This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate deriv... See more...

Aliases for FPGS Gene

Aliases for FPGS Gene

  • Folylpolyglutamate Synthase 2 3 5
  • Folylpolyglutamate Synthase, Mitochondrial 3 4
  • Tetrahydrofolylpolyglutamate Synthase 3 4
  • Folylpoly-Gamma-Glutamate Synthetase 3 4
  • Tetrahydrofolate Synthase 3 4
  • EC 6.3.2.17 4 50
  • FPGS 5

External Ids for FPGS Gene

Previous GeneCards Identifiers for FPGS Gene

  • GC09P121679
  • GC09P122211
  • GC09P124018
  • GC09P125941
  • GC09P127644
  • GC09P129604
  • GC09P130556
  • GC09P100181

Summaries for FPGS Gene

Entrez Gene Summary for FPGS Gene

  • This gene encodes the folylpolyglutamate synthetase enzyme. This enzyme has a central role in establishing and maintaining both cytosolic and mitochondrial folylpolyglutamate concentrations and, therefore, is essential for folate homeostasis and the survival of proliferating cells. This enzyme catalyzes the ATP-dependent addition of glutamate moieties to folate and folate derivatives. Alternative splicing results in transcript variants encoding different isoforms. [provided by RefSeq, Jan 2014]

GeneCards Summary for FPGS Gene

FPGS (Folylpolyglutamate Synthase) is a Protein Coding gene. Diseases associated with FPGS include Retroperitoneal Liposarcoma and Cutis Laxa, Autosomal Dominant 2. Among its related pathways are Metabolism of water-soluble vitamins and cofactors and Folate biosynthesis. Gene Ontology (GO) annotations related to this gene include ligase activity and tetrahydrofolylpolyglutamate synthase activity.

UniProtKB/Swiss-Prot Summary for FPGS Gene

  • Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.

Gene Wiki entry for FPGS Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FPGS Gene

Genomics for FPGS Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FPGS Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FPGS on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FPGS

Top Transcription factor binding sites by QIAGEN in the FPGS gene promoter:
  • ATF
  • p300
  • p53

Genomic Locations for FPGS Gene

Latest Assembly
chr9:127,794,597-127,814,520
(GRCh38/hg38)
Size:
19,924 bases
Orientation:
Plus strand

Previous Assembly
chr9:130,565,137-130,576,360
(GRCh37/hg19 by Entrez Gene)
Size:
11,224 bases
Orientation:
Plus strand

chr9:130,556,876-130,576,606
(GRCh37/hg19 by Ensembl)
Size:
19,731 bases
Orientation:
Plus strand

Genomic View for FPGS Gene

Genes around FPGS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FPGS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FPGS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FPGS Gene

Proteins for FPGS Gene

  • Protein details for FPGS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q05932-FOLC_HUMAN
    Recommended name:
    Folylpolyglutamate synthase, mitochondrial
    Protein Accession:
    Q05932
    Secondary Accessions:
    • B3KPW4
    • B7Z2Z3
    • F5H0K6
    • Q5JU19
    • Q5JU22
    • Q6P2P6

    Protein attributes for FPGS Gene

    Size:
    587 amino acids
    Molecular mass:
    64609 Da
    Cofactor:
    Name=K(+); Xref=ChEBI:CHEBI:29103;
    Cofactor:
    Name=NH4(+); Xref=ChEBI:CHEBI:28938;
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAA35852.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
    Miscellaneous:
    • [Isoform 2]: Produced by alternative initiation at Met-43 of isoform 1.
    • [Isoform 3]: Produced by alternative splicing of isoform 1.
    • [Isoform 4]: Produced by alternative splicing of isoform 1.

