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Aliases for FOXS1 Gene

Aliases for FOXS1 Gene

  • Forkhead Box S1 2 3 5
  • Forkhead-Related Transcription Factor 10 3 4
  • Forkhead-Like 18 Protein 3 4
  • FREAC-10 3 4
  • FREAC10 3 4
  • FKHL18 3 4
  • Forkhead-Related Transcription Factor FREAC-10 3
  • Forkhead-Related Activator 10 3
  • Forkhead (Drosophila)-Like 18 2
  • Forkhead-Like 18 (Drosophila) 2
  • Forkhead Box Protein S1 3

External Ids for FOXS1 Gene

Previous HGNC Symbols for FOXS1 Gene

  • FKHL18

Previous GeneCards Identifiers for FOXS1 Gene

  • GC20M029896
  • GC20M030432
  • GC20M027221

Summaries for FOXS1 Gene

Entrez Gene Summary for FOXS1 Gene

  • The forkhead family of transcription factors belongs to the winged helix class of DNA-binding proteins. The protein encoded by this intronless gene contains a forkhead domain and is found predominantly in aorta and kidney. The function of the encoded protein is unknown. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXS1 Gene

FOXS1 (Forkhead Box S1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXC2.

UniProtKB/Swiss-Prot for FOXS1 Gene

  • Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).

Additional gene information for FOXS1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXS1 Gene

Genomics for FOXS1 Gene

GeneHancer (GH) Regulatory Elements for FOXS1 Gene

Promoters and enhancers for FOXS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH20J031840 Enhancer 1.4 Ensembl ENCODE dbSUPER 650.7 +1.6 1584 6.6 HDGF PKNOX1 SIN3A YBX1 ZNF48 TCF12 GLIS2 ZNF207 ZNF143 ATF7 FOXS1 GC20M031845 ASXL1 MYLK2 POFUT1 TSPY26P TTLL9 TM9SF4 BAK1P1 PLAGL2
GH20J031860 Enhancer 1.1 Ensembl ENCODE 23.5 -15.9 -15931 2.6 HDGF PKNOX1 SIN3A GLIS2 ZNF143 ZNF207 SP3 GLIS1 WT1 SP7 FOXS1 DUSP15 MYLK2 TTLL9
GH20J031879 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 8.9 -34.3 -34281 1.4 PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YBX1 YY1 SLC30A9 E2F8 TTLL9 ASXL1 BAK1P1 TM9SF4 PLAGL2 DUSP15 FOXS1 MYLK2 RNU1-94P
GH20J031969 Enhancer 1.3 ENCODE dbSUPER 10.6 -122.9 -122934 0.2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 ZNF213 E2F8 PDRG1 XKR7 ENSG00000278012 RSL24D1P6 FOXS1 TTLL9
GH20J031808 Enhancer 0.2 dbSUPER 12 +36.8 36809 0.9 ENSG00000230801 FOXS1 DUSP15 TTLL9 TPX2 RNA5SP481 CCM2L TM9SF4 HM13 MYLK2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXS1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXS1 gene promoter:
  • Nkx2-5
  • GATA-2
  • AhR
  • AML1a
  • SRF
  • SRF (504 AA)
  • GCNF-2
  • GCNF-1
  • GCNF
  • NF-kappaB

Genomic Locations for FOXS1 Gene

Genomic Locations for FOXS1 Gene
chr20:31,844,300-31,845,619
(GRCh38/hg38)
Size:
1,320 bases
Orientation:
Minus strand
chr20:30,432,103-30,433,420
(GRCh37/hg19)
Size:
1,318 bases
Orientation:
Minus strand

Genomic View for FOXS1 Gene

Genes around FOXS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXS1 Gene

Proteins for FOXS1 Gene

  • Protein details for FOXS1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43638-FOXS1_HUMAN
    Recommended name:
    Forkhead box protein S1
    Protein Accession:
    O43638
    Secondary Accessions:
    • Q96D28

    Protein attributes for FOXS1 Gene

    Size:
    330 amino acids
    Molecular mass:
    35434 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXS1 Gene

Post-translational modifications for FOXS1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXS1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXS1 Gene

Domains & Families for FOXS1 Gene

Gene Families for FOXS1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXS1 Gene

Suggested Antigen Peptide Sequences for FOXS1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXS1: view

No data available for UniProtKB/Swiss-Prot for FOXS1 Gene

Function for FOXS1 Gene

Molecular function for FOXS1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional repressor that suppresses transcription from the FASLG, FOXO3 and FOXO4 promoters. May have a role in the organization of the testicular vasculature (By similarity).

Phenotypes From GWAS Catalog for FOXS1 Gene

Gene Ontology (GO) - Molecular Function for FOXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM,IBA 19274049
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding ISS --
GO:0003700 DNA binding transcription factor activity TAS 9325056
genes like me logo Genes that share ontologies with FOXS1: view
genes like me logo Genes that share phenotypes with FOXS1: view

Animal Models for FOXS1 Gene

MGI Knock Outs for FOXS1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FOXS1 Gene

Localization for FOXS1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXS1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS,IBA --
genes like me logo Genes that share ontologies with FOXS1: view

Pathways & Interactions for FOXS1 Gene

SuperPathways for FOXS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXS1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001568 blood vessel development ISS --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
genes like me logo Genes that share ontologies with FOXS1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXS1 Gene

Drugs & Compounds for FOXS1 Gene

No Compound Related Data Available

Transcripts for FOXS1 Gene

mRNA/cDNA for FOXS1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(31) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXS1 Gene

Forkhead box S1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXS1 Gene

No ASD Table

Relevant External Links for FOXS1 Gene

GeneLoc Exon Structure for
FOXS1
ECgene alternative splicing isoforms for
FOXS1

Expression for FOXS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXS1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXS1 Gene

This gene is overexpressed in Artery - Coronary (x10.6), Artery - Aorta (x8.3), and Artery - Tibial (x7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXS1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FOXS1 Gene:

FOXS1

SOURCE GeneReport for Unigene cluster for FOXS1 Gene:

Hs.516971

Evidence on tissue expression from TISSUES for FOXS1 Gene

  • Muscle(4.2)
genes like me logo Genes that share expression patterns with FOXS1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXS1 Gene

Orthologs for FOXS1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXS1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXS1 34 33
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FOXS1 33
  • 90.3 (n)
cow
(Bos Taurus)
Mammalia FOXS1 34 33
  • 87.27 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxs1 33
  • 79.82 (n)
mouse
(Mus musculus)
Mammalia Foxs1 16 34 33
  • 79.53 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXS1 34
  • 47 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXS1 33
  • 64.25 (n)
lizard
(Anolis carolinensis)
Reptilia FOXS1 34
  • 43 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxc1b 34
  • 26 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta croc 34
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 20 (a)
ManyToMany
Species where no ortholog for FOXS1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXS1 Gene

ENSEMBL:
Gene Tree for FOXS1 (if available)
TreeFam:
Gene Tree for FOXS1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXS1: view image

Paralogs for FOXS1 Gene

Paralogs for FOXS1 Gene

(11) SIMAP similar genes for FOXS1 Gene using alignment to 1 proteins:

  • FOXS1_HUMAN
genes like me logo Genes that share paralogs with FOXS1: view

Variants for FOXS1 Gene

Sequence variations from dbSNP and Humsavar for FOXS1 Gene

SNP ID Clin Chr 20 pos Variation AA Info Type
rs1002921569 -- 31,847,495(-) C/T upstream_transcript_variant
rs1003232111 -- 31,846,041(-) G/A upstream_transcript_variant
rs1003255487 -- 31,846,278(-) A/C upstream_transcript_variant
rs1003307837 -- 31,846,072(-) G/A upstream_transcript_variant
rs1003308306 -- 31,845,069(-) C/T coding_sequence_variant, synonymous_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXS1 Gene

Variant ID Type Subtype PubMed ID
dgv4300n100 CNV gain 25217958

Variation tolerance for FOXS1 Gene

Residual Variation Intolerance Score: 95.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.83; 47.88% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXS1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXS1 Gene

Disorders for FOXS1 Gene

Additional Disease Information for FOXS1

No disorders were found for FOXS1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXS1 Gene

Publications for FOXS1 Gene

  1. Chromosome localization, sequence analysis, and expression pattern identify FKHL 18 as a novel human forkhead gene. (PMID: 9325056) Cederberg A … Enerbäck S (Genomics 1997) 2 3 4 58
  2. Comparative genomics of vertebrate Fox cluster loci. (PMID: 17062144) Wotton KR … Shimeld SM (BMC genomics 2006) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P … Rogers J (Nature 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FOXS1 Gene

Sources for FOXS1 Gene

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