FOXO3 Gene (Protein Coding)

Forkhead Box O3

GC06P108559
GIFtS:
44
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same p... See more...

Aliases for FOXO3 Gene

Aliases for FOXO3 Gene

  • Forkhead Box O3 2 3 5
  • Forkhead In Rhabdomyosarcoma-Like 1 3 4
  • Forkhead Box Protein O3 3 4
  • AF6q21 2 3
  • FKHRL1 3 4
  • FOXO3A 3 4
  • FOXO2 2 3
  • Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma-Like 1 3
  • Forkhead Homolog (Rhabdomyosarcoma) Like 1 3
  • Forkhead Box O3A 3
  • AF6q21 Protein 4
  • FKHRL1P2 3
  • FOXO3A- 3
  • FOXO3 5

External Ids for FOXO3 Gene

Previous HGNC Symbols for FOXO3 Gene

  • FKHRL1
  • FOXO3A

Previous GeneCards Identifiers for FOXO3 Gene

  • GC06P108988
  • GC06P108881
  • GC06P106448

Summaries for FOXO3 Gene

Entrez Gene Summary for FOXO3 Gene

  • This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

CIViC Summary for FOXO3 Gene

GeneCards Summary for FOXO3 Gene

FOXO3 (Forkhead Box O3) is a Protein Coding gene. Diseases associated with FOXO3 include Chromosome 6Q Deletion and Aging. Among its related pathways are RET signaling and Beta-Adrenergic Signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein kinase binding. An important paralog of this gene is FOXO1.

UniProtKB/Swiss-Prot Summary for FOXO3 Gene

  • Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity).

Gene Wiki entry for FOXO3 Gene

Additional gene information for FOXO3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXO3 Gene

Genomics for FOXO3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FOXO3 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXO3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXO3

Top Transcription factor binding sites by QIAGEN in the FOXO3 gene promoter:
  • AP-1
  • STAT5A

Genomic Locations for FOXO3 Gene

Latest Assembly
chr6:108,559,825-108,684,774
(GRCh38/hg38)
Size:
124,950 bases
Orientation:
Plus strand

Previous Assembly
chr6:108,881,028-109,005,977
(GRCh37/hg19 by Entrez Gene)
Size:
124,950 bases
Orientation:
Plus strand

chr6:108,881,038-109,005,977
(GRCh37/hg19 by Ensembl)
Size:
124,940 bases
Orientation:
Plus strand

Genomic View for FOXO3 Gene

Genes around FOXO3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXO3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXO3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FOXO3 Gene

Proteins for FOXO3 Gene

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  • Protein details for FOXO3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O43524-FOXO3_HUMAN
    Recommended name:
    Forkhead box protein O3
    Protein Accession:
    O43524
    Secondary Accessions:
    • B4DVZ6
    • E1P5E6
    • O15171
    • Q5T2I7
    • Q9BZ04

    Protein attributes for FOXO3 Gene

    Size:
    673 amino acids
    Molecular mass:
    71277 Da
    Quaternary structure:
    • Upon metabolic stress, forms a complex composed of FOXO3, SIRT3 and mitochondrial RNA polymerase POLRMT; the complex is recruited to mtDNA in a SIRT3-dependent manner (PubMed:23283301). Also forms a complex composed of FOXO3, SIRT3, TFAM and POLRMT (PubMed:29445193). Interacts with SIRT2; the interaction occurs independently of SIRT2 deacetylase activity (By similarity). Interacts with YWHAB/14-3-3-beta and YWHAZ/14-3-3-zeta, which are required for cytosolic sequestration (PubMed:16751106). Upon oxidative stress, interacts with STK4/MST1, which disrupts interaction with YWHAB/14-3-3-beta and leads to nuclear translocation (PubMed:16751106). Interacts with PIM1 (PubMed:18593906). Interacts with DDIT3/CHOP (PubMed:22761832). Interacts (deacetylated form) with SKP2 (PubMed:21841822). Interacts with CHUK and IKBKB (PubMed:15084260, PubMed:22313691). Interacts with CAMK2A, CAMK2B and calcineurin A (By similarity). Interacts FOXO3; this interaction represses FOXO3 transactivation (PubMed:20181828).

