Aliases for FOXO6 Gene
External Ids for FOXO6 Gene
- HGNC: 24814
- Entrez Gene: 100132074
- Ensembl: ENSG00000204060
- OMIM: 611457
- UniProtKB: A8MYZ6
Previous GeneCards Identifiers for FOXO6 Gene
- GC01U900892
- GC01P041599
- GC01P041827
Summaries for FOXO6 Gene
GeneCards Summary for FOXO6 Gene
FOXO6 (Forkhead Box O6) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXO3.
UniProtKB/Swiss-Prot for FOXO6 Gene
-
Transcriptional activator.
Additional gene information for FOXO6 Gene
- Monarch Initiative
- Search for FOXO6 at DataMed
- Search for FOXO6 at HumanCyc
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXO6 Gene
Genomics for FOXO6 Gene
GeneHancer (GH) Regulatory Elements for FOXO6 Gene
Promoters and enhancers for FOXO6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXO6 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FOXO6 gene promoter:
-
- RP58
- STAT3
- Spz1
- Nkx2-5
- HOXA5
- Meis-1
- E47
- Tal-1
- HOXA9
- HOXA9B
Regulatory Element Products
Genomic Locations for FOXO6 Gene
Genomic Locations for FOXO6 Gene
- chr1:41,361,922-41,383,591
- (GRCh38/hg38)
- Size:
- 21,670 bases
- Orientation:
- Plus strand
- chr1:41,827,227-41,856,020
- (GRCh37/hg19)
- Size:
- 28,794 bases
- Orientation:
- Plus strand
Genomic View for FOXO6 Gene
Genes around FOXO6 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 1p34.2 by Entrez Gene
- 1p34.2 by HGNC
- 1p34.2 by Ensembl
FOXO6 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXO6 Gene
Proteins for FOXO6 Gene
-
Protein details for FOXO6 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- A8MYZ6-FOXO6_HUMAN
- Recommended name:
- Forkhead box protein O6
- Protein Accession:
- A8MYZ6
Protein attributes for FOXO6 Gene
- Size:
- 492 amino acids
- Molecular mass:
- 50595 Da
- Quaternary structure:
- No Data Available
Protein Expression for FOXO6 Gene
Post-translational modifications for FOXO6 Gene
- Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FOXO6 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FOXO6
- Novus Biologicals Antibodies for FOXO6
-
Abcam antibodies for FOXO6
- Invitrogen Antibodies for FOXO6 (AFLGC-FOXO6)
- GeneTex Foxo6 Antibody for FOXO6
-
Boster Bio Antibodies for FOXO6
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for FOXO6
- Origene Custom Protein Services for FOXO6
- Search GeneTex for Proteins for FOXO6
Assay Products
No data available for DME Specific Peptides for FOXO6 Gene
Domains & Families for FOXO6 Gene
Gene Families for FOXO6 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Protein Domains for FOXO6 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXO6 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FOXO6 Gene
Function for FOXO6 Gene
Molecular function for FOXO6 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional activator.
Phenotypes From GWAS Catalog for FOXO6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | ISS | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 23714368 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for FOXO6 Gene
- MGI mutant phenotypes for FOXO6:
- inferred from 2 alleles
Animal Models for FOXO6 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FOXO6
-
CRISPR Products
-
OriGene CRISPR knockouts for FOXO6
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- genomics-online: gRNA clones - Search results for 33 available Foxo6 gene related products
- Overview of 33 available Foxo6 gene related products
- Applied Biological Materials CRISPR for FOXO6
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA for FOXO6 Gene
- miRTarBase miRNAs that target FOXO6
-
- hsa-mir-6840-3p (MIRT455823)
- hsa-mir-149-3p (MIRT737727)
- hsa-mir-3175 (MIRT740658)
- hsa-mir-345-5p (MIRT741420)
- hsa-mir-4434 (MIRT744395)
- hsa-mir-4516 (MIRT745748)
- hsa-mir-4700-3p (MIRT747267)
- hsa-mir-4723-5p (MIRT747650)
- hsa-mir-4728-5p (MIRT747823)
- hsa-mir-5698 (MIRT751282)
- hsa-mir-5703 (MIRT751351)
- hsa-mir-6785-5p (MIRT755818)
- hsa-mir-6825-5p (MIRT756979)
- hsa-mir-6870-5p (MIRT757983)
- hsa-mir-6878-5p (MIRT758204)
- hsa-mir-6883-5p (MIRT758403)
- hsa-mir-7111-5p (MIRT759040)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXO6
- Browse OriGene Inhibitory RNA Products For FOXO6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO6
- genomics-online: shRNA clones - Search results for 33 available Foxo6 gene related products
- Overview of 33 available Foxo6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FOXO6
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXO6
- Applied Biological Materials Clones for FOXO6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXO6 Gene
Localization for FOXO6 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXO6 Gene
- Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity). {ECO:0000250}.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | ISS | -- |
| GO:0005737 | cytoplasm | ISS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXO6 Gene
Pathways & Interactions for FOXO6 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FoxO signaling pathway | ||
Pathways by source for FOXO6 Gene
1 KEGG pathway for FOXO6 Gene
Interacting Proteins for FOXO6 Gene
SIGNOR curated interactions for FOXO6 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | ISS,IEA | -- |
| GO:0007613 | memory | IEA | -- |
| GO:0009653 | anatomical structure morphogenesis | IBA | -- |
Transcripts for FOXO6 Gene
mRNA/cDNA for FOXO6 Gene
- (1) REFSEQ mRNAs :
- (2) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000372591 2398 bps (uc057fid.1)
- ENST00000641094 1476 bps
CRISPR Products
-
OriGene CRISPR knockouts for FOXO6
