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Aliases for FOXRED2 Gene
Aliases for FOXRED2 Gene
- FAD Dependent Oxidoreductase Domain Containing 2 2 3 5
- ERFAD 2 3 4
- Endoplasmic Reticulum Flavoprotein Associated With Degradation 3 4
- FAD-Dependent Oxidoreductase Domain-Containing Protein 2 3 4
- ER Flavoprotein Associated With Degradation 2 3
- FAD-Dependent Oxidoreductase Domain Containing 2 2
- FLJ23322 2
- FOXRED2 5
External Ids for FOXRED2 Gene
- HGNC: 26264
- Entrez Gene: 80020
- Ensembl: ENSG00000100350
- OMIM: 613777
- UniProtKB: Q8IWF2
Previous GeneCards Identifiers for FOXRED2 Gene
- GC22M035214
- GC22M036883
- GC22M019851
Summaries for FOXRED2 Gene
GeneCards Summary for FOXRED2 Gene
FOXRED2 (FAD Dependent Oxidoreductase Domain Containing 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is FMO4.
UniProtKB/Swiss-Prot Summary for FOXRED2 Gene
-
Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.
Additional gene information for FOXRED2 Gene
- HGNC(26264)
- Entrez Gene(80020)
- Ensembl(ENSG00000100350)
- OMIM(613777)
- UniProtKB(Q8IWF2)
- Open Targets Platform(ENSG00000100350)
- Search for FOXRED2 at DataMed
- Search for FOXRED2 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXRED2 Gene
Genomics for FOXRED2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FOXRED2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXRED2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXRED2
- Top Transcription factor binding sites by QIAGEN in the FOXRED2 gene promoter:
-
- MZF-1
- Pax-2
- Pax-2a
- STAT3
- USF-1
Genomic Locations for FOXRED2 Gene
Genomic Locations for FOXRED2 Gene
- chr22:36,487,190-36,507,101
- (GRCh38/hg38)
- Size:
- 19,912 bases
- Orientation:
- Minus strand
- chr22:36,883,233-36,903,148
- (GRCh37/hg19)
- Size:
- 19,916 bases
- Orientation:
- Minus strand
Genomic View for FOXRED2 Gene
Genes around FOXRED2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 22q12.3 by HGNC
- 22q12.3 by Entrez Gene
- 22q12.3 by Ensembl
FOXRED2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXRED2 Gene
Proteins for FOXRED2 Gene
-
Protein details for FOXRED2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q8IWF2-FXRD2_HUMAN
- Recommended name:
- FAD-dependent oxidoreductase domain-containing protein 2
- Protein Accession:
- Q8IWF2
- B2RDI4
- Q8N378
- Q96BD1
- Q9H5L5
- Q9H6M8
Protein attributes for FOXRED2 Gene
- Size:
- 684 amino acids
- Molecular mass:
- 77791 Da
- Cofactor:
- Name=FAD; Xref=ChEBI:CHEBI:57692;
- Quaternary structure:
-
- Interacts with SEL1L. May interact with OS9 and DNAJC10. Interacts with TXNDC16 (PubMed:21359175).
Protein Expression for FOXRED2 Gene
Post-translational modifications for FOXRED2 Gene
Other Protein References for FOXRED2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Creative Diagnostics Anti-FOXRED2 (aa 34-170) polyclonal antibody
- Creative Biolabs Mouse Anti-FOXRED2 Recombinant Antibody (CBXF-1796)
-
Custom Antibody ServicesOriGene Antibodies for FOXRED2
- Novus Biologicals Antibodies for FOXRED2
- Invitrogen Antibodies for FOXRED2 (AFLGC-FOXRED2)
-
Biorbyt antibodies for FOXRED2
-
Boster Bio Antibodies for FOXRED2
-
Custom Antibody ServicesProSci Antibodies for FOXRED2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXRED2
Protein Products
-
OriGene Purified Proteins for FOXRED2
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXRED2
- Origene Custom Protein Services for FOXRED2
- antibodies-online: Show 2 available FOXRED2 Proteins ranked by validation data
- Compare Top FOXRED2 Proteins
-
Quality Products:
-
Signalway Proteins for FOXRED2
No data available for DME Specific Peptides for FOXRED2 Gene
Domains & Families for FOXRED2 Gene
Gene Families for FOXRED2 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FOXRED2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXRED2 Gene
- GenScript: Design optimal peptide antigens:
-
- Endoplasmic reticulum flavoprotein associated with degradation (FXRD2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q8IWF2- Family:
-
- Belongs to the FOXRED2 family.
