This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010] See more...

Aliases for FPR1 Gene

Aliases for FPR1 Gene

  • Formyl Peptide Receptor 1 2 3 5
  • N-Formylpeptide Chemoattractant Receptor 3 4
  • FMet-Leu-Phe Receptor 3 4
  • FMLP Receptor 3 4
  • FPR 3 4
  • N-Formyl Peptide Receptor 4
  • FMLP 3

External Ids for FPR1 Gene

Previous GeneCards Identifiers for FPR1 Gene

  • GC19M052879
  • GC19M052610
  • GC19M056924
  • GC19M056940
  • GC19M052249
  • GC19M048579

Summaries for FPR1 Gene

Entrez Gene Summary for FPR1 Gene

  • This gene encodes a G protein-coupled receptor of mammalian phagocytic cells that is a member of the G-protein coupled receptor 1 family. The protein mediates the response of phagocytic cells to invasion of the host by microorganisms and is important in host defense and inflammation.[provided by RefSeq, Jul 2010]

GeneCards Summary for FPR1 Gene

FPR1 (Formyl Peptide Receptor 1) is a Protein Coding gene. Diseases associated with FPR1 include Susceptibility To Localized Juvenile Periodontitis and Periodontitis. Among its related pathways are Signaling by GPCR and Innate Immune System. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and RAGE receptor binding. An important paralog of this gene is FPR2.

UniProtKB/Swiss-Prot Summary for FPR1 Gene

  • High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685).

Tocris Summary for FPR1 Gene

  • The formyl peptide receptor family, FPR1, FPR2 and FPR3 (formerly FPR, FPRL1 and FPRL2 respectively) are Gi-protein-coupled receptors that are expressed mainly by mammalian phagocytic leukocytes. FPRs are involved in antibacterial host defence and inflammation.

Gene Wiki entry for FPR1 Gene

Additional gene information for FPR1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FPR1 Gene

Genomics for FPR1 Gene

GeneHancer (GH) Regulatory Elements for FPR1 Gene

Promoters and enhancers for FPR1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J051803 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 503.5 -2.0 -1989 5.6 CTCF ZBTB11 TCF7 AFF1 REST HES1 CUX1 ZNF740 CTBP1 TEAD1 FPR1 piR-37044 SIGLEC14 FPR3 SIGLEC8 RPL7P51 SIGLEC5 ZNF577 ENSG00000269483 ZNF766
GH19J051749 Promoter/Enhancer 1.4 EPDnew FANTOM5 Ensembl ENCODE 549.9 +53.5 53509 4 POLR2A FOS SPI1 CEBPB JUND ATF3 FPR1 FPR2 piR-38580-149 SIGLEC10 ZNF350
GH19J051731 Enhancer 1.2 FANTOM5 Ensembl ENCODE 45 +65.5 65509 16.8 RBM25 CREB1 CTCF TRIM24 NCOR1 PBX2 SPI1 FOSL1 BCOR TAL1 FPR1 FPR2 HAS1 FPR3 SIGLEC10 SIGLEC14 MIR125A MIR99B MIRLET7E SPACA6
GH19J051621 Enhancer 1.3 FANTOM5 Ensembl ENCODE dbSUPER 28.6 +183.3 183309 2.8 EP300 BCL11A TCF12 CBFB CTCF PBX2 SPI1 BATF IRF4 POU2F2 RPL9P33 lnc-ZNF175-4 FPR2 FPR1 SIGLEC14 SIGLEC10 ZNF350 SIGLEC5 HSALNG0127238 ENSG00000268500
GH19J051771 Enhancer 1 FANTOM5 ENCODE dbSUPER 28.2 +32.3 32254 1.1 CTCF SPI1 GABPA POLR2A GABPB1 ESRRA ZNF316 FOXA1 ENSG00000286236 FPR2 FPR1 SIGLEC10 ZNF350 SIGLEC14 piR-41525-349
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FPR1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FPR1

Top Transcription factor binding sites by QIAGEN in the FPR1 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • FOXO1
  • FOXO1a
  • FOXO4
  • STAT3

Genomic Locations for FPR1 Gene

Genomic Locations for FPR1 Gene
chr19:51,745,172-51,804,110
(GRCh38/hg38)
Size:
58,939 bases
Orientation:
Minus strand
chr19:52,248,425-52,307,363
(GRCh37/hg19)
Size:
58,939 bases
Orientation:
Minus strand

Genomic View for FPR1 Gene

Genes around FPR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPR1 Gene

Proteins for FPR1 Gene

  • Protein details for FPR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P21462-FPR1_HUMAN
    Recommended name:
    fMet-Leu-Phe receptor
    Protein Accession:
    P21462
    Secondary Accessions:
    • Q14939
    • Q7Z6A4
    • Q86U52
    • Q9NS48

    Protein attributes for FPR1 Gene

    Size:
    350 amino acids
    Molecular mass:
    38446 Da
    Quaternary structure:
    • Interacts with S.aureus chemotaxis inhibitory protein (CHIPS); the interaction blocks the receptor and may thus inhibit the immune response.

neXtProt entry for FPR1 Gene

Post-translational modifications for FPR1 Gene

  • Phosphorylated; which is necessary for desensitization.
  • Glycosylation at Asn4 and Asn10
  • Modification sites at PhosphoSitePlus

Other Protein References for FPR1 Gene

Antibody Products

  • Abcam antibodies for FPR1
  • Boster Bio Antibodies for FPR1

No data available for DME Specific Peptides for FPR1 Gene

Domains & Families for FPR1 Gene

Gene Families for FPR1 Gene

HGNC:
IUPHAR :
Human Protein Atlas (HPA):
  • G-protein coupled receptors
  • Predicted membrane proteins

Protein Domains for FPR1 Gene

Blocks:
  • Formyl-methionyl peptide receptor signature
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FPR1 Gene

GenScript: Design optimal peptide antigens:
  • N-formylpeptide chemoattractant receptor (FPR1_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P21462

UniProtKB/Swiss-Prot:

FPR1_HUMAN :
  • Belongs to the G-protein coupled receptor 1 family.
Family:
  • Belongs to the G-protein coupled receptor 1 family.
genes like me logo Genes that share domains with FPR1: view

Function for FPR1 Gene

Molecular function for FPR1 Gene

UniProtKB/Swiss-Prot Function:
High affinity receptor for N-formyl-methionyl peptides (fMLP), which are powerful neutrophil chemotactic factors (PubMed:2161213, PubMed:2176894, PubMed:10514456, PubMed:15153520). Binding of fMLP to the receptor stimulates intracellular calcium mobilization and superoxide anion release (PubMed:2161213, PubMed:1712023, PubMed:15153520). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1712023, PubMed:10514456). Receptor for TAFA4, mediates its effects on chemoattracting macrophages, promoting phagocytosis and increasing ROS release (PubMed:25109685).
GENATLAS Biochemistry:
formyl peptide (bacterial) receptor 1,mediating chemotaxis and inducing leukocyte activation,(formyl-Met-Leu-Phe),G protein coupled,secretin receptor superfamily

Phenotypes From GWAS Catalog for FPR1 Gene

Gene Ontology (GO) - Molecular Function for FPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001664 G protein-coupled receptor binding IDA 10823817
GO:0004930 G protein-coupled receptor activity IEA,IBA 21873635
GO:0004982 N-formyl peptide receptor activity IEA,IDA 12218158
GO:0005124 scavenger receptor binding IEA --
GO:0005515 protein binding IPI 22447027
genes like me logo Genes that share ontologies with FPR1: view
genes like me logo Genes that share phenotypes with FPR1: view

Animal Models for FPR1 Gene

MGI Knock Outs for FPR1:
  • Fpr1 Fpr1<tm1b(KOMP)Wtsi>
  • Fpr1 Fpr1<tm1Gao>

Animal Model Products

CRISPR Products

miRNA for FPR1 Gene

miRTarBase miRNAs that target FPR1

Clone Products

  • Addgene plasmids for FPR1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FPR1 Gene

Localization for FPR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPR1 Gene

Cell membrane; Multi-pass membrane protein. Note=Internalizes in presence of its ligand, TAFA4. {ECO:0000269 PubMed:25109685}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FPR1 gene
Compartment Confidence
plasma membrane 5
lysosome 4
extracellular 2
cytoskeleton 2
mitochondrion 2
nucleus 2
endoplasmic reticulum 2
endosome 2
cytosol 2
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005623 cell IEA --
GO:0005737 cytoplasm ISS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with FPR1: view

Pathways & Interactions for FPR1 Gene

genes like me logo Genes that share pathways with FPR1: view

Pathways by source for FPR1 Gene

SIGNOR curated interactions for FPR1 Gene

Activates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FPR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity TAS 10857861
GO:0002430 complement receptor mediated signaling pathway IBA 21873635
GO:0006935 chemotaxis TAS,IEA --
GO:0006954 inflammatory response IBA 21873635
GO:0007165 signal transduction TAS,IEA 10820279
genes like me logo Genes that share ontologies with FPR1: view

Drugs & Compounds for FPR1 Gene

(72) Drugs for FPR1 Gene - From: DrugBank, ApexBio, DGIdb, IUPHAR, HMDB, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclosporin A Approved, Investigational, Vet_approved Pharma Antagonist, Inhibition, Inhibitor, inhibitor Immunosuppressive agent, Immunosuppressant drug, Calcineurin inhibitor 0
chenodeoxycholic acid Approved Pharma Antagonist, Full agonist, Agonist 41
deoxycholic acid Approved Pharma Antagonist, Full agonist, Agonist 49
Nedocromil Approved, Investigational Pharma Target, antagonist 5
Calcium Approved Nutra 7884

(39) Additional Compounds for FPR1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(4) Tocris Compounds for FPR1 Gene

Compound Action Cas Number
FPR A14 FPR agonist 329691-12-5
MMK 1 Potent and selective FPR2 agonist 271246-66-3
N-Formyl-Met-Leu-Phe Endogenous FPR1 agonist 59880-97-6
WKYMVM Selective FPR2 and FPR3 receptor agonist 187986-11-4

(9) ApexBio Compounds for FPR1 Gene

Compound Action Cas Number
Ac9-25 284040-76-2
Boc-MLF 67247-12-5
Cyclosporin H Selective and competitive formyl peptide receptor antagonist 83602-39-5
FPR A14 329691-12-5
MMK 1 271246-66-3
N-Formyl-Met-Leu-Phe 59880-97-6
PBP 10 794466-43-6
WKYMVM 187986-11-4
WRW4 878557-55-2
genes like me logo Genes that share compounds with FPR1: view

Drug Products

Transcripts for FPR1 Gene

mRNA/cDNA for FPR1 Gene

2 REFSEQ mRNAs :
9 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

  • Addgene plasmids for FPR1

Alternative Splicing Database (ASD) splice patterns (SP) for FPR1 Gene

No ASD Table

Relevant External Links for FPR1 Gene

GeneLoc Exon Structure for
FPR1

Expression for FPR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FPR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FPR1 Gene

This gene is overexpressed in Whole Blood (x47.4).

Protein differential expression in normal tissues from HIPED for FPR1 Gene

This gene is overexpressed in Monocytes (33.3) and Neutrophil (30.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FPR1 Gene



Protein tissue co-expression partners for FPR1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FPR1

SOURCE GeneReport for Unigene cluster for FPR1 Gene:

Hs.753

mRNA Expression by UniProt/SwissProt for FPR1 Gene:

P21462-FPR1_HUMAN
Tissue specificity: Neutrophils.

