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This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
FOXO4 (Forkhead Box O4) is a Protein Coding gene. Diseases associated with FOXO4 include Skin Sarcoma and Sarcomatoid Squamous Cell Skin Carcinoma. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and RET signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and enzyme binding. An important paralog of this gene is FOXO1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 11689711 |
GO:0003677 | DNA binding | IEA,IDA | 10783894 |
GO:0003700 | DNA-binding transcription factor activity | IBA,IDA | 10783894 |
GO:0005515 | protein binding | IPI | 15084259 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IBA,TAS | 22972301 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA,IDA | 16964248 |
GO:0005829 | cytosol | TAS | 22972301 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways | ||
3 | GAB1 signalosome |
.89
|
|
4 | Constitutive Signaling by AKT1 E17K in Cancer | ||
5 | Deubiquitination |
.74
|
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
GO:0006355 | regulation of transcription, DNA-templated | IDA | 15126506 |
GO:0006366 | transcription by RNA polymerase II | TAS | 10783894 |
GO:0007049 | cell cycle | IEA | -- |
GO:0007050 | cell cycle arrest | IDA | 10783894 |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
NAD | Experimental | Pharma | Agonist, Full agonist, Activator | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
---|
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||
SP2: | - | ||||||||||||
SP3: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FOXO4 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FOXO4 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FOXO4 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Foxo4 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Foxo4 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FOXO4 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FOXO4 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FOXO4 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100492831 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | LOC563719 30 |
|
||
FOXO4 31 |
|
OneToOne | |||
Fruit Fly (Drosophila melanogaster) |
Insecta | foxo 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | daf-16 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HCM1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3143 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
---|---|---|---|---|---|
788055 | Benign: not provided | 71,100,917(+) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
esv1584074 | OTHER | inversion | 17803354 |
esv33082 | CNV | loss | 17666407 |
Disorder | Aliases | PubMed IDs |
---|---|---|
skin sarcoma |
|
|
sarcomatoid squamous cell skin carcinoma |
|
|
balloon cell malignant melanoma |
|
|
connective tissue benign neoplasm |
|
|
cutaneous leiomyosarcoma |
|
|