This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX ... See more...

Aliases for FOXR1 Gene

Aliases for FOXR1 Gene

  • Forkhead Box R1 2 3 5
  • Forkhead Box Protein N5 3 4
  • Forkhead Box Protein R1 3 4
  • FOXN5 3 4
  • Forkhead Box R1 Variant 1 3
  • Forkhead Box R1 Variant 2 3
  • DLNB13 3

External Ids for FOXR1 Gene

Previous GeneCards Identifiers for FOXR1 Gene

  • GC11P118379
  • GC11P118347
  • GC11P118843
  • GC11P114782

Summaries for FOXR1 Gene

Entrez Gene Summary for FOXR1 Gene

  • This gene encodes a member of the forkhead box (FOX) family of transcription factors. FOX family members are monomeric, helix-turn-helix proteins with a core DNA-binding domain of approximately 110 aa. Many FOX transcription factors play roles in determining cell fates during early development. This forkhead box protein lacks the C-terminal basic region found in many other FOX family members. It is located within the 11q23.3 region which is commonly deleted in neuroblastomas. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXR1 Gene

FOXR1 (Forkhead Box R1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is FOXR2.

Additional gene information for FOXR1 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXR1 Gene

Genomics for FOXR1 Gene

GeneHancer (GH) Regulatory Elements for FOXR1 Gene

Promoters and enhancers for FOXR1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXR1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXR1 gene promoter:
  • AML1a
  • deltaCREB
  • MAZR
  • p53
  • Pax-4a
  • Roaz
  • RP58
  • S8
  • SEF-1 (1)
  • Spz1

Genomic Locations for FOXR1 Gene

Genomic Locations for FOXR1 Gene
chr11:118,971,543-118,981,291
(GRCh38/hg38)
Size:
9,749 bases
Orientation:
Plus strand
chr11:118,842,417-118,852,001
(GRCh37/hg19)
Size:
9,585 bases
Orientation:
Plus strand

Genomic View for FOXR1 Gene

Genes around FOXR1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXR1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXR1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXR1 Gene

Proteins for FOXR1 Gene

  • Protein details for FOXR1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6PIV2-FOXR1_HUMAN
    Recommended name:
    Forkhead box protein R1
    Protein Accession:
    Q6PIV2
    Secondary Accessions:
    • B0YJ15
    • Q08AS8
    • Q86UT9
    • Q8IXX2

    Protein attributes for FOXR1 Gene

    Size:
    292 amino acids
    Molecular mass:
    33310 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXR1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXR1 Gene

Post-translational modifications for FOXR1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXR1 Gene

No data available for DME Specific Peptides for FOXR1 Gene

Domains & Families for FOXR1 Gene

Gene Families for FOXR1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXR1 Gene

Suggested Antigen Peptide Sequences for FOXR1 Gene

GenScript: Design optimal peptide antigens:
  • Forkhead box R1 variant 2 (B0YJ16_HUMAN)
  • Forkhead box protein N5 (FOXR1_HUMAN)
genes like me logo Genes that share domains with FOXR1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXR1 Gene

Function for FOXR1 Gene

Phenotypes From GWAS Catalog for FOXR1 Gene

Gene Ontology (GO) - Molecular Function for FOXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXR1: view
genes like me logo Genes that share phenotypes with FOXR1: view

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXR1 Gene

Localization for FOXR1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXR1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXR1 gene
Compartment Confidence
nucleus 4
cytosol 1
plasma membrane 0
extracellular 0

Gene Ontology (GO) - Cellular Components for FOXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FOXR1: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXR1 Gene

Pathways & Interactions for FOXR1 Gene

PathCards logo

SuperPathways for FOXR1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXR1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with FOXR1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXR1 Gene

Drugs & Compounds for FOXR1 Gene

No Compound Related Data Available

Transcripts for FOXR1 Gene

mRNA/cDNA for FOXR1 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXR1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1:
SP2: -

Relevant External Links for FOXR1 Gene

GeneLoc Exon Structure for
FOXR1
ECgene alternative splicing isoforms for
FOXR1

Expression for FOXR1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXR1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXR1 Gene

This gene is overexpressed in Testis (x42.2) and Ovary (x4.1).

Protein differential expression in normal tissues from HIPED for FOXR1 Gene

This gene is overexpressed in Fetal Liver (41.2) and Fetal gut (27.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXR1 Gene



Protein tissue co-expression partners for FOXR1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXR1 Gene:

FOXR1

SOURCE GeneReport for Unigene cluster for FOXR1 Gene:

Hs.116679

Evidence on tissue expression from TISSUES for FOXR1 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with FOXR1: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXR1 Gene

Orthologs for FOXR1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXR1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXR1 33 32
  • 99.43 (n)
OneToOne
cow
(Bos Taurus)
Mammalia LOC788135 32
  • 86.14 (n)
FOXR1 33
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXR1 33 32
  • 85.91 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxr1 32
  • 80.05 (n)
mouse
(Mus musculus)
Mammalia Foxr1 17 33 32
  • 73.48 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 33
  • 52 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 33
  • 42 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii FOXR1 33
  • 30 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 33
  • 5 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 33
  • 7 (a)
OneToMany
Species where no ortholog for FOXR1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXR1 Gene

ENSEMBL:
Gene Tree for FOXR1 (if available)
TreeFam:
Gene Tree for FOXR1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXR1: view image

Paralogs for FOXR1 Gene

(1) SIMAP similar genes for FOXR1 Gene using alignment to 4 proteins:

  • FOXR1_HUMAN
  • B0YJ16_HUMAN
  • H0YCU3_HUMAN
  • Q08AS8_HUMAN
genes like me logo Genes that share paralogs with FOXR1: view

Variants for FOXR1 Gene

Sequence variations from dbSNP and Humsavar for FOXR1 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000345189 -- 118,971,596(+) C/G 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000420406 -- 118,971,299(+) AGAG/AG upstream_transcript_variant
rs1000536717 -- 118,972,756(+) T/C intron_variant
rs1000639502 -- 118,977,824(+) C/A/T intron_variant
rs1001220690 -- 118,972,619(+) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXR1 Gene

Variant ID Type Subtype PubMed ID
nsv819166 CNV loss 19587683

Variation tolerance for FOXR1 Gene

Residual Variation Intolerance Score: 75.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.41; 42.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXR1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXR1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXR1 Gene

Disorders for FOXR1 Gene

Additional Disease Information for FOXR1

No disorders were found for FOXR1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXR1 Gene

Publications for FOXR1 Gene

  1. Identification and characterization of human FOXN5 and rat Foxn5 genes in silico. (PMID: 15067358) Katoh M … Katoh M (International journal of oncology 2004) 2 3 23 56
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 56
  3. Human FOX gene family (Review). (PMID: 15492844) Katoh M … Katoh M (International journal of oncology 2004) 3 23 56
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 56
  5. Chromosome 11q23 aberrations activating FOXR1 in B-cell lymphoma. (PMID: 27284737) Pommerenke C … Quentmeier H (Blood cancer journal 2016) 3 56

Products for FOXR1 Gene

Sources for FOXR1 Gene