation at Asn4 and Asn10
  • Modification sites at PhosphoSitePlus

Other Protein References for FPR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FPR3 Gene

Domains & Families for FPR3 Gene

Gene Families for FPR3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for FPR3 Gene

InterPro:
Blocks:
  • Formyl-methionyl peptide receptor signature
ProtoNet:

Suggested Antigen Peptide Sequences for FPR3 Gene

GenScript: Design optimal peptide antigens:
  • Formyl peptide receptor-like 2 (FPR3_HUMAN)
  • cDNA FLJ77388, highly similar to Homo sapiens formyl peptide receptor-like 2 (FPRL2), mRNA (Q6L5J4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25089

UniProtKB/Swiss-Prot:

FPR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FPR3: view

Function for FPR3 Gene

Molecular function for FPR3 Gene

UniProtKB/Swiss-Prot Function:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Phenotypes From GWAS Catalog for FPR3 Gene

Gene Ontology (GO) - Molecular Function for FPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004875 complement receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IBA 21873635
GO:0004982 N-formyl peptide receptor activity TAS,IBA 21873635
genes like me logo Genes that share ontologies with FPR3: view
genes like me logo Genes that share phenotypes with FPR3: view

Animal Model Products

CRISPR Products

miRNA for FPR3 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FPR3 Gene

Localization for FPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR3 Gene

Cell membrane. Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FPR3 gene
Compartment Confidence
plasma membrane 5
extracellular 2
mitochondrion 2
nucleus 2
cytosol 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS,IEA --
genes like me logo Genes that share ontologies with FPR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FPR3 Gene

Pathways & Interactions for FPR3 Gene

genes like me logo Genes that share pathways with FPR3: view

Pathways by source for FPR3 Gene

2 Qiagen pathways for FPR3 Gene
  • fMLP Pathway
  • Transendothelial Migration of Leukocytes

SIGNOR curated interactions for FPR3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for FPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002430 complement receptor mediated signaling pathway IBA 21873635
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction TAS 8198572
GO:0007186 G protein-coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FPR3: view

Drugs & Compounds for FPR3 Gene

(17) Drugs for FPR3 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
WKYMVM Pharma Agonist, Full agonist Selective FPR2 and FPR3 receptor agonist 0
FPR A14 Pharma FPR agonist 0
MMK 1 Pharma Potent and selective FPR2 agonist 0
N-Formyl-Met-Leu-Phe Pharma Endogenous FPR1 agonist 0
annexin I-(2-26) Pharma Agonist, Full agonist 0

(1) Additional Compounds for FPR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for FPR3 Gene

Compound Action Cas Number
FPR A14 FPR agonist 329691-12-5
MMK 1 Potent and selective FPR2 agonist 271246-66-3
N-Formyl-Met-Leu-Phe Endogenous FPR1 agonist 59880-97-6
WKYMVM Selective FPR2 and FPR3 receptor agonist 187986-11-4

(9) ApexBio Compounds for FPR3 Gene

Compound Action Cas Number
Ac9-25 284040-76-2
Boc-MLF 67247-12-5
Cyclosporin H Selective and competitive formyl peptide receptor antagonist 83602-39-5
FPR A14 329691-12-5
MMK 1 271246-66-3
N-Formyl-Met-Leu-Phe 59880-97-6
PBP 10 794466-43-6
WKYMVM 187986-11-4
WRW4 878557-55-2
genes like me logo Genes that share compounds with FPR3: view

Drug Products

Transcripts for FPR3 Gene

mRNA/cDNA for FPR3 Gene

1 REFSEQ mRNAs :
10 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPR3

Alternative Splicing Database (ASD) splice patterns (SP) for FPR3 Gene

No ASD Table

Relevant External Links for FPR3 Gene

GeneLoc Exon Structure for
FPR3

Expression for FPR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FPR3 Gene

mRNA differential expression in normal tissues according to GTEx for FPR3 Gene

This gene is overexpressed in Lung (x4.7).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FPR3

SOURCE GeneReport for Unigene cluster for FPR3 Gene:

Hs.445466

Evidence on tissue expression from TISSUES for FPR3 Gene

  • Lung(2.6)
  • Spleen(2.5)
  • Intestine(2.4)
  • Lymph node(2.4)
  • Blood(2.3)
  • Heart(2.3)
  • Nervous system(2.2)
  • Liver(2.1)
genes like me logo Genes that share expression patterns with FPR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FPR3 Gene

Orthologs for FPR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FPR3 30 31
  • 99.62 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fpr-rs4 31
  • 59 (a)
OneToMany
Fpr-rs3 31
  • 57 (a)
OneToMany
Fpr-rs6 31
  • 54 (a)
OneToMany
Fpr-rs7 31
  • 54 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 44 (a)
ManyToMany
-- 31
  • 40 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 31
  • 32 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii BX649278.1 31
  • 17 (a)
ManyToMany
Species where no ortholog for FPR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FPR3 Gene

ENSEMBL:
Gene Tree for FPR3 (if available)
TreeFam:
Gene Tree for FPR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FPR3: view image

Paralogs for FPR3 Gene

Paralogs for FPR3 Gene

(17) SIMAP similar genes for FPR3 Gene using alignment to 1 proteins:

  • FPR3_HUMAN
genes like me logo Genes that share paralogs with FPR3: view

Variants for FPR3 Gene

Additional dbSNP identifiers (rs#s) for FPR3 Gene

Structural Variations from Database of Genomic Variants (DGV) for FPR3 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3625n100 CNV gain 25217958
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3644680 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv458733 CNV gain 19166990
nsv470151 CNV gain 18288195
nsv524403 CNV gain 19592680
nsv579997 CNV gain 21841781
nsv580001 CNV gain 21841781

Variation tolerance for FPR3 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FPR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FPR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FPR3 Gene

Disorders for FPR3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FPR3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rubeosis iridis
- elite association - COSMIC cancer census association via MalaCards
Search FPR3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FPR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FPR3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FPR3 Gene

Publications for FPR3 Gene

  1. Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes. (PMID: 8198572) Durstin M … Murphy PM (Biochemical and biophysical research communications 1994) 2 3 4
  2. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PMID: 1612600) Bao L … Gerard C (Genomics 1992) 2 3 4
  3. Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils. (PMID: 19342677) Devosse T … Parmentier M (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 23
  4. The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2. (PMID: 16002663) Kang HK … Bae YS (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 23
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4

Products for FPR3 Gene

Sources for FPR3 Gene