Free for academic non-profit institutions. Other users need a Commercial license
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppresso... See more...
Aliases for FOXP1 Gene
Aliases for FOXP1 Gene
External Ids for FOXP1 Gene
- HGNC: 3823
- Entrez Gene: 27086
- Ensembl: ENSG00000114861
- OMIM: 605515
- UniProtKB: Q9H334
Previous GeneCards Identifiers for FOXP1 Gene
- GC03P069520
- GC03M070584
- GC03M070811
- GC03M071088
Summaries for FOXP1 Gene
-
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Forkhead box P1 protein contains both DNA-binding- and protein-protein binding-domains. This gene may act as a tumor suppressor as it is lost in several tumor types and maps to a chromosomal region (3p14.1) reported to contain a tumor suppressor gene(s). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXP1 Gene
FOXP1 (Forkhead Box P1) is a Protein Coding gene. Diseases associated with FOXP1 include Mental Retardation With Language Impairment And With Or Without Autistic Features and Lymphoma, Mucosa-Associated Lymphoid Type. Among its related pathways are Transcriptional regulation of pluripotent stem cells and Developmental Biology. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is ENSG00000285708.
UniProtKB/Swiss-Prot Summary for FOXP1 Gene
-
Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735).
-
[Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).
Additional gene information for FOXP1 Gene
- HGNC(3823)
- Entrez Gene(27086)
- Ensembl(ENSG00000114861)
- OMIM(605515)
- UniProtKB(Q9H334)
- Open Targets Platform(ENSG00000114861)
- Monarch Initiative
- Search for FOXP1 at DataMed
- Search for FOXP1 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXP1 Gene
Genomics for FOXP1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FOXP1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXP1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXP1
- Top Transcription factor binding sites by QIAGEN in the FOXP1 gene promoter:
-
- aMEF-2
- COMP1
- MEF-2A
- NF-kappaB
- NF-kappaB1
- Nkx3-1
- Nkx3-1 v1
- RelA
Genomic Locations for FOXP1 Gene
Genomic Locations for FOXP1 Gene
- chr3:70,952,817-71,583,989
- (GRCh38/hg38)
- Size:
- 631,173 bases
- Orientation:
- Minus strand
- chr3:71,003,844-71,633,140
- (GRCh37/hg19)
- Size:
- 629,297 bases
- Orientation:
- Minus strand
Genomic View for FOXP1 Gene
Genes around FOXP1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 3p13 by HGNC
- 3p13 by Entrez Gene
- 3p13 by Ensembl
FOXP1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXP1 Gene
Proteins for FOXP1 Gene
-
Protein details for FOXP1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H334-FOXP1_HUMAN
- Recommended name:
- Forkhead box protein P1
- Protein Accession:
- Q9H334
- A3QVP8
- B3KV70
- G5E9V8
- Q8NAN6
- Q9BSG9
- Q9H332
- Q9H333
- Q9P0R1
Protein attributes for FOXP1 Gene
- Size:
- 677 amino acids
- Molecular mass:
- 75317 Da
- Quaternary structure:
-
- Forms homodimers and heterodimers with FOXP2 and FOXP4 (PubMed:25027557). Dimerization is required for DNA-binding. Self-associates (PubMed:26647308). Interacts with CTBP1 (By similarity). Interacts with NCOR2 and AR (PubMed:18347093, PubMed:18640093). Interacts with FOXP2 (PubMed:26647308). Interacts with TBR1 (PubMed:30250039). Interacts with AURKA; this interaction facilitates the phosphorylation of FOXP1, which suppresses the expression of FBXL7 (PubMed:28218735).
- SequenceCaution:
-
- Sequence=AAF36135.1; Type=Frameshift; Evidence={ECO:0000305}; Sequence=AAG47634.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=ABI33105.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB55005.1; Type=Erroneous initiation; Evidence={ECO:0000305};
- Miscellaneous:
-
- [Isoform 3]: Incomplete sequence.
- [Isoform 4]: Incomplete sequence.
- [Isoform 7]: May be due to competing acceptor splice site.
