Free for academic non-profit institutions. Other users need a Commercial license

Aliases for FOXO6 Gene

Aliases for FOXO6 Gene

  • Forkhead Box O6 2 3 5

External Ids for FOXO6 Gene

Previous GeneCards Identifiers for FOXO6 Gene

  • GC01U900892
  • GC01P041599
  • GC01P041827

Summaries for FOXO6 Gene

GeneCards Summary for FOXO6 Gene

FOXO6 (Forkhead Box O6) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXO3.

UniProtKB/Swiss-Prot for FOXO6 Gene

  • Transcriptional activator.

Additional gene information for FOXO6 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXO6 Gene

Genomics for FOXO6 Gene

GeneHancer (GH) Regulatory Elements for FOXO6 Gene

Promoters and enhancers for FOXO6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I041357 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 556.2 -2.2 -2156 4.9 FOXA2 PKNOX1 ATF1 SIN3A ZBTB7B GLIS2 GATA2 ZNF143 FOS ATF7 FOXO6 SLFNL1 RPL36AP9
GH01I041238 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE 16.9 -120.8 -120798 5.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 YBX1 YY1 SLC30A9 ENSG00000235358 SCMH1 LOC102723924 EXO5 FOXO6 CTPS1 PIR51229
GH01I041380 Enhancer 1.3 Ensembl ENCODE dbSUPER 29.7 +20.3 20313 4 PKNOX1 SMAD1 ZFP64 ZNF133 SIN3A FEZF1 BRCA1 GLIS2 SP3 TSHZ1 LOC101929901 FOXO6 NFYC-AS1 LOC105378672 EXO5 LOC105378678
GH01I041364 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 22.1 +5.4 5432 5.2 PKNOX1 KLF17 SIN3A ZNF335 ZNF143 IKZF2 EGR2 ZNF263 ELF1 ZNF398 GC01P041369 PIR34819 FOXO6 ENSG00000235358 SCMH1
GH01I041386 Enhancer 1 ENCODE dbSUPER 22.8 +25.5 25472 2.5 NFIB KLF17 SIN3A GLIS2 ZNF366 EGR2 ZNF680 USF2 ZNF398 SP1 FOXO6 ZFP69 EDN2 LOC101929901 LOC105378678
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FOXO6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXO6 gene promoter:

Genomic Locations for FOXO6 Gene

Genomic Locations for FOXO6 Gene
chr1:41,361,922-41,383,591
(GRCh38/hg38)
Size:
21,670 bases
Orientation:
Plus strand
chr1:41,827,227-41,856,020
(GRCh37/hg19)

Genomic View for FOXO6 Gene

Genes around FOXO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXO6 Gene

Proteins for FOXO6 Gene

  • Protein details for FOXO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYZ6-FOXO6_HUMAN
    Recommended name:
    Forkhead box protein O6
    Protein Accession:
    A8MYZ6

    Protein attributes for FOXO6 Gene

    Size:
    492 amino acids
    Molecular mass:
    50595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXO6 Gene

Post-translational modifications for FOXO6 Gene

  • Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXO6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXO6 Gene

Domains & Families for FOXO6 Gene

Gene Families for FOXO6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FOXO6 Gene

Suggested Antigen Peptide Sequences for FOXO6 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXO6: view

No data available for UniProtKB/Swiss-Prot for FOXO6 Gene

Function for FOXO6 Gene

Molecular function for FOXO6 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator.

Phenotypes From GWAS Catalog for FOXO6 Gene

Gene Ontology (GO) - Molecular Function for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISS --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 23714368
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXO6: view
genes like me logo Genes that share phenotypes with FOXO6: view

Animal Models for FOXO6 Gene

MGI Knock Outs for FOXO6:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXO6 Gene

Localization for FOXO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO6 Gene

Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXO6 gene
Compartment Confidence
nucleus 5

Gene Ontology (GO) - Cellular Components for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with FOXO6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXO6 Gene

Pathways & Interactions for FOXO6 Gene

SuperPathways for FOXO6 Gene

SuperPathway Contained pathways
1 FoxO signaling pathway
genes like me logo Genes that share pathways with FOXO6: view

Pathways by source for FOXO6 Gene

1 KEGG pathway for FOXO6 Gene

SIGNOR curated interactions for FOXO6 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,ISS --
GO:0007613 memory IEA --
GO:0009653 anatomical structure morphogenesis IBA --
genes like me logo Genes that share ontologies with FOXO6: view

Drugs & Compounds for FOXO6 Gene

No Compound Related Data Available

Transcripts for FOXO6 Gene

mRNA/cDNA for FOXO6 Gene

(1) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO6 Gene

No ASD Table

Relevant External Links for FOXO6 Gene

GeneLoc Exon Structure for
FOXO6
ECgene alternative splicing isoforms for
FOXO6

Expression for FOXO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXO6 Gene

This gene is overexpressed in Pituitary (x6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXO6 Gene



NURSA nuclear receptor signaling pathways regulating expression of FOXO6 Gene:

FOXO6
genes like me logo Genes that share expression patterns with FOXO6: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXO6 Gene

Orthologs for FOXO6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXO6 Gene

Organism Taxonomy Gene Similarity Type Details
rat
(Rattus norvegicus)
Mammalia Foxo6 33
  • 91.99 (n)
mouse
(Mus musculus)
Mammalia Foxo6 33 16 34
  • 91.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia FOXO6 34
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXO6 34
  • 62 (a)
OneToOne
cow
(Bos Taurus)
Mammalia FOXO6 34
  • 45 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXO6 34
  • 39 (a)
OneToOne
chicken
(Gallus gallus)
Aves LOC100857767 33
  • 73.85 (n)
FOXO6 34
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXO6 34
  • 30 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxo6 33
  • 65.4 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-206a7.2 33
  • 62.94 (n)
FOXO6 (2 of 2) 34
  • 28 (a)
OneToMany
FOXO6 (1 of 2) 34
  • 27 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta foxo 34
  • 23 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daf-16 34
  • 21 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCM1 34
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3143 34
  • 18 (a)
OneToMany
Species where no ortholog for FOXO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXO6 Gene

ENSEMBL:
Gene Tree for FOXO6 (if available)
TreeFam:
Gene Tree for FOXO6 (if available)

Paralogs for FOXO6 Gene

Paralogs for FOXO6 Gene

(2) SIMAP similar genes for FOXO6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXO6: view

Variants for FOXO6 Gene

Sequence variations from dbSNP and Humsavar for FOXO6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000024681 -- 41,383,494(+) C/G 3_prime_UTR_variant
rs1000042416 -- 41,383,764(+) A/G downstream_transcript_variant
rs1000070231 -- 41,370,773(+) C/T intron_variant
rs1000176731 -- 41,366,056(+) C/T intron_variant
rs1000228298 -- 41,376,524(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXO6 Gene

Variant ID Type Subtype PubMed ID
esv3410216 CNV insertion 20981092
nsv1078367 CNV deletion 25765185
nsv1078372 CNV deletion 25765185
nsv1126196 CNV deletion 24896259
nsv508171 CNV deletion 20534489
nsv546104 CNV loss 21841781

Variation tolerance for FOXO6 Gene

Gene Damage Index Score: 8.36; 85.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXO6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXO6 Gene

Disorders for FOXO6 Gene

Additional Disease Information for FOXO6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FOXO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXO6 Gene

Publications for FOXO6 Gene

  1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 44 58
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
  3. FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. (PMID: 12857750) Jacobs FM … Smidt MP (The Journal of biological chemistry 2003) 2 3 58
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 58
  5. FoxO6 inhibits cell proliferation in lung carcinoma through up-regulation of USP7. (PMID: 25695151) Hu HJ … Guo XX (Molecular medicine reports 2015) 3 58

Products for FOXO6 Gene

Sources for FOXO6 Gene

Content
Loading form....