Free for academic non-profit institutions. Other users need a Commercial license
Aliases for FPR2 Gene
Aliases for FPR2 Gene
External Ids for FPR2 Gene
- HGNC: 3827
- NCBI Entrez Gene: 2358
- Ensembl: ENSG00000171049
- OMIM®: 136538
- UniProtKB/Swiss-Prot: P25090
Previous HGNC Symbols for FPR2 Gene
- FPRL1
Previous GeneCards Identifiers for FPR2 Gene
- GC19P056955
- GC19P052264
- GC19P048595
Summaries for FPR2 Gene
GeneCards Summary for FPR2 Gene
FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include Rubeosis Iridis and Alzheimer Disease. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR3.
UniProtKB/Swiss-Prot Summary for FPR2 Gene
-
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).
-
The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.
Additional gene information for FPR2 Gene
- HGNC (3827)
- NCBI Entrez Gene (2358)
- Ensembl (ENSG00000171049)
- OMIM® (136538)
- UniProtKB/Swiss-Prot (P25090)
- Open Targets Platform(ENSG00000171049)
- Monarch Initiative
- Search for FPR2 at DataMed
- Search for FPR2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FPR2 Gene
Genomics for FPR2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FPR2 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH19J051749 | Promoter/Enhancer | 1.4 | EPDnew FANTOM5 Ensembl ENCODE | 280.6 | -1.4 | -1425 | 4 | JUND SPI1 CEBPB ATF3 | FPR1 FPR2 piR-38580-149 SIGLEC10 ZNF350 HSALNG0127255 HAS1 | |
| GH19J051760 | Promoter | 0.4 | EPDnew | 250.4 | +8.9 | 8901 | 0.1 | POLR2A | FPR2 piR-41525-349 HSALNG0127256 FPR3 FPR1 | |
| GH19J051761 | Promoter | 0.4 | EPDnew | 250.4 | +9.1 | 9135 | 0.1 | POLR2A | FPR2 piR-41525-349 HSALNG0127256 FPR3 FPR1 | |
| GH19J051731 | Enhancer | 1.2 | FANTOM5 Ensembl ENCODE | 37.8 | -13.4 | -13425 | 16.8 | ZNF395 GABPA VEZF1 TAL1 FOSL1 SPI1 ATF1 POLR2A MAX TCF12 | HSALNG0127254 FPR1 FPR2 HAS1 FPR3 SIGLEC10 SIGLEC14 MIR125A MIR99B MIRLET7E | |
| GH19J051621 | Enhancer | 1.3 | FANTOM5 Ensembl ENCODE dbSUPER | 34.7 | -131.2 | -131225 | 2.8 | BCL11A IRF4 CBFB SPI1 BHLHE40 BATF POLR2A MYC IRF5 MAX | RPL9P33 lnc-ZNF175-4 FPR2 FPR1 SIGLEC14 SIGLEC10 ZNF350 SIGLEC5 HSALNG0127238 ENSG00000268500 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FPR2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FPR2
- Top Transcription factor binding sites by QIAGEN in the FPR2 gene promoter:
-
- AP-1
- ATF-2
- STAT3
Genomic Locations for FPR2 Gene
Latest Assembly
- chr19:51,752,026-51,770,531
- (GRCh38/hg38)
- Size:
- 18,506 bases
- Orientation:
- Plus strand
Previous Assembly
- chr19:52,264,433-52,273,784
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 9,352 bases
- Orientation:
- Plus strand
- chr19:52,255,279-52,273,779
- (GRCh37/hg19 by Ensembl)
- Size:
- 18,501 bases
- Orientation:
- Plus strand
Genomic View for FPR2 Gene
Genes around FPR2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.41 by HGNC
- 19q13.41 by Entrez Gene
- 19q13.41 by Ensembl
FPR2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FPR2 Gene
Proteins for FPR2 Gene
-
Protein details for FPR2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P25090-FPR2_HUMAN
- Recommended name:
- N-formyl peptide receptor 2
- Protein Accession:
- P25090
- A8K3E2
Protein attributes for FPR2 Gene
- Size:
- 351 amino acids
- Molecular mass:
- 38964 Da
- Quaternary structure:
-
- Interacts with Amyloid-beta protein 42, product of APP; the interaction takes place at the cell surface and the complex is then rapidly internalized.
- (Microbial infection) Interacts with Staphylococcus aureus protein SSL13; this interaction leads to the activation of neutrophils.
