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Aliases for FOXRED2 Gene
Aliases for FOXRED2 Gene
- FAD Dependent Oxidoreductase Domain Containing 2 2 3 5
- ERFAD 2 3 4
- Endoplasmic Reticulum Flavoprotein Associated With Degradation 3 4
- FAD-Dependent Oxidoreductase Domain-Containing Protein 2 3 4
- ER Flavoprotein Associated With Degradation 2 3
- FAD-Dependent Oxidoreductase Domain Containing 2 2
- FLJ23322 2
- FOXRED2 5
External Ids for FOXRED2 Gene
- HGNC: 26264
- NCBI Entrez Gene: 80020
- Ensembl: ENSG00000100350
- OMIM®: 613777
- UniProtKB/Swiss-Prot: Q8IWF2
Previous GeneCards Identifiers for FOXRED2 Gene
- GC22M035214
- GC22M036883
- GC22M019851
Summaries for FOXRED2 Gene
GeneCards Summary for FOXRED2 Gene
FOXRED2 (FAD Dependent Oxidoreductase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is FMO5.
UniProtKB/Swiss-Prot Summary for FOXRED2 Gene
-
Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.
Additional gene information for FOXRED2 Gene
- HGNC (26264)
- NCBI Entrez Gene (80020)
- Ensembl (ENSG00000100350)
- OMIM® (613777)
- UniProtKB/Swiss-Prot (Q8IWF2)
- Open Targets Platform(ENSG00000100350)
- Search for FOXRED2 at DataMed
- Search for FOXRED2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXRED2 Gene
Genomics for FOXRED2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FOXRED2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXRED2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXRED2
- Top Transcription factor binding sites by QIAGEN in the FOXRED2 gene promoter:
-
- MZF-1
- Pax-2
- Pax-2a
- STAT3
- USF-1
Genomic Locations for FOXRED2 Gene
Latest Assembly
- chr22:36,487,190-36,507,043
- (GRCh38/hg38)
- Size:
- 19,854 bases
- Orientation:
- Minus strand
Previous Assembly
- chr22:36,883,237-36,903,087
- (GRCh37/hg19 by Entrez Gene)
- Size:
- 19,851 bases
- Orientation:
- Minus strand
- chr22:36,883,237-36,903,148
- (GRCh37/hg19 by Ensembl)
- Size:
- 19,912 bases
- Orientation:
- Minus strand
Genomic View for FOXRED2 Gene
Genes around FOXRED2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.3 by HGNC
- 22q12.3 by Entrez Gene
- 22q12.3 by Ensembl
FOXRED2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXRED2 Gene
Proteins for FOXRED2 Gene
-
Protein details for FOXRED2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IWF2-FXRD2_HUMAN
- Recommended name:
- FAD-dependent oxidoreductase domain-containing protein 2
- Protein Accession:
- Q8IWF2
- B2RDI4
- Q8N378
- Q96BD1
- Q9H5L5
- Q9H6M8
Protein attributes for FOXRED2 Gene
- Size:
- 684 amino acids
- Molecular mass:
- 77791 Da
- Cofactor:
- Name=FAD; Xref=ChEBI:CHEBI:57692;
- Quaternary structure:
-
- Interacts with SEL1L. May interact with OS9 and DNAJC10. Interacts with TXNDC16 (PubMed:21359175).
Protein Expression for FOXRED2 Gene
Post-translational modifications for FOXRED2 Gene
Other Protein References for FOXRED2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibodies for research
-
Custom Antibody ServicesOriGene Antibodies for FOXRED2
- Novus Biologicals Antibodies for FOXRED2
- Invitrogen Antibodies for FOXRED2 (AFLGC-FOXRED2)
-
Biorbyt antibodies for FOXRED2
-
Boster Bio Antibodies for FOXRED2
-
Custom Antibody ServicesProSci Antibodies for FOXRED2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXRED2
Protein products for research
-
OriGene Purified Proteins for FOXRED2
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXRED2
- Origene Custom Protein Services for FOXRED2
- antibodies-online: Show 2 available FOXRED2 Proteins ranked by validation data
- Compare Top FOXRED2 Proteins
-
Quality Products:
Assay products for research
No data available for DME Specific Peptides for FOXRED2 Gene
Domains & Families for FOXRED2 Gene
Gene Families for FOXRED2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FOXRED2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXRED2 Gene
- GenScript: Design optimal peptide antigens:
-
- Endoplasmic reticulum flavoprotein associated with degradation (FXRD2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8IWF2- Family:
-
- Belongs to the FOXRED2 family.
