Aliases for FOXO6 Gene

Aliases for FOXO6 Gene

  • Forkhead Box O6 2 3 5
  • Forkhead Box Protein O6 3 4
  • FOXO6 5

External Ids for FOXO6 Gene

Previous GeneCards Identifiers for FOXO6 Gene

  • GC01U900892
  • GC01P041599
  • GC01P041827

Summaries for FOXO6 Gene

GeneCards Summary for FOXO6 Gene

FOXO6 (Forkhead Box O6) is a Protein Coding gene. Diseases associated with FOXO6 include Rhabdomyosarcoma 2. Among its related pathways are Shigellosis and B Cell Receptor Signaling Pathway (sino). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXO3.

UniProtKB/Swiss-Prot Summary for FOXO6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXO6 Gene

Genomics for FOXO6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FOXO6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J041357 Promoter/Enhancer 2.2 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 606.1 -1.1 -1069 6.1 SP1 CREB1 CTCF PRDM10 ZNF629 RFX1 SOX13 JUND FOXA1 LARP7 FOXO6 EXO5 SLFNL1 piR-60146-003 SCMH1
GH01J041380 Promoter/Enhancer 1.4 ENCODE CraniofacialAtlas dbSUPER 29.7 +20.8 20801 4 ZNF629 KDM1A ZNF692 LARP7 ZIC2 PKNOX1 PATZ1 EZH2 ZNF600 ZNF341 FOXO6 FOXO6-AS1 HSALNG0002949 EDN2
GH01J041365 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 22.1 +5.6 5633 5.7 PRDM10 RFX1 BACH1 LARP7 ZNF143 ZIC2 PKNOX1 PATZ1 TCF12 IKZF2 piR-41820 FOXO6 ENSG00000235358 SCMH1 EDN2
GH01J041238 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 16.9 -120.3 -120310 5.6 HNRNPL CREB1 GATAD2A ATF7 PRDM10 ZNF629 TFE3 LEF1 SOX13 IKZF1 ENSG00000235358 SCMH1 ENSG00000287400 lnc-SCMH1-1 EXO5 FOXO6 CTPS1 piR-61101-016 SLFNL1
GH01J041370 Enhancer 1.2 ENCODE CraniofacialAtlas dbSUPER 22.1 +10.3 10331 3 LEF1 IKZF1 KDM1A ZNF692 ZNF300 ZIC2 PATZ1 SOX6 ZNF341 EP300 FOXO6 EXO5 FOXO6-AS1 piR-41820 EDN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXO6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXO6

Top Transcription factor binding sites by QIAGEN in the FOXO6 gene promoter:
  • E47
  • HOXA5
  • HOXA9
  • HOXA9B
  • Meis-1
  • Nkx2-5
  • RP58
  • Spz1
  • STAT3
  • Tal-1

Genomic Locations for FOXO6 Gene

Genomic Locations for FOXO6 Gene
chr1:41,361,434-41,383,590
(GRCh38/hg38)
Size:
22,157 bases
Orientation:
Plus strand
chr1:41,827,227-41,856,020
(GRCh37/hg19)
Size:
28,794 bases
Orientation:
Plus strand

Genomic View for FOXO6 Gene

Genes around FOXO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXO6 Gene

Proteins for FOXO6 Gene

  • Protein details for FOXO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MYZ6-FOXO6_HUMAN
    Recommended name:
    Forkhead box protein O6
    Protein Accession:
    A8MYZ6

    Protein attributes for FOXO6 Gene

    Size:
    492 amino acids
    Molecular mass:
    50595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXO6 Gene

Post-translational modifications for FOXO6 Gene

  • Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXO6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXO6 Gene

Domains & Families for FOXO6 Gene

Gene Families for FOXO6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FOXO6 Gene

Suggested Antigen Peptide Sequences for FOXO6 Gene

GenScript: Design optimal peptide antigens:
  • Forkhead box protein O6 (FOXO6_HUMAN)
genes like me logo Genes that share domains with FOXO6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXO6 Gene

Function for FOXO6 Gene

Molecular function for FOXO6 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator.

Phenotypes From GWAS Catalog for FOXO6 Gene

Gene Ontology (GO) - Molecular Function for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IEA,ISS --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 23714368
GO:0008134 transcription factor binding IBA 21873635
genes like me logo Genes that share ontologies with FOXO6: view
genes like me logo Genes that share phenotypes with FOXO6: view

Animal Models for FOXO6 Gene

MGI Knock Outs for FOXO6:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO6

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXO6 Gene

Localization for FOXO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO6 Gene

Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity). {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXO6 gene
Compartment Confidence
nucleus 5
plasma membrane 2
extracellular 2
mitochondrion 2
cytosol 2
cytoskeleton 1
peroxisome 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with FOXO6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXO6 Gene

Pathways & Interactions for FOXO6 Gene

genes like me logo Genes that share pathways with FOXO6: view

Pathways by source for FOXO6 Gene

2 Sino Biological pathways for FOXO6 Gene
2 KEGG pathways for FOXO6 Gene

SIGNOR curated interactions for FOXO6 Gene

Activates:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,ISS --
GO:0007613 memory IEA --
GO:0008286 insulin receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with FOXO6: view

Drugs & Compounds for FOXO6 Gene

No Compound Related Data Available

Transcripts for FOXO6 Gene

mRNA/cDNA for FOXO6 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO6

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO6 Gene

No ASD Table

Relevant External Links for FOXO6 Gene

GeneLoc Exon Structure for
FOXO6

Expression for FOXO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXO6 Gene

This gene is overexpressed in Pituitary (x6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXO6 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXO6

Evidence on tissue expression from TISSUES for FOXO6 Gene

  • Blood(2.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with FOXO6: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXO6 Gene

Orthologs for FOXO6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXO6 Gene

Organism Taxonomy Gene Similarity Type Details
Rat
(Rattus norvegicus)
Mammalia Foxo6 30
  • 91.99 (n)
Mouse
(Mus musculus)
Mammalia Foxo6 30 17 31
  • 91.65 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FOXO6 31
  • 74 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FOXO6 31
  • 62 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia FOXO6 31
  • 45 (a)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FOXO6 31
  • 39 (a)
OneToOne
Chicken
(Gallus gallus)
Aves LOC100857767 30
  • 73.85 (n)
FOXO6 31
  • 31 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia FOXO6 31
  • 30 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia foxo6 30
  • 65.4 (n)
Zebrafish
(Danio rerio)
Actinopterygii si:ch211-206a7.2 30
  • 62.94 (n)
FOXO6 (2 of 2) 31
  • 28 (a)
OneToMany
FOXO6 (1 of 2) 31
  • 27 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta foxo 31
  • 23 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea daf-16 31
  • 21 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCM1 31
  • 12 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3143 31
  • 18 (a)
OneToMany
Species where no ortholog for FOXO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FOXO6 Gene

ENSEMBL:
Gene Tree for FOXO6 (if available)
TreeFam:
Gene Tree for FOXO6 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXO6: view image

Paralogs for FOXO6 Gene

(2) SIMAP similar genes for FOXO6 Gene using alignment to 2 proteins:

  • FOXO6_HUMAN
  • A6NCE0_HUMAN
genes like me logo Genes that share paralogs with FOXO6: view

Variants for FOXO6 Gene

Additional dbSNP identifiers (rs#s) for FOXO6 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXO6 Gene

Variant ID Type Subtype PubMed ID
esv3410216 CNV insertion 20981092
nsv1078367 CNV deletion 25765185
nsv1078372 CNV deletion 25765185
nsv1126196 CNV deletion 24896259
nsv508171 CNV deletion 20534489
nsv546104 CNV loss 21841781

Variation tolerance for FOXO6 Gene

Gene Damage Index Score: 8.36; 85.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXO6

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXO6 Gene

Disorders for FOXO6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXO6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
rhabdomyosarcoma 2
  • rms2
- elite association - COSMIC cancer census association via MalaCards
Search FOXO6 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOXO6

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FOXO6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXO6 Gene

Publications for FOXO6 Gene

  1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 41
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4
  3. FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. (PMID: 12857750) Jacobs FM … Smidt MP (The Journal of biological chemistry 2003) 2 3
  4. Silencing of FOXO6 inhibits the proliferation, invasion, and glycolysis in colorectal cancer cells. (PMID: 30321450) Li Q … Qin C (Journal of cellular biochemistry 2019) 3
  5. 5-Hydroxytryptamine Receptor 1D Aggravates Hepatocellular Carcinoma Progression Through FoxO6 in AKT-Dependent and Independent Manners. (PMID: 30561038) Zuo X … Wang X (Hepatology (Baltimore, Md.) 2019) 3

Products for FOXO6 Gene

Sources for FOXO6 Gene