Protein Expression for FPR2 Gene
Post-translational modifications for FPR2 Gene
Other Protein References for FPR2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences FPR2 / FPRL1 Antibody (LS-A1880) and FPR2 / FPRL1 Antibody (LS-A1878)
- G Biosciences Immunotag™ FPRL1 Antibody
- NSJ Bioreagents FPR2 Antibody / FPRL1
- HUABIO FPR2 Antibody (R1510-13) and FPR2 Antibody (R1511-25)
-
Custom Antibody ServicesOriGene Antibodies for FPR2
- Novus Biologicals Antibodies for FPR2
-
Abcam antibodies for FPR2
- Invitrogen Antibodies for FPR2 (AFLGC-FPR2)
- antibodies-online: Show 26 available FPR2 Antibodies ranked by validation data
-
Boster Bio Antibodies for FPR2
-
Custom Antibody ServicesProSci Antibodies for FPR2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FPR2
Protein products for research
-
OriGene Purified Proteins for FPR2
- Search Origene for MassSpec and Protein Over-expression Lysates for FPR2
- Origene Custom Protein Services for FPR2
- antibodies-online: Search results for available FPR2 related products ranked by validation data
-
Abcam proteins for FPR2
Assay products for research
No data available for DME Specific Peptides for FPR2 Gene
Domains & Families for FPR2 Gene
Gene Families for FPR2 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for FPR2 Gene
- InterPro:
- Blocks:
-
- Formyl-methionyl peptide receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for FPR2 Gene
- GenScript: Design optimal peptide antigens:
-
- RFP (FPR2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P25090- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for FPR2 Gene
Molecular function for FPR2 Gene
- UniProtKB/Swiss-Prot Function:
- Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).
Phenotypes From GWAS Catalog for FPR2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001540 | amyloid-beta binding | ISS | -- |
| GO:0004875 | complement receptor activity | IBA | 21873635 |
| GO:0004930 | G protein-coupled receptor activity | IEA,NAS | 11316806 |
| GO:0004982 | N-formyl peptide receptor activity | IEA,IBA | 21873635 |
| GO:0005124 | scavenger receptor binding | IPI | 20141570 |
Phenotypes for FPR2 Gene
- MGI mutant phenotypes for FPR2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FPR2:
Animal Models for research
-
Taconic Biosciences Mouse Models for FPR2
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for FPR2 - Starting at $85 >
- * FPR2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for FPR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FPR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FPR2
miRNA for FPR2 Gene
- miRTarBase miRNAs that target FPR2
-
- hsa-miR-7152-5p (MIRT446574)
- hsa-miR-3074-5p (MIRT446575)
- hsa-miR-1200 (MIRT446576)
- hsa-miR-378a-5p (MIRT446577)
- hsa-miR-4487 (MIRT446578)
- hsa-miR-558 (MIRT446579)
- hsa-miR-3160-3p (MIRT446580)
- hsa-miR-4427 (MIRT446581)
- hsa-miR-3140-5p (MIRT446582)
- mmu-miR-335-3p (MIRT594429)
- hsa-miR-6878-3p (MIRT619722)
- hsa-miR-640 (MIRT619723)
- hsa-miR-6821-3p (MIRT619724)
- hsa-miR-6790-3p (MIRT619725)
- hsa-miR-3653-5p (MIRT619726)
- hsa-miR-372-5p (MIRT619727)
- hsa-miR-371a-5p (MIRT619728)
- hsa-miR-616-5p (MIRT619729)
- hsa-miR-373-5p (MIRT619730)
- hsa-miR-371b-5p (MIRT619731)
- hsa-miR-1248 (MIRT619732)
- hsa-miR-5088-3p (MIRT619733)
- hsa-miR-3934-5p (MIRT619734)
- hsa-miR-764 (MIRT619735)
- hsa-miR-125a-3p (MIRT619736)
- hsa-miR-6744-3p (MIRT629661)
- hsa-miR-4757-5p (MIRT629662)
- hsa-miR-6778-3p (MIRT629663)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FPR2
- Browse OriGene Inhibitory RNA Products For FPR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPR2
Clone products for research
- Applied Biological Materials (abm): Clones for FPR2 - Starting at $45 >
- * FPR2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for FPR2
- Addgene plasmids for FPR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FPR2
Cell Lines for research
-
Horizon Cell Lines for FPR2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FPR2 Gene
Localization for FPR2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FPR2 Gene
- Cell membrane. Multi-pass membrane protein. Note=Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized. {ECO:0000269 PubMed:11689470}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endosome | 2 |
| cytosol | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0035579 | specific granule membrane | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FPR2 Gene
