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This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same p... See more...
Aliases for FOXO3 Gene
Aliases for FOXO3 Gene
External Ids for FOXO3 Gene
- HGNC: 3821
- Entrez Gene: 2309
- Ensembl: ENSG00000118689
- OMIM: 602681
- UniProtKB: O43524
Previous HGNC Symbols for FOXO3 Gene
- FKHRL1
- FOXO3A
Previous GeneCards Identifiers for FOXO3 Gene
- GC06P108988
- GC06P108881
- GC06P106448
Summaries for FOXO3 Gene
-
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXO3 Gene
FOXO3 (Forkhead Box O3) is a Protein Coding gene. Diseases associated with FOXO3 include Chromosome 6Q Deletion and Rhabdomyosarcoma. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and RET signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein kinase binding. An important paralog of this gene is FOXO1.
UniProtKB/Swiss-Prot Summary for FOXO3 Gene
-
Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity).
Additional gene information for FOXO3 Gene
- HGNC(3821)
- Entrez Gene(2309)
- Ensembl(ENSG00000118689)
- OMIM(602681)
- UniProtKB(O43524)
- Open Targets Platform(ENSG00000118689)
- Monarch Initiative
- Search for FOXO3 at DataMed
- Search for FOXO3 at HumanCyc
No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXO3 Gene
Genomics for FOXO3 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FOXO3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXO3 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXO3
- Top Transcription factor binding sites by QIAGEN in the FOXO3 gene promoter:
-
- AP-1
- STAT5A
Genomic Locations for FOXO3 Gene
Genomic Locations for FOXO3 Gene
- chr6:108,559,825-108,684,774
- (GRCh38/hg38)
- Size:
- 124,950 bases
- Orientation:
- Plus strand
- chr6:108,881,026-109,005,977
- (GRCh37/hg19)
- Size:
- 124,952 bases
- Orientation:
- Plus strand
Genomic View for FOXO3 Gene
Genes around FOXO3 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 6q21 by HGNC
- 6q21 by Entrez Gene
- 6q21 by Ensembl
FOXO3 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXO3 Gene
Proteins for FOXO3 Gene
-
Protein details for FOXO3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O43524-FOXO3_HUMAN
- Recommended name:
- Forkhead box protein O3
- Protein Accession:
- O43524
- B4DVZ6
- E1P5E6
- O15171
- Q5T2I7
- Q9BZ04
Protein attributes for FOXO3 Gene
- Size:
- 673 amino acids
- Molecular mass:
- 71277 Da
- Quaternary structure:
-
- Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3-dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (PubMed:29445193). Interacts with SIRT2; the interaction occurs independently of SIRT2 deacetylase activity (By similarity). Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration (PubMed:16751106). Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation (PubMed:16751106). Interacts with PIM1 (PubMed:18593906). Interacts with DDIT3/CHOP (PubMed:22761832). Interacts (deacetylated form) with SKP2 (PubMed:21841822). Interacts with CHUK and IKBKB (PubMed:15084260, PubMed:22313691). Interacts with CAMK2A, CAMK2B and calcineurin A (By similarity). Interacts FOXO3; this interaction represses FOXO3 transactivation (PubMed:20181828).
Three dimensional structures from OCA and Proteopedia for FOXO3 Gene
Protein Expression for FOXO3 Gene
Post-translational modifications for FOXO3 Gene
- In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB (PubMed:10102273). This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm (PubMed:10102273). Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis (PubMed:10102273). Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue (PubMed:10102273, PubMed:11154281). Phosphorylated by STK4/MST1 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation (PubMed:16751106). Phosphorylated by PIM1 (PubMed:18593906). Phosphorylation by AMPK leads to the activation of transcriptional activity without affecting subcellular localization (PubMed:17711846). In response to metabolic stress, phosphorylated by AMPK on Ser-30 which mediates FOXO3 mitochondrial translocation (PubMed:29445193). Phosphorylation by MAPKAPK5 promotes nuclear localization and DNA-binding, leading to induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). Phosphorylated by CHUK/IKKA and IKBKB/IKKB (PubMed:15084260). TNF-induced inactivation of FOXO3 requires its phosphorylation at Ser-644 by IKBKB/IKKB which promotes FOXO3 retention in the cytoplasm, polyubiquitination and ubiquitin-mediated proteasomal degradation (PubMed:15084260). May be dephosphorylated by calcineurin A on Ser-299 which abolishes FOXO3 transcriptional activity (By similarity). In cancer cells, ERK mediated-phosphorylation of Ser-12 is required for mitochondrial translocation of FOXO3 in response to metabolic stress or chemotherapeutic agents (PubMed:29445193).