    Alternative splice isoforms for FPGS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FPGS Gene

Selected DME Specific Peptides for FPGS Gene

Q05932:
  • EKIAWQKGGIFK
  • NADQQNFTVTLDQVLLRCL
  • YFRFLTLMA
  • VLVTGSLHLVGGVL
  • DHTSLLG

Post-translational modifications for FPGS Gene

  • Ubiquitination at Lys66, Lys107, Lys124, Lys154, and Lys248
  • Modification sites at PhosphoSitePlus

Domains & Families for FPGS Gene

Gene Families for FPGS Gene

Human Protein Atlas (HPA):
  • Enzymes
  • Predicted intracellular proteins

Protein Domains for FPGS Gene

Suggested Antigen Peptide Sequences for FPGS Gene

GenScript: Design optimal peptide antigens:
  • Tetrahydrofolylpolyglutamate synthase (FOLC_HUMAN)
  • Folylpolyglutamate synthetase cytosolic isoform (Q96DJ6_HUMAN)
  • Folylpolyglutamate synthetase mitochondrial isoform (Q96DJ7_HUMAN)
  • Folylpolyglutamate synthetase cytosolic isoform (Q96LE3_HUMAN)
  • Folylpolyglutamate synthetase mitochondrial isoform (Q96LE4_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q05932

UniProtKB/Swiss-Prot:

FOLC_HUMAN :
  • Belongs to the folylpolyglutamate synthase family.
Family:
  • Belongs to the folylpolyglutamate synthase family.
genes like me logo Genes that share domains with FPGS: view

Function for FPGS Gene

Molecular function for FPGS Gene

UniProtKB/Swiss-Prot Function:
Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Unsubstituted reduced folates are the preferred substrates. Metabolizes methotrexate (MTX) to polyglutamates.
UniProtKB/Swiss-Prot CatalyticActivity:
Reaction=(6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n + ATP + L-glutamate = (6S)-5,6,7,8-tetrahydrofolyl-(gamma-L-Glu)n+1 + ADP + H(+) + phosphate; Xref=Rhea:RHEA:10580, Rhea:RHEA-COMP:14738, Rhea:RHEA-COMP:14740, ChEBI:CHEBI:15378, ChEBI:CHEBI:29985, ChEBI:CHEBI:30616, ChEBI:CHEBI:43474, ChEBI:CHEBI:141005, ChEBI:CHEBI:456216; EC=6.3.2.17; Evidence={ECO:0000269|PubMed:1409616, ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:18672898, ECO:0000269|PubMed:8408018, ECO:0000269|PubMed:8408020, ECO:0000269|PubMed:8662720};.
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=201 uM for L-glutamate (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=200 uM for MgATP (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=59 uM for pteroylglutamic acid (PteGlu) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=16 uM for PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=20 uM for PteGlu(3) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=12 uM for PteGlu(4) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=64 uM for PteGlu(5) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=0.81 uM for H(2)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=47 uM for H(2)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=1.6 uM for (6ambo)-tetrahydropteroylpoly-gamma-glutamate (H(4)PteGlu) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=4.4 uM for (6S)-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=3.3 uM for (6S)-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=1.4 uM for (6S)-H(4)PteGlu(3) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=1.6 uM for (6S)-H(4)PteGlu(4) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=1.4 uM for (6S)-H(4)PteGlu(5) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=3.7 uM for (6R)-10-formyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=2.7 uM for (6R)-10-formyl-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=105 uM for (6S)-5-formyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=13 uM for (6S)-5-formyl-H(4)PteGlu(2) (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=48 uM for (6S)-5-methyl-H(4)PteGlu (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=4.4 uM for aminopterin (isoform 2 at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720}; KM=55.5 uM for methotrexate (isoform 2, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269|PubMed:17875718}; KM=52.6 uM for methotrexate (isoform 1, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269|PubMed:17875718}; KM=71 uM for methotrexate (Glu-1) (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:8662720}; KM=50 uM for methotrexate (Glu-2) (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:8662720}; KM=148 uM for methotrexate (Glu-3) (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:8662720}; KM=5.3 uM for 5-deazaacyclotetrahydrofolate (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:8662720}; KM=2.8 uM for 2-methyl-5,8-dideazaisofolate (isoform 2, at 37 degrees Celsius in the presence of 1 mM ATP and 2 mM L-glutamate) {ECO:0000269|PubMed:8662720}; KM=1702 uM for glutamic acid (isoform 2, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269|PubMed:17875718}; KM=2068 uM for glutamic acid (isoform 1, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269|PubMed:17875718}; Vmax=0.34 umol/h/mg enzyme with methotrexate as substrate (isoform 2, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269|PubMed:17875718}; Vmax=0.05 umol/h/mg enzyme with methotrexate as substrate (isoform 1, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269|PubMed:17875718}; Vmax=1.26 umol/h/mg enzyme with glutamic acid as substrate (isoform 2, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269|PubMed:17875718}; Vmax=0.25 umol/h/mg enzyme with glutamic acid as substrate (isoform 1, at 37 degrees Celsius in the presence of 10 mM ATP and pH 8.5) {ECO:0000269|PubMed:17875718}; pH dependence: Optimum pH is 9.6 (isoform 2). {ECO:0000269|PubMed:17875718, ECO:0000269|PubMed:8662720};
UniProtKB/Swiss-Prot EnzymeRegulation:
Activated by 10 mM sodium bicarbonate.
GENATLAS Biochemistry:
folylpoly-gamma-glutamate synthase

