Aliases for FPR2 Gene

Aliases for FPR2 Gene

  • Formyl Peptide Receptor 2 2 3 5
  • Formyl Peptide Receptor-Like 1 2 3 4
  • LXA4R 2 3 4
  • HM63 2 3 4
  • N-Formyl Peptide Receptor 2 3 4
  • FMLP-Related Receptor I 3 4
  • LXA4 Receptor 3 4
  • FMLP-R-II 2 3
  • FMLP-R-I 3 4
  • FMLPX 2 3
  • FPR2A 2 3
  • FPRH1 3 4
  • FPRH2 2 3
  • FPRL1 3 4
  • ALXR 2 3
  • ALX 2 3
  • RFP 3 4
  • Lipoxin A4 Receptor (Formyl Peptide Receptor Related) 3
  • Lipoxin A4 Receptor 4
  • FPR2 5

External Ids for FPR2 Gene

Previous HGNC Symbols for FPR2 Gene

  • FPRL1

Previous GeneCards Identifiers for FPR2 Gene

  • GC19P056955
  • GC19P052264
  • GC19P048595

Summaries for FPR2 Gene

GeneCards Summary for FPR2 Gene

FPR2 (Formyl Peptide Receptor 2) is a Protein Coding gene. Diseases associated with FPR2 include Rubeosis Iridis and Bacterial Infectious Disease. Among its related pathways are A-beta Pathways: Uptake and Degradation and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and N-formyl peptide receptor activity. An important paralog of this gene is FPR3.

UniProtKB/Swiss-Prot Summary for FPR2 Gene

  • Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).

Tocris Summary for FPR2 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.

Gene Wiki entry for FPR2 Gene

No data available for Entrez Gene Summary , CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FPR2 Gene

Genomics for FPR2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FPR2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051749 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 280.7 -1.4 -1425 4 JUND SPI1 CEBPB ATF3 FPR1 FPR2 piR-38580-149 SIGLEC10 ZNF350 HSALNG0127255 HAS1
GH19J051761 Promoter 0.4 EPDnew 250.4 +9.1 9135 0.1 POLR2A FPR2 piR-41525-349 HSALNG0127256 FPR3 FPR1
GH19J051760 Promoter 0.4 EPDnew 250.4 +8.9 8901 0.1 POLR2A FPR2 piR-41525-349 HSALNG0127256 FPR3 FPR1
GH19J051731 Enhancer 1.2 FANTOM5 Ensembl ENCODE 37.8 -13.4 -13425 16.8 CTCF GABPA TAL1 ATF1 SPI1 MAX POLR2A ZNF384 TCF12 TEAD4 HSALNG0127254 FPR1 FPR2 HAS1 FPR3 SIGLEC10 SIGLEC14 MIR125A MIR99B MIRLET7E
GH19J051621 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 34.7 -131.2 -131225 2.8 BCLAF1 CTCF BCL11A IRF4 CBFB BHLHE40 SPI1 MYC MAX POLR2A RPL9P33 lnc-ZNF175-4 FPR2 FPR1 SIGLEC14 SIGLEC10 ZNF350 SIGLEC5 HSALNG0127238 ENSG00000268500
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FPR2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FPR2

Top Transcription factor binding sites by QIAGEN in the FPR2 gene promoter:
  • AP-1
  • ATF-2
  • STAT3

Genomic Locations for FPR2 Gene

Latest Assembly
chr19:51,752,026-51,770,531
(GRCh38/hg38)
Size:
18,506 bases
Orientation:
Plus strand

Previous Assembly
chr19:52,264,433-52,273,784
(GRCh37/hg19 by Entrez Gene)
Size:
9,352 bases
Orientation:
Plus strand

chr19:52,255,279-52,273,779
(GRCh37/hg19 by Ensembl)
Size:
18,501 bases
Orientation:
Plus strand

Genomic View for FPR2 Gene

Genes around FPR2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPR2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR2 Gene

Proteins for FPR2 Gene

  • Protein details for FPR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P25090-FPR2_HUMAN
    Recommended name:
    N-formyl peptide receptor 2
    Protein Accession:
    P25090
    Secondary Accessions:
    • A8K3E2

    Protein attributes for FPR2 Gene

    Size:
    351 amino acids
    Molecular mass:
    38964 Da
    Quaternary structure:
    • Interacts with Amyloid-beta protein 42, product of APP; the interaction takes place at the cell surface and the complex is then rapidly internalized.
    • (Microbial infection) Interacts with Staphylococcus aureus protein SSL13; this interaction leads to the activation of neutrophils.

    Three dimensional structures from OCA and Proteopedia for FPR2 Gene

neXtProt entry for FPR2 Gene

Post-translational modifications for FPR2 Gene

  • Glycosylation at Asn4
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for FPR2 Gene

Domains & Families for FPR2 Gene

Gene Families for FPR2 Gene

Protein Domains for FPR2 Gene

InterPro:
Blocks:
  • Formyl-methionyl peptide receptor signature

Suggested Antigen Peptide Sequences for FPR2 Gene

GenScript: Design optimal peptide antigens:
  • RFP (FPR2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P25090

UniProtKB/Swiss-Prot:

FPR2_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FPR2: view

Function for FPR2 Gene

Molecular function for FPR2 Gene

UniProtKB/Swiss-Prot Function:
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).