- Deacetylation by SIRT1 or SIRT2 stimulates interaction of FOXO3 with SKP2 and facilitates SCF(SKP2)-mediated FOXO3 ubiquitination and proteasomal degradation (PubMed:21841822). Deacetylation by SIRT2 stimulates FOXO3-mediated transcriptional activity in response to oxidative stress (By similarity). Deacetylated by SIRT3 (PubMed:23283301). Deacetylation by SIRT3 stimulates FOXO3-mediated mtDNA transcriptional activity in response to metabolic stress (PubMed:23283301).
- Heavily methylated by SET9 which decreases stability, while moderately increasing transcriptional activity. The main methylation site is Lys-271. Methylation doesn't affect subcellular location.
- Polyubiquitinated. Ubiquitinated by a SCF complex containing SKP2, leading to proteasomal degradation.
- The N-terminus is cleaved following import into the mitochondrion.
-
Glycosylation at Asn431
- NX_O43524 (NX_O43524-1)
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- FOXO3_HUMAN (1253)
Other Protein References for FOXO3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents FOXO3A Antibody (Rabbit Monoclonal)
- BioLegend FOXO3 Antibody
-
Custom Antibody ServicesOriGene Antibodies for FOXO3
- AM31785PU-N
- AM31786PU-N
- AM31787PU-N
- AM31788PU-N
- AM31789PU-N
- AP00319PU-N
- AP08296PU-N
- AP20683PU-N
- AP20805PU-N
- AP20889PU-N
- AP23030PU-N
- AP31192PU-N
- CF809449
- CF809456
- CF809457
- TA302661
- TA307540
- TA309991
- TA319652
- TA321349
- TA321350
- TA324516
- TA325478
- TA325479
- TA809449
- TA809449S
- TA809456
- TA809456S
- TA809457
- TA809457S
- Novus Biologicals Antibodies for FOXO3
-
Abcam antibodies for FOXO3
- Invitrogen Antibodies for FOXO3 (AFLGC-FOXO3)
- antibodies-online: Show 83 available FOXO3 Antibodies ranked by validation data
- Compare Top FOXO3 Antibodies
-
Recommended
- 279 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 110 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 135 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
-
Boster Bio Antibodies for FOXO3
-
Custom Antibody ServicesProSci Antibodies for FOXO3
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXO3
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXO3
- Origene Custom Protein Services for FOXO3
-
Abcam proteins for FOXO3
Assay Products
No data available for DME Specific Peptides for FOXO3 Gene
Domains & Families for FOXO3 Gene
Gene Families for FOXO3 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXO3 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXO3 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ53219, highly similar to Forkhead box protein O3A (B4DVZ6_HUMAN)
- Forkhead in rhabdomyosarcoma-like 1 (FOXO3_HUMAN)
- Fork head-like protein (Q9UPC2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXO3 Gene
Function for FOXO3 Gene
Molecular function for FOXO3 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity).
Phenotypes From GWAS Catalog for FOXO3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | ISS | -- |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001221 | transcription cofactor binding | IEA | -- |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 20371612 |
Phenotypes for FOXO3 Gene
- MGI mutant phenotypes for FOXO3:
-
inferred from 7 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- renal/urinary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- hearing/vestibular/ear phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- GenomeRNAi human phenotypes for FOXO3:
Animal Models for FOXO3 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXO3 - Select products 50% OFF >
- * FOXO3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXO3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXO3
miRNA for FOXO3 Gene
- miRTarBase miRNAs that target FOXO3
-
- hsa-miR-222-3p (MIRT000433)
- hsa-miR-221-3p (MIRT000434)
- hsa-miR-182-5p (MIRT000671)
- hsa-miR-197-3p (MIRT004198)
- hsa-miR-155-5p (MIRT004495)
- hsa-miR-96-5p (MIRT005450)
- mmu-miR-182-5p (MIRT006025)
- hsa-miR-23a-3p (MIRT006284)
- hsa-miR-9-5p (MIRT007326)
- mmu-miR-301b-3p (MIRT007830)
- mmu-miR-223-3p (MIRT009681)
- mmu-miR-19b-3p (MIRT012446)
- mmu-miR-297a-5p (MIRT012992)
- hsa-miR-335-5p (MIRT017201)
- hsa-miR-744-5p (MIRT037525)
- hsa-miR-615-3p (MIRT039975)
- hsa-miR-26a-5p (MIRT050180)
- hsa-let-7c-5p (MIRT051735)
- hsa-miR-126-3p (MIRT053249)
- rno-miR-132-3p (MIRT053322)
- rno-miR-212-3p (MIRT053323)
- mmu-miR-212-3p (MIRT054175)
- mmu-miR-132-3p (MIRT054176)
- hsa-miR-29a-3p (MIRT054878)
- hsa-miR-21-5p (MIRT217307)
- hsa-miR-590-5p (MIRT217309)
- hsa-miR-548c-3p (MIRT217310)
- hsa-miR-126-5p (MIRT217321)
- hsa-miR-340-5p (MIRT217322)
- hsa-miR-621 (MIRT217323)
- hsa-miR-4714-3p (MIRT315203)
- hsa-miR-4795-5p (MIRT315219)
- hsa-miR-217 (MIRT315221)
- hsa-miR-548av-3p (MIRT315226)
- hsa-miR-671-5p (MIRT409788)
- hsa-miR-3622a-3p (MIRT409789)
- hsa-miR-3622b-3p (MIRT409790)
- hsa-miR-4786-3p (MIRT409792)
- hsa-miR-6079 (MIRT409793)
- hsa-miR-223-3p (MIRT438227)
- hsa-miR-218-5p (MIRT440613)
- hsa-miR-4795-3p (MIRT544595)
- hsa-miR-6069 (MIRT544596)
- hsa-miR-665 (MIRT544597)
- hsa-miR-5590-3p (MIRT544598)
- hsa-miR-142-5p (MIRT544599)
- hsa-miR-1179 (MIRT544600)
- hsa-miR-6828-5p (MIRT562327)
- hsa-miR-1228-3p (MIRT562328)
- hsa-miR-6882-5p (MIRT562329)
- hsa-miR-4328 (MIRT563750)
- hsa-miR-4275 (MIRT563751)
- hsa-miR-100-3p (MIRT563752)
- hsa-miR-3927-5p (MIRT658089)
- hsa-miR-6832-3p (MIRT658090)
- hsa-miR-498 (MIRT668263)
- hsa-miR-4279 (MIRT668264)
- hsa-miR-525-5p (MIRT668265)
- hsa-miR-520a-5p (MIRT668266)
- hsa-miR-1976 (MIRT668267)
- hsa-miR-3653-5p (MIRT668268)
- hsa-miR-6747-3p (MIRT668269)
- hsa-miR-6727-3p (MIRT668270)
- hsa-miR-4722-3p (MIRT668271)
- hsa-miR-5089-5p (MIRT677034)
- hsa-miR-23b-5p (MIRT677035)
- hsa-miR-23a-5p (MIRT677036)
- hsa-miR-6506-5p (MIRT677037)
- hsa-miR-619-5p (MIRT677038)
- rno-miR-27a-3p (MIRT731854)
- mmu-miR-9-5p (MIRT732772)
- hsa-miR-592 (MIRT733196)
- hsa-miR-31-5p (MIRT734600)
- hsa-miR-93-5p (MIRT735009)
- mmu-miR-34a-3p (MIRT735150)
- hsa-miR-30c-5p (MIRT735311)
Transcription Factor Targets for FOXO3 Gene
Targeted motifs for FOXO3 Gene
HOMER Transcription Factor Regulatory Elements motif FOXO3
- Consensus sequence: DGTAAACA Submotif: canonical Cell Type: U2OS
miRNA Products
Inhibitory RNA Products
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- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO3
Clone Products
- Applied Biological Materials (abm): Clones for FOXO3 - Select products 50% OFF >
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-
- MG226631
- MR226631
- MR226631L3
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- RC202894L1
- RC202894L2
- RC202894L3
- RC202894L4
- RC209846
- RC209846L1
- RC209846L2
- RC209846L3
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- RG202894
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- RR210446
- RR210446L3
- RR210446L4
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- RC209846L3V
- RC209846L4V
- RR210446L3V
- RR210446L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FOXO3
- Addgene plasmids for FOXO3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXO3
No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for FOXO3 Gene
Localization for FOXO3 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXO3 Gene
- Cytoplasm, cytosol. Nucleus. Mitochondrion matrix. Mitochondrion outer membrane. Peripheral membrane protein. Cytoplasmic side. Note=Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). {ECO:0000250 UniProtKB:Q9WVH4, ECO:0000269 PubMed:10102273, ECO:0000269 PubMed:15084260, ECO:0000269 PubMed:16751106, ECO:0000269 PubMed:23283301, ECO:0000269 PubMed:29445193}.
