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FOXRED2 (FAD Dependent Oxidoreductase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is FMO5.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005515 | protein binding | IPI | 19706418 |
GO:0016491 | oxidoreductase activity | IEA | -- |
GO:0050660 | flavin adenine dinucleotide binding | IDA | 19706418 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0005783 | endoplasmic reticulum | IEA | -- |
GO:0005788 | endoplasmic reticulum lumen | IBA,IDA | 19706418 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0030433 | ubiquitin-dependent ERAD pathway | IMP | 19706418 |
GO:0055114 | oxidation-reduction process | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
FAD | Approved | Pharma | 0 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||||||||||||||||
SP5: | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | - | |||||||||||||||||||||||||||||||||||||||
SP7: | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | ||||||||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||||||||
SP10: | - | - | - | - |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FOXRED2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FOXRED2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Foxred2 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FOXRED2 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Foxred2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FOXRED2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FOXRED2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FOXRED2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FOXRED2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | foxred2 30 |
|
||
Str.14404 30 |
|
||||
Zebrafish (Danio rerio) |
Actinopterygii | foxred2 30 31 |
|
OneToOne | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6197 31 |
|
OneToMany | |
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
-- 31 |
|
OneToMany | |||
Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.10616 30 |
|
SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs2277841 | - |
p.Asn308Ser |
|||
rs35748020 | - |
p.Glu637Asp |
|||
rs35813894 | - |
p.Lys374Arg |
|||
rs56767103 | - |
p.Arg71Cys |
|||
rs760718 | - |
p.Phe179Leu |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv2760722 | CNV | gain | 21179565 |
nsv1060004 | CNV | gain | 25217958 |
nsv520497 | CNV | gain | 19592680 |
nsv834186 | CNV | loss | 17160897 |
No disorders were found for FOXRED2 Gene.