Aliases for FPGS Gene
External Ids for FPGS Gene
Previous GeneCards Identifiers for FPGS Gene
This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]
GeneCards Summary for FPGS Gene
FPGS (Folylpolyglutamate Synthase) is a Protein Coding gene. Diseases associated with FPGS include Retroperitoneal Liposarcoma and Cutis Laxa, Autosomal Dominant 2. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Biosynthesis of cofactors. Gene Ontology (GO) annotations related to this gene include ligase activity and tetrahydrofolylpolyglutamate synthase activity.
UniProtKB/Swiss-Prot Summary for FPGS Gene
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.