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This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010] See more...
Aliases for FPR1 Gene
Aliases for FPR1 Gene
External Ids for FPR1 Gene
- HGNC: 3826
- NCBI Entrez Gene: 2357
- Ensembl: ENSG00000171051
- OMIM®: 136537
- UniProtKB/Swiss-Prot: P21462
Previous GeneCards Identifiers for FPR1 Gene
- GC19M052879
- GC19M052610
- GC19M056924
- GC19M056940
- GC19M052249
- GC19M048579
Summaries for FPR1 Gene
-
This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]
GeneCards Summary for FPR1 Gene
FPR1 (Formyl Peptide Receptor 1) is a Protein Coding gene. Diseases associated with FPR1 include Susceptibility To Localized Juvenile Periodontitis and Periodontitis. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and RAGE receptor binding. An important paralog of this gene is FPR2.
UniProtKB/Swiss-Prot Summary for FPR1 Gene
-
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685).
-
The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.
Additional gene information for FPR1 Gene
- HGNC (3826)
- NCBI Entrez Gene (2357)
- Ensembl (ENSG00000171051)
- OMIM® (136537)
- UniProtKB/Swiss-Prot (P21462)
- Open Targets Platform(ENSG00000171051)
- Monarch Initiative
- Search for FPR1 at DataMed
- Search for FPR1 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FPR1 Gene
Genomics for FPR1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FPR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FPR1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FPR1
- Top Transcription factor binding sites by QIAGEN in the FPR1 gene promoter:
-
- AP-1
- ATF-2
- c-Jun
- FOXO1
- FOXO1a
- FOXO4
- STAT3
Genomic Locations for FPR1 Gene
Latest Assembly
- chr19:51,745,172-51,804,110
- (GRCh38/hg38)
- Size:
- 58,939 bases
- Orientation:
- Minus strand
Previous Assembly
- chr19:52,248,425-52,255,131
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 6,707 bases
- Orientation:
- Minus strand
- chr19:52,248,425-52,307,363
- (GRCh37/hg19 by Ensembl)
- Size:
- 58,939 bases
- Orientation:
- Minus strand
Genomic View for FPR1 Gene
Genes around FPR1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 19q13.41 by HGNC
- 19q13.41 by Entrez Gene
- 19q13.41 by Ensembl
FPR1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FPR1 Gene
Proteins for FPR1 Gene
-
Protein details for FPR1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P21462-FPR1_HUMAN
- Recommended name:
- fMet-Leu-Phe receptor
- Protein Accession:
- P21462
- Q14939
- Q7Z6A4
- Q86U52
- Q9NS48
Protein attributes for FPR1 Gene
- Size:
- 350 amino acids
- Molecular mass:
- 38446 Da
- Quaternary structure:
-
- Interacts with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response.
Protein Expression for FPR1 Gene
Post-translational modifications for FPR1 Gene
- Phosphorylated; which is necessary for desensitization.
-
Glycosylation at Asn4 and Asn10
- NX_P21462 (NX_P21462-1)
- Modification sites at PhosphoSitePlus
Other Protein References for FPR1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
- LifeSpan BioSciences FPR1 / FPR Antibody (LS-A2086) and FPR1 / FPR Antibody (LS-A2087)
- G Biosciences Immunotag™ FPR1 Antibody
- Alomone Labs, Ltd. Anti-Human FPR1 (extracellular)-ATTO-488 Antibody
- HUABIO FPR1 Antibody (R1511-35) and FPR1 Antibody (R1511-36)
-
Custom Antibody ServicesOriGene Antibodies for FPR1
- Novus Biologicals Antibodies for FPR1
-
Abcam antibodies for FPR1
- Invitrogen Antibodies for FPR1 (AFLGC-FPR1)
- Sino Biological Antibodies for FPR1
Protein products for research
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FPR1
- Origene Custom Protein Services for FPR1
- Novus Biologicals proteins for FPR1
- antibodies-online: Show 5 available FPR1 Proteins ranked by validation data
- Compare Top FPR1 Proteins
-
Quality Products:
-
Abcam proteins for FPR1
Assay products for research
- antibodies-online: Show 9 available FPR1 Elisa Kits ranked by validation data
- Compare Top FPR1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for FPR1 Gene
Domains & Families for FPR1 Gene
Gene Families for FPR1 Gene
- HGNC:
- IUPHAR :
- Human Protein Atlas (HPA):
-
- G-protein coupled receptors
- Predicted membrane proteins
Protein Domains for FPR1 Gene
- InterPro:
- Blocks:
-
- Formyl-methionyl peptide receptor signature
- ProtoNet:
Suggested Antigen Peptide Sequences for FPR1 Gene
- GenScript: Design optimal peptide antigens:
-
- N-formylpeptide chemoattractant receptor (FPR1_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P21462- Family:
-
- Belongs to the G-protein coupled receptor 1 family.