Phenotypes From GWAS Catalog for FPR2 Gene

Gene Ontology (GO) - Molecular Function for FPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001540 amyloid-beta binding ISS --
GO:0004875 complement receptor activity IBA 21873635
GO:0004930 G protein-coupled receptor activity IEA,NAS 11316806
GO:0004982 N-formyl peptide receptor activity IEA,IBA 21873635
GO:0005124 scavenger receptor binding IPI 20141570
genes like me logo Genes that share ontologies with FPR2: view
genes like me logo Genes that share phenotypes with FPR2: view

Animal Models for FPR2 Gene

MGI Knock Outs for FPR2:
  • Fpr2 Fpr2<tm1.2Jimw>
  • Fpr2 Fpr2<tm1Rjf>

Animal Models for research

  • Taconic Biosciences Mouse Models for FPR2

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPR2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FPR2 Gene

Localization for FPR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR2 Gene

Cell membrane. Multi-pass membrane protein. Note=Associates with Amyloid-beta protein 42, product of APP, at the cell surface and the complex is then rapidly internalized. {ECO:0000269 PubMed:11689470}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FPR2 gene
Compartment Confidence
plasma membrane 5
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endosome 2
cytosol 2
lysosome 2
peroxisome 1
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane IEA,TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0035579 specific granule membrane TAS --
genes like me logo Genes that share ontologies with FPR2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FPR2 Gene

Pathways & Interactions for FPR2 Gene

genes like me logo Genes that share pathways with FPR2: view

Pathways by source for FPR2 Gene

4 GeneGo (Thomson Reuters) pathways for FPR2 Gene
  • Inhibitory action of Lipoxin A4 on PDGF, EGF and LTD4 signaling
  • Inhibitory action of Lipoxins and Resolvin E1 on neutrophil functions
  • Inhibitory action of Lipoxins on neutrophil migration
  • Inhibitory action of Lipoxins on Superoxide production in neutrophils
1 R&D Systems pathway for FPR2 Gene
9 Qiagen pathways for FPR2 Gene
  • Akt Signaling
  • Antioxidant Action of Vitamin-C
  • Chemokine Signaling
  • fMLP Pathway
  • Molecular Mechanisms of Cancer

SIGNOR curated interactions for FPR2 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FPR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001774 microglial cell activation ISS --
GO:0001934 positive regulation of protein phosphorylation IGI 20141570
GO:0002430 complement receptor mediated signaling pathway IBA 21873635
GO:0002768 immune response-regulating cell surface receptor signaling pathway IDA 25505240
GO:0006898 receptor-mediated endocytosis ISS --
genes like me logo Genes that share ontologies with FPR2: view

Drugs & Compounds for FPR2 Gene

(60) Drugs for FPR2 Gene - From: ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
LL-37 Investigational Pharma Agonist, Full agonist 0
WKYMVM Pharma Agonist, Full agonist Selective FPR2 and FPR3 receptor agonist 0
FPR A14 Pharma FPR agonist 0
MMK 1 Pharma Potent and selective FPR2 agonist 0
N-Formyl-Met-Leu-Phe Pharma Endogenous FPR1 agonist 0

(10) Additional Compounds for FPR2 Gene - From: IUPHAR and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
amyloid &beta;<sub>42</sub>
Agonist, Full agonist

(4) Tocris Compounds for FPR2 Gene

Compound Action Cas Number
FPR A14 FPR agonist 329691-12-5
MMK 1 Potent and selective FPR2 agonist 271246-66-3
N-Formyl-Met-Leu-Phe Endogenous FPR1 agonist 59880-97-6
WKYMVM Selective FPR2 and FPR3 receptor agonist 187986-11-4

(9) ApexBio Compounds for FPR2 Gene

Compound Action Cas Number
Ac9-25 284040-76-2
Boc-MLF 67247-12-5
Cyclosporin H Selective and competitive formyl peptide receptor antagonist 83602-39-5
FPR A14 329691-12-5
MMK 1 271246-66-3
N-Formyl-Met-Leu-Phe 59880-97-6
PBP 10 794466-43-6
WKYMVM 187986-11-4
WRW4 878557-55-2
genes like me logo Genes that share compounds with FPR2: view

Drug products for research

Transcripts for FPR2 Gene

mRNA/cDNA for FPR2 Gene

2 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPR2

Alternative Splicing Database (ASD) splice patterns (SP) for FPR2 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b · 3c
SP1: -
SP2: - -
SP3:

Relevant External Links for FPR2 Gene

GeneLoc Exon Structure for
FPR2

Expression for FPR2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FPR2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FPR2 Gene

This gene is overexpressed in Whole Blood (x46.2).