Enzyme Numbers (IUBMB) for FPGS Gene

Phenotypes From GWAS Catalog for FPGS Gene

Gene Ontology (GO) - Molecular Function for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0004326 tetrahydrofolylpolyglutamate synthase activity IEA,TAS --
GO:0005524 ATP binding IEA --
GO:0016874 ligase activity IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with FPGS: view
genes like me logo Genes that share phenotypes with FPGS: view

Animal Models for FPGS Gene

MGI Knock Outs for FPGS:
  • Fpgs Fpgs<tm1a(EUCOMM)Hmgu>

Animal Models for research

  • Taconic Biosciences Mouse Models for FPGS

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPGS

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FPGS Gene

Localization for FPGS Gene

Subcellular locations from UniProtKB/Swiss-Prot for FPGS Gene

[Isoform 1]: Mitochondrion inner membrane. Mitochondrion matrix.
[Isoform 2]: Cytoplasm.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FPGS gene
Compartment Confidence
mitochondrion 5
cytosol 4
plasma membrane 1
extracellular 1
cytoskeleton 1
nucleus 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm TAS,IBA 21873635
GO:0005739 mitochondrion TAS,IBA 21873635
GO:0005743 mitochondrial inner membrane IEA --
GO:0005759 mitochondrial matrix TAS --
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with FPGS: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FPGS Gene

Pathways & Interactions for FPGS Gene

genes like me logo Genes that share pathways with FPGS: view

UniProtKB/Swiss-Prot Q05932-FOLC_HUMAN

  • Pathway: Cofactor biosynthesis; tetrahydrofolylpolyglutamate biosynthesis.

Gene Ontology (GO) - Biological Process for FPGS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001889 liver development IEA --
GO:0006139 nucleobase-containing compound metabolic process TAS 7721888
GO:0006536 glutamate metabolic process IDA 3619447
GO:0006730 one-carbon metabolic process IEA --
GO:0006760 folic acid-containing compound metabolic process IDA 3619447
genes like me logo Genes that share ontologies with FPGS: view

No data available for SIGNOR curated interactions for FPGS Gene

Drugs & Compounds for FPGS Gene

(27) Drugs for FPGS Gene - From: DrugBank, PharmGKB, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methotrexate Approved Pharma Enzyme, substrate Folate antagonist,inhibits DFHR 1884
Raltitrexed Approved, Investigational Pharma Target, antagonist 50
Glutamic acid Approved Nutra Target 324
Pralatrexate Approved, Investigational Pharma Enzyme, substrate Antifolate,a folate analog, RFC-1 targeted DHFR inhibitor 0
Warfarin Approved Pharma 637