Function for FPR1 Gene
Molecular function for FPR1 Gene
- UniProtKB/Swiss-Prot Function:
- High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685).
- GENATLAS Biochemistry:
- formyl peptide (bacterial) receptor 1,mediating chemotaxis and inducing leukocyte activation,(formyl-Met-Leu-Phe),G protein coupled,secretin receptor superfamily
Phenotypes From GWAS Catalog for FPR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001664 | G protein-coupled receptor binding | IDA | 10823817 |
| GO:0004875 | complement receptor activity | IBA | 21873635 |
| GO:0004930 | G protein-coupled receptor activity | IEA,IBA | 21873635 |
| GO:0004982 | N-formyl peptide receptor activity | IEA,IDA | 12218158 |
| GO:0005124 | scavenger receptor binding | IEA | -- |
Phenotypes for FPR1 Gene
- MGI mutant phenotypes for FPR1:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for FPR1:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Reduced mammosphere formation
- Two nuclei (binuclear)
- Decreased viability in pancreas lineage
- Decreased epidermal growth factor (EGF) endocytosis, increased transferrin (TF) endocytosis
- Decreased shRNA abundance
- Increased S DNA content
- Increased cell number in G1, small nuclei in G1
Animal Models for research
-
Taconic Biosciences Mouse Models for FPR1
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for FPR1 - Starting at $85 >
- * FPR1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for FPR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FPR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FPR1
miRNA for FPR1 Gene
- miRTarBase miRNAs that target FPR1
-
- hsa-miR-335-5p (MIRT018871)
- hsa-miR-4762-3p (MIRT617085)
- hsa-miR-3192-3p (MIRT617086)
- hsa-miR-3119 (MIRT617087)
- hsa-miR-4502 (MIRT617088)
- hsa-miR-4465 (MIRT630718)
- hsa-miR-26b-5p (MIRT630719)
- hsa-miR-26a-5p (MIRT630720)
- hsa-miR-1297 (MIRT630721)
- hsa-miR-4772-3p (MIRT630722)
- hsa-miR-7113-3p (MIRT630723)
- hsa-miR-6791-5p (MIRT630724)
- hsa-miR-4292 (MIRT630725)
- hsa-miR-4308 (MIRT630726)
- hsa-miR-1306-5p (MIRT630727)
- hsa-miR-202-5p (MIRT639046)
- hsa-miR-337-3p (MIRT639047)
- hsa-miR-3156-3p (MIRT639048)
- hsa-miR-1260b (MIRT639049)
- hsa-miR-1260a (MIRT639050)
- hsa-miR-188-3p (MIRT639051)
- hsa-miR-103a-2-5p (MIRT639052)
- hsa-miR-2277-3p (MIRT639053)
- hsa-miR-4778-3p (MIRT639054)
- hsa-miR-3927-5p (MIRT639055)
- hsa-miR-1224-3p (MIRT639056)
- hsa-miR-382-3p (MIRT639057)
- hsa-miR-1304-3p (MIRT642297)
- hsa-miR-6890-3p (MIRT642298)
- hsa-miR-5096 (MIRT642299)
- hsa-miR-7156-5p (MIRT642300)
- hsa-miR-4273 (MIRT642301)
- hsa-miR-3187-3p (MIRT642302)
- hsa-miR-4435 (MIRT642303)
- hsa-miR-588 (MIRT642304)
- hsa-miR-4701-5p (MIRT642305)
- hsa-miR-548s (MIRT642306)
- hsa-miR-516a-5p (MIRT642307)
- hsa-miR-197-3p (MIRT642308)
- hsa-miR-2117 (MIRT642309)
- hsa-miR-4687-3p (MIRT642310)
- hsa-miR-4755-3p (MIRT642311)
- hsa-miR-26b-3p (MIRT642312)
- hsa-miR-4716-5p (MIRT642313)
- hsa-miR-6823-5p (MIRT642314)
- hsa-miR-4781-3p (MIRT642315)
- hsa-miR-6079 (MIRT661109)
- hsa-miR-3202 (MIRT661110)
- hsa-miR-4533 (MIRT661111)
- hsa-miR-342-3p (MIRT661112)
- hsa-miR-383-3p (MIRT661113)
- hsa-miR-1228-3p (MIRT661114)
- hsa-miR-4758-5p (MIRT661115)
- hsa-miR-1238-5p (MIRT661116)
- hsa-miR-4745-5p (MIRT661117)
- hsa-miR-4481 (MIRT661118)
- hsa-miR-1200 (MIRT689319)
- hsa-miR-202-3p (MIRT689320)
- hsa-miR-98-5p (MIRT689321)
- hsa-miR-4458 (MIRT689322)
- hsa-miR-4500 (MIRT689323)
- hsa-let-7i-5p (MIRT689324)
- hsa-let-7g-5p (MIRT689325)
- hsa-let-7f-5p (MIRT689326)
- hsa-let-7e-5p (MIRT689327)
- hsa-let-7d-5p (MIRT689328)
- hsa-let-7c-5p (MIRT689329)
- hsa-let-7b-5p (MIRT689330)
- hsa-let-7a-5p (MIRT689331)
- hsa-miR-4786-5p (MIRT689332)
- hsa-miR-7162-3p (MIRT689333)
- hsa-miR-1976 (MIRT689334)
- hsa-miR-3653-5p (MIRT689335)
- hsa-miR-544b (MIRT689336)
- hsa-miR-4324 (MIRT689337)
- hsa-miR-6849-3p (MIRT689338)
- hsa-miR-6891-5p (MIRT689339)
- hsa-miR-4293 (MIRT689340)
- hsa-miR-3173-3p (MIRT689341)
- hsa-miR-4428 (MIRT689342)
- hsa-miR-498 (MIRT715704)
- hsa-miR-4279 (MIRT715705)
- hsa-miR-6747-3p (MIRT715706)
- hsa-miR-4722-3p (MIRT715707)
- hsa-miR-6727-3p (MIRT715708)
- hsa-miR-24-3p (MIRT784310)
- hsa-miR-326 (MIRT784854)