Protein differential expression in normal tissues from HIPED for FPR2 Gene

This gene is overexpressed in Monocytes (68.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FPR2 Gene



Protein tissue co-expression partners for FPR2 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FPR2

SOURCE GeneReport for Unigene cluster for FPR2 Gene:

Hs.99855

mRNA Expression by UniProt/SwissProt for FPR2 Gene:

P25090-FPR2_HUMAN
Tissue specificity: Expressed abundantly in the lung and neutrophils. Also found in the spleen and testis.

Evidence on tissue expression from TISSUES for FPR2 Gene

  • Blood(4.9)
  • Heart(4.6)
  • Bone marrow(4.4)
  • Spleen(3.2)
  • Lung(3)
  • Intestine(2.7)
  • Nervous system(2.4)
  • Liver(2.3)
genes like me logo Genes that share expression patterns with FPR2: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FPR2 Gene

Orthologs for FPR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FPR2 29 30
  • 99.43 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FPR2 29
  • 86.23 (n)
Mouse
(Mus musculus)
Mammalia Fpr2 29 16 30
  • 76.67 (n)
OneToMany
Fpr3 30
  • 74 (a)
OneToMany
Rat
(Rattus norvegicus)
Mammalia Fpr2 29
  • 76.54 (n)
Oppossum
(Monodelphis domestica)
Mammalia -- 30
  • 48 (a)
ManyToMany
-- 30
  • 45 (a)
ManyToMany
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 34 (a)
OneToMany
Zebrafish
(Danio rerio)
Actinopterygii zgc:194202 30
  • 23 (a)
ManyToMany
Species where no ortholog for FPR2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FPR2 Gene

ENSEMBL:
Gene Tree for FPR2 (if available)
TreeFam:
Gene Tree for FPR2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FPR2: view image
Alliance of Genome Resources:
Additional Orthologs for FPR2

Paralogs for FPR2 Gene

Paralogs for FPR2 Gene

(37) SIMAP similar genes for FPR2 Gene using alignment to 4 proteins:

  • FPR2_HUMAN
  • M0QXD3_HUMAN
  • M0QZ89_HUMAN
  • M0R222_HUMAN
genes like me logo Genes that share paralogs with FPR2: view

Variants for FPR2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FPR2 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
rs74602258 Benign: not provided 51,768,878(+) T/C
NM_001005738.2(FPR2):c.220T>C (p.Phe74Leu)
MISSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FPR2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FPR2 Gene

Variant ID Type Subtype PubMed ID
dgv1067e212 CNV gain 25503493
dgv143e55 CNV gain 17911159
dgv3625n100 CNV gain 25217958
dgv3626n100 CNV gain 25217958
dgv6523n54 CNV gain 21841781
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv458733 CNV gain 19166990
nsv470151 CNV gain 18288195
nsv524403 CNV gain 19592680
nsv579997 CNV gain 21841781

Variation tolerance for FPR2 Gene

Residual Variation Intolerance Score: 35.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FPR2 Gene

Human Gene Mutation Database (HGMD)
FPR2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FPR2
Leiden Open Variation Database (LOVD)
FPR2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPR2 Gene

Disorders for FPR2 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FPR2 Gene - From: COP

Disorder Aliases PubMed IDs
rubeosis iridis
bacterial infectious disease
  • bacterial infections
alzheimer disease
  • ad
- elite association - COSMIC cancer census association via MalaCards
Search FPR2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FPR2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FPR2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FPR2 Gene

Publications for FPR2 Gene

  1. Beta amyloid peptide (Abeta42) is internalized via the G-protein-coupled receptor FPRL1 and forms fibrillar aggregates in macrophages. (PMID: 11689470) Yazawa H … Wang JM (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2001) 3 4 22
  2. Identification of a human enterocyte lipoxin A4 receptor that is regulated by interleukin (IL)-13 and interferon gamma and inhibits tumor necrosis factor alpha-induced IL-8 release. (PMID: 9547339) Gronert K … Serhan CN (The Journal of experimental medicine 1998) 3 4 22
  3. Aspirin-triggered 15-epi-lipoxin A4 (LXA4) and LXA4 stable analogues are potent inhibitors of acute inflammation: evidence for anti-inflammatory receptors. (PMID: 9151906) Takano T … Serhan CN (The Journal of experimental medicine 1997) 3 4 22
  4. Lipoxin A4 stable analogs are potent mimetics that stimulate human monocytes and THP-1 cells via a G-protein-linked lipoxin A4 receptor. (PMID: 9054386) Maddox JF … Serhan CN (The Journal of biological chemistry 1997) 2 3 22
  5. Molecular cloning of cDNAs encoding a LD78 receptor and putative leukocyte chemotactic peptide receptors. (PMID: 7505609) Nomura H … Matsushima K (International immunology 1993) 3 4 22

Products for FPR2 Gene

Sources for FPR2 Gene