Pathways & Interactions for FPR2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors |
.34
|
|
| 2 | Akt Signaling |
Akt Signaling
.60
p38 Signaling
.60
|
Tec Kinases Signaling
.55
|
| 3 | Signaling by GPCR | ||
| 4 | Innate Immune System |
.61
|
|
| 5 | RET signaling | ||
Pathways by source for FPR2 Gene
2 BioSystems pathways for FPR2 Gene
13 Reactome pathways for FPR2 Gene
3 KEGG pathways for FPR2 Gene
4 GeneGo (Thomson Reuters) pathways for FPR2 Gene
- Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
- Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
- Inhibitory action of Lipoxins on neutrophil migration
- Inhibitory action of Lipoxins on Superoxide production in neutrophils
1 R&D Systems pathway for FPR2 Gene
9 Qiagen pathways for FPR2 Gene
- Akt Signaling
- Antioxidant Action of Vitamin-C
- Chemokine Signaling
- fMLP Pathway
- Molecular Mechanisms of Cancer
Interacting Proteins for FPR2 Gene
Selected Interacting proteins:
P25090-FPR2_HUMAN
ENSP00000468897
for FPR2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FPR2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001774 | microglial cell activation | ISS | -- |
| GO:0001934 | positive regulation of protein phosphorylation | IGI | 20141570 |
| GO:0002430 | complement receptor mediated signaling pathway | IBA | 21873635 |
| GO:0002768 | immune response-regulating cell surface receptor signaling pathway | IDA | 25505240 |
| GO:0006898 | receptor-mediated endocytosis | ISS | -- |
Drugs & Compounds for FPR2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| LL-37 | Investigational | Pharma | Agonist, Full agonist | 0 | ||
| WKYMVM | Pharma | Agonist, Full agonist | Selective FPR2 and FPR3 receptor agonist | 0 | ||
| FPR A14 | Pharma | FPR agonist | 0 | |||
| MMK 1 | Pharma | Potent and selective FPR2 agonist | 0 | |||
| N-Formyl-Met-Leu-Phe | Pharma | Endogenous FPR1 agonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| amyloid β<sub>42</sub> |
|
Agonist, Full agonist |
|
(4) Tocris Compounds for FPR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| FPR A14 | FPR agonist | 329691-12-5 |
| MMK 1 | Potent and selective FPR2 agonist | 271246-66-3 |
| N-Formyl-Met-Leu-Phe | Endogenous FPR1 agonist | 59880-97-6 |
| WKYMVM | Selective FPR2 and FPR3 receptor agonist | 187986-11-4 |
(9) ApexBio Compounds for FPR2 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ac9-25 | 284040-76-2 | |
| Boc-MLF | 67247-12-5 | |
| Cyclosporin H | Selective and competitive formyl peptide receptor antagonist | 83602-39-5 |
| FPR A14 | 329691-12-5 | |
| MMK 1 | 271246-66-3 | |
| N-Formyl-Met-Leu-Phe | 59880-97-6 | |
| PBP 10 | 794466-43-6 | |
| WKYMVM | 187986-11-4 | |
| WRW4 | 878557-55-2 |
Transcripts for FPR2 Gene
mRNA/cDNA for FPR2 Gene
- 2 REFSEQ mRNAs :
- 11 NCBI additional mRNA sequence :
- 6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000340023 1938 nts (view in UCSC)
- ENST00000598776 2621 nts (view in UCSC)
- ENST00000598953 1544 nts (view in UCSC)
- ENST00000599326 576 nts (view in UCSC)
- ENST00000600258 985 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for FPR2 - Starting at $85 >
- * FPR2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for FPR2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FPR2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FPR2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FPR2
- Browse OriGene Inhibitory RNA Products For FPR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPR2
Clone products for research
- Applied Biological Materials (abm): Clones for FPR2 - Starting at $45 >
- * FPR2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for FPR2
- Addgene plasmids for FPR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FPR2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | · | 3c |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | - | |||||||||||
| SP3: |
Relevant External Links for FPR2 Gene
- GeneLoc Exon Structure for
- FPR2
Expression for FPR2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for FPR2 Gene
This gene is overexpressed in Whole Blood (x46.2).
This gene is overexpressed in Monocytes (68.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FPR2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FPR2
SOURCE GeneReport for Unigene cluster for FPR2 Gene:
Hs.99855mRNA Expression by UniProt/SwissProt for FPR2 Gene:
P25090-FPR2_HUMAN
Tissue specificity:
Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.