- hsa-miR-330-5p (MIRT784870)
- hsa-miR-4284 (MIRT785585)
- hsa-miR-483-3p (MIRT786860)
- hsa-miR-486-5p (MIRT786884)
- hsa-miR-514a-5p (MIRT787165)
- hsa-miR-5693 (MIRT787789)
- hsa-miR-7977 (MIRT789629)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FPR1
- Browse OriGene Inhibitory RNA Products For FPR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPR1
Clone products for research
- Applied Biological Materials (abm): Clones for FPR1 - Starting at $45 >
- * FPR1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for FPR1
- Addgene plasmids for FPR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FPR1
Cell Lines for research
-
Horizon Cell Lines for FPR1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FPR1 Gene
Localization for FPR1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FPR1 Gene
- Cell membrane. Multi-pass membrane protein. Note=Internalizes in presence of its ligand, TAFA4. {ECO:0000269 PubMed:25109685}.
| Compartment | Confidence |
|---|---|
| plasma membrane | 5 |
| lysosome | 4 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| nucleus | 2 |
| endosome | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| golgi apparatus | 1 |
- Golgi apparatus (2)
- Nucleoli (2)
- Nucleoplasm (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | ISS | -- |
| GO:0005886 | plasma membrane | IEA,TAS | -- |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA | -- |
| GO:0030667 | secretory granule membrane | TAS | -- |
Pathways & Interactions for FPR1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Peptide ligand-binding receptors |
.34
|
|
| 2 | Signaling by GPCR | ||
| 3 | Innate Immune System |
.61
|
|
| 4 | Cytokine Signaling in Immune system | ||
| 5 | Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 | ||
Pathways by source for FPR1 Gene
2 BioSystems pathways for FPR1 Gene
4 KEGG pathways for FPR1 Gene
1 GeneGo (Thomson Reuters) pathway for FPR1 Gene
- Cytoskeleton remodeling_RalA regulation pathway
Interacting Proteins for FPR1 Gene
Selected Interacting proteins:
P21462-FPR1_HUMAN
ENSP00000471493
for FPR1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FPR1
SIGNOR curated interactions for FPR1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000187 | activation of MAPK activity | TAS | 10857861 |
| GO:0002430 | complement receptor mediated signaling pathway | IBA | 21873635 |
| GO:0006935 | chemotaxis | IEA | -- |
| GO:0006954 | inflammatory response | IBA | 21873635 |
| GO:0007165 | signal transduction | IEA,TAS | 10820279 |
Drugs & Compounds for FPR1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Cyclosporin A | Approved, Investigational, Vet_approved | Pharma | Antagonist, inhibitor | Immunosuppressive agent, Calcineurin inhibitor | 0 | |
| Nedocromil | Approved, Investigational | Pharma | Target, antagonist | 5 | ||
| chenodeoxycholic acid | Approved | Pharma | Antagonist | 30 | ||
| deoxycholic acid | Approved | Pharma | Antagonist | 51 | ||
| FAD | Approved | Pharma | Target, Target | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
(4) Tocris Compounds for FPR1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| FPR A14 | FPR agonist | 329691-12-5 |
| MMK 1 | Potent and selective FPR2 agonist | 271246-66-3 |
| N-Formyl-Met-Leu-Phe | Endogenous FPR1 agonist | 59880-97-6 |
| WKYMVM | Selective FPR2 and FPR3 receptor agonist | 187986-11-4 |
(9) ApexBio Compounds for FPR1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Ac9-25 | 284040-76-2 | |
| Boc-MLF | 67247-12-5 | |
| Cyclosporin H | Selective and competitive formyl peptide receptor antagonist | 83602-39-5 |
| FPR A14 | 329691-12-5 | |
| MMK 1 | 271246-66-3 | |
| N-Formyl-Met-Leu-Phe | 59880-97-6 | |
| PBP 10 | 794466-43-6 | |
| WKYMVM | 187986-11-4 | |
| WRW4 | 878557-55-2 |
Transcripts for FPR1 Gene
mRNA/cDNA for FPR1 Gene
- 2 REFSEQ mRNAs :
- 9 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000304748 1298 nts (view in UCSC)
- ENST00000594900 587 nts (view in UCSC)
- ENST00000595042 1965 nts (view in UCSC)
- ENST00000600815 742 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for FPR1 - Starting at $85 >
- * FPR1 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for FPR1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FPR1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FPR1