Protein Expression for FOXP1 Gene
Post-translational modifications for FOXP1 Gene
Other Protein References for FOXP1 Gene
- ENSEMBL proteins:
-
- ENSP00000497369
- ENSP00000318902
- ENSP00000419393
- ENSP00000418524
- ENSP00000496932
- ENSP00000498174
- ENSP00000482847
- ENSP00000418225
- ENSP00000498110
- ENSP00000497693
- ENSP00000333560
- ENSP00000496841
- ENSP00000497077
- ENSP00000418102
- ENSP00000497563
- ENSP00000497567
- ENSP00000417857
- ENSP00000498015
- ENSP00000497430
- ENSP00000420736
- ENSP00000496990
- ENSP00000496810
- ENSP00000497976
- ENSP00000497096
- ENSP00000497344
- ENSP00000496968
- ENSP00000418883
- ENSP00000497435
- ENSP00000497237
- ENSP00000497454
- ENSP00000497181
- ENSP00000497418
- ENSP00000417941
- ENSP00000497710
- ENSP00000484963
- ENSP00000418784
- ENSP00000479663
- ENSP00000497138
- ENSP00000497417
- ENSP00000477918
- ENSP00000318721
- ENSP00000496873
- ENSP00000497914
- ENSP00000497405
- ENSP00000498063
- ENSP00000497992
- ENSP00000496852
- ENSP00000501439
- ENSP00000484803
- REFSEQ proteins:
-
- XP_006713165.1
- XP_006713166.1
- XP_006713167.1
- XP_011531887.1
- XP_016861654.1
- XP_016861656.1
- XP_016861657.1
- NP_001012523.1
- NP_001231737.1
- NP_001231739.1
- NP_001231741.1
- NP_001231742.1
- NP_001231743.1
- NP_001231744.2
- NP_001231745.1
- NP_001336266.2
- NP_001336267.1
- NP_001336269.1
- NP_001336270.1
- NP_001336271.1
- NP_001336272.1
- NP_001336273.1
- NP_001357477.1
- NP_116071.2
Antibody Products
- G Biosciences Immunotag™ FOXP1 Antibody
- NSJ Bioreagents FOXP1 Antibody
-
Custom Antibody ServicesOriGene Antibodies for FOXP1
- Novus Biologicals Antibodies for FOXP1
-
Abcam antibodies for FOXP1
- Invitrogen Antibodies for FOXP1 (AFLGC-FOXP1)
- antibodies-online: Show 37 available FOXP1 Antibodies ranked by validation data
- Compare Top FOXP1 Antibodies
-
Recommended
- 132 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 11 FACS Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 58 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 30 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXP1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXP1
- Origene Custom Protein Services for FOXP1
-
Signalway Proteins for FOXP1
-
Abcam proteins for FOXP1
Assay Products
No data available for DME Specific Peptides for FOXP1 Gene
Domains & Families for FOXP1 Gene
Gene Families for FOXP1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Plasma proteins
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXP1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXP1 Gene
- GenScript: Design optimal peptide antigens:
-
- FOXP1 protein (A3KMG1_HUMAN)
- Forkhead box protein P1 (FOXP1_HUMAN)
- Forkhead box P1, isoform CRA_a (Q548T7_HUMAN)
- FOXP1 protein (Q6IAJ1_HUMAN)
- cDNA FLJ35064 fis, clone PEBLM1000147, moderately similar to Glutamine (Q)-rich factor 1, QRF-1 (Q8NAN6_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q9H334UniProtKB/Swiss-Prot:
FOXP1_HUMAN :- The leucine-zipper is required for dimerization and transcriptional repression.
- Domain:
-
- The leucine-zipper is required for dimerization and transcriptional repression.