Function for FOXRED2 Gene
Molecular function for FOXRED2 Gene
- UniProtKB/Swiss-Prot Function:
- Probable flavoprotein which may function in endoplasmic reticulum associated degradation (ERAD). May bind non-native proteins in the endoplasmic reticulum and target them to the ubiquitination machinery for subsequent degradation.
Phenotypes From GWAS Catalog for FOXRED2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005515 | protein binding | IPI | 19706418 |
| GO:0016491 | oxidoreductase activity | IEA | -- |
| GO:0050660 | flavin adenine dinucleotide binding | IDA | 19706418 |
Phenotypes for FOXRED2 Gene
- MGI mutant phenotypes for FOXRED2:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for FOXRED2:
-
- Decreased hepcidin::fluc mRNA expression
- no effect
- Decreased viability ratio
- Increased gamma-H2AX phosphorylation
- Decreased Salmonella proliferation
- Negative genetic interaction between MUS81-/- and MUS81+/+
- Negative genetic interaction between PTTG1-/- and PTTG1+/+
- Negative genetic interaction between PTEN-/- and PTEN+/+
- No cells
Animal Models for FOXRED2 Gene
- MGI Knock Outs for FOXRED2:
-
- Foxred2 Foxred2<tm1.1(KOMP)Vlcg>
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXRED2 - Select products 50% OFF >
- * FOXRED2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXRED2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXRED2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXRED2
miRNA for FOXRED2 Gene
- miRTarBase miRNAs that target FOXRED2
-
- mmu-miR-425-5p (MIRT008439)
- mmu-miR-15a-5p (MIRT011510)
- hsa-miR-124-3p (MIRT022860)
- hsa-miR-744-5p (MIRT037694)
- hsa-miR-378a-3p (MIRT043936)
- hsa-miR-186-5p (MIRT045033)
- hsa-miR-99a-5p (MIRT048677)
- hsa-miR-93-5p (MIRT048865)
- hsa-let-7b-5p (MIRT052050)
- hsa-miR-7702 (MIRT454125)
- hsa-miR-6819-5p (MIRT454126)
- hsa-miR-6812-5p (MIRT454127)
- hsa-miR-6737-5p (MIRT454128)
- hsa-miR-6742-5p (MIRT454129)
- hsa-miR-6769a-5p (MIRT454130)
- hsa-miR-6769b-5p (MIRT454131)
- hsa-miR-92a-2-5p (MIRT454132)
- hsa-miR-654-5p (MIRT454133)
- hsa-miR-6747-5p (MIRT454134)
- hsa-miR-541-3p (MIRT454135)
- hsa-miR-4651 (MIRT454136)
- hsa-miR-608 (MIRT454137)
- hsa-miR-4664-5p (MIRT454138)
- hsa-miR-342-5p (MIRT454139)
- hsa-miR-6770-5p (MIRT454140)
- hsa-miR-1253 (MIRT454141)
- hsa-miR-759 (MIRT454142)
- hsa-miR-4524b-3p (MIRT454143)
- hsa-miR-527 (MIRT691473)
- hsa-miR-518a-5p (MIRT691474)
- hsa-miR-548aw (MIRT691475)
- hsa-miR-4504 (MIRT691476)
- hsa-miR-335-5p (MIRT691477)
- hsa-miR-5089-5p (MIRT691478)
- hsa-miR-6878-3p (MIRT691479)
- hsa-miR-7151-3p (MIRT691480)
- hsa-miR-5095 (MIRT691481)
- hsa-miR-6744-3p (MIRT691482)
- hsa-miR-4757-5p (MIRT691483)
- hsa-miR-5589-5p (MIRT691484)
- hsa-miR-4731-5p (MIRT691485)
- hsa-miR-6778-3p (MIRT691486)
- hsa-miR-6506-5p (MIRT691487)
- hsa-miR-619-5p (MIRT691488)
- hsa-miR-150-5p (MIRT691489)
- hsa-miR-186-3p (MIRT691490)
- hsa-miR-3934-5p (MIRT691491)
- hsa-miR-520h (MIRT691492)
- hsa-miR-520g-3p (MIRT691493)
- hsa-miR-6504-3p (MIRT691494)
- hsa-miR-512-3p (MIRT691495)
- hsa-miR-552-3p (MIRT691496)
- hsa-miR-520e (MIRT691497)
- hsa-miR-520d-3p (MIRT691498)
- hsa-miR-520c-3p (MIRT691499)
- hsa-miR-520b (MIRT691500)
- hsa-miR-520a-3p (MIRT691501)
- hsa-miR-373-3p (MIRT691502)
- hsa-miR-372-3p (MIRT691503)
- hsa-miR-302e (MIRT691504)
- hsa-miR-302d-3p (MIRT691505)
- hsa-miR-302c-3p (MIRT691506)
- hsa-miR-302b-3p (MIRT691507)
- hsa-miR-302a-3p (MIRT691508)
- hsa-miR-526b-3p (MIRT691509)
- hsa-miR-519d-3p (MIRT691510)
- hsa-miR-20b-5p (MIRT691511)
- hsa-miR-20a-5p (MIRT691512)
- hsa-miR-17-5p (MIRT691513)
- hsa-miR-106b-5p (MIRT691514)
- hsa-miR-106a-5p (MIRT691515)
- hsa-miR-10a-5p (MIRT761143)
- hsa-miR-10b-5p (MIRT761167)
- hsa-miR-3190-5p (MIRT765365)
- hsa-miR-3926 (MIRT767709)
- hsa-miR-548s (MIRT774500)
- hsa-miR-6732-3p (MIRT777991)
- hsa-miR-6849-3p (MIRT780283)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXRED2
- Browse OriGene Inhibitory RNA Products For FOXRED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXRED2
Clone Products
- Applied Biological Materials (abm): Clones for FOXRED2 - Select products 50% OFF >
- * FOXRED2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FOXRED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXRED2
