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Aliases for FOXQ1 Gene

Aliases for FOXQ1 Gene

  • Forkhead Box Q1 2 3 5
  • Hepatocyte Nuclear Factor 3 Forkhead Homolog 1 3 4
  • HNF-3/Forkhead-Like Protein 1 3 4
  • HFH-1 3 4
  • HFH1 3 4
  • Winged Helix/Forkhead Transcription Factor 3
  • Forkhead Box Protein Q1 3

External Ids for FOXQ1 Gene

Previous GeneCards Identifiers for FOXQ1 Gene

  • GC06P001302
  • GC06P001257

Summaries for FOXQ1 Gene

Entrez Gene Summary for FOXQ1 Gene

  • FOXQ1 is a member of the FOX gene family, which is characterized by a conserved 110-amino acid DNA-binding motif called the forkhead or winged helix domain. FOX genes are involved in embryonic development, cell cycle regulation, tissue-specific gene expression, cell signaling, and tumorigenesis (Bieller et al., 2001 [PubMed 11747606]).[supplied by OMIM, May 2009]

GeneCards Summary for FOXQ1 Gene

FOXQ1 (Forkhead Box Q1) is a Protein Coding gene. Diseases associated with FOXQ1 include Ritscher-Schinzel Syndrome. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXD2.

UniProtKB/Swiss-Prot for FOXQ1 Gene

  • Plays a role in hair follicle differentiation.

Additional gene information for FOXQ1 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXQ1 Gene

Genomics for FOXQ1 Gene

GeneHancer (GH) Regulatory Elements for FOXQ1 Gene

Promoters and enhancers for FOXQ1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH06J001309 Promoter/Enhancer 1.9 Ensembl ENCODE dbSUPER 650.7 +1.7 1679 8.6 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF143 PAF1 FOXQ1 EXOC2 RN7SL352P LOC105374880 GC06M001309 LINC01394
GH06J001285 Enhancer 0.9 Ensembl ENCODE 13.9 -25.6 -25571 2.9 MXI1 JUN MAX RAD21 RFX5 POLR2A SMC3 RCOR1 FOSL2 FOS FOXQ1 GC06M001274 LOC105374879
GH06J001608 Promoter/Enhancer 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.5 +299.4 299353 5.9 HDGF PKNOX1 ARNT SIN3A FEZF1 ZNF2 ZNF48 YY1 GLIS2 ZNF213 FOXC1 GC06P001612 GC06P001611 RN7SL352P FOXQ1
GH06J001226 Enhancer 1 dbSUPER 7.6 -83.0 -83009 6.3 FOXA2 MLX ARID4B DMAP1 ZNF48 ETS1 YY1 SLC30A9 ATF7 NFKBIZ FOXQ1 GC06M001234 GC06P001205
GH06J001056 Enhancer 0.7 FANTOM5 dbSUPER 5.5 -256.7 -256687 0.3 SSRP1 ZNF614 POLR2A KDM1A HMG20A GC06M001056 FOXQ1 GC06P001048 LINC01622
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXQ1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXQ1 gene promoter:
  • AML1a
  • LCR-F1
  • RFX1
  • Pax-5

Genomic Locations for FOXQ1 Gene

Genomic Locations for FOXQ1 Gene
chr6:1,312,440-1,314,758
(GRCh38/hg38)
Size:
2,319 bases
Orientation:
Plus strand
chr6:1,312,675-1,314,993
(GRCh37/hg19)
Size:
2,319 bases
Orientation:
Plus strand

Genomic View for FOXQ1 Gene

Genes around FOXQ1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXQ1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXQ1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXQ1 Gene

Proteins for FOXQ1 Gene

  • Protein details for FOXQ1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C009-FOXQ1_HUMAN
    Recommended name:
    Forkhead box protein Q1
    Protein Accession:
    Q9C009
    Secondary Accessions:
    • Q9NS06

    Protein attributes for FOXQ1 Gene

    Size:
    403 amino acids
    Molecular mass:
    41526 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXQ1 Gene

Post-translational modifications for FOXQ1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXQ1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXQ1 Gene

Domains & Families for FOXQ1 Gene

Gene Families for FOXQ1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXQ1 Gene

Suggested Antigen Peptide Sequences for FOXQ1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXQ1: view

No data available for UniProtKB/Swiss-Prot for FOXQ1 Gene

Function for FOXQ1 Gene

Molecular function for FOXQ1 Gene

UniProtKB/Swiss-Prot Function:
Plays a role in hair follicle differentiation.