Function for FOXP1 Gene
Molecular function for FOXP1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional repressor (PubMed:18347093, PubMed:26647308). Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential (By similarity). Plays an important role in the specification and differentiation of lung epithelium. Acts cooperatively with FOXP4 to regulate lung secretory epithelial cell fate and regeneration by restricting the goblet cell lineage program; the function may involve regulation of AGR2. Essential transcriptional regulator of B-cell development. Involved in regulation of cardiac muscle cell proliferation. Involved in the columnar organization of spinal motor neurons. Promotes the formation of the lateral motor neuron column (LMC) and the preganglionic motor column (PGC) and is required for respective appropriate motor axon projections. The segment-appropriate generation of spinal chord motor columns requires cooperation with other Hox proteins. Can regulate PITX3 promoter activity; may promote midbrain identity in embryonic stem cell-derived dopamine neurons by regulating PITX3. Negatively regulates the differentiation of T follicular helper cells T(FH)s. Involved in maintenance of hair follicle stem cell quiescence; the function probably involves regulation of FGF18 (By similarity). Represses transcription of various pro-apoptotic genes and cooperates with NF-kappa B-signaling in promoting B-cell expansion by inhibition of caspase-dependent apoptosis (PubMed:25267198). Binds to CSF1R promoter elements and is involved in regulation of monocyte differentiation and macrophage functions; repression of CSF1R in monocytes seems to involve NCOR2 as corepressor (PubMed:15286807, PubMed:18799727, PubMed:18347093). Involved in endothelial cell proliferation, tube formation and migration indicative for a role in angiogenesis; the role in neovascularization seems to implicate suppression of SEMA5B (PubMed:24023716). Can negatively regulate androgen receptor signaling (PubMed:18640093). Acts as a transcriptional activator of the FBXL7 promoter; this activity is regulated by AURKA (PubMed:28218735).
- UniProtKB/Swiss-Prot Function:
- [Isoform 8]: Involved in transcriptional regulation in embryonic stem cells (ESCs). Stimulates expression of transcription factors that are required for pluripotency and decreases expression of differentiation-associated genes. Has distinct DNA-binding specifities as compared to the canonical form and preferentially binds DNA with the sequence 5'-CGATACAA-3' (or closely related sequences) (PubMed:21924763). Promotes ESC self-renewal and pluripotency (By similarity).
- UniProtKB/Swiss-Prot Induction:
- By androgen in an isoform-specific manner; expression of isoform 4 is greatly induced.
Phenotypes From GWAS Catalog for FOXP1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001046 | core promoter sequence-specific DNA binding | IDA | 28218735 |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 18347093 |
Phenotypes for FOXP1 Gene
- GenomeRNAi human phenotypes for FOXP1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXP1 - Select products 50% OFF >
- * FOXP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXP1
miRNA for FOXP1 Gene
- miRTarBase miRNAs that target FOXP1
-
- hsa-miR-1-3p (MIRT001054)
- hsa-miR-122-5p (MIRT003088)
- gga-miR-9-5p (MIRT005498)
- hsa-miR-34a-5p (MIRT005546)
- mmu-miR-425-5p (MIRT008784)
- mmu-miR-223-3p (MIRT009799)
- mmu-miR-17-5p (MIRT010184)
- mmu-miR-34a-5p (MIRT011069)
- mmu-miR-34b-5p (MIRT012923)
- mmu-miR-181a-5p (MIRT014432)