Evidence on tissue expression from TISSUES for FPR2 Gene
- Blood(4.9)
- Heart(4.5)
- Bone marrow(4.4)
- Spleen(3.2)
- Lung(3)
- Intestine(2.7)
- Nervous system(2.4)
- Liver(2.3)
Primer products for research
-
OriGene qPCR primer pairs for FPR2
-
OriGene qPCR primer pairs and template standards for FPR2
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FPR2 Gene
Orthologs for FPR2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FPR2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FPR2 30 |
|
||
| Mouse (Mus musculus) |
Mammalia | Fpr2 30 17 31 |
|
OneToMany | |
| Fpr3 31 |
|
OneToMany | |||
| Rat (Rattus norvegicus) |
Mammalia | Fpr2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | zgc:194202 31 |
|
ManyToMany |
- Species where no ortholog for FPR2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FPR2 Gene
- ENSEMBL:
- Gene Tree for FPR2 (if available)
- TreeFam:
- Gene Tree for FPR2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FPR2: view image
Paralogs for FPR2 Gene
(37) SIMAP similar genes for FPR2 Gene using alignment to 4 proteins:
- FPR2_HUMAN
- M0QXD3_HUMAN
- M0QZ89_HUMAN
- M0R222_HUMAN
Variants for FPR2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FPR2 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs74602258 | Benign: not provided | 51,768,878(+) |
T/C NM_001005738.2(FPR2):c.220T>C (p.Phe74Leu) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1067e212 | CNV | gain | 25503493 |
| dgv143e55 | CNV | gain | 17911159 |
| dgv3625n100 | CNV | gain | 25217958 |
| dgv3626n100 | CNV | gain | 25217958 |
| dgv6523n54 | CNV | gain | 21841781 |
| esv2758767 | CNV | gain+loss | 17122850 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv458733 | CNV | gain | 19166990 |
| nsv470151 | CNV | gain | 18288195 |
| nsv524403 | CNV | gain | 19592680 |
| nsv579997 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.30;
25.83% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FPR2 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPR2 Gene
Disorders for FPR2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rubeosis iridis |
|
|
| alzheimer disease |
|
|
| bacterial infectious disease |
|
|
Search FPR2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FPR2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FPR2 Gene
Publications for FPR2 Gene
- Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages. (PMID: 11689470) Yazawa H … Wang JM (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001) 3 4 23
- Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. (PMID: 9547339) Gronert K … Serhan CN (The Journal of experimental medicine 1998) 3 4 23
- Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. (PMID: 9151906) Takano T … Serhan CN (The Journal of experimental medicine 1997) 3 4 23
- Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. (PMID: 9054386) Maddox JF … Serhan CN (The Journal of biological chemistry 1997) 2 3 23
- Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PMID: 7505609) Nomura H … Matsushima K (International immunology 1993) 3 4 23
ExternalLinks
Products for FPR2 Gene
- Custom Antibody ServicesOriGene Antibodies for FPR2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FPR2
- Search Origene for MassSpec and Protein Over-expression Lysates for FPR2
- Origene Custom Protein Services for FPR2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FPR2
- Browse OriGene Inhibitory RNA Products For FPR2
- OriGene qPCR primer pairs for FPR2
- OriGene qPCR primer pairs and template standards for FPR2
- OriGene CRISPR knockouts for FPR2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FPR2
- Sino Biological Human cDNA Clone for FPR2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FPR2
- Novus Biologicals proteins and lysates for FPR2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for FPR2
- Abcam proteins for FPR2
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Taconic Biosciences Mouse Models for FPR2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- Invitrogen Antibodies for FPR2 (AFLGC-FPR2)
- ApexBio compounds for FPR2
- VectorBuilder Custom and pre-made DNA vectors for FPR2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FPR2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FPR2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FPR2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FPR2
- Addgene plasmids for FPR2
- antibodies-online: Show 26 available FPR2 Antibodies ranked by validation data
- antibodies-online: Show 55 available FPR2 Elisa Kits ranked by validation data
- Compare Top FPR2 Elisa Kits
- antibodies-online: Search results for available FPR2 related products ranked by validation data
- Santa Cruz Biotechnology (SCBT) Antibodies for FPR2
- Search Santa Cruz Biotechnology (SCBT) for FPR2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FPR2
- Horizon Cell Lines for FPR2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FPR2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FPR2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FPR2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPR2
- Boster Bio Antibodies for FPR2
- Browse Boster Bio ELISA Kits
Sources for FPR2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB