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Aliases for FPGT Gene

Aliases for FPGT Gene

  • Fucose-1-Phosphate Guanylyltransferase 2 3 3 5
  • GDP-L-Fucose Diphosphorylase 3 4
  • GFPP 3 4
  • Fucose-1-Phosphate Guanyltransferase 3
  • GDP-Beta-L-Fucose Pyrophosphorylase 3
  • GDP-L-Fucose Pyrophosphorylase 4
  • EC 2.7.7.30 4

External Ids for FPGT Gene

Previous GeneCards Identifiers for FPGT Gene

  • GC01P074785
  • GC01P073586
  • GC01P074048
  • GC01P074033
  • GC01P074375
  • GC01P074663

Summaries for FPGT Gene

Entrez Gene Summary for FPGT Gene

  • L-fucose is a key sugar in glycoproteins and other complex carbohydrates since it may be involved in many of the functional roles of these macromolecules, such as in cell-cell recognition. The fucosyl donor for these fucosylated oligosaccharides is GDP-beta-L-fucose. There are two alternate pathways for the biosynthesis of GDP-fucose; the major pathway converts GDP-alpha-D-mannose to GDP-beta-L-fucose. The protein encoded by this gene participates in an alternate pathway that is present in certain mammalian tissues, such as liver and kidney, and appears to function as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids. This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate, and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream TNNI3 interacting kinase (TNNI3K) gene. [provided by RefSeq, Dec 2010]

GeneCards Summary for FPGT Gene

FPGT (Fucose-1-Phosphate Guanylyltransferase) is a Protein Coding gene. Among its related pathways are Metabolism of proteins and Synthesis of substrates in N-glycan biosythesis. Gene Ontology (GO) annotations related to this gene include transferase activity, transferring phosphorus-containing groups and fucose-1-phosphate guanylyltransferase activity.

UniProtKB/Swiss-Prot for FPGT Gene

  • Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.

Gene Wiki entry for FPGT Gene

Additional gene information for FPGT Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FPGT Gene

Genomics for FPGT Gene

GeneHancer (GH) Regulatory Elements for FPGT Gene

Promoters and enhancers for FPGT Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J074197 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.1 146 2.1 HDGF ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF207 SP3 LRRIQ3 FPGT FPGT-TNNI3K TNNI3K
GH01J074199 Enhancer 0.6 ENCODE 650.7 +1.5 1500 0.2 HDAC1 BHLHE40 MAX CEBPG MNT ATF4 IKZF1 SPI1 LRRIQ3 FPGT-TNNI3K FPGT TNNI3K
GH01J074201 Promoter 0.5 EPDnew 650.7 +3.2 3181 0.1 FPGT FPGT-TNNI3K TNNI3K
GH01J074235 Promoter 0.5 EPDnew 0.3 +37.2 37156 0.1 TNNI3K LRRC53 FPGT FPGT-TNNI3K
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FPGT on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FPGT gene promoter:
  • STAT5A
  • GCNF-2
  • GCNF-1
  • GCNF
  • GATA-1
  • RSRFC4
  • AREB6
  • p53
  • c-Myb

Genomic Locations for FPGT Gene

Genomic Locations for FPGT Gene
chr1:74,198,212-74,234,086
(GRCh38/hg38)
Size:
35,875 bases
Orientation:
Plus strand
chr1:74,663,896-74,699,770
(GRCh37/hg19)
Size:
35,875 bases
Orientation:
Plus strand

Genomic View for FPGT Gene

Genes around FPGT on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPGT Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPGT Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPGT Gene

Proteins for FPGT Gene

  • Protein details for FPGT Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O14772-FPGT_HUMAN
    Recommended name:
    Fucose-1-phosphate guanylyltransferase
    Protein Accession:
    O14772
    Secondary Accessions:
    • A0A0A0MRP2
    • A6NMH3
    • B4DRX2
    • B4E2Y7
    • E9PNQ2
    • Q8N5J7

    Protein attributes for FPGT Gene

    Size:
    607 amino acids
    Molecular mass:
    68010 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAC73005.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAC82511.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=AAH32308.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAG65299.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence={ECO:0000305};

    Alternative splice isoforms for FPGT Gene

neXtProt entry for FPGT Gene

Post-translational modifications for FPGT Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FPGT Gene

Domains & Families for FPGT Gene

Gene Families for FPGT Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Plasma proteins
  • Predicted intracellular proteins

Protein Domains for FPGT Gene

Suggested Antigen Peptide Sequences for FPGT Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FPGT: view

No data available for UniProtKB/Swiss-Prot for FPGT Gene

Function for FPGT Gene

Molecular function for FPGT Gene

UniProtKB/Swiss-Prot Function:
Catalyzes the formation of GDP-L-fucose from GTP and L-fucose-1-phosphate. Functions as a salvage pathway to reutilize L-fucose arising from the turnover of glycoproteins and glycolipids.
UniProtKB/Swiss-Prot CatalyticActivity:
GTP + beta-L-fucose 1-phosphate = diphosphate + GDP-L-fucose.

Enzyme Numbers (IUBMB) for FPGT Gene

Gene Ontology (GO) - Molecular Function for FPGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003824 catalytic activity TAS 9804772
GO:0005525 GTP binding IEA --
GO:0016740 transferase activity IEA --
GO:0016772 transferase activity, transferring phosphorus-containing groups IEA --
GO:0016779 nucleotidyltransferase activity IEA --
genes like me logo Genes that share ontologies with FPGT: view
genes like me logo Genes that share phenotypes with FPGT: view

Animal Model Products

Clone Products

No data available for Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FPGT Gene

Localization for FPGT Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPGT Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FPGT gene
Compartment Confidence
cytosol 4

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FPGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS 9804772
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FPGT: view

Pathways & Interactions for FPGT Gene

genes like me logo Genes that share pathways with FPGT: view

Interacting Proteins for FPGT Gene

Gene Ontology (GO) - Biological Process for FPGT Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006004 fucose metabolic process TAS 9804772
genes like me logo Genes that share ontologies with FPGT: view

No data available for SIGNOR curated interactions for FPGT Gene

Drugs & Compounds for FPGT Gene

(3) Drugs for FPGT Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Phosphoric acid Approved Pharma 0
Guanosine diphosphate Experimental Pharma 0
Guanosine triphosphate Experimental Pharma 0

(3) Additional Compounds for FPGT Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Fucose 1-phosphate
  • 6-Deoxy-1-O-phosphono-L-galactopyranose
  • 6-Deoxy-L-galactose 1-phosphate
  • L-Fucose 1-phosphate
  • Fucose 1-phosphoric acid
  • 6-Deoxy-L-galactose 1-phosphoric acid
16562-58-6
GDP-L-fucose
  • (6-Deoxy-beta-L-galactopyranosyl) ester
  • GDP Fucose
  • GDP-beta-L-Fucose
  • Guanosine diphosphate fucose
  • Guanosine diphosphofucose
15839-70-0
pyrophosphate
  • [(ho)2P(O)OP(O)(OH)2]
  • Acide diphosphorique
  • Diphosphorsaeure
  • H4P2O7
  • PYROphosphATE
14000-31-8
genes like me logo Genes that share compounds with FPGT: view

Transcripts for FPGT Gene

mRNA/cDNA for FPGT Gene

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FPGT Gene

No ASD Table

Relevant External Links for FPGT Gene

GeneLoc Exon Structure for
FPGT
ECgene alternative splicing isoforms for
FPGT

Expression for FPGT Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FPGT Gene

Protein differential expression in normal tissues from HIPED for FPGT Gene

This gene is overexpressed in Testis (8.4), Islet of Langerhans (7.4), Stomach (6.2), and Pancreas (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FPGT Gene



NURSA nuclear receptor signaling pathways regulating expression of FPGT Gene:

FPGT

mRNA Expression by UniProt/SwissProt for FPGT Gene:

O14772-FPGT_HUMAN
Tissue specificity: Expressed in many tissues.

Evidence on tissue expression from TISSUES for FPGT Gene

  • Kidney(4.2)
  • Intestine(4)
genes like me logo Genes that share expression patterns with FPGT: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FPGT Gene

Orthologs for FPGT Gene

This gene was present in the common ancestor of animals.

Orthologs for FPGT Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FPGT 34 33
  • 98.37 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FPGT 34 33
  • 89.91 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FPGT 34 33
  • 89.7 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fpgt 16 34 33
  • 79.7 (n)
rat
(Rattus norvegicus)
Mammalia Fpgt 33
  • 77.62 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FPGT 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FPGT 34 33
  • 66.9 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FPGT 34
  • 64 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fpgt 33
  • 59.06 (n)
zebrafish
(Danio rerio)
Actinopterygii fpgt 34 33
  • 58.3 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea CELE_K03H1.13 33
  • 45.99 (n)
K03H1.13 34
  • 29 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 39 (a)
OneToOne
Species where no ortholog for FPGT was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FPGT Gene

ENSEMBL:
Gene Tree for FPGT (if available)
TreeFam:
Gene Tree for FPGT (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FPGT: view image

Paralogs for FPGT Gene

(1) SIMAP similar genes for FPGT Gene using alignment to 6 proteins:

  • FPGT_HUMAN
  • A0PJA8_HUMAN
  • E9PK10_HUMAN
  • E9PMK0_HUMAN
  • E9PMM4_HUMAN
  • H0YDF0_HUMAN
genes like me logo Genes that share paralogs with FPGT: view

No data available for Paralogs for FPGT Gene

Variants for FPGT Gene

Sequence variations from dbSNP and Humsavar for FPGT Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000113417 -- 74,206,413(+) A/G 3_prime_UTR_variant
rs1000575833 -- 74,205,619(+) T/G 3_prime_UTR_variant, coding_sequence_variant, synonymous_variant
rs1000576305 -- 74,200,511(+) T/C intron_variant
rs1000629671 -- 74,204,269(+) A/G intron_variant
rs1000840670 -- 74,206,579(+) A/G/T 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for FPGT Gene

Variant ID Type Subtype PubMed ID
dgv28e214 CNV gain 21293372
esv3893723 CNV gain 25118596
nsv1002115 CNV gain 25217958
nsv522147 CNV loss 19592680

Variation tolerance for FPGT Gene

Gene Damage Index Score: 1.92; 35.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FPGT Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FPGT

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPGT Gene

Disorders for FPGT Gene

Additional Disease Information for FPGT

No disorders were found for FPGT Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FPGT Gene

Publications for FPGT Gene

  1. GDP-L-fucose pyrophosphorylase. Purification, cDNA cloning, and properties of the enzyme. (PMID: 9804772) Pastuszak I … Elbein AD (The Journal of biological chemistry 1998) 2 3 4 22 58
  2. Purification, crystallization and preliminary X-ray characterization of the human GTP fucose pyrophosphorylase. (PMID: 16582493) Quirk S … Seley-Radtke KL (Acta crystallographica. Section F, Structural biology and crystallization communications 2006) 3 22 58
  3. Substrate discrimination by the human GTP fucose pyrophosphorylase. (PMID: 16086588) Quirk S … Seley KL (Biochemistry 2005) 3 22 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58

Products for FPGT Gene

Sources for FPGT Gene

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