- mmu-miR-128-3p (MIRT015619)
- gga-miR-128-3p (MIRT016023)
- hsa-miR-335-5p (MIRT018196)
- hsa-miR-33a-5p (MIRT028242)
- hsa-miR-22-3p (MIRT030641)
- hsa-miR-1229-3p (MIRT036350)
- hsa-miR-320a (MIRT044777)
- hsa-miR-100-5p (MIRT048404)
- hsa-miR-9-5p (MIRT054798)
- hsa-miR-512-5p (MIRT121004)
- hsa-miR-218-5p (MIRT121011)
- hsa-miR-4276 (MIRT210677)
- hsa-miR-105-5p (MIRT308398)
- hsa-miR-7853-5p (MIRT308406)
- hsa-miR-578 (MIRT446839)
- hsa-miR-548aw (MIRT446840)
- hsa-miR-526b-5p (MIRT446841)
- hsa-miR-1468-3p (MIRT446842)
- hsa-miR-548x-5p (MIRT446843)
- hsa-miR-548g-5p (MIRT446844)
- hsa-miR-548f-5p (MIRT446845)
- hsa-miR-548aj-5p (MIRT446846)
- hsa-miR-1181 (MIRT489639)
- hsa-miR-5195-5p (MIRT489641)
- hsa-miR-4480 (MIRT496889)
- hsa-miR-577 (MIRT496890)
- hsa-miR-497-3p (MIRT496891)
- hsa-miR-1277-5p (MIRT557800)
- hsa-miR-607 (MIRT557801)
- hsa-miR-3671 (MIRT557802)
- hsa-miR-190a-3p (MIRT557803)
- hsa-miR-223-5p (MIRT557804)
- hsa-miR-511-3p (MIRT557805)
- hsa-miR-5011-5p (MIRT557806)
- mmu-miR-5101 (MIRT583455)
- mmu-miR-335-3p (MIRT594430)
- mmu-miR-692 (MIRT594937)
- mmu-miR-129-5p (MIRT594938)
- mmu-miR-1897-5p (MIRT594939)
- hsa-let-7c-3p (MIRT613030)
- hsa-miR-486-5p (MIRT613031)
- hsa-miR-8485 (MIRT613032)
- hsa-miR-649 (MIRT613033)
- hsa-miR-335-3p (MIRT613034)
- hsa-miR-30e-3p (MIRT613035)
- hsa-miR-30d-3p (MIRT613036)
- hsa-miR-30a-3p (MIRT613037)
- hsa-miR-6882-3p (MIRT613038)
- hsa-miR-27b-5p (MIRT613039)
- hsa-miR-152-3p (MIRT613040)
- hsa-miR-148b-3p (MIRT613041)
- hsa-miR-148a-3p (MIRT613042)
- hsa-miR-556-5p (MIRT613043)
- hsa-miR-512-3p (MIRT613044)
- hsa-miR-208b-5p (MIRT613045)
- hsa-miR-208a-5p (MIRT613046)
- hsa-miR-367-5p (MIRT630463)
- hsa-miR-4639-5p (MIRT630464)
- hsa-miR-4517 (MIRT635565)
- hsa-miR-19b-3p (MIRT727649)
- hsa-miR-19a-3p (MIRT727650)
- hsa-miR-6507-3p (MIRT776616)
- hsa-miR-1264 (MIRT783245)
- hsa-miR-431-5p (MIRT785725)
- hsa-miR-561-3p (MIRT787708)
- hsa-miR-6821-5p (MIRT788956)
Targeted motifs for FOXP1 Gene
HOMER Transcription Factor Regulatory Elements motif FOXP1
- Consensus sequence: NYYTGTTTACHN Submotif: canonical Cell Type: H9 GEO ID: GSE31006
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXP1
- Browse OriGene Inhibitory RNA Products For FOXP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXP1
Clone Products
- Applied Biological Materials (abm): Clones for FOXP1 - Select products 50% OFF >
- * FOXP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209941
- MG226917
- MR209941
- MR209941L3
- MR209941L4
- MR226917
- MR230566
- MR230847
- RC213862
- RC213862L1
- RC213862L2
- RC213862L3
- RC213862L4
- RC216342
- RC216342L3
- RC216342L4
- RC234475
- RC234528
- RC234692
- RC234697
- RC234698
- RC234703
- RC234729
- RG213862
- RG216342
- RG234475
- RG234528
- RG234692
- RG234697
- RG234698
- RG234703
- RG234729
- RR212150
- RR212150L3
- RR212150L4
- MR209941L3V
- MR209941L4V
- RC213862L1V
- RC213862L2V
- RC213862L3V
- RC213862L4V
- RC216342L3V
- RC216342L4V
- RR212150L3V
- RR212150L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FOXP1
- Addgene plasmids for FOXP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXP1
Cell Line Products
-
Horizon Cell Lines for FOXP1
No data available for Enzyme Numbers (IUBMB) , Animal Models and Transcription Factor Targets for FOXP1 Gene
Localization for FOXP1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXP1 Gene
- Nucleus. Note=Not found in the nucleolus. {ECO:0000269 PubMed:26647308}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| cytosol | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA,IDA | 25027557 |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for FOXP1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Wnt / Hedgehog / Notch | ||
