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Aliases for FPR3 Gene

Aliases for FPR3 Gene

  • Formyl Peptide Receptor 3 2 3 5
  • Formyl Peptide Receptor-Like 2 2 3 4
  • FMLP-Related Receptor II 3 4
  • FMLP-R-II 3 4
  • FPRL2 3 4
  • FPRH1 3 4
  • N-Formyl Peptide Receptor 3 3
  • FML2_HUMAN 3
  • RMLP-R-I 3
  • FMLPY 3
  • FPRH2 3

External Ids for FPR3 Gene

Previous HGNC Symbols for FPR3 Gene

  • FPRL2

Previous GeneCards Identifiers for FPR3 Gene

  • GC19P056992
  • GC19P052298
  • GC19P048629

Summaries for FPR3 Gene

GeneCards Summary for FPR3 Gene

FPR3 (Formyl Peptide Receptor 3) is a Protein Coding gene. Among its related pathways are Peptide ligand-binding receptors and fMLP Pathway. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot for FPR3 Gene

  • Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Tocris Summary for FPR3 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.

Gene Wiki entry for FPR3 Gene

Additional gene information for FPR3 Gene

No data available for Entrez Gene Summary , CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPR3 Gene

Genomics for FPR3 Gene

GeneHancer (GH) Regulatory Elements for FPR3 Gene

Promoters and enhancers for FPR3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051798 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 661 +4.5 4468 3 SMAD1 ATF1 ARNT NCOA2 YY1 TCF12 ZNF766 GATA2 FOS ATF7 FPR3 SIGLEC14 ZNF649 SIGLEC8 FPR1 ZNF350 SIGLEC6 FPR2 SIGLEC12 SIGLEC10
GH19J051796 Enhancer 1.2 FANTOM5 dbSUPER 692.7 +1.2 1184 0.4 PKNOX1 SMAD1 ATF1 ARNT TCF12 POLR2B ZNF766 GATA2 E2F8 ATF7 FPR3 SIGLEC6 SIGLEC14 ZNF350 SIGLEC10 FPR1 SIGLEC12 FPR2
GH19J051795 Promoter/Enhancer 1 EPDnew dbSUPER 650.7 0.0 -19 0.1 MEIS2 GATA3 PKNOX1 ZNF184 ADNP FPR3 FPR1 LOC105372448
GH19J051792 Enhancer 0.6 dbSUPER 689 -1.8 -1763 1.6 BCOR MEIS2 PKNOX1 TEAD4 CBFA2T3 ZMYM3 ZEB2 TCF12 HDAC2 CBFA2T2 FPR3 KLK8 LOC105372448 FPR1
GH19J051784 Enhancer 1.3 Ensembl ENCODE dbSUPER 33.2 -9.2 -9171 3.8 PKNOX1 ATF1 IRF4 TCF12 ZNF766 E2F8 ATF7 CAVIN1 JUNB NCOA1 FPR3 ZNF841 ZNF616 ZNF137P ZNF577 ZNF175 ZNF808 ENSG00000269825 ZNF836 ZNF83
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FPR3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FPR3 gene promoter:
  • ATF

Genomic Locations for FPR3 Gene

Genomic Locations for FPR3 Gene
chr19:51,795,158-51,826,474
(GRCh38/hg38)
Size:
31,317 bases
Orientation:
Plus strand
chr19:52,298,411-52,329,442
(GRCh37/hg19)
Size:
31,032 bases
Orientation:
Plus strand

Genomic View for FPR3 Gene

Genes around FPR3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPR3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPR3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR3 Gene

Proteins for FPR3 Gene

  • Protein details for FPR3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25089-FPR3_HUMAN
    Recommended name:
    N-formyl peptide receptor 3
    Protein Accession:
    P25089

    Protein attributes for FPR3 Gene

    Size:
    353 amino acids
    Molecular mass:
    39965 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FPR3 Gene

Post-translational modifications for FPR3 Gene

  • Glycosylation at Asn10 and Asn4
  • Modification sites at PhosphoSitePlus

Other Protein References for FPR3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FPR3 Gene

Domains & Families for FPR3 Gene

Gene Families for FPR3 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Graphical View of Domain Structure for InterPro Entry

P25089

UniProtKB/Swiss-Prot:

FPR3_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FPR3: view

Function for FPR3 Gene

Molecular function for FPR3 Gene

UniProtKB/Swiss-Prot Function:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Phenotypes From GWAS Catalog for FPR3 Gene

Gene Ontology (GO) - Molecular Function for FPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004871 obsolete signal transducer activity IEA --
GO:0004875 complement receptor activity IBA --
GO:0004930 G-protein coupled receptor activity IEA,IBA --
GO:0004982 N-formyl peptide receptor activity IBA,TAS --
genes like me logo Genes that share ontologies with FPR3: view
genes like me logo Genes that share phenotypes with FPR3: view

Animal Model Products

miRNA for FPR3 Gene

Clone Products

  • Addgene plasmids for FPR3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FPR3 Gene

Localization for FPR3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR3 Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FPR3 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for FPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane TAS --
GO:0005887 integral component of plasma membrane IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane TAS 8198572
genes like me logo Genes that share ontologies with FPR3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FPR3 Gene

Pathways & Interactions for FPR3 Gene

genes like me logo Genes that share pathways with FPR3: view

Gene Ontology (GO) - Biological Process for FPR3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002430 complement receptor mediated signaling pathway IBA --
GO:0006935 chemotaxis IEA --
GO:0006954 inflammatory response IBA --
GO:0007165 signal transduction TAS 8198572
GO:0007186 G-protein coupled receptor signaling pathway TAS --
genes like me logo Genes that share ontologies with FPR3: view