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXO6
- genomics-online: gRNA clones - Search results for 33 available Foxo6 gene related products
- Overview of 33 available Foxo6 gene related products
- Applied Biological Materials CRISPR for FOXO6
-
Vectors and viruses for KO, Activation, Repression, and more
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXO6
- Browse OriGene Inhibitory RNA Products For FOXO6
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO6
- genomics-online: shRNA clones - Search results for 33 available Foxo6 gene related products
- Overview of 33 available Foxo6 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FOXO6
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- Applied Biological Materials Clones for FOXO6
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FOXO6 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Juxtaglomerular Cells Afferent Arteriole
-
Smooth Muscle (Muscoskeletal System)
- Juxtaglomerular Cells Afferent Arteriole
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
-
Thymus (Hematopoietic System)
- Double Positive Thymocytes Thymus
-
Blood (Cardiovascular System)
- Double Positive Thymocytes Thymus
mRNA differential expression in normal tissues according to GTEx for FOXO6 Gene
This gene is overexpressed in Pituitary (x6.6).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXO6 Gene
NURSA nuclear receptor signaling pathways regulating expression of FOXO6 Gene:
FOXO6Primer Products
-
OriGene qPCR primer pairs for FOXO6
- genomics-online: primer clones - Search results for 33 available Foxo6 gene related products
- Overview of 33 available Foxo6 gene related products
Gene Expression Assay Products
No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXO6 Gene
Orthologs for FOXO6 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| rat (Rattus norvegicus) |
Mammalia | Foxo6 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Foxo6 16 34 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FOXO6 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FOXO6 34 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FOXO6 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FOXO6 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC100857767 33 |
|
||
| FOXO6 34 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | FOXO6 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | foxo6 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | si:ch211-206a7.2 33 |
|
||
| FOXO6 (2 of 2) 34 |
|
OneToMany | |||
| FOXO6 (1 of 2) 34 |
|
OneToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | foxo 34 |
|
OneToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | daf-16 34 |
|
OneToMany | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HCM1 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3143 34 |
|
OneToMany |
- Species where no ortholog for FOXO6 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for FOXO6 Gene
- ENSEMBL:
- Gene Tree for FOXO6 (if available)
- TreeFam:
- Gene Tree for FOXO6 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXO6: view image
Paralogs for FOXO6 Gene
Variants for FOXO6 Gene
| SNP ID | Clin | Chr 01 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000024681 | -- | 41,383,494(+) | C/G | 3_prime_UTR_variant | |
| rs1000042416 | -- | 41,383,764(+) | A/G | downstream_transcript_variant | |
| rs1000070231 | -- | 41,370,773(+) | C/T | intron_variant | |
| rs1000176731 | -- | 41,366,056(+) | C/T | intron_variant | |
| rs1000228298 | -- | 41,376,524(+) | C/G | intron_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv3410216 | CNV | insertion | 20981092 |
| nsv1078367 | CNV | deletion | 25765185 |
| nsv1078372 | CNV | deletion | 25765185 |
| nsv1126196 | CNV | deletion | 24896259 |
| nsv508171 | CNV | deletion | 20534489 |
| nsv546104 | CNV | loss | 21841781 |
Gene Damage Index Score:
8.36;
85.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXO6 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FOXO6
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXO6 Gene
Disorders for FOXO6 Gene
Additional Disease Information for FOXO6
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for FOXO6 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXO6 Gene
Publications for FOXO6 Gene
- Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 44 58
- The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 58
- FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. (PMID: 12857750) Jacobs FM … Smidt MP (The Journal of biological chemistry 2003) 2 3 58
- Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer. (PMID: 28404958) Wang JH … Cui SZ (Oncotarget 2017) 3 58
- Bipolar disorder risk gene FOXO6 modulates negative symptoms in schizophrenia: a neuroimaging genetics study. (PMID: 28234206) Shenker JJ … Lepage M (Journal of psychiatry & neuroscience : JPN 2017) 3 58
Products for FOXO6 Gene
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- GeneTex Foxo6 Antibody for FOXO6
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Sources for FOXO6 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
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- (125) NCBI Bookshelf
- (126) ClinVar
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- (128) ViGene Biosciences
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- (133) ENCODE
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- (135) Horizon
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- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
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