Function for FOXRED2 Gene
Molecular function for FOXRED2 Gene
- UniProtKB/Swiss-Prot Function:
- Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.
Phenotypes From GWAS Catalog for FOXRED2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19706418 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0050660 | flavin adenine dinucleotide binding | IDA | 19706418 |
Phenotypes for FOXRED2 Gene
- MGI mutant phenotypes for FOXRED2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FOXRED2:
-
- Increased gamma-H2AX phosphorylation
- Decreased hepcidin::fluc mRNA expression
- no effect
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Decreased viability ratio
- Negative genetic interaction between PTEN-/- and PTEN+/+
- No cells
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Decreased Salmonella proliferation
Animal Models for FOXRED2 Gene
- MGI Knock Outs for FOXRED2:
-
- Foxred2 Foxred2<tm1.1(KOMP)Vlcg>
Animal Models for research
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for FOXRED2 - Starting at $85 >
- * FOXRED2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for FOXRED2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXRED2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXRED2
miRNA for FOXRED2 Gene
- miRTarBase miRNAs that target FOXRED2
-
- mmu-miR-425-5p (MIRT008439)
- mmu-miR-15a-5p (MIRT011510)
- hsa-miR-124-3p (MIRT022860)
- hsa-miR-744-5p (MIRT037694)
- hsa-miR-378a-3p (MIRT043936)
- hsa-miR-186-5p (MIRT045033)
- hsa-miR-99a-5p (MIRT048677)
- hsa-miR-93-5p (MIRT048865)
- hsa-let-7b-5p (MIRT052050)
- hsa-miR-7702 (MIRT454125)
- hsa-miR-6819-5p (MIRT454126)
- hsa-miR-6812-5p (MIRT454127)
- hsa-miR-6737-5p (MIRT454128)
- hsa-miR-6742-5p (MIRT454129)
- hsa-miR-6769a-5p (MIRT454130)
- hsa-miR-6769b-5p (MIRT454131)
- hsa-miR-92a-2-5p (MIRT454132)
- hsa-miR-654-5p (MIRT454133)
- hsa-miR-6747-5p (MIRT454134)
- hsa-miR-541-3p (MIRT454135)
- hsa-miR-4651 (MIRT454136)
- hsa-miR-608 (MIRT454137)
- hsa-miR-4664-5p (MIRT454138)
- hsa-miR-342-5p (MIRT454139)
- hsa-miR-6770-5p (MIRT454140)
- hsa-miR-1253 (MIRT454141)
- hsa-miR-759 (MIRT454142)
- hsa-miR-4524b-3p (MIRT454143)
- hsa-miR-527 (MIRT691473)
- hsa-miR-518a-5p (MIRT691474)
- hsa-miR-548aw (MIRT691475)
- hsa-miR-4504 (MIRT691476)
- hsa-miR-335-5p (MIRT691477)
- hsa-miR-5089-5p (MIRT691478)
- hsa-miR-6878-3p (MIRT691479)
- hsa-miR-7151-3p (MIRT691480)
- hsa-miR-5095 (MIRT691481)
- hsa-miR-6744-3p (MIRT691482)
- hsa-miR-4757-5p (MIRT691483)
- hsa-miR-5589-5p (MIRT691484)
- hsa-miR-4731-5p (MIRT691485)
- hsa-miR-6778-3p (MIRT691486)
- hsa-miR-6506-5p (MIRT691487)
- hsa-miR-619-5p (MIRT691488)
- hsa-miR-150-5p (MIRT691489)
- hsa-miR-186-3p (MIRT691490)
- hsa-miR-3934-5p (MIRT691491)
- hsa-miR-520h (MIRT691492)
- hsa-miR-520g-3p (MIRT691493)
- hsa-miR-6504-3p (MIRT691494)
- hsa-miR-512-3p (MIRT691495)
- hsa-miR-552-3p (MIRT691496)
- hsa-miR-520e (MIRT691497)
- hsa-miR-520d-3p (MIRT691498)
- hsa-miR-520c-3p (MIRT691499)
- hsa-miR-520b (MIRT691500)
- hsa-miR-520a-3p (MIRT691501)
- hsa-miR-373-3p (MIRT691502)
- hsa-miR-372-3p (MIRT691503)
- hsa-miR-302e (MIRT691504)
- hsa-miR-302d-3p (MIRT691505)
- hsa-miR-302c-3p (MIRT691506)