Evidence on tissue expression from TISSUES for FPR1 Gene

  • Bone marrow(4.4)
  • Kidney(4.2)
  • Blood(3.1)
  • Spleen(2.3)
  • Intestine(2.2)
  • Lung(2)
genes like me logo Genes that share expression patterns with FPR1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FPR1 Gene

Orthologs for FPR1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FPR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPR1 31 30
  • 98.95 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fpr1 17 31 30
  • 78.64 (n)
rat
(Rattus norvegicus)
Mammalia Fpr1 30
  • 76.26 (n)
dog
(Canis familiaris)
Mammalia FPR1 31
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 45 (a)
ManyToMany
-- 31
  • 41 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 26 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 31 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii si:ch73-113g13.2 31
  • 19 (a)
ManyToMany
Species where no ortholog for FPR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FPR1 Gene

ENSEMBL:
Gene Tree for FPR1 (if available)
TreeFam:
Gene Tree for FPR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FPR1: view image

Paralogs for FPR1 Gene

Paralogs for FPR1 Gene

(35) SIMAP similar genes for FPR1 Gene using alignment to 3 proteins:

  • FPR1_HUMAN
  • M0QZT0_HUMAN
  • M0R315_HUMAN

Pseudogenes.org Pseudogenes for FPR1 Gene

genes like me logo Genes that share paralogs with FPR1: view

Variants for FPR1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FPR1 Gene

SNP ID Clinical significance and condition Chr 19 pos Variation AA Info Type
566652 Uncertain Significance: Periodontitis 51,746,461(-) A/T MISSENSE_VARIANT
575041 Uncertain Significance: Periodontitis 51,746,586(-) G/A MISSENSE_VARIANT
575332 Uncertain Significance: Periodontitis 51,746,190(-) G/A MISSENSE_VARIANT
640589 Uncertain Significance: Periodontitis 51,746,436(-) G/A MISSENSE_VARIANT
641997 Uncertain Significance: Periodontitis 51,746,285(-) C/T MISSENSE_VARIANT

Additional dbSNP identifiers (rs#s) for FPR1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FPR1 Gene

Variant ID Type Subtype PubMed ID
dgv143e55 CNV gain 17911159
dgv3625n100 CNV gain 25217958
dgv3626n100 CNV gain 25217958
esv2758767 CNV gain+loss 17122850
nsv1140251 OTHER inversion 24896259
nsv458733 CNV gain 19166990
nsv470151 CNV gain 18288195
nsv524403 CNV gain 19592680
nsv579997 CNV gain 21841781

Variation tolerance for FPR1 Gene

Residual Variation Intolerance Score: 83.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.67; 82.90% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FPR1 Gene

Human Gene Mutation Database (HGMD)
FPR1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FPR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPR1 Gene

Disorders for FPR1 Gene

MalaCards: The human disease database

(14) MalaCards diseases for FPR1 Gene - From: Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
susceptibility to localized juvenile periodontitis
periodontitis
  • chronic pericementitis
periodontitis, aggressive, 1
  • periodontitis, juvenile; jpd; jp
aggressive periodontitis
  • periodontitis, juvenile
plague
  • yersiniosis
- elite association - COSMIC cancer census association via MalaCards
Search FPR1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FPR1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FPR1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FPR1 Gene

Publications for FPR1 Gene

  1. Evaluation of human leukocyte N-formylpeptide receptor (FPR1) SNPs in aggressive periodontitis patients. (PMID: 12595898) Zhang Y … Hart TC (Genes and immunity 2003) 2 3 23 41 54
  2. Formylpeptide receptor single nucleotide polymorphism 348T>C and its relationship to polymorphonuclear leukocyte chemotaxis in aggressive periodontitis. (PMID: 19722801) Maney P … Walters JD (Journal of periodontology 2009) 3 23 41 54
  3. Functional polymorphisms of the FPR1 gene and aggressive periodontitis in Japanese. (PMID: 17927965) Gunji T … Ishikawa I (Biochemical and biophysical research communications 2007) 3 23 41 54
  4. Analysis of a missense variant of the human N-formyl peptide receptor that is associated with agonist-independent beta-arrestin association and indices of inflammation. (PMID: 16953235) Bhattacharya M … Ferguson SS (The pharmacogenomics journal 2007) 3 23 41 54
  5. Differential phosphorylation paradigms dictate desensitization and internalization of the N-formyl peptide receptor. (PMID: 10514456) Maestes DC … Prossnitz ER (The Journal of biological chemistry 1999) 3 4 23 54

Products for FPR1 Gene

Sources for FPR1 Gene