No data available for SIGNOR curated interactions for FPR3 Gene

Drugs & Compounds for FPR3 Gene

(17) Drugs for FPR3 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Approved Nutra 0
WKYMVM Pharma Full agonist, Agonist Selective FPR2 and FPR3 receptor agonist 0
FPR A14 Pharma FPR agonist 0
MMK 1 Pharma Potent and selective FPR2 agonist 0
N-Formyl-Met-Leu-Phe Pharma Endogenous FPR1 agonist 0

(1) Additional Compounds for FPR3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for FPR3 Gene

Compound Action Cas Number
FPR A14 FPR agonist 329691-12-5
MMK 1 Potent and selective FPR2 agonist 271246-66-3
N-Formyl-Met-Leu-Phe Endogenous FPR1 agonist 59880-97-6
WKYMVM Selective FPR2 and FPR3 receptor agonist 187986-11-4

(9) ApexBio Compounds for FPR3 Gene

Compound Action Cas Number
Ac9-25 284040-76-2
Boc-MLF 67247-12-5
Cyclosporin H Selective and competitive formyl peptide receptor antagonist 83602-39-5
FPR A14 329691-12-5
MMK 1 271246-66-3
N-Formyl-Met-Leu-Phe 59880-97-6
PBP 10 794466-43-6
WKYMVM 187986-11-4
WRW4 878557-55-2
genes like me logo Genes that share compounds with FPR3: view

Drug Products

Transcripts for FPR3 Gene

mRNA/cDNA for FPR3 Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FPR3 Gene

Formyl peptide receptor 3:
Representative Sequences:

Clone Products

  • Addgene plasmids for FPR3

Alternative Splicing Database (ASD) splice patterns (SP) for FPR3 Gene

No ASD Table

Relevant External Links for FPR3 Gene

GeneLoc Exon Structure for
FPR3
ECgene alternative splicing isoforms for
FPR3

Expression for FPR3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FPR3 Gene

mRNA differential expression in normal tissues according to GTEx for FPR3 Gene

This gene is overexpressed in Lung (x4.7).

NURSA nuclear receptor signaling pathways regulating expression of FPR3 Gene:

FPR3

SOURCE GeneReport for Unigene cluster for FPR3 Gene:

Hs.445466
genes like me logo Genes that share expression patterns with FPR3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FPR3 Gene

Orthologs for FPR3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPR3 34 33
  • 99.62 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fpr-rs4 34
  • 59 (a)
OneToMany
Fpr-rs3 34
  • 57 (a)
OneToMany
Fpr-rs6 34
  • 54 (a)
OneToMany
Fpr-rs7 34
  • 54 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 44 (a)
ManyToMany
-- 34
  • 40 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 32 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii BX649278.1 34
  • 17 (a)
ManyToMany
Species where no ortholog for FPR3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FPR3 Gene

ENSEMBL:
Gene Tree for FPR3 (if available)
TreeFam:
Gene Tree for FPR3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FPR3: view image

Paralogs for FPR3 Gene

Paralogs for FPR3 Gene

(17) SIMAP similar genes for FPR3 Gene using alignment to 1 proteins:

  • FPR3_HUMAN
genes like me logo Genes that share paralogs with FPR3: view

Variants for FPR3 Gene

Sequence variations from dbSNP and Humsavar for FPR3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000029854 -- 51,814,204(+) T/C genic_upstream_transcript_variant, intron_variant
rs1000325392 -- 51,820,648(+) G/C intron_variant
rs1000369472 -- 51,796,193(+) G/T genic_upstream_transcript_variant, intron_variant
rs1000468745 -- 51,801,122(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000508464 -- 51,815,867(+) AAAAAGAAAAA/AAAAA genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FPR3 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3625n100 CNV gain 25217958
dgv3626n100 CNV gain 25217958
dgv425n27 CNV gain 19166990
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
esv3644680 CNV gain 21293372
nsv1140251 OTHER inversion 24896259
nsv458733 CNV gain 19166990
nsv470151 CNV gain 18288195
nsv524403 CNV gain 19592680
nsv579997 CNV gain 21841781
nsv580001 CNV gain 21841781

Variation tolerance for FPR3 Gene

Residual Variation Intolerance Score: 38% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.39; 8.66% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FPR3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FPR3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPR3 Gene

Disorders for FPR3 Gene

Additional Disease Information for FPR3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FPR3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FPR3 Gene

Publications for FPR3 Gene

  1. Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes. (PMID: 8198572) Durstin M … Murphy PM (Biochemical and biophysical research communications 1994) 2 3 4 58
  2. Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19. (PMID: 1612600) Bao L … Gerard C (Genomics 1992) 2 3 4 58
  3. Formyl peptide receptor-like 2 is expressed and functional in plasmacytoid dendritic cells, tissue-specific macrophage subpopulations, and eosinophils. (PMID: 19342677) Devosse T … Parmentier M (Journal of immunology (Baltimore, Md. : 1950) 2009) 3 22 58
  4. The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2. (PMID: 16002663) Kang HK … Bae YS (Journal of immunology (Baltimore, Md. : 1950) 2005) 3 22 58
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58

Products for FPR3 Gene

  • Addgene plasmids for FPR3

Sources for FPR3 Gene

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