- hsa-miR-302b-3p (MIRT691507)
- hsa-miR-302a-3p (MIRT691508)
- hsa-miR-526b-3p (MIRT691509)
- hsa-miR-519d-3p (MIRT691510)
- hsa-miR-20b-5p (MIRT691511)
- hsa-miR-20a-5p (MIRT691512)
- hsa-miR-17-5p (MIRT691513)
- hsa-miR-106b-5p (MIRT691514)
- hsa-miR-106a-5p (MIRT691515)
- hsa-miR-10a-5p (MIRT761143)
- hsa-miR-10b-5p (MIRT761167)
- hsa-miR-3190-5p (MIRT765365)
- hsa-miR-3926 (MIRT767709)
- hsa-miR-548s (MIRT774500)
- hsa-miR-6732-3p (MIRT777991)
- hsa-miR-6849-3p (MIRT780283)
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXRED2
- Browse OriGene Inhibitory RNA Products For FOXRED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXRED2
Clone products for research
- Applied Biological Materials (abm): Clones for FOXRED2 - Starting at $45 >
- * FOXRED2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for FOXRED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXRED2
Cell Lines for research
-
Horizon Cell Lines for FOXRED2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXRED2 Gene
Localization for FOXRED2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXRED2 Gene
- Endoplasmic reticulum lumen.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| nucleus | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005788 | endoplasmic reticulum lumen | IBA,IDA | 19706418 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXRED2 Gene
Pathways & Interactions for FOXRED2 Gene
Interacting Proteins for FOXRED2 Gene
Selected Interacting proteins:
Q8IWF2-FXRD2_HUMAN
ENSP00000380401
for FOXRED2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FOXRED2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030433 | ubiquitin-dependent ERAD pathway | IMP | 19706418 |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FOXRED2 Gene
Drugs & Compounds for FOXRED2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| FAD | Approved | Pharma | 0 |
Transcripts for FOXRED2 Gene
mRNA/cDNA for FOXRED2 Gene
- 4 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000216187 3933 nts (view in UCSC)
- ENST00000366463 2489 nts (view in UCSC)
- ENST00000397223 2184 nts (view in UCSC)
- ENST00000397224 4906 nts (view in UCSC)
- ENST00000423980 567 nts (view in UCSC)
CRISPR products for research
- Applied Biological Materials (abm): CRISPR Clones for FOXRED2 - Starting at $85 >
- * FOXRED2 CRISPR as ready-to-use vector or virus: Non-viral | Lenti- | Adeno- | AAV- | siRNA - Browse All
- * Cas9 Nucleases, Nickases, Null Mutants, and GFP tag also available.
-
OriGene CRISPR knockouts for FOXRED2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXRED2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXRED2
miRNA products for research
Inhibitory RNAs for research
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXRED2
- Browse OriGene Inhibitory RNA Products For FOXRED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXRED2
Clone products for research
- Applied Biological Materials (abm): Clones for FOXRED2 - Starting at $45 >
- * FOXRED2 as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Retro- | Protein Vector - Browse All
- * Viral Packaging Services and High Titer Production Services also available.