| Compartment | Confidence |
|---|---|
| mitochondrion | 5 |
| nucleus | 5 |
| cytosol | 5 |
| plasma membrane | 3 |
| extracellular | 3 |
| cytoskeleton | 3 |
| lysosome | 3 |
| peroxisome | 2 |
| endoplasmic reticulum | 2 |
| endosome | 2 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005623 | cell | IEA | -- |
| GO:0005634 | nucleus | IBA,IMP | 29445193 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005737 | cytoplasm | IBA,IDA | 10102273 |
Pathways & Interactions for FOXO3 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | RET signaling |
.92
|
|
| 2 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways | ||
| 3 | GAB1 signalosome |
.89
|
|
| 4 | Constitutive Signaling by AKT1 E17K in Cancer | ||
| 5 | AMP-activated Protein Kinase (AMPK) Signaling | ||
Pathways by source for FOXO3 Gene
4 Sino Biological pathways for FOXO3 Gene
24 BioSystems pathways for FOXO3 Gene
33 Reactome pathways for FOXO3 Gene
14 KEGG pathways for FOXO3 Gene
4 GeneGo (Thomson Reuters) pathways for FOXO3 Gene
- Development IGF-1 receptor signaling
- Signal transduction AKT signaling
- Signal transduction PTEN pathway
- Translation Non-genomic (rapid) action of Androgen Receptor
10 R&D Systems pathways for FOXO3 Gene
9 Qiagen pathways for FOXO3 Gene
- 14-3-3 and Regulation of BAD Activity
- 14-3-3 Induced Apoptosis
- Angiopoietin-TIE2 Signaling
- ErbB2-ErbB3 Heterodimers
- ERK5 Signaling
2 Cell Signaling Technology pathways for FOXO3 Gene
Interacting Proteins for FOXO3 Gene
Selected Interacting proteins:
O43524-FOXO3_HUMAN
ENSP00000385824
for FOXO3 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FOXO3
SIGNOR curated interactions for FOXO3 Gene
- Activates:
- Inactivates:
- Is activated by:
- Is inactivated by:
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 18787191 |
| GO:0001542 | ovulation from ovarian follicle | IEA | -- |
| GO:0001544 | initiation of primordial ovarian follicle growth | IEA | -- |
| GO:0001547 | antral ovarian follicle growth | IEA | -- |
| GO:0001556 | oocyte maturation | IEA | -- |
Transcripts for FOXO3 Gene
mRNA/cDNA for FOXO3 Gene
- 2 REFSEQ mRNAs :
- 17 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000343882 7308 nts (view in UCSC)
- ENST00000406360 7296 nts (view in UCSC)
- ENST00000540898 2553 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXO3 - Select products 50% OFF >
- * FOXO3 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXO3
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXO3
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXO3
- Browse OriGene Inhibitory RNA Products For FOXO3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO3
Clone Products
- Applied Biological Materials (abm): Clones for FOXO3 - Select products 50% OFF >
- * FOXO3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG226631
- MR226631
- MR226631L3
- MR226631L4
- RC202894
- RC202894L1
- RC202894L2
- RC202894L3
- RC202894L4
- RC209846
- RC209846L1
- RC209846L2
- RC209846L3
- RC209846L4
- RG202894
- RG209846
- RR210446
- RR210446L3
- RR210446L4
- MR226631L3V
- MR226631L4V
- RC202894L1V
- RC202894L2V
- RC202894L3V
- RC202894L4V
- RC209846L1V
- RC209846L2V
- RC209846L3V
- RC209846L4V
- RR210446L3V
- RR210446L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FOXO3
- Addgene plasmids for FOXO3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXO3
Relevant External Links for FOXO3 Gene
- GeneLoc Exon Structure for
- FOXO3
Expression for FOXO3 Gene
This gene is overexpressed in Bone marrow mesenchymal stem cell (27.6) and Cervix (21.2).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXO3 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXO3
SOURCE GeneReport for Unigene cluster for FOXO3 Gene:
Hs.220950mRNA Expression by UniProt/SwissProt for FOXO3 Gene:
O43524-FOXO3_HUMAN
Tissue specificity:
Ubiquitous.