    Three dimensional structures from OCA and Proteopedia for FOXO3 Gene

    Alternative splice isoforms for FOXO3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXO3 Gene

Protein Expression for FOXO3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FOXO3 Gene

  • In the presence of survival factors such as IGF-1, phosphorylated on Thr-32 and Ser-253 by AKT1/PKB (PubMed:10102273). This phosphorylated form then interacts with 14-3-3 proteins and is retained in the cytoplasm (PubMed:10102273). Survival factor withdrawal induces dephosphorylation and promotes translocation to the nucleus where the dephosphorylated protein induces transcription of target genes and triggers apoptosis (PubMed:10102273). Although AKT1/PKB doesn't appear to phosphorylate Ser-315 directly, it may activate other kinases that trigger phosphorylation at this residue (PubMed:10102273, PubMed:11154281). Phosphorylated by STK4/MST1 on Ser-209 upon oxidative stress, which leads to dissociation from YWHAB/14-3-3-beta and nuclear translocation (PubMed:16751106). Phosphorylated by PIM1 (PubMed:18593906). Phosphorylation by AMPK leads to the activation of transcriptional activity without affecting subcellular localization (PubMed:17711846). In response to metabolic stress, phosphorylated by AMPK on Ser-30 which mediates FOXO3 mitochondrial translocation (PubMed:29445193). Phosphorylation by MAPKAPK5 promotes nuclear localization and DNA-binding, leading to induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). Phosphorylated by CHUK/IKKA and IKBKB/IKKB (PubMed:15084260). TNF-induced inactivation of FOXO3 requires its phosphorylation at Ser-644 by IKBKB/IKKB which promotes FOXO3 retention in the cytoplasm, polyubiquitination and ubiquitin-mediated proteasomal degradation (PubMed:15084260). May be dephosphorylated by calcineurin A on Ser-299 which abolishes FOXO3 transcriptional activity (By similarity). In cancer cells, ERK mediated-phosphorylation of Ser-12 is required for mitochondrial translocation of FOXO3 in response to metabolic stress or chemotherapeutic agents (PubMed:29445193).
  • Deacetylation by SIRT1 or SIRT2 stimulates interaction of FOXO3 with SKP2 and facilitates SCF(SKP2)-mediated FOXO3 ubiquitination and proteasomal degradation (PubMed:21841822). Deacetylation by SIRT2 stimulates FOXO3-mediated transcriptional activity in response to oxidative stress (By similarity). Deacetylated by SIRT3 (PubMed:23283301). Deacetylation by SIRT3 stimulates FOXO3-mediated mtDNA transcriptional activity in response to metabolic stress (PubMed:23283301).
  • Heavily methylated by SET9 which decreases stability, while moderately increasing transcriptional activity. The main methylation site is Lys-271. Methylation doesn't affect subcellular location.
  • Polyubiquitinated. Ubiquitinated by a SCF complex containing SKP2, leading to proteasomal degradation.
  • The N-terminus is cleaved following import into the mitochondrion.
  • Glycosylation at Asn431
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • FOXO3_HUMAN (1253)

Other Protein References for FOXO3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibodies for research

  • Abcam antibodies for FOXO3

No data available for DME Specific Peptides for FOXO3 Gene

Domains & Families for FOXO3 Gene

Gene Families for FOXO3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXO3 Gene

InterPro:

Suggested Antigen Peptide Sequences for FOXO3 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ53219, highly similar to Forkhead box protein O3A (B4DVZ6_HUMAN)
  • Forkhead in rhabdomyosarcoma-like 1 (FOXO3_HUMAN)
  • Fork head-like protein (Q9UPC2_HUMAN)
genes like me logo Genes that share domains with FOXO3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXO3 Gene

Function for FOXO3 Gene

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  6. Cell Lines for research

Molecular function for FOXO3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator that recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3' and regulates different processes, such as apoptosis and autophagy (PubMed:10102273, PubMed:16751106, PubMed:21329882). Acts as a positive regulator of autophagy in skeletal muscle: in starved cells, enters the nucleus following dephosphorylation and binds the promoters of autophagy genes, such as GABARAP1L, MAP1LC3B and ATG12, thereby activating their expression, resulting in proteolysis of skeletal muscle proteins (By similarity). Triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress (PubMed:10102273, PubMed:16751106). Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation (PubMed:21329882). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription (PubMed:23283301). In response to metabolic stress, translocates into the mitochondria where it promotes mtDNA transcription. Also acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity).

Phenotypes From GWAS Catalog for FOXO3 Gene

Gene Ontology (GO) - Molecular Function for FOXO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding ISS --
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding ISS --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 20371612
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific ISS --
genes like me logo Genes that share ontologies with FOXO3: view
genes like me logo Genes that share phenotypes with FOXO3: view

Animal Models for FOXO3 Gene

MGI Knock Outs for FOXO3:

Animal Models for research

miRNA for FOXO3 Gene

miRTarBase miRNAs that target FOXO3

Transcription Factor Targets for FOXO3 Gene

Selected GeneGlobe predicted Target genes for FOXO3
Targeted motifs for FOXO3 Gene
HOMER Transcription Factor Regulatory Elements motif FOXO3
  • Consensus sequence: DGTAAACA Submotif: canonical Cell Type: U2OS

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO3

No data available for Enzyme Numbers (IUBMB) and Human Phenotype Ontology for FOXO3 Gene

Localization for FOXO3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO3 Gene

Cytoplasm, cytosol. Nucleus. Mitochondrion matrix. Mitochondrion outer membrane. Peripheral membrane protein. Cytoplasmic side. Note=Retention in the cytoplasm contributes to its inactivation (PubMed:10102273, PubMed:15084260, PubMed:16751106). Translocates to the nucleus upon oxidative stress and in the absence of survival factors (PubMed:10102273, PubMed:16751106). Translocates from the cytosol to the nucleus following dephosphorylation in response to autophagy-inducing stimuli (By similarity). Translocates in a AMPK-dependent manner into the mitochondrion in response to metabolic stress (PubMed:23283301, PubMed:29445193). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). {ECO:0000250 UniProtKB:Q9WVH4, ECO:0000269 PubMed:10102273, ECO:0000269 PubMed:15084260, ECO:0000269 PubMed:16751106, ECO:0000269 PubMed:23283301, ECO:0000269 PubMed:29445193}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXO3 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 3
lysosome 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (4)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IBA,IMP 29445193
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 10102273
GO:0005739 colocalizes_with mitochondrion IEA,IDA 23283301
genes like me logo Genes that share ontologies with FOXO3: view

Pathways & Interactions for FOXO3 Gene

genes like me logo Genes that share pathways with FOXO3: view

Pathways by source for FOXO3 Gene

4 GeneGo (Thomson Reuters) pathways for FOXO3 Gene
  • Development IGF-1 receptor signaling
  • Signal transduction AKT signaling
  • Signal transduction PTEN pathway
  • Translation Non-genomic (rapid) action of Androgen Receptor
9 Qiagen pathways for FOXO3 Gene
  • 14-3-3 and Regulation of BAD Activity
  • 14-3-3 Induced Apoptosis
  • Angiopoietin-TIE2 Signaling
  • ErbB2-ErbB3 Heterodimers
  • ERK5 Signaling
2 Cell Signaling Technology pathways for FOXO3 Gene

SIGNOR curated interactions for FOXO3 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FOXO3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 18787191
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II ISS --
GO:0006390 mitochondrial transcription IMP 29445193
GO:0006417 regulation of translation IDA 21329882
genes like me logo Genes that share ontologies with FOXO3: view

Drugs & Compounds for FOXO3 Gene

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(14) Drugs for FOXO3 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(6) Additional Compounds for FOXO3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOXO3: view

Transcripts for FOXO3 Gene

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  1. CRISPR products for research
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  3. Inhibitory RNAs for research
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mRNA/cDNA for FOXO3 Gene

2 REFSEQ mRNAs :
18 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO3

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO3 Gene

No ASD Table

Relevant External Links for FOXO3 Gene

GeneLoc Exon Structure for
FOXO3

Expression for FOXO3 Gene

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  2. Gene Expression Assays for research

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXO3 Gene

mRNA expression in normal human tissues for FOXO3 Gene
mRNA expression by GTEx for FOXO3 GenemRNA expression by BioGPS for FOXO3 Gene

Protein differential expression in normal tissues from HIPED for FOXO3 Gene

This gene is overexpressed in Bone marrow mesenchymal stem cell (27.6) and Cervix (21.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXO3 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXO3

SOURCE GeneReport for Unigene cluster for FOXO3 Gene:

Hs.220950

mRNA Expression by UniProt/SwissProt for FOXO3 Gene:

O43524-FOXO3_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for FOXO3 Gene

  • Muscle(4.7)
  • Nervous system(4.5)
  • Stomach(4.5)
  • Eye(3.9)
  • Heart(3)
  • Bone marrow(2.9)
  • Pancreas(2.9)
  • Liver(2.8)
  • Blood(2.8)
  • Lung(2.8)
  • Kidney(2.8)
  • Intestine(2.7)
  • Skin(2.7)
  • Spleen(2.6)
  • Lymph node(2.6)
  • Adrenal gland(2.4)
  • Thyroid gland(2.4)
genes like me logo Genes that share expression patterns with FOXO3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXO3 Gene

Orthologs for FOXO3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXO3 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia FOXO3 29 30
  • 99.75 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia FOXO3 29 30
  • 91.17 (n)
 OneToOne
Dog
(Canis familiaris)
 Mammalia FOXO3 29 30
  • 90.81 (n)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Foxo3 29 16 30
  • 89.68 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Foxo3 29
  • 89.38 (n)
Oppossum
(Monodelphis domestica)
 Mammalia FOXO3 30
  • 83 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia FOXO3 30
  • 79 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves FOXO3 29 30
  • 79.24 (n)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia foxo3 29
  • 70.79 (n)
Str.14701 29
African clawed frog
(Xenopus laevis)
 Amphibia Xl.2074 29
Zebrafish
(Danio rerio)
 Actinopterygii foxo3b 29 30
  • 62.34 (n)
 OneToMany
foxo3a 30
  • 58 (a)
 OneToMany
-- 29
Fruit Fly
(Drosophila melanogaster)
 Insecta foxo 30
  • 32 (a)
 OneToMany
Worm
(Caenorhabditis elegans)
 Secernentea daf-16 30
  • 28 (a)
 OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HCM1 30
  • 15 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea CSA.3143 30
  • 25 (a)
 OneToMany
Species where no ortholog for FOXO3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FOXO3 Gene

ENSEMBL:
Gene Tree for FOXO3 (if available)
TreeFam:
Gene Tree for FOXO3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXO3: view image
Alliance of Genome Resources:
Additional Orthologs for FOXO3

Paralogs for FOXO3 Gene

Paralogs for FOXO3 Gene

(4) SIMAP similar genes for FOXO3 Gene using alignment to 2 proteins:

  • FOXO3_HUMAN
  • B4DVZ6_HUMAN

Pseudogenes.org Pseudogenes for FOXO3 Gene

genes like me logo Genes that share paralogs with FOXO3: view

Variants for FOXO3 Gene

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  1. SNP Genotyping and Copy Number Assays for research

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXO3 Gene

SNP ID Clinical significance and condition Chr 06 pos Variation AA Info Type
rs111556510 Benign: not provided 108,561,627(+) C/T
NM_001455.4(FOXO3):c.419C>T (p.Ala140Val) 		MISSENSE
rs145259784 Benign: not provided 108,663,854(+) G/A
NM_001455.4(FOXO3):c.1021G>A (p.Ala341Thr) 		MISSENSE
rs150320900 Benign: not provided 108,561,712(+) C/T
NM_001455.4(FOXO3):c.504C>T (p.Arg168=) 		SYNONYMOUS
rs1554209779 Other: Choroid plexus carcinoma 108,561,791(+) A/T
NM_001455.4(FOXO3):c.583A>T (p.Lys195Ter) 		NONSENSE
rs1554218944 Other: Medulloblastoma 108,663,532(+) G/A
NM_001455.4(FOXO3):c.699G>A (p.Trp233Ter) 		NONSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FOXO3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FOXO3 Gene

Variant ID Type Subtype PubMed ID
dgv10904n54 CNV loss 21841781
esv22566 CNV loss 19812545
esv2651848 CNV deletion 19546169
nsv1017621 CNV gain 25217958
nsv1133101 OTHER inversion 24896259
nsv5433 CNV insertion 18451855
nsv604476 CNV gain 21841781
nsv604477 CNV gain 21841781
nsv604482 CNV gain 21841781
nsv823817 CNV gain 20364138
nsv830767 CNV gain 17160897
nsv950490 CNV duplication 24416366
nsv950491 CNV duplication 24416366
nsv981171 CNV duplication 23825009

Variation tolerance for FOXO3 Gene

Residual Variation Intolerance Score: 45.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.51; 55.40% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXO3 Gene

Human Gene Mutation Database (HGMD)
FOXO3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXO3
Leiden Open Variation Database (LOVD)
FOXO3

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXO3 Gene

Disorders for FOXO3 Gene

MalaCards: The human disease database

(18) MalaCards diseases for FOXO3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
chromosome 6q deletion
  • 6q deletion
aging
rhabdomyosarcoma
cervix carcinoma
  • cancer of cervix
lung cancer
  • lung cancer, susceptibility to
- elite association - COSMIC cancer census association via MalaCards
Search FOXO3 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FOXO3_HUMAN
  • Note=A chromosomal aberration involving FOXO3 is found in secondary acute leukemias. Translocation t(6;11)(q21;q23) with KMT2A/MLL1.

Additional Disease Information for FOXO3

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FOXO3: view

No data available for Genatlas for FOXO3 Gene

Publications for FOXO3 Gene

  1. Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily. (PMID: 9479491) Anderson MJ ā€¦ Arden KC (Genomics 1998) 2 3 4 22
  2. Association of FOXO3A variation with human longevity confirmed in German centenarians. (PMID: 19196970) Flachsbart F ā€¦ Nebel A (Proceedings of the National Academy of Sciences of the United States of America 2009) 3 22 40
  3. Polymorphisms in FOXO gene family and association analysis with BMI. (PMID: 16571842) Kim JR ā€¦ Shin HD (Obesity (Silver Spring, Md.) 2006) 3 22 40
  4. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. (PMID: 15084260) Hu MC ā€¦ Hung MC (Cell 2004) 3 4 22
  5. Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). (PMID: 11154281) Brunet A ā€¦ Greenberg ME (Molecular and cellular biology 2001) 3 4 22

ExternalLinks

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Products for FOXO3 Gene

  • Addgene plasmids for FOXO3

Sources for FOXO3 Gene