Aliases for FOXRED1 Gene
External Ids for FOXRED1 Gene
Previous GeneCards Identifiers for FOXRED1 Gene
This gene encodes a protein that contains a FAD-dependent oxidoreductase domain. The encoded protein is localized to the mitochondria and may function as a chaperone protein required for the function of mitochondrial complex I. Mutations in this gene are associated with mitochondrial complex I deficiency. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2010]
GeneCards Summary for FOXRED1 Gene
FOXRED1 (FAD Dependent Oxidoreductase Domain Containing 1) is a Protein Coding gene. Diseases associated with FOXRED1 include Mitochondrial Complex I Deficiency, Nuclear Type 19 and Mitochondrial Complex I Deficiency, Nuclear Type 1. Gene Ontology (GO) annotations related to this gene include oxidoreductase activity. An important paralog of this gene is DMGDH.
UniProtKB/Swiss-Prot Summary for FOXRED1 Gene
Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:20858599, PubMed:25678554). Involved in mid-late stages of complex I assembly (PubMed:25678554).