Evidence on tissue expression from TISSUES for FOXO3 Gene
- Muscle(4.7)
- Nervous system(4.6)
- Stomach(4.5)
- Eye(4)
- Heart(3.2)
- Blood(3.1)
- Bone marrow(3.1)
- Liver(3.1)
- Pancreas(3.1)
- Kidney(3)
- Lung(3)
- Intestine(3)
- Skin(3)
- Spleen(2.8)
- Lymph node(2.8)
- Adrenal gland(2.6)
- Thyroid gland(2.6)
- Bone(2.2)
Primer Products
-
OriGene qPCR primer pairs for FOXO3
-
OriGene qPCR primer pairs and template standards for FOXO3
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXO3 Gene
Orthologs for FOXO3 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FOXO3 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FOXO3 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FOXO3 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Foxo3 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Foxo3 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | FOXO3 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FOXO3 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FOXO3 30 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | foxo3 30 |
|
||
| Str.14701 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.2074 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | foxo3b 30 31 |
|
OneToMany | |
| foxo3a 31 |
|
OneToMany | |||
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | foxo 31 |
|
OneToMany | |
| Worm (Caenorhabditis elegans) |
Secernentea | daf-16 31 |
|
OneToMany | |
| Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HCM1 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3143 31 |
|
OneToMany |
- Species where no ortholog for FOXO3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
Evolution for FOXO3 Gene
- ENSEMBL:
- Gene Tree for FOXO3 (if available)
- TreeFam:
- Gene Tree for FOXO3 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXO3: view image
Paralogs for FOXO3 Gene
Paralogs for FOXO3 Gene
- FOXO1 5
- FOXO4 5
- FOXO6 5
- FOXO3B 5
- FOXM1 5
- FOXK1 5
- FOXK2 5
- FOXJ3 5
- FOXL1 5
- FOXJ2 5
- FOXD2 5
- FOXA2 5
- FOXC2 5
- FOXC1 5
- FOXN1 5
- FOXL2 5
- FOXD3 5
- FOXD4L1 5
- FOXD1 5
- FOXI3 5
- FOXD4 5
- FOXE1 5
- FOXA1 5
- FOXF1 5
- FOXD4L6 5
- FOXI2 5
- FOXD4L5 5
- FOXB1 5
- FOXE3 5
- FOXD4L4 5
- FOXA3 5
- FOXJ1 5
- FOXD4L3 5
- FOXB2 5
- FOXP1 5
- FOXS1 5
- ENSG00000285708 5
- FOXQ1 5
- FOXH1 5
- FOXL3 5
- FOXP3 5
- FOXR1 5
- FOXR2 5
(4) SIMAP similar genes for FOXO3 Gene using alignment to 2 proteins:
- FOXO3_HUMAN
- B4DVZ6_HUMAN
Pseudogenes.org Pseudogenes for FOXO3 Gene
Variants for FOXO3 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXO3 Gene
| SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 719100 | Benign: not provided | 108,561,712(+) | C/T | SYNONYMOUS_VARIANT | |
| 719133 | Benign: not provided | 108,664,018(+) | G/A | SYNONYMOUS_VARIANT | |
| 719678 | Likely Benign: not provided | 108,664,327(+) | C/T | SYNONYMOUS_VARIANT | |
| 735237 | Likely Benign: not provided | 108,561,640(+) | C/T | SYNONYMOUS_VARIANT | |
| 769687 | Benign: not provided | 108,663,580(+) | G/A | SYNONYMOUS_VARIANT |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv10904n54 | CNV | loss | 21841781 |
| esv22566 | CNV | loss | 19812545 |
| esv2651848 | CNV | deletion | 19546169 |
| nsv1017621 | CNV | gain | 25217958 |
| nsv1133101 | OTHER | inversion | 24896259 |
| nsv5433 | CNV | insertion | 18451855 |
| nsv604476 | CNV | gain | 21841781 |
| nsv604477 | CNV | gain | 21841781 |
| nsv604482 | CNV | gain | 21841781 |
| nsv823817 | CNV | gain | 20364138 |
| nsv830767 | CNV | gain | 17160897 |
| nsv950490 | CNV | duplication | 24416366 |
| nsv950491 | CNV | duplication | 24416366 |
| nsv981171 | CNV | duplication | 23825009 |
Residual Variation Intolerance Score:
45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.51;
55.40% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXO3 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXO3 Gene
Disorders for FOXO3 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| chromosome 6q deletion |
|
|
| rhabdomyosarcoma |
|
|
| aging |
|
|
| cervix carcinoma |
|
|
| lung cancer |
|
|
Search FOXO3 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FOXO3_HUMAN- Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with KMT2A/MLL1.