- Sino Biological Human cDNA Clone for FOXRED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXRED2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - |
Relevant External Links for FOXRED2 Gene
- GeneLoc Exon Structure for
- FOXRED2
Expression for FOXRED2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
This gene is overexpressed in Liver, secretome (61.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXRED2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXRED2
SOURCE GeneReport for Unigene cluster for FOXRED2 Gene:
Hs.387601Evidence on tissue expression from TISSUES for FOXRED2 Gene
- Nervous system(4.9)
- Intestine(4.8)
- Pancreas(4.8)
- Eye(4.6)
- Liver(4.4)
- Lung(4.3)
- Bone(3.7)
- Skin(3.4)
Primer products for research
-
OriGene qPCR primer pairs for FOXRED2
-
OriGene qPCR primer pairs and template standards for FOXRED2
Gene Expression Assays for research
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXRED2 Gene
Orthologs for FOXRED2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FOXRED2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FOXRED2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Foxred2 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FOXRED2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Foxred2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | FOXRED2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FOXRED2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FOXRED2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FOXRED2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | foxred2 30 |
|
||
| Str.14404 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | foxred2 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6197 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.10616 30 |
|
- Species where no ortholog for FOXRED2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FOXRED2 Gene
- ENSEMBL:
- Gene Tree for FOXRED2 (if available)
- TreeFam:
- Gene Tree for FOXRED2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXRED2: view image
Paralogs for FOXRED2 Gene
Variants for FOXRED2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXRED2 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2277841 | - |
p.Asn308Ser |
|||
| rs35748020 | - |
p.Glu637Asp |
|||
| rs35813894 | - |
p.Lys374Arg |
|||
| rs56767103 | - |
p.Arg71Cys |
|||
| rs760718 | - |
p.Phe179Leu |
All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2760722 | CNV | gain | 21179565 |
| nsv1060004 | CNV | gain | 25217958 |
| nsv520497 | CNV | gain | 19592680 |
| nsv834186 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.80;
73.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXRED2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FOXRED2
SNP Genotyping and Copy Number Assays for research
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXRED2 Gene
Disorders for FOXRED2 Gene
Additional Disease Information for FOXRED2
- Atlas
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
- Open Targets Platform
No disorders were found for FOXRED2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXRED2 Gene
Publications for FOXRED2 Gene
- Identification of the PDI-family member ERp90 as an interaction partner of ERFAD. (PMID: 21359175) Riemer J … Ellgaard L (PloS one 2011) 3 4
- Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity. (PMID: 20972601) Shim S … Jung YK (Cellular and molecular life sciences : CMLS 2011) 2 3
- A luminal flavoprotein in endoplasmic reticulum-associated degradation. (PMID: 19706418) Riemer J … Ellgaard L (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4
ExternalLinks
Products for FOXRED2 Gene
- Custom Antibody ServicesOriGene Antibodies for FOXRED2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FOXRED2
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXRED2
- Origene Custom Protein Services for FOXRED2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXRED2
- Browse OriGene Inhibitory RNA Products For FOXRED2
- OriGene qPCR primer pairs for FOXRED2
- OriGene qPCR primer pairs and template standards for FOXRED2
- OriGene CRISPR knockouts for FOXRED2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOXRED2
- Sino Biological Human cDNA Clone for FOXRED2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FOXRED2
- Novus Biologicals proteins and lysates for FOXRED2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for FOXRED2 (AFLGC-FOXRED2)
- VectorBuilder Custom and pre-made DNA vectors for FOXRED2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FOXRED2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FOXRED2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FOXRED2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FOXRED2
- antibodies-online: Show 18 available FOXRED2 Antibodies ranked by validation data
- Compare Top FOXRED2 Antibodies
- antibodies-online: Search results for available FOXRED2 related products ranked by validation data
- antibodies-online: Show 2 available FOXRED2 Proteins ranked by validation data
- Compare Top FOXRED2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for FOXRED2
- Search Santa Cruz Biotechnology (SCBT) for FOXRED2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOXRED2
- Custom Antibody ServicesProSci Antibodies for FOXRED2
- Search for FOXRED2 Proteins at ProSci
- Horizon Cell Lines for FOXRED2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXRED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXRED2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FOXRED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXRED2
- Boster Bio Antibodies for FOXRED2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for FOXRED2
Sources for FOXRED2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM® (Updated: 05-Mar-2021)
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) MedlinePlus Genetics
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNAcentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Open Targets Platform
- (175) 5SRRNADB
- (176) snoDB
- (177) MirGeneDB