| 2 | MicroRNAs in cancer | ||
| 3 | Developmental Biology | ||
| 4 | Transcriptional regulation of pluripotent stem cells | ||
Pathways by source for FOXP1 Gene
2 Reactome pathways for FOXP1 Gene
1 KEGG pathway for FOXP1 Gene
1 Cell Signaling Technology pathway for FOXP1 Gene
Interacting Proteins for FOXP1 Gene
Selected Interacting proteins:
Q9H334-FOXP1_HUMAN
ENSP00000484803
for FOXP1 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FOXP1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0002903 | negative regulation of B cell apoptotic process | IDA | 25267198 |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IMP | 30111844 |
| GO:0010468 | regulation of gene expression | IMP | 28218735 |
Transcripts for FOXP1 Gene
mRNA/cDNA for FOXP1 Gene
- 17 REFSEQ mRNAs :
- 31 NCBI additional mRNA sequence :
- 77 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000318779 843 nts (view in UCSC)
- ENST00000318789 7088 nts (view in UCSC)
- ENST00000327590 5813 nts (view in UCSC)
- ENST00000460805 664 nts (view in UCSC)
- ENST00000468577 1839 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXP1 - Select products 50% OFF >
- * FOXP1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXP1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXP1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXP1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXP1
- Browse OriGene Inhibitory RNA Products For FOXP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXP1
Clone Products
- Applied Biological Materials (abm): Clones for FOXP1 - Select products 50% OFF >
- * FOXP1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG209941
- MG226917
- MR209941
- MR209941L3
- MR209941L4
- MR226917
- MR230566
- MR230847
- RC213862
- RC213862L1
- RC213862L2
- RC213862L3
- RC213862L4
- RC216342
- RC216342L3
- RC216342L4
- RC234475
- RC234528
- RC234692
- RC234697
- RC234698
- RC234703
- RC234729
- RG213862
- RG216342
- RG234475
- RG234528
- RG234692
- RG234697
- RG234698
- RG234703
- RG234729
- RR212150
- RR212150L3
- RR212150L4
- MR209941L3V
- MR209941L4V
- RC213862L1V
- RC213862L2V
- RC213862L3V
- RC213862L4V
- RC216342L3V
- RC216342L4V
- RR212150L3V
- RR212150L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FOXP1
- Addgene plasmids for FOXP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXP1
| ExUns: | 1 | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16 | ^ | 17a | · | 17b | ^ | 18 | ^ | 19 | ^ | 20 | ^ | 21 | ^ | 22 | ^ | 23 | ^ | 24 | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: |
| ExUns: | 25a | · | 25b | ^ | 26a | · | 26b | ^ | 27 |
|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | |||||||
| SP2: | |||||||||
| SP3: | |||||||||
| SP4: | |||||||||
| SP5: | |||||||||
| SP6: | |||||||||
| SP7: | |||||||||
| SP8: |
Relevant External Links for FOXP1 Gene
- GeneLoc Exon Structure for
- FOXP1
Expression for FOXP1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
This gene is overexpressed in Fetal testis (19.8), Lymph node (11.1), CD4 Tcells (9.7), Peripheral blood mononuclear cells (8.3), and CD8 Tcells (7.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXP1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXP1
SOURCE GeneReport for Unigene cluster for FOXP1 Gene:
Hs.59368mRNA Expression by UniProt/SwissProt for FOXP1 Gene:
Q9H334-FOXP1_HUMAN
Tissue specificity:
Isoform 8 is specifically expressed in embryonic stem cells.
