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FOXO6 (Forkhead Box O6) is a Protein Coding gene. Diseases associated with FOXO6 include Rhabdomyosarcoma 2. Among its related pathways are Shigellosis and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXO3.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | IEA,ISS | -- |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IBA | 21873635 |
GO:0005515 | protein binding | IPI | 23714368 |
GO:0008134 | transcription factor binding | IBA | 21873635 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | ISS | -- |
GO:0005737 | cytoplasm | ISS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | FoxO signaling pathway | ||
2 | Shigellosis | ||
3 | AMP-activated Protein Kinase (AMPK) Signaling | ||
4 | B Cell Receptor Signaling Pathway (sino) |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,ISS | -- |
GO:0007613 | memory | IEA | -- |
GO:0008286 | insulin receptor signaling pathway | IBA | 21873635 |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Rat (Rattus norvegicus) |
Mammalia | Foxo6 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Foxo6 30 17 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FOXO6 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FOXO6 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FOXO6 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FOXO6 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | LOC100857767 30 |
|
||
FOXO6 31 |
|
OneToOne | |||
Lizard (Anolis carolinensis) |
Reptilia | FOXO6 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | foxo6 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | si:ch211-206a7.2 30 |
|
||
FOXO6 (2 of 2) 31 |
|
OneToMany | |||
FOXO6 (1 of 2) 31 |
|
OneToMany | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | foxo 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | daf-16 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HCM1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3143 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv3410216 | CNV | insertion | 20981092 |
nsv1078367 | CNV | deletion | 25765185 |
nsv1078372 | CNV | deletion | 25765185 |
nsv1126196 | CNV | deletion | 24896259 |
nsv508171 | CNV | deletion | 20534489 |
nsv546104 | CNV | loss | 21841781 |
Disorder | Aliases | PubMed IDs |
---|---|---|
rhabdomyosarcoma 2 |
|
|