Phenotypes From GWAS Catalog for FOXQ1 Gene

Gene Ontology (GO) - Molecular Function for FOXQ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM,IBA 19274049
GO:0001078 transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding IEA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with FOXQ1: view
genes like me logo Genes that share phenotypes with FOXQ1: view

Animal Models for FOXQ1 Gene

MGI Knock Outs for FOXQ1:

Animal Model Products

Transcription Factor Targets for FOXQ1 Gene

Selected GeneGlobe predicted Target genes for FOXQ1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and HOMER Transcription for FOXQ1 Gene

Localization for FOXQ1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXQ1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXQ1 gene
Compartment Confidence
nucleus 5
cytosol 2
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOXQ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXQ1: view

Pathways & Interactions for FOXQ1 Gene

SuperPathways for FOXQ1 Gene

SuperPathway Contained pathways
1 Preimplantation Embryo
genes like me logo Genes that share pathways with FOXQ1: view

Pathways by source for FOXQ1 Gene

1 BioSystems pathway for FOXQ1 Gene

Gene Ontology (GO) - Biological Process for FOXQ1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXQ1: view

No data available for SIGNOR curated interactions for FOXQ1 Gene

Drugs & Compounds for FOXQ1 Gene

No Compound Related Data Available

Transcripts for FOXQ1 Gene

mRNA/cDNA for FOXQ1 Gene

(1) REFSEQ mRNAs :
(1) Additional mRNA sequences :
(47) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXQ1 Gene

Forkhead box Q1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXQ1 Gene

No ASD Table

Relevant External Links for FOXQ1 Gene

GeneLoc Exon Structure for
FOXQ1
ECgene alternative splicing isoforms for
FOXQ1

Expression for FOXQ1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXQ1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXQ1 Gene

This gene is overexpressed in Bladder (x7.7), Stomach (x6.9), Minor Salivary Gland (x5.6), Skin - Sun Exposed (Lower leg) (x4.7), and Skin - Not Sun Exposed (Suprapubic) (x4.5).

Protein differential expression in normal tissues from HIPED for FOXQ1 Gene

This gene is overexpressed in NK cells (60.4) and CD8 Tcells (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXQ1 Gene



Protein tissue co-expression partners for FOXQ1 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXQ1 Gene:

FOXQ1

SOURCE GeneReport for Unigene cluster for FOXQ1 Gene:

Hs.591352

mRNA Expression by UniProt/SwissProt for FOXQ1 Gene:

Q9C009-FOXQ1_HUMAN
Tissue specificity: Expressed predominantly in the stomach, trachea, bladder and salivary gland.

Evidence on tissue expression from TISSUES for FOXQ1 Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with FOXQ1: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXQ1 Gene

Orthologs for FOXQ1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXQ1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXQ1 34 33
  • 95.22 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxq1 33
  • 82.37 (n)
mouse
(Mus musculus)
Mammalia Foxq1 16 34 33
  • 81.7 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXQ1 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 27 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 34
  • 37 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia foxq1 33
  • 58.44 (n)
zebrafish
(Danio rerio)
Actinopterygii foxq1b 34 33
  • 64.55 (n)
OneToMany
foxq1a 34
  • 51 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2314 33
fruit fly
(Drosophila melanogaster)
Insecta bin 34
  • 14 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea let-381 34
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 36 (a)
OneToOne
Cin.14119 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.14119 33
Species where no ortholog for FOXQ1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXQ1 Gene

ENSEMBL:
Gene Tree for FOXQ1 (if available)
TreeFam:
Gene Tree for FOXQ1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXQ1: view image

Paralogs for FOXQ1 Gene

genes like me logo Genes that share paralogs with FOXQ1: view

Variants for FOXQ1 Gene

Sequence variations from dbSNP and Humsavar for FOXQ1 Gene

SNP ID Clin Chr 06 pos Variation AA Info Type
rs1000469060 -- 1,312,599(+) G/A 5_prime_UTR_variant
rs1001130890 -- 1,314,674(+) C/G 3_prime_UTR_variant
rs1001449230 -- 1,311,001(+) C/T upstream_transcript_variant
rs1002143293 -- 1,313,578(+) G/C coding_sequence_variant, missense_variant
rs1002195569 -- 1,313,450(+) C/T coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXQ1 Gene

Variant ID Type Subtype PubMed ID
dgv5910n100 CNV gain 25217958
esv3576090 CNV gain 25503493
nsv1017614 CNV loss 25217958
nsv1126740 CNV deletion 24896259
nsv823393 CNV gain 20364138

Variation tolerance for FOXQ1 Gene

Gene Damage Index Score: 7.59; 82.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXQ1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXQ1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXQ1 Gene

Disorders for FOXQ1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXQ1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ritscher-schinzel syndrome
  • craniocerebellocardiac dysplasia
- elite association - COSMIC cancer census association via MalaCards
Search FOXQ1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOXQ1

genes like me logo Genes that share disorders with FOXQ1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXQ1 Gene

Publications for FOXQ1 Gene

  1. Isolation and characterization of the human forkhead gene FOXQ1. (PMID: 11747606) Bieller A … Zoll B (DNA and cell biology 2001) 2 3 4 22 58
  2. Genome-wide association study of pancreatic cancer in Japanese population. (PMID: 20686608) Low SK … Sakamoto H (PloS one 2010) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Transforming growth factor-beta 2 is a transcriptional target for Akt/protein kinase B via forkhead transcription factor. (PMID: 12011061) Samatar AA … Kumar CC (The Journal of biological chemistry 2002) 2 3 58
  5. The winged helix/forkhead transcription factor Foxq1 regulates differentiation of hair in satin mice. (PMID: 11309849) Hong HK … Chakravarti A (Genesis (New York, N.Y. : 2000) 2001) 3 4 58

Products for FOXQ1 Gene

Sources for FOXQ1 Gene

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