Evidence on tissue expression from TISSUES for FOXP1 Gene
- Blood(4.6)
- Lung(4.6)
- Liver(4.5)
- Kidney(4.5)
- Nervous system(4.2)
- Lymph node(2.9)
- Muscle(2.8)
- Bone marrow(2.7)
- Spleen(2.7)
- Heart(2.7)
- Intestine(2.6)
- Skin(2.4)
- Stomach(2.4)
- Thyroid gland(2.3)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXP1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- eye
- eyelid
- face
- forehead
- head
- lip
- mouth
- nose
- skull
Thorax:
- esophagus
- lung
Abdomen:
- intestine
- large intestine
- stomach
Pelvis:
- rectum
General:
- skin
- sweat gland
Primer Products
-
OriGene qPCR primer pairs for FOXP1
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for FOXP1 Gene
Orthologs for FOXP1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FOXP1 30 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FOXP1 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FOXP1 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FOXP1 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FOXP1 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Foxp1 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FOXP1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FOXP1 31 |
|
OneToOne | |
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.33069 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | Str.6946 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | foxp1b 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | CG16899 32 |
|
|
|
| FoxP 31 |
|
OneToMany | |||
| Worm (Caenorhabditis elegans) |
Secernentea | fkh-8 31 |
|
ManyToMany | |
| fkh-7 31 |
|
ManyToMany | |||
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for FOXP1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for FOXP1 Gene
- ENSEMBL:
- Gene Tree for FOXP1 (if available)
- TreeFam:
- Gene Tree for FOXP1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXP1: view image
Paralogs for FOXP1 Gene
Paralogs for FOXP1 Gene
- ENSG00000285708 5
- FOXP3 5
- FOXK2 5
- FOXM1 5
- FOXJ3 5
- FOXK1 5
- FOXD1 5
- FOXA2 5
- FOXO3 5
- FOXO1 5
- FOXA1 5
- FOXC2 5
- FOXN1 5
- FOXO4 5
- FOXL2 5
- FOXD3 5
- FOXI2 5
- FOXJ2 5
- FOXD2 5
- FOXD4L1 5
- FOXI3 5
- FOXJ1 5
- FOXL1 5
- FOXQ1 5
- FOXC1 5
- FOXD4L6 5
- FOXD4L5 5
- FOXO6 5
- FOXB1 5
- FOXE3 5
- FOXD4L4 5
- FOXD4 5
- FOXE1 5
- FOXD4L3 5
- FOXS1 5
- FOXF1 5
- FOXL3 5
- FOXH1 5
- FOXA3 5
- FOXB2 5
- FOXR2 5
- FOXO3B 5
- FOXR1 5
(8) SIMAP similar genes for FOXP1 Gene using alignment to 10 proteins:
- FOXP1_HUMAN
- A3KMG1_HUMAN
- C9IYY1_HUMAN
- C9J0F0_HUMAN
- C9J5T4_HUMAN
- E9PFD3_HUMAN
- G5E965_HUMAN
- H0Y882_HUMAN
- Q548T7_HUMAN
- Q6IAJ1_HUMAN
Variants for FOXP1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXP1 Gene
| SNP ID | Clinical significance and condition | Chr 03 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 643127 | Likely Pathogenic: not provided | 70,987,993(-) | C/A | SPLICE_DONOR_VARIANT | |
| 689737 | Pathogenic: Mental retardation with language impairment and with or without autistic features | 71,041,351(-) | TGA/T | FRAMESHIFT_VARIANT,NON_CODING_TRANSCRIPT_VARIANT | |
| 691264 | Likely Pathogenic: Intellectual disability | 71,001,034(-) | C/G | MISSENSE_VARIANT | |
| 691269 | Pathogenic: Mental retardation with language impairment and with or without autistic features | 70,970,806(-) | C/T | SPLICE_ACCEPTOR_VARIANT | |
| 691271 | Pathogenic: Mental retardation with language impairment and with or without autistic features | 70,987,993(-) | C/T | SPLICE_DONOR_VARIANT |
Residual Variation Intolerance Score:
5.98% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.58;
30.47% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXP1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXP1 Gene
Disorders for FOXP1 Gene
(32) MalaCards diseases for FOXP1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| mental retardation with language impairment and with or without autistic features |
|
|
| lymphoma, mucosa-associated lymphoid type |
|
|
| autism |
|
|
| leukemia, acute lymphoblastic 3 |
|
|
| visual epilepsy |
|
|
Search FOXP1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FOXP1_HUMAN- Note=A chromosomal aberration involving FOXP1 is found in acute lymphoblastic leukemia. Translocation t(9;3)(p13;p14.1) with PAX5.
