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This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. This gene likely functions as a trigger for apoptosis through expression of genes necessary for cell death. Translocation of this gene with the MLL gene is associated with secondary acute leukemia. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]
FOXO3 (Forkhead Box O3) is a Protein Coding gene. Diseases associated with FOXO3 include Chromosome 6Q Deletion and Rhabdomyosarcoma. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and RET signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein kinase binding. An important paralog of this gene is FOXO1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000976 | transcription regulatory region sequence-specific DNA binding | ISS | -- |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001221 | transcription cofactor binding | IEA | -- |
GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IDA | 20371612 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005623 | cell | IEA | -- |
GO:0005634 | nucleus | IBA,IMP | 29445193 |
GO:0005654 | nucleoplasm | TAS | -- |
GO:0005737 | cytoplasm | IBA,IDA | 10102273 |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | RET signaling |
.92
|
|
2 | Common Cytokine Receptor Gamma-Chain Family Signaling Pathways | ||
3 | GAB1 signalosome |
.89
|
|
4 | Constitutive Signaling by AKT1 E17K in Cancer | ||
5 | AMP-activated Protein Kinase (AMPK) Signaling |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 18787191 |
GO:0001542 | ovulation from ovarian follicle | IEA | -- |
GO:0001544 | initiation of primordial ovarian follicle growth | IEA | -- |
GO:0001547 | antral ovarian follicle growth | IEA | -- |
GO:0001556 | oocyte maturation | IEA | -- |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FOXO3 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FOXO3 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FOXO3 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Foxo3 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Foxo3 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FOXO3 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FOXO3 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FOXO3 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | foxo3 30 |
|
||
Str.14701 30 |
|
||||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.2074 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | foxo3b 30 31 |
|
OneToMany | |
foxo3a 31 |
|
OneToMany | |||
-- 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | foxo 31 |
|
OneToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | daf-16 31 |
|
OneToMany | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HCM1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | CSA.3143 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
719100 | Benign: not provided | 108,561,712(+) | C/T | SYNONYMOUS_VARIANT | |
719133 | Benign: not provided | 108,664,018(+) | G/A | SYNONYMOUS_VARIANT | |
719678 | Likely Benign: not provided | 108,664,327(+) | C/T | SYNONYMOUS_VARIANT | |
735237 | Likely Benign: not provided | 108,561,640(+) | C/T | SYNONYMOUS_VARIANT | |
769687 | Benign: not provided | 108,663,580(+) | G/A | SYNONYMOUS_VARIANT |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv10904n54 | CNV | loss | 21841781 |
esv22566 | CNV | loss | 19812545 |
esv2651848 | CNV | deletion | 19546169 |
nsv1017621 | CNV | gain | 25217958 |
nsv1133101 | OTHER | inversion | 24896259 |
nsv5433 | CNV | insertion | 18451855 |
nsv604476 | CNV | gain | 21841781 |
nsv604477 | CNV | gain | 21841781 |
nsv604482 | CNV | gain | 21841781 |
nsv823817 | CNV | gain | 20364138 |
nsv830767 | CNV | gain | 17160897 |
nsv950490 | CNV | duplication | 24416366 |
nsv950491 | CNV | duplication | 24416366 |
nsv981171 | CNV | duplication | 23825009 |
Disorder | Aliases | PubMed IDs |
---|---|---|
chromosome 6q deletion |
|
|
rhabdomyosarcoma |
|
|
aging |
|
|
cervix carcinoma |
|
|
lung cancer |
|
|