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This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located... See more...
Aliases for FOXO4 Gene
Aliases for FOXO4 Gene
- Forkhead Box O4 2 3 5
- AFX1 2 3 4
- Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 7 2 3
- Fork Head Domain Transcription Factor AFX1 3 4
- Forkhead Box Protein O4 3 4
- MLLT7 3 4
- AFX 3 4
- Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 7 2
- FOXO4 5
External Ids for FOXO4 Gene
- HGNC: 7139
- Entrez Gene: 4303
- Ensembl: ENSG00000184481
- OMIM: 300033
- UniProtKB: P98177
Previous HGNC Symbols for FOXO4 Gene
- MLLT7
Previous GeneCards Identifiers for FOXO4 Gene
- GC0XP070233
- GC0XP070316
- GC0XP064135
- GC0XP071096
Summaries for FOXO4 Gene
-
This gene encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2010]
GeneCards Summary for FOXO4 Gene
FOXO4 (Forkhead Box O4) is a Protein Coding gene. Diseases associated with FOXO4 include Skin Sarcoma and Sarcomatoid Squamous Cell Skin Carcinoma. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and RET signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and enzyme binding. An important paralog of this gene is FOXO1.
UniProtKB/Swiss-Prot Summary for FOXO4 Gene
-
Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
Additional gene information for FOXO4 Gene
- HGNC(7139)
- Entrez Gene(4303)
- Ensembl(ENSG00000184481)
- OMIM(300033)
- UniProtKB(P98177)
- Open Targets Platform(ENSG00000184481)
- Monarch Initiative
- Search for FOXO4 at DataMed
- Search for FOXO4 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXO4 Gene
Genomics for FOXO4 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FOXO4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXO4 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXO4
- Top Transcription factor binding sites by QIAGEN in the FOXO4 gene promoter:
-
- c-Myb
- E47
- Evi-1
- GR
- GR-alpha
- GR-beta
- HFH-1
- IRF-2
- Tal-1
Genomic Locations for FOXO4 Gene
Genomic Locations for FOXO4 Gene
- chrX:71,095,851-71,103,534
- (GRCh38/hg38)
- Size:
- 7,684 bases
- Orientation:
- Plus strand
- chrX:70,315,999-70,323,385
- (GRCh37/hg19)
- Size:
- 7,387 bases
- Orientation:
- Plus strand
Genomic View for FOXO4 Gene
Genes around FOXO4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- Xq13.1 by HGNC
- Xq13.1 by Entrez Gene
- Xq13.1 by Ensembl
FOXO4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXO4 Gene
Proteins for FOXO4 Gene
-
Protein details for FOXO4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P98177-FOXO4_HUMAN
- Recommended name:
- Forkhead box protein O4
- Protein Accession:
- P98177
- B7WPJ7
- O43821
- Q13720
- Q3KPF1
- Q8TDK9
Protein attributes for FOXO4 Gene
- Size:
- 505 amino acids
- Molecular mass:
- 53684 Da
- Quaternary structure:
-
- Interacts with CREBBP/CBP, CTNNB1, MYOCD, SIRT1, SRF and YWHAZ. Acetylated by CREBBP/CBP and deacetylated by SIRT1. Binding of YWHAZ inhibits DNA-binding. Interacts with USP7; the interaction is enhanced in presence of hydrogen peroxide and occurs independently of TP53. Interacts with NLK, and this inhibits monoubiquitination and transcriptional activity. Interacts with FOXK1; the interaction inhibits MEF2C transactivation activity (By similarity).
Protein Expression for FOXO4 Gene
Post-translational modifications for FOXO4 Gene
- Acetylation by CREBBP/CBP, which is induced by peroxidase stress, inhibits transcriptional activity. Deacetylation by SIRT1 is NAD-dependent and stimulates transcriptional activity.
- Phosphorylation by PKB/AKT1 inhibits transcriptional activity and is responsible for cytoplasmic localization. May be phosphorylated at multiple sites by NLK.
- Monoubiquitinated; monoubiquitination is induced by oxidative stress and reduced by deacetylase inhibitors; results in its relocalization to the nucleus and its increased transcriptional activity. Deubiquitinated by USP7; deubiquitination is induced by oxidative stress; enhances its interaction with USP7 and consequently, deubiquitination; increases its translocation to the cytoplasm and inhibits its transcriptional activity. Hydrogene-peroxide-induced ubiquitination and USP7-mediated deubiquitination have no major effect on its protein stability.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FOXO4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for FOXO4
- AP00084PU-N
- AP00150PU-N
- AP02424PU-N
- AP02424PU-S
- AP02683PU-N
- AP02683PU-S
- AP07944PU-N
- AP20362PU-N
- AP20684PU-N
- AP20806PU-N
- AP21031PU-N
- AP31193PU-N
- AP31195PU-N
- CF808579
- CF808589
- CF808593
- CF808604
- CF808678
- CF810532
- CF810612
- TA302491
- TA309984
- TA312290
- TA319683
- TA319684
- TA324038
- TA324039
- TA324822
- TA325480
- TA325481
- TA325482
- TA325483
- TA808579
- TA808579S
- TA808589
- TA808589S
- TA808593
- TA808593S
- TA808604
- TA808604S
- TA808678
- TA808678S
- TA810532
- TA810532S
- TA810612
- TA810612S
- Novus Biologicals Antibodies for FOXO4
-
Abcam antibodies for FOXO4
- Invitrogen Antibodies for FOXO4 (AFLGC-FOXO4)
- antibodies-online: Show 78 available FOXO4 Antibodies ranked by validation data
- Compare Top FOXO4 Antibodies
-
Recommended
- 232 WB Antibodies (anti-human)
- 36 IF (p) Antibodies (anti-human)
- 5 IHC (p) Antibodies (anti-human)
- 3 IHC Antibodies (anti-human)
- 142 WB Antibodies (anti-mouse)
- 36 IF (p) Antibodies (anti-mouse)
- 2 IHC Antibodies (anti-mouse)
- 1 IHC (p) Antibody (anti-mouse)
- 75 WB Antibodies (anti-rat)
- 36 IF (p) Antibodies (anti-rat)
- 2 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
-
Boster Bio Antibodies for FOXO4
-
Custom Antibody ServicesProSci Antibodies for FOXO4
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXO4
Protein Products
-
OriGene Purified Proteins for FOXO4
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXO4
- Origene Custom Protein Services for FOXO4
No data available for DME Specific Peptides for FOXO4 Gene
Domains & Families for FOXO4 Gene
Gene Families for FOXO4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXO4 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXO4 Gene
- GenScript: Design optimal peptide antigens:
-
- Fork head domain transcription factor AFX1 (FOXO4_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXO4 Gene
Function for FOXO4 Gene
Molecular function for FOXO4 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 11689711 |
| GO:0003677 | DNA binding | IEA,IDA | 10783894 |
| GO:0003700 | DNA-binding transcription factor activity | IBA,IDA | 10783894 |
| GO:0005515 | protein binding | IPI | 15084259 |
Phenotypes for FOXO4 Gene
- MGI mutant phenotypes for FOXO4:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for FOXO4:
-
- no effect
- Decreased viability
- shRNA abundance <= 50%
- shRNA abundance <= 25%
- Reduced mammosphere formation
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased IL-8 secretion
- Increased viability with MLN4924 (a NAE inhibitor)
- Decreased viability in ovarian lineage
- Decreased Aire reporter expression
- Reduced beta-catenin activity and colon cancer cell proliferation
Animal Models for FOXO4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for FOXO4
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXO4 - Select products 50% OFF >
- * FOXO4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXO4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXO4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXO4
miRNA for FOXO4 Gene
- miRTarBase miRNAs that target FOXO4
Transcription Factor Targets for FOXO4 Gene
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXO4
- Browse OriGene Inhibitory RNA Products For FOXO4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO4
Clone Products
- Applied Biological Materials (abm): Clones for FOXO4 - Select products 50% OFF >
- * FOXO4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FOXO4
- Addgene plasmids for FOXO4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXO4
Cell Line Products
-
Horizon Cell Lines for FOXO4
No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology and HOMER Transcription for FOXO4 Gene
Localization for FOXO4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXO4 Gene
- Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. Dephosphorylation triggers nuclear translocation. Monoubiquitination increases nuclear localization. When deubiquitinated, translocated from nucleus to cytoplasm.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| lysosome | 2 |
| peroxisome | 1 |
| endosome | 1 |
| golgi apparatus | 1 |
- Cytosol (3)
- Nuclear speckles (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,TAS | 22972301 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA,IDA | 16964248 |
| GO:0005829 | cytosol | TAS | 22972301 |
Pathways & Interactions for FOXO4 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways | ||
| 3 | GAB1 signalosome |
.89
|
|
| 4 | Constitutive Signaling by AKT1 E17K in Cancer | ||
| 5 | Deubiquitination |
.74
|
|
Pathways by source for FOXO4 Gene
2 Sino Biological pathways for FOXO4 Gene
8 BioSystems pathways for FOXO4 Gene
28 Reactome pathways for FOXO4 Gene
3 KEGG pathways for FOXO4 Gene
7 R&D Systems pathways for FOXO4 Gene
1 Cell Signaling Technology pathway for FOXO4 Gene
Interacting Proteins for FOXO4 Gene
Selected Interacting proteins:
P98177-FOXO4_HUMAN
ENSP00000363377
for FOXO4 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FOXO4
SIGNOR curated interactions for FOXO4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IBA | 21873635 |
| GO:0006355 | regulation of transcription, DNA-templated | IDA | 15126506 |
| GO:0006366 | transcription by RNA polymerase II | TAS | 10783894 |
| GO:0007049 | cell cycle | IEA | -- |
| GO:0007050 | cell cycle arrest | IDA | 10783894 |
Drugs & Compounds for FOXO4 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| NAD | Experimental | Pharma | Agonist, Full agonist, Activator | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Transcripts for FOXO4 Gene
mRNA/cDNA for FOXO4 Gene
- 2 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000341558 1353 nts (view in UCSC)
- ENST00000374259 3644 nts (view in UCSC)
- ENST00000464598 306 nts (view in UCSC)
- ENST00000466874 657 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXO4 - Select products 50% OFF >
- * FOXO4 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXO4
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXO4
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXO4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXO4
- Browse OriGene Inhibitory RNA Products For FOXO4
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO4
Clone Products
- Applied Biological Materials (abm): Clones for FOXO4 - Select products 50% OFF >
- * FOXO4 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FOXO4
- Addgene plasmids for FOXO4
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXO4
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||
| SP2: | - | ||||||||||||
| SP3: |
Relevant External Links for FOXO4 Gene
- GeneLoc Exon Structure for
- FOXO4
Expression for FOXO4 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Inner Cell Mass (Early Embryonic Tissues)
-
Blood (Hematopoietic System)
- Erythroblasts Hematopoietic Bone Marrow
-
Placenta (Extraembryonic Tissues)
This gene is overexpressed in Fetal ovary (51.3), Placenta (8.9), and Fetal testis (8.8).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXO4 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXO4
SOURCE GeneReport for Unigene cluster for FOXO4 Gene:
Hs.584654mRNA Expression by UniProt/SwissProt for FOXO4 Gene:
P98177-FOXO4_HUMAN
Tissue specificity:
Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Isoform zeta is most abundant in the liver, kidney, and pancreas.
Evidence on tissue expression from TISSUES for FOXO4 Gene
- Blood(4.5)
- Bone marrow(4.5)
- Muscle(3.1)
- Nervous system(2.9)
- Heart(2.8)
- Liver(2.7)
- Intestine(2.6)
- Kidney(2.6)
- Skin(2.6)
- Spleen(2.4)
- Pancreas(2.3)
- Lung(2.3)
- Lymph node(2.2)
- Adrenal gland(2.2)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXO4 Gene
Germ Layers:
- mesoderm
Systems:
- cardiovascular
Regions:
General:
- blood
- bone marrow
- white blood cell
Primer Products
-
OriGene qPCR primer pairs for FOXO4
-
OriGene qPCR primer pairs and template standards for FOXO4
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues for FOXO4 Gene
Orthologs for FOXO4 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FOXO4 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FOXO4 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FOXO4 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Foxo4 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Foxo4 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | FOXO4 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FOXO4 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FOXO4 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | LOC100492831 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | LOC563719 30 |
|
||
| FOXO4 31 |
|
OneToOne | |||
| Fruit Fly (Drosophila melanogaster) |
Insecta | foxo 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | daf-16 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HCM1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3143 31 |
|
OneToMany |
- Species where no ortholog for FOXO4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for FOXO4 Gene
- ENSEMBL:
- Gene Tree for FOXO4 (if available)
- TreeFam:
- Gene Tree for FOXO4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXO4: view image
Paralogs for FOXO4 Gene
Paralogs for FOXO4 Gene
- FOXO1 5
- FOXO3 5
- FOXO6 5
- FOXM1 5
- FOXJ3 5
- FOXO3B 5
- FOXK1 5
- FOXK2 5
- FOXC2 5
- FOXC1 5
- FOXD3 5
- FOXJ2 5
- FOXD1 5
- FOXL1 5
- FOXI2 5
- FOXD2 5
- FOXA2 5
- FOXI3 5
- FOXJ1 5
- FOXQ1 5
- FOXD4L6 5
- FOXL2 5
- FOXD4L5 5
- FOXH1 5
- FOXE3 5
- FOXD4L4 5
- FOXE1 5
- FOXD4L3 5
- FOXS1 5
- FOXA1 5
- FOXF1 5
- FOXN1 5
- FOXB1 5
- FOXD4L1 5
- FOXA3 5
- FOXD4 5
- FOXP1 5
- ENSG00000285708 5
- FOXB2 5
- FOXP3 5
- FOXL3 5
- FOXR2 5
- FOXR1 5
(4) SIMAP similar genes for FOXO4 Gene using alignment to 1 proteins:
- FOXO4_HUMAN
Variants for FOXO4 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXO4 Gene
| SNP ID | Clinical significance and condition | Chr 0X pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 788055 | Benign: not provided | 71,100,917(+) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv1584074 | OTHER | inversion | 17803354 |
| esv33082 | CNV | loss | 17666407 |
Residual Variation Intolerance Score:
43% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.53;
11.45% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXO4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FOXO4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXO4 Gene
Disorders for FOXO4 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| skin sarcoma |
|
|
| sarcomatoid squamous cell skin carcinoma |
|
|
| balloon cell malignant melanoma |
|
|
| connective tissue benign neoplasm |
|
|
| cutaneous leiomyosarcoma |
|
|
Search FOXO4 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FOXO4_HUMAN- Note=A chromosomal aberration involving FOXO4 is found in acute leukemias. Translocation t(X;11)(q13;q23) with KMT2A/MLL1. The result is a rogue activator protein.
Additional Disease Information for FOXO4
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for FOXO4 Gene
Publications for FOXO4 Gene
- Constitutively active FOXO4 inhibits Akt activity, regulates p27 Kip1 stability, and suppresses HER2-mediated tumorigenicity. (PMID: 15688030) Yang H … Lee MH (Oncogene 2005) 3 4 23
- Regulation of intracellular localization and transcriptional activity of FOXO4 by protein kinase B through phosphorylation at the motif sites conserved among the FOXO family. (PMID: 16272144) Matsuzaki H … Kikkawa U (Journal of biochemistry 2005) 3 4 23
- Phenotypic modulation of smooth muscle cells through interaction of Foxo4 and myocardin. (PMID: 16054032) Liu ZP … Olson EN (Developmental cell 2005) 3 4 23
- Solution structure of the DNA binding domain of the human forkhead transcription factor AFX (FOXO4). (PMID: 11352721) Weigelt J … Wikström M (Biochemistry 2001) 3 4 23
- Regulation of nuclear translocation of forkhead transcription factor AFX by protein kinase B. (PMID: 10518537) Takaishi H … Nishizuka Y (Proceedings of the National Academy of Sciences of the United States of America 1999) 3 4 23
ExternalLinks
Products for FOXO4 Gene
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Sources for FOXO4 Gene
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