Cell Line Products
-
Horizon Cell Lines for FOXRED2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXRED2 Gene
Localization for FOXRED2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXRED2 Gene
- Endoplasmic reticulum lumen.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| nucleus | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | IEA | -- |
| GO:0005788 | endoplasmic reticulum lumen | IBA,IDA | 19706418 |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXRED2 Gene
Pathways & Interactions for FOXRED2 Gene
Interacting Proteins for FOXRED2 Gene
Selected Interacting proteins:
Q8IWF2-FXRD2_HUMAN
ENSP00000380401
for FOXRED2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FOXRED2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0030433 | ubiquitin-dependent ERAD pathway | IBA,IMP | 19706418 |
| GO:0055114 | oxidation-reduction process | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for FOXRED2 Gene
Drugs & Compounds for FOXRED2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| FAD | Approved | Pharma | 0 |
Transcripts for FOXRED2 Gene
mRNA/cDNA for FOXRED2 Gene
- 4 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000216187 3933 nts (view in UCSC)
- ENST00000366463 2489 nts (view in UCSC)
- ENST00000397223 2184 nts (view in UCSC)
- ENST00000397224 4967 nts (view in UCSC)
- ENST00000423980 567 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXRED2 - Select products 50% OFF >
- * FOXRED2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXRED2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXRED2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXRED2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXRED2
- Browse OriGene Inhibitory RNA Products For FOXRED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXRED2
Clone Products
- Applied Biological Materials (abm): Clones for FOXRED2 - Select products 50% OFF >
- * FOXRED2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FOXRED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXRED2
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11a | · | 11b | · | 11c | · | 11d | ^ | 12 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||||||||||||||
| SP3: | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP5: | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | |||||||||||||||||||||||||||||||||||||||
| SP7: | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||
| SP10: | - | - | - | - |
Relevant External Links for FOXRED2 Gene
- GeneLoc Exon Structure for
- FOXRED2
Expression for FOXRED2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
This gene is overexpressed in Liver, secretome (61.1).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXRED2 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXRED2
SOURCE GeneReport for Unigene cluster for FOXRED2 Gene:
Hs.387601Evidence on tissue expression from TISSUES for FOXRED2 Gene
- Nervous system(4.9)
- Intestine(4.8)
- Pancreas(4.8)
- Eye(4.6)
- Liver(4.4)
- Lung(4.3)
- Bone(3.7)
- Skin(3.4)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for FOXRED2
-
OriGene qPCR primer pairs and template standards for FOXRED2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXRED2 Gene
Orthologs for FOXRED2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FOXRED2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FOXRED2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Foxred2 30 17 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FOXRED2 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Foxred2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | FOXRED2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FOXRED2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FOXRED2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FOXRED2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | foxred2 30 |
|
||
| Str.14404 30 |
|
||||
| Zebrafish (Danio rerio) |
Actinopterygii | foxred2 30 31 |
|
OneToOne | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.6197 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| -- 31 |
|
OneToMany | |||
| Sea Vase (Ciona intestinalis) |
Ascidiacea | Cin.10616 30 |
|
