Aliases for FOXO6 Gene

Aliases for FOXO6 Gene

  • Forkhead Box O6 2 3 5
  • Forkhead Box Protein O6 3 4

External Ids for FOXO6 Gene

Previous GeneCards Identifiers for FOXO6 Gene

  • GC01U900892
  • GC01P041599
  • GC01P041827

Summaries for FOXO6 Gene

GeneCards Summary for FOXO6 Gene

FOXO6 (Forkhead Box O6) is a Protein Coding gene. Among its related pathways are FoxO signaling pathway. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXO3.

UniProtKB/Swiss-Prot Summary for FOXO6 Gene

Additional gene information for FOXO6 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXO6 Gene

Genomics for FOXO6 Gene

GeneHancer (GH) Regulatory Elements for FOXO6 Gene

Promoters and enhancers for FOXO6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXO6 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXO6 gene promoter:
  • E47
  • HOXA5
  • HOXA9
  • HOXA9B
  • Meis-1
  • Nkx2-5
  • RP58
  • Spz1
  • STAT3
  • Tal-1

Genomic Locations for FOXO6 Gene

Genomic Locations for FOXO6 Gene
21,670 bases
Plus strand
28,794 bases
Plus strand

Genomic View for FOXO6 Gene

Genes around FOXO6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXO6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXO6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXO6 Gene

Proteins for FOXO6 Gene

  • Protein details for FOXO6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein O6
    Protein Accession:

    Protein attributes for FOXO6 Gene

    492 amino acids
    Molecular mass:
    50595 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXO6 Gene

Post-translational modifications for FOXO6 Gene

  • Phosphorylation of Ser-184 is be important in regulating the transacriptional activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXO6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXO6 Gene

Domains & Families for FOXO6 Gene

Gene Families for FOXO6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for FOXO6 Gene

Suggested Antigen Peptide Sequences for FOXO6 Gene

GenScript: Design optimal peptide antigens:
  • Forkhead box protein O6 (FOXO6_HUMAN)
genes like me logo Genes that share domains with FOXO6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXO6 Gene

Function for FOXO6 Gene

Molecular function for FOXO6 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator.

Phenotypes From GWAS Catalog for FOXO6 Gene

Gene Ontology (GO) - Molecular Function for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IEA,ISS --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IBA 21873635
GO:0005515 protein binding IPI 23714368
GO:0008134 transcription factor binding IBA 21873635
genes like me logo Genes that share ontologies with FOXO6: view
genes like me logo Genes that share phenotypes with FOXO6: view

Animal Models for FOXO6 Gene

MGI Knock Outs for FOXO6:

Animal Model Products

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXO6 Gene

Localization for FOXO6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO6 Gene

Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity). {ECO:0000250}.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXO6 gene
Compartment Confidence
nucleus 4

Gene Ontology (GO) - Cellular Components for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus ISS --
GO:0005737 cytoplasm ISS --
genes like me logo Genes that share ontologies with FOXO6: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXO6 Gene

Pathways & Interactions for FOXO6 Gene

PathCards logo

SuperPathways for FOXO6 Gene

SuperPathway Contained pathways
1 FoxO signaling pathway
genes like me logo Genes that share pathways with FOXO6: view

Pathways by source for FOXO6 Gene

1 KEGG pathway for FOXO6 Gene

SIGNOR curated interactions for FOXO6 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for FOXO6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,ISS --
GO:0007613 memory IEA --
GO:0008286 insulin receptor signaling pathway IBA 21873635
genes like me logo Genes that share ontologies with FOXO6: view

Drugs & Compounds for FOXO6 Gene

No Compound Related Data Available

Transcripts for FOXO6 Gene

mRNA/cDNA for FOXO6 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO6 Gene

No ASD Table

Relevant External Links for FOXO6 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXO6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXO6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXO6 Gene

This gene is overexpressed in Pituitary (x6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXO6 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXO6 Gene:

genes like me logo Genes that share expression patterns with FOXO6: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXO6 Gene

Orthologs for FOXO6 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXO6 Gene

Organism Taxonomy Gene Similarity Type Details
(Rattus norvegicus)
Mammalia Foxo6 32
  • 91.99 (n)
(Mus musculus)
Mammalia Foxo6 17 33 32
  • 91.65 (n)
(Ornithorhynchus anatinus)
Mammalia FOXO6 33
  • 74 (a)
(Canis familiaris)
Mammalia FOXO6 33
  • 62 (a)
(Bos Taurus)
Mammalia FOXO6 33
  • 45 (a)
(Monodelphis domestica)
Mammalia FOXO6 33
  • 39 (a)
(Gallus gallus)
Aves LOC100857767 32
  • 73.85 (n)
FOXO6 33
  • 31 (a)
(Anolis carolinensis)
Reptilia FOXO6 33
  • 30 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxo6 32
  • 65.4 (n)
(Danio rerio)
Actinopterygii si:ch211-206a7.2 32
  • 62.94 (n)
FOXO6 (2 of 2) 33
  • 28 (a)
FOXO6 (1 of 2) 33
  • 27 (a)
fruit fly
(Drosophila melanogaster)
Insecta foxo 33
  • 23 (a)
(Caenorhabditis elegans)
Secernentea daf-16 33
  • 21 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCM1 33
  • 12 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3143 33
  • 18 (a)
Species where no ortholog for FOXO6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXO6 Gene

Gene Tree for FOXO6 (if available)
Gene Tree for FOXO6 (if available)
Evolutionary constrained regions (ECRs) for FOXO6: view image

Paralogs for FOXO6 Gene

(2) SIMAP similar genes for FOXO6 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with FOXO6: view

Variants for FOXO6 Gene

Sequence variations from dbSNP and Humsavar for FOXO6 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000024681 -- 41,383,494(+) C/G/T 3_prime_UTR_variant
rs1000042416 -- 41,383,764(+) A/G downstream_transcript_variant
rs1000070231 -- 41,370,773(+) C/T intron_variant
rs1000176731 -- 41,366,056(+) C/G/T intron_variant
rs1000228298 -- 41,376,524(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXO6 Gene

Variant ID Type Subtype PubMed ID
esv3410216 CNV insertion 20981092
nsv1078367 CNV deletion 25765185
nsv1078372 CNV deletion 25765185
nsv1126196 CNV deletion 24896259
nsv508171 CNV deletion 20534489
nsv546104 CNV loss 21841781

Variation tolerance for FOXO6 Gene

Gene Damage Index Score: 8.36; 85.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXO6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXO6 Gene

Disorders for FOXO6 Gene

Additional Disease Information for FOXO6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FOXO6 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXO6 Gene

Publications for FOXO6 Gene

  1. Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. (PMID: 21926972) Psychiatric GWAS Consortium Bipolar Disorder Working Group (Nature genetics 2011) 3 43 56
  2. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 56
  3. FoxO6, a novel member of the FoxO class of transcription factors with distinct shuttling dynamics. (PMID: 12857750) Jacobs FM … Smidt MP (The Journal of biological chemistry 2003) 2 3 56
  4. The long noncoding RNA NORAD promotes the growth of gastric cancer cells by sponging miR-608. (PMID: 30453063) Miao Z … Tian L (Gene 2019) 3 56
  5. Elevated FOXO6 expression correlates with progression and prognosis in gastric cancer. (PMID: 28404958) Wang JH … Cui SZ (Oncotarget 2017) 3 56

Products for FOXO6 Gene

Sources for FOXO6 Gene