Additional Disease Information for FOXO3
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for Genatlas for FOXO3 Gene
Publications for FOXO3 Gene
- Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. (PMID: 9479491) Anderson MJ … Arden KC (Genomics 1998) 2 3 4 23
- Association of FOXO3A variation with human longevity confirmed in German centenarians. (PMID: 19196970) Flachsbart F … Nebel A (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 23 41
- Polymorphisms in FOXO gene family and association analysis with BMI. (PMID: 16571842) Kim JR … Shin HD (Obesity (Silver Spring, Md.) 2006) 3 23 41
- IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. (PMID: 15084260) Hu MC … Hung MC (Cell 2004) 3 4 23
- Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). (PMID: 11154281) Brunet A … Greenberg ME (Molecular and cellular biology 2001) 3 4 23
ExternalLinks
Products for FOXO3 Gene
- Custom Antibody ServicesOriGene Antibodies for FOXO3
- AM31785PU-N
- AM31786PU-N
- AM31787PU-N
- AM31788PU-N
- AM31789PU-N
- AP00319PU-N
- AP08296PU-N
- AP20683PU-N
- AP20805PU-N
- AP20889PU-N
- AP23030PU-N
- AP31192PU-N
- CF809449
- CF809456
- CF809457
- TA302661
- TA307540
- TA309991
- TA319652
- TA321349
- TA321350
- TA324516
- TA325478
- TA325479
- TA809449
- TA809449S
- TA809456
- TA809456S
- TA809457
- TA809457S
- Browse OriGene ELISA Kits
- Custom Assay Services
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- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXO3
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- OriGene qPCR primer pairs for FOXO3
- OriGene qPCR primer pairs and template standards for FOXO3
- MG226631
- MR226631
- MR226631L3
- MR226631L4
- RC202894
- RC202894L1
- RC202894L2
- RC202894L3
- RC202894L4
- RC209846
- RC209846L1
- RC209846L2
- RC209846L3
- RC209846L4
- RG202894
- RG209846
- RR210446
- RR210446L3
- RR210446L4
- MR226631L3V
- MR226631L4V
- RC202894L1V
- RC202894L2V
- RC202894L3V
- RC202894L4V
- RC209846L1V
- RC209846L2V
- RC209846L3V
- RC209846L4V
- RR210446L3V
- RR210446L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOXO3
- Sino Biological Human cDNA Clone for FOXO3
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FOXO3
- Novus Biologicals proteins and lysates for FOXO3
- Browse Antibodies
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- Abcam antibodies for FOXO3
- Abcam proteins for FOXO3
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- Invitrogen Antibodies for FOXO3 (AFLGC-FOXO3)
- VectorBuilder Custom and pre-made DNA vectors for FOXO3 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FOXO3 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FOXO3 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FOXO3 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FOXO3
- Addgene plasmids for FOXO3
- antibodies-online: Show 83 available FOXO3 Antibodies ranked by validation data
- Compare Top FOXO3 Antibodies
- Recommended
- 279 WB Antibodies (anti-human)
- 24 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 4 IHC (p) Antibodies (anti-human)
- 1 IF Antibody (anti-human)
- 110 WB Antibodies (anti-rat)
- 24 IF (p) Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- 1 IHC (p) Antibody (anti-rat)
- 135 WB Antibodies (anti-mouse)
- 24 IF (p) Antibodies (anti-mouse)
- 6 IHC Antibodies (anti-mouse)
- 2 IHC (p) Antibodies (anti-mouse)
- antibodies-online: Show 55 available FOXO3 Elisa Kits ranked by validation data
- Compare Top FOXO3 Elisa Kits
- antibodies-online: Show 10 available FOXO3 Proteins ranked by validation data
- Compare Top FOXO3 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FOXO3
- Search Santa Cruz Biotechnology (SCBT) for FOXO3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOXO3
- Custom Antibody ServicesProSci Antibodies for FOXO3
- Search for FOXO3 Proteins at ProSci
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXO3
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXO3
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FOXO3
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO3
- Boster Bio Antibodies for FOXO3
Sources for FOXO3 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131)