- Species where no ortholog for FOXRED2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FOXRED2 Gene
- ENSEMBL:
- Gene Tree for FOXRED2 (if available)
- TreeFam:
- Gene Tree for FOXRED2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXRED2: view image
Paralogs for FOXRED2 Gene
Variants for FOXRED2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXRED2 Gene
| SNP ID | Clinical significance and condition | Chr 22 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2277841 | - | p.Asn308Ser | |||
| rs35748020 | - | p.Glu637Asp | |||
| rs35813894 | - | p.Lys374Arg | |||
| rs56767103 | - | p.Arg71Cys | |||
| rs760718 | - | p.Phe179Leu |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2760722 | CNV | gain | 21179565 |
| nsv1060004 | CNV | gain | 25217958 |
| nsv520497 | CNV | gain | 19592680 |
| nsv834186 | CNV | loss | 17160897 |
Residual Variation Intolerance Score:
73.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
5.80;
73.72% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXRED2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FOXRED2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXRED2 Gene
Disorders for FOXRED2 Gene
Additional Disease Information for FOXRED2
No disorders were found for FOXRED2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXRED2 Gene
Publications for FOXRED2 Gene
- Identification of the PDI-family member ERp90 as an interaction partner of ERFAD. (PMID: 21359175) Riemer J … Ellgaard L (PloS one 2011) 3 4
- Amyloid β-induced FOXRED2 mediates neuronal cell death via inhibition of proteasome activity. (PMID: 20972601) Shim S … Jung YK (Cellular and molecular life sciences : CMLS 2011) 2 3
- A luminal flavoprotein in endoplasmic reticulum-associated degradation. (PMID: 19706418) Riemer J … Ellgaard L (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 4
- A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins JE … Dunham I (Genome biology 2004) 3 4
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
ExternalLinks
Products for FOXRED2 Gene
- Custom Antibody ServicesOriGene Antibodies for FOXRED2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FOXRED2
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXRED2
- Origene Custom Protein Services for FOXRED2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXRED2
- Browse OriGene Inhibitory RNA Products For FOXRED2
- OriGene qPCR primer pairs for FOXRED2
- OriGene qPCR primer pairs and template standards for FOXRED2
- OriGene CRISPR knockouts for FOXRED2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOXRED2
- Sino Biological Human cDNA Clone for FOXRED2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FOXRED2
- Novus Biologicals proteins and lysates for FOXRED2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for FOXRED2 (AFLGC-FOXRED2)
- VectorBuilder Custom and pre-made DNA vectors for FOXRED2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FOXRED2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FOXRED2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FOXRED2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FOXRED2
- antibodies-online: Show 18 available FOXRED2 Antibodies ranked by validation data
- Compare Top FOXRED2 Antibodies
- antibodies-online: Search results for available FOXRED2 related products ranked by validation data
- antibodies-online: Show 2 available FOXRED2 Proteins ranked by validation data
- Compare Top FOXRED2 Proteins
- Quality Products:
- Santa Cruz Biotechnology (SCBT) Antibodies for FOXRED2
- Search Santa Cruz Biotechnology (SCBT) for FOXRED2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOXRED2
- Custom Antibody ServicesProSci Antibodies for FOXRED2
- Search for FOXRED2 Proteins at ProSci
- Horizon Cell Lines for FOXRED2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXRED2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXRED2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FOXRED2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXRED2
- Boster Bio Antibodies for FOXRED2
- Browse Boster Bio ELISA Kits
- Biorbyt antibodies for FOXRED2
- Signalway Proteins for FOXRED2
Sources for FOXRED2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB