FOXO3B Gene (Protein Coding)

Forkhead Box O3B

GC17M020244
GIFtS:
17
See more...

Aliases for FOXO3B Gene

Aliases for FOXO3B Gene

  • Forkhead Box O3B 2 3 5
  • Forkhead Box Protein O3B 3 4
  • Forkhead (Drosophila) Homolog (Rhabdomyosarcoma) Like 1 Pseudogene 1 2
  • Forkhead(Drosophila) Homolog (Rhabdomyosarcoma) 1 Like Pseudogene 1 3
  • Forkhead Box O3B (Pseudogene) 3
  • Forkhead Box O3B Pseudogene 2
  • FKHRL1P1 3
  • ZNF286C 3
  • FOXO3B 5

External Ids for FOXO3B Gene

Previous HGNC Symbols for FOXO3B Gene

  • FKHRL1P1

Previous GeneCards Identifiers for FOXO3B Gene

  • GC17U990029
  • GC17M018518
  • GC17M018776
  • GC17M018517
  • GC17M018565
  • GC17M018590
  • GC17M018665
  • GC17M019880

Summaries for FOXO3B Gene

GeneCards Summary for FOXO3B Gene

FOXO3B (Forkhead Box O3B) is a Protein Coding gene. An important paralog of this gene is FOXO3.

UniProtKB/Swiss-Prot Summary for FOXO3B Gene

Additional gene information for FOXO3B Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXO3B Gene

Genomics for FOXO3B Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FOXO3B Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXO3B on the GeneHancer Hub at the UCSC Golden Path

Top Transcription factor binding sites by QIAGEN in the FOXO3B gene promoter:
  • AP-1
  • GR
  • GR-alpha
  • HNF-4alpha1
  • NRF-2
  • p53
  • POU2F1
  • POU2F1a
  • Roaz
  • SEF-1 (1)

Genomic Locations for FOXO3B Gene

Latest Assembly
chr17:18,667,629-18,682,314
(GRCh38/hg38)
Size:
14,686 bases
Orientation:
Minus strand

Previous Assembly
chr17:18,570,942-18,585,627
(GRCh37/hg19 by Entrez Gene)
Size:
14,686 bases
Orientation:
Minus strand

chr17:18,574,259-18,576,186
(GRCh37/hg19 by Ensembl)
Size:
1,928 bases
Orientation:
Minus strand

Genomic View for FOXO3B Gene

Genes around FOXO3B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXO3B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXO3B Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FOXO3B Gene

Proteins for FOXO3B Gene

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  • Protein details for FOXO3B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0A2Z4LIS9-FXO3B_HUMAN
    Recommended name:
    Forkhead box protein O3B
    Protein Accession:
    A0A2Z4LIS9

    Protein attributes for FOXO3B Gene

    Size:
    290 amino acids
    Molecular mass:
    29900 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXO3B Gene

Post-translational modifications for FOXO3B Gene

No Post-translational modifications

Other Protein References for FOXO3B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXO3B Gene

Domains & Families for FOXO3B Gene

Protein Domains for FOXO3B Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with FOXO3B: view

No data available for Gene Families , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXO3B Gene

Function for FOXO3B Gene

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  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Molecular function for FOXO3B Gene

UniProtKB/Swiss-Prot Function:
Transcription factor.
GENATLAS Biochemistry:
Drosophila forkhead gene homolog 1,like-sequence pseudogene 1

Phenotypes From GWAS Catalog for FOXO3B Gene

Gene Ontology (GO) - Molecular Function for FOXO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXO3B: view
genes like me logo Genes that share phenotypes with FOXO3B: view

Transcription Factor Targets for FOXO3B Gene

Selected GeneGlobe predicted Target genes for FOXO3B

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA and HOMER Transcription for FOXO3B Gene

Localization for FOXO3B Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO3B Gene

Cytoplasm, cytosol. Note=Does not translocate to the nucleus upon phosphorylation. {ECO:0000269 PubMed:29925039}.

Gene Ontology (GO) - Cellular Components for FOXO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol IEA --
genes like me logo Genes that share ontologies with FOXO3B: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for FOXO3B Gene

Pathways & Interactions for FOXO3B Gene

PathCards logo

SuperPathways for FOXO3B Gene

No Data Available

Interacting Proteins for FOXO3B Gene

Gene Ontology (GO) - Biological Process for FOXO3B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FOXO3B: view

No data available for Pathways by source and SIGNOR curated interactions for FOXO3B Gene

Drugs & Compounds for FOXO3B Gene

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No Compound Related Data Available

Transcripts for FOXO3B Gene

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mRNA/cDNA for FOXO3B Gene

2 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO3B Gene

No ASD Table

Relevant External Links for FOXO3B Gene

GeneLoc Exon Structure for
FOXO3B

Expression for FOXO3B Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXO3B Gene

mRNA expression in normal human tissues for FOXO3B Gene
mRNA expression by GTEx for FOXO3B GenemRNA expression by BioGPS for FOXO3B Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXO3B

SOURCE GeneReport for Unigene cluster for FOXO3B Gene:

Hs.592126
genes like me logo Genes that share expression patterns with FOXO3B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXO3B Gene

Orthologs for FOXO3B Gene

Evolution for FOXO3B Gene

ENSEMBL:
Gene Tree for FOXO3B (if available)
TreeFam:
Gene Tree for FOXO3B (if available)

No data available for Orthologs for FOXO3B Gene

Paralogs for FOXO3B Gene

Variants for FOXO3B Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FOXO3B Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FOXO3B Gene

Variant ID Type Subtype PubMed ID
esv3572454 CNV gain 25503493
nsv1057803 CNV loss 25217958
nsv1060744 CNV gain 25217958
nsv499818 OTHER inversion 21111241
nsv523721 CNV gain 19592680
nsv827913 CNV gain 20364138
nsv833389 CNV gain 17160897
nsv9504 CNV gain+loss 18304495

Additional Variant Information for FOXO3B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXO3B

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP and Variation tolerance for FOXO3B Gene

Disorders for FOXO3B Gene

Additional Disease Information for FOXO3B

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FOXO3B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXO3B Gene

Publications for FOXO3B Gene

  1. A splice junction-targeted CRISPR approach (spJCRISPR) reveals human FOXO3B to be a protein-coding gene. (PMID: 29925039) Santo EE … Paik J (Gene 2018) 2 3 4
  2. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. (PMID: 9479491) Anderson MJ … Arden KC (Genomics 1998) 2 3
  3. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  4. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3
  5. Genetic investigation of FOXO3A requires special attention due to sequence homology with FOXO3B. (PMID: 22588664) Flachsbart F … Nebel A (European journal of human genetics : EJHG 2013) 3

ExternalLinks

View latest publications for FOXO3B gene in Mastermind

Products for FOXO3B Gene

Sources for FOXO3B Gene