(32) Additional Compounds for FPGS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
7,8-Dihydropteroic acid
  • 4-(((2-Amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl)amino)benzoic acid
  • 7,8-Dihydropteroate
  • Dihydropteroate
  • Dihydropteroinsaeure
  • 4-(((2-Amino-1,4,7,8-tetrahydro-4-oxo-6-pteridinyl)methyl)amino)benzoate
2134-76-1
ADP
  • 5'-Adenylphosphoric acid
  • Adenosine 5'-diphosphate
  • ADENOSINE-5'-diphosphATE
  • H3ADP
  • 5'-Adenylphosphate
58-64-0
Tetrahydrofolyl-[Glu](2)
  • Tetrahydropteroyldiglutamate
  • (6S)-H4PteGlu2
  • Tetrahydropteroyldiglutamic acid
  • Tetrahydrofolyl-[glu](n+1)
  • Tetrahydropteroyl-[gamma-glu]N
Tetrahydrofolyl-[Glu](n)
  • Tetrahydrofolyl-[glu](n+1)
  • Tetrahydropteroyl-[gamma-glu]N
  • Tetrahydropteroyl-[gamma-glu]n+1
  • THF-L-Glutamic acid
  • THF-Polyglutamate
genes like me logo Genes that share compounds with FPGS: view

Transcripts for FPGS Gene

mRNA/cDNA for FPGS Gene

3 REFSEQ mRNAs :
17 NCBI additional mRNA sequence :
21 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FPGS

Alternative Splicing Database (ASD) splice patterns (SP) for FPGS Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c · 6d ^ 7 ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ^ 12a · 12b · 12c ^ 13 ^ 14 ^
SP1: - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - -
SP4: - - - - - - - -
SP5: - - - - - - -
SP6: -
SP7: - -
SP8: - - - - -
SP9: - -
SP10: - -
SP11: -
SP12: - -
SP13: - - - - -
SP14: - -
SP15:

ExUns: 15 ^ 16a · 16b ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6: -
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:

Relevant External Links for FPGS Gene

GeneLoc Exon Structure for
FPGS

Expression for FPGS Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FPGS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lymph (Hematopoietic System)
  • Liver (Hepatobiliary System)
  • Ovary (Reproductive System)

Protein differential expression in normal tissues from HIPED for FPGS Gene

This gene is overexpressed in Adrenal (12.2), Lymph node (12.2), Platelet (12.1), Liver (9.9), Ovary (8.9), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FPGS Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FPGS

SOURCE GeneReport for Unigene cluster for FPGS Gene:

Hs.335084

Evidence on tissue expression from TISSUES for FPGS Gene

  • Lung(4.5)
  • Blood(4.3)
  • Nervous system(3.1)
  • Skin(2.9)
  • Intestine(2.3)
  • Liver(2.3)
genes like me logo Genes that share expression patterns with FPGS: view

Primer products for research

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FPGS Gene

Orthologs for FPGS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for FPGS Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FPGS 29 30
  • 96.49 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FPGS 29 30
  • 86.93 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FPGS 29 30
  • 86.66 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Fpgs 29 16 30
  • 82.51 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Fpgs 29
  • 80.75 (n)
Platypus
(Ornithorhynchus anatinus)
Mammalia -- 30
  • 70 (a)
OneToMany
-- 30
  • 68 (a)
OneToMany
Oppossum
(Monodelphis domestica)
Mammalia FPGS 30
  • 59 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FPGS 29 30
  • 71 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FPGS 30
  • 63 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia fpgs 29
  • 66.42 (n)
Zebrafish
(Danio rerio)
Actinopterygii fpgs 29 30
  • 63.43 (n)
OneToOne
wufk51d09 29
Fruit Fly
(Drosophila melanogaster)
Insecta CG2543 29 30 31
  • 54.03 (n)
OneToMany
CG31773 30
  • 20 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004679 29
  • 47.55 (n)
Worm
(Caenorhabditis elegans)
Secernentea F25B5.6 29 30
  • 47.07 (n)
OneToOne
F25B5.6a 31
  • 36 (a)
F25B5.6b 31
  • 36 (a)
A. gosspyii yeast
(Eremothecium gossypii)
Saccharomycetes AGOS_ACR134W 29
  • 54.97 (n)
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes MET7 29 30 32
  • 47.75 (n)
OneToOne
K. Lactis Yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0F11297g 29
  • 47.31 (n)
Thale Cress
(Arabidopsis thaliana)
eudicotyledons DFB 29
  • 49.82 (n)
Rice
(Oryza sativa)
Liliopsida Os03g0111100 29
  • 50 (n)
Bread mold
(Neurospora crassa)
Ascomycetes NCU00892 29
  • 50.99 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.8819 30
  • 50 (a)
OneToMany
-- 30
  • 43 (a)
OneToMany
Fission Yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC1709.17 29
  • 45.97 (n)
Species where no ortholog for FPGS was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FPGS Gene

ENSEMBL:
Gene Tree for FPGS (if available)
TreeFam:
Gene Tree for FPGS (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FPGS: view image
Alliance of Genome Resources:
Additional Orthologs for FPGS

Paralogs for FPGS Gene

No data available for Paralogs for FPGS Gene

Variants for FPGS Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FPGS Gene

SNP ID Clinical significance and condition Chr 09 pos Variation AA Info Type
rs103463582 -- p.Phe13Leu
rs10760502 -- p.Ile22Val
rs12686275 -- p.Val437Asp
rs17855900 -- p.Ala489Val
rs200314440 -- p.Ser499Phe

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FPGS Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FPGS Gene

Variant ID Type Subtype PubMed ID
dgv12879n54 CNV loss 21841781
dgv12880n54 CNV loss 21841781
esv3891727 CNV gain 25118596
nsv466575 CNV loss 19166990
nsv466576 CNV loss 19166990
nsv471323 CNV loss 18288195
nsv615373 CNV loss 21841781
nsv615374 CNV loss 21841781

Variation tolerance for FPGS Gene

Residual Variation Intolerance Score: 64.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.15% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FPGS Gene

Human Gene Mutation Database (HGMD)
FPGS
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FPGS
Leiden Open Variation Database (LOVD)
FPGS

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FPGS Gene

Disorders for FPGS Gene

MalaCards: The human disease database

(7) MalaCards diseases for FPGS Gene - From: COP and GCD

Disorder Aliases PubMed IDs
retroperitoneal liposarcoma
  • giant pelvic retroperitoneal liposarcoma
cutis laxa, autosomal dominant 2
  • adcl2
cutis laxa, autosomal dominant 1
  • adcl1
cutis laxa, autosomal dominant 3
  • adcl3
childhood acute lymphocytic leukemia
  • childhood acute lymphoblastic leukemia
- elite association - COSMIC cancer census association via MalaCards
Search FPGS in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FPGS

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FPGS: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FPGS Gene

Publications for FPGS Gene

  1. Genes involved with folate uptake and distribution and their association with colorectal cancer risk. (PMID: 20037791) Figueiredo JC … Haile RW (Cancer causes & control : CCC 2010) 3 22 40
  2. Phase II trial of pemetrexed plus bevacizumab for second-line therapy of patients with advanced non-small-cell lung cancer: NCCTG and SWOG study N0426. (PMID: 19841321) Adjei AA … Zinner RG (Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2010) 3 22 40
  3. Outcomes of methotrexate therapy for psoriasis and relationship to genetic polymorphisms. (PMID: 19016697) Warren RB … Griffiths CE (The British journal of dermatology 2009) 3 22 40
  4. Concentration-dependent processivity of multiple glutamate ligations catalyzed by folylpoly-gamma-glutamate synthetase. (PMID: 18672898) Tomsho JW … Coward JK (Biochemistry 2008) 3 4 22
  5. Associations between single nucleotide polymorphisms in folate uptake and metabolizing genes with blood folate, homocysteine, and DNA uracil concentrations. (PMID: 18842806) DeVos L … Crott JW (The American journal of clinical nutrition 2008) 3 22 40

Products for FPGS Gene

Sources for FPGS Gene