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FPR1
- Browse OriGene Inhibitory RNA Products For FPR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPR1
Clone products for research
- Applied Biological Materials (abm): Clones for FPR1 - Starting at $45 >
- * FPR1 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for FPR1
- Addgene plasmids for FPR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FPR1
Relevant External Links for FPR1 Gene
- GeneLoc Exon Structure for
- FPR1
Expression for FPR1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
- Monocytes Peripheral Blood
-
Eye (Sensory Organs)
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
-
Epithelial Cells
- Adult Retinal Pigmented Epithelium Cells Retinal Pigmented Epithelium
- Umbilical Cord (Extraembryonic Tissues)
- Bone (Muscoskeletal System)
mRNA differential expression in normal tissues according to GTEx for FPR1 Gene
This gene is overexpressed in Whole Blood (x47.4).
This gene is overexpressed in Monocytes (33.3) and Neutrophil (30.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FPR1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FPR1
SOURCE GeneReport for Unigene cluster for FPR1 Gene:
Hs.753mRNA Expression by UniProt/SwissProt for FPR1 Gene:
P21462-FPR1_HUMAN
Tissue specificity:
Neutrophils.
Evidence on tissue expression from TISSUES for FPR1 Gene
- Bone marrow(4.6)
- Kidney(4.3)
- Blood(3.2)
- Intestine(2.9)
- Spleen(2.9)
- Nervous system(2.7)
- Lung(2.5)
- Heart(2.4)
- Lymph node(2.2)
- Liver(2.2)
Primer products for research
-
OriGene qPCR primer pairs for FPR1
Gene Expression Assays for research
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FPR1 Gene
Orthologs for FPR1 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FPR1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fpr1 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fpr1 30 |
|
||
| Dog (Canis familiaris) |
Mammalia | FPR1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
ManyToMany | |
| -- 31 |
|
ManyToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | -- 31 |
|
ManyToMany | |
| Lizard (Anolis carolinensis) |
Reptilia | -- 31 |
|
OneToMany | |
| Zebrafish (Danio rerio) |
Actinopterygii | si:ch73-113g13.2 31 |
|
ManyToMany |
- Species where no ortholog for FPR1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FPR1 Gene
- ENSEMBL:
- Gene Tree for FPR1 (if available)
- TreeFam:
- Gene Tree for FPR1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FPR1: view image
Paralogs for FPR1 Gene
(35) SIMAP similar genes for FPR1 Gene using alignment to 3 proteins:
- FPR1_HUMAN
- M0QZT0_HUMAN
- M0R315_HUMAN
Pseudogenes.org Pseudogenes for FPR1 Gene
Variants for FPR1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FPR1 Gene
| SNP ID | Clinical significance and condition | Chr 19 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 834692 | Benign: N-FORMYLPEPTIDE RECEPTOR POLYMORPHISM | 51,746,427(-) |
T/A NM_002029.4(FPR1):c.568A>T (p.Arg190Trp) |
MISSENSE | |
| 835264 | Uncertain Significance: Periodontitis | 51,746,097(-) |
G/C NM_002029.4(FPR1):c.898C>G (p.Leu300Val) |
MISSENSE | |
| 836559 | Uncertain Significance: Periodontitis | 51,746,259(-) |
C/A NM_002029.4(FPR1):c.736G>T (p.Val246Phe) |
MISSENSE | |
| 838179 | Uncertain Significance: Periodontitis | 51,746,955(-) |
C/T NM_002029.4(FPR1):c.40G>A (p.Gly14Arg) |
MISSENSE | |
| 840695 | Uncertain Significance: Periodontitis | 51,746,043(-) |
C/T NM_002029.4(FPR1):c.952G>A (p.Ala318Thr) |
MISSENSE |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv143e55 | CNV | gain | 17911159 |
| dgv3625n100 | CNV | gain | 25217958 |
| dgv3626n100 | CNV | gain | 25217958 |
| esv2758767 | CNV | gain+loss | 17122850 |
| nsv1140251 | OTHER | inversion | 24896259 |
| nsv458733 | CNV | gain | 19166990 |
| nsv470151 | CNV | gain | 18288195 |
| nsv524403 | CNV | gain | 19592680 |
| nsv579997 | CNV | gain | 21841781 |
Residual Variation Intolerance Score:
83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
7.67;
82.90% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FPR1 Gene
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPR1 Gene
Disorders for FPR1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| susceptibility to localized juvenile periodontitis |
|
|
| periodontitis |
|
|
| pulmonary coin lesion |
|
|
| aggressive periodontitis |
|
|
| rubeosis iridis |
|
|
Search FPR1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FPR1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FPR1 Gene
Publications for FPR1 Gene
- Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients. (PMID: 12595898) Zhang Y … Hart TC (Genes and immunity 2003) 2 3 23 41
- Formylpeptide receptor single nucleotide polymorphism 348T>C and its relationship to polymorphonuclear leukocyte chemotaxis in aggressive periodontitis. (PMID: 19722801) Maney P … Walters JD (Journal of periodontology 2009) 3 23 41
- Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese. (PMID: 17927965) Gunji T … Ishikawa I (Biochemical and biophysical research communications 2007) 3 23 41
- Analysis of a missense variant of the human N-formyl peptide receptor that is associated with agonist-independent beta-arrestin association and indices of inflammation. (PMID: 16953235) Bhattacharya M … Ferguson SS (The pharmacogenomics journal 2007) 3 23 41
- Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. (PMID: 10514456) Maestes DC … Prossnitz ER (The Journal of biological chemistry 1999) 3 4 23
ExternalLinks
Products for FPR1 Gene
- Custom Antibody ServicesOriGene Antibodies for FPR1
- Browse OriGene ELISA Kits
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- Taconic Biosciences Mouse Models for FPR1
- Find your next knockout model in the Taconic Knockout Repository
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- Humanized Mice
- Invitrogen Antibodies for FPR1 (AFLGC-FPR1)
- ApexBio compounds for FPR1
- VectorBuilder Custom and pre-made DNA vectors for FPR1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FPR1 (ie. lentivirus, AAV, adenovirus)
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- VectorBuilder Virus packaging for FPR1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FPR1
- Addgene plasmids for FPR1
- antibodies-online: Show 34 available FPR1 Antibodies ranked by validation data
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- antibodies-online: Show 9 available FPR1 Elisa Kits ranked by validation data
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- antibodies-online: Show 5 available FPR1 Proteins ranked by validation data
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- Quality Products:
- Horizon Cell Lines for FPR1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FPR1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FPR1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FPR1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPR1
Sources for FPR1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
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- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
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- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
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- (50) miRBase
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- (55) TGDB
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- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
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- (89) antibodies-online
- (90) CYP
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- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (109) Disease Ontology
- (110) MedlinePlus Genetics
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- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
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- (122) ENCODE
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- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
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- (139) DataMed
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- (143) Applied Biosystems
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- (148) RNAcentral
- (149) LncRNADisease
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- (152) DiseaseEnhancer
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