- Mental retardation with language impairment and autistic features (MRLIAF) [MIM:613670]: A developmental disorder characterized by mild to moderate mental retardation, language impairment, and autistic features. Patients show global delay, delayed walking, severely delayed speech development, and behavioral abnormalities, including irritability, hyperactivity, aggression, and stereotypical rigid behaviors. {ECO:0000269 PubMed:20950788, ECO:0000269 PubMed:26647308}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for FOXP1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for FOXP1 Gene
Publications for FOXP1 Gene
- The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p. (PMID: 11751404) Banham AH … Cordell JL (Cancer research 2001) 2 3 4 23
- Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia. (PMID: 19352412) Vernes SC … Fisher SE (European journal of human genetics : EJHG 2009) 3 4 41
- Functional characterization of TBR1 variants in neurodevelopmental disorder. (PMID: 30250039) den Hoed J … Fisher SE (Scientific reports 2018) 3 4
- Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis. (PMID: 28218735) Kamran M … Liu Q (Oncogenesis 2017) 3 4
- Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder. (PMID: 26647308) Sollis E … Fisher SE (Human molecular genetics 2016) 3 4
ExternalLinks
Products for FOXP1 Gene
- Custom Antibody ServicesOriGene Antibodies for FOXP1
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXP1
- Origene Custom Protein Services for FOXP1
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXP1
- Browse OriGene Inhibitory RNA Products For FOXP1
- OriGene qPCR primer pairs for FOXP1
- OriGene CRISPR knockouts for FOXP1
- MG209941
- MG226917
- MR209941
- MR209941L3
- MR209941L4
- MR226917
- MR230566
- MR230847
- RC213862
- RC213862L1
- RC213862L2
- RC213862L3
- RC213862L4
- RC216342
- RC216342L3
- RC216342L4
- RC234475
- RC234528
- RC234692
- RC234697
- RC234698
- RC234703
- RC234729
- RG213862
- RG216342
- RG234475
- RG234528
- RG234692
- RG234697
- RG234698
- RG234703
- RG234729
- RR212150
- RR212150L3
- RR212150L4
- MR209941L3V
- MR209941L4V
- RC213862L1V
- RC213862L2V
- RC213862L3V
- RC213862L4V
- RC216342L3V
- RC216342L4V
- RR212150L3V
- RR212150L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOXP1
- Sino Biological Human cDNA Clone for FOXP1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FOXP1
- Novus Biologicals proteins and lysates for FOXP1
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for FOXP1
- Abcam proteins for FOXP1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for FOXP1 (AFLGC-FOXP1)
- VectorBuilder Custom and pre-made DNA vectors for FOXP1 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FOXP1 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FOXP1 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FOXP1 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FOXP1
- Addgene plasmids for FOXP1
- antibodies-online: Show 37 available FOXP1 Antibodies ranked by validation data
- Compare Top FOXP1 Antibodies
- Recommended
- 132 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 11 FACS Antibodies (anti-human)
- 7 IHC (p) Antibodies (anti-human)
- 4 IHC Antibodies (anti-human)
- 1 IP Antibody (anti-human)
- 58 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 4 IHC (p) Antibodies (anti-mouse)
- 3 FACS Antibodies (anti-mouse)
- 1 IP Antibody (anti-mouse)
- 30 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 3 IHC (p) Antibodies (anti-rat)
- 1 FACS Antibody (anti-rat)
- 1 IP Antibody (anti-rat)
- antibodies-online: Show 32 available FOXP1 Elisa Kits ranked by validation data
- Compare Top FOXP1 Elisa Kits
- antibodies-online: Show 9 available FOXP1 Proteins ranked by validation data
- Compare Top FOXP1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FOXP1
- Search Santa Cruz Biotechnology (SCBT) for FOXP1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOXP1
- Horizon Cell Lines for FOXP1
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXP1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXP1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FOXP1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXP1
- Signalway Proteins for FOXP1
Sources for FOXP1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB