This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008] See more...

Aliases for FOXO1 Gene

Aliases for FOXO1 Gene

  • Forkhead Box O1 2 3 5
  • Forkhead Box Protein O1A 3 4
  • Forkhead Box Protein O1 3 4
  • FOXO1A 3 4
  • FKH1 2 3
  • FKHR 3 4
  • Forkhead, Drosophila, Homolog Of, In Rhabdomyosarcoma 3
  • Forkhead Homolog In Rhabdomyosarcoma 2
  • Forkhead In Rhabdomyosarcoma 4
  • FOXO1 5

External Ids for FOXO1 Gene

Previous HGNC Symbols for FOXO1 Gene

  • FKHR
  • FOXO1A

Previous GeneCards Identifiers for FOXO1 Gene

  • GC13M040028
  • GC13M041129
  • GC13M021931

Summaries for FOXO1 Gene

Entrez Gene Summary for FOXO1 Gene

  • This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in myogenic growth and differentiation. Translocation of this gene with PAX3 has been associated with alveolar rhabdomyosarcoma. [provided by RefSeq, Jul 2008]

CIViC Summary for FOXO1 Gene

GeneCards Summary for FOXO1 Gene

FOXO1 (Forkhead Box O1) is a Protein Coding gene. Diseases associated with FOXO1 include Rhabdomyosarcoma 2 and Glioma. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Transcriptional misregulation in cancer. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and chromatin binding. An important paralog of this gene is FOXO3.

UniProtKB/Swiss-Prot Summary for FOXO1 Gene

  • Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). lso acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity).

Gene Wiki entry for FOXO1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXO1 Gene

Genomics for FOXO1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FOXO1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J040661 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 600.7 +1.5 1537 7.1 SP1 HNRNPL GATAD2A CTCF PRDM10 POLR2A ZNF692 BACH1 FOS LARP7 FOXO1 piR-43842 NAA16 LINC00548 TPTE2P5 CYCSP34 SLC25A15 lnc-SLC25A15-6
GH13J040770 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 11.2 -104.9 -104938 3.6 SP1 CREB1 GATAD2A ATF7 TEAD4 PRDM10 ZNF629 TFE3 RFX1 SIX5 MRPS31 LINC00548 KBTBD6 ELF1 NAA16 FOXO1 SUGT1P3 WBP4 SLC25A15 lnc-MRPS31-1
GH13J040401 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 10.8 +263.9 263897 2.7 JUND PRDM1 IKZF2 SP1 HDAC1 CEBPA SOX13 CEBPB RUNX3 GATAD2B LINC00598 FOXO1 RN7SKP2 lnc-FOXO1-3 RF00017-1396 LINC00548 COG6
GH13J040561 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 11.3 +102.6 102567 4.5 GATAD2A ATF7 PRDM10 ZNF629 TFE3 SOX13 NFKBIZ RCOR2 PRDM1 RELA FOXO1 ENSG00000288542 WBP4 RF00994-270 piR-57460-145 COG6
GH13J040584 Promoter/Enhancer 1.3 Ensembl ENCODE dbSUPER 11.9 +78.4 78430 6.9 BACH1 RELA TCF12 IKZF2 RCOR1 TRIM22 ZNF600 PKNOX1 EED ARID3A TPTE2P5 FOXO1 COG6 SLC25A15 WBP4 RF00994-270 ENSG00000288542
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXO1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXO1

Top Transcription factor binding sites by QIAGEN in the FOXO1 gene promoter:
  • AP-1
  • COUP
  • COUP-TF
  • COUP-TF1
  • HNF-4alpha1

Genomic Locations for FOXO1 Gene

Genomic Locations for FOXO1 Gene
chr13:40,555,667-40,666,641
(GRCh38/hg38)
Size:
110,975 bases
Orientation:
Minus strand
chr13:41,129,801-41,240,734
(GRCh37/hg19)
Size:
110,934 bases
Orientation:
Minus strand

Genomic View for FOXO1 Gene

Genes around FOXO1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXO1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXO1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXO1 Gene

Proteins for FOXO1 Gene

  • Protein details for FOXO1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12778-FOXO1_HUMAN
    Recommended name:
    Forkhead box protein O1
    Protein Accession:
    Q12778
    Secondary Accessions:
    • O43523
    • Q5VYC7
    • Q6NSK6

    Protein attributes for FOXO1 Gene

    Size:
    655 amino acids
    Molecular mass:
    69662 Da
    Quaternary structure:
    • Interacts with LRPPRC. Interacts with RUNX2; the interaction inhibits RUNX2 transcriptional activity and mediates the IGF1/insulin-dependent BGLAP expression in osteoblasts Interacts with PPP2R1A; the interaction regulates the dephosphorylation of FOXO1 at Thr-24 and Ser-256 leading to its nuclear import. Interacts (acetylated form) with PPARG. Interacts with XBP1 isoform 2; this interaction is direct and leads to FOXO1 ubiquitination and degradation via the proteasome pathway (By similarity). Interacts with NLK. Interacts with SIRT1; the interaction results in the deacetylation of FOXO1 leading to activation of FOXO1-mediated transcription of genes involved in DNA repair and stress resistance. Binds to CDK1. Interacts with the 14-3-3 proteins, YWHAG and YWHAZ; the interactions require insulin-stimulated phosphorylation on Thr-24, promote nuclear exit and loss of transcriptional activity. Interacts with SKP2; the interaction ubiquitinates FOXO1 leading to its proteosomal degradation. The interaction requires the presence of KRIT1. Interacts (via the C-terminal half) with ATF4 (via its DNA-binding domain); the interaction occurs in osteoblasts, regulates glucose homeostasis via suppression of beta-cell proliferation and subsequent decrease in insulin production. Interacts with PRMT1; the interaction methylates FOXO1, prevents PKB/AKT1 phosphorylation and retains FOXO1 in the nucleus. Interacts with EP300 and CREBBP; the interactions acetylate FOXO1. Interacts with SIRT2; the interaction is disrupted in response to oxidative stress or serum deprivation, leading to increased level of acetylated FOXO1, which promotes stress-induced autophagy by stimulating E1-like activating enzyme ATG7. Interacts (acetylated form) with ATG7; the interaction is increased in response to oxidative stress or serum deprivation and promotes the autophagic process leading to cell death. Interacts (via the Fork-head domain) with CEBPA; the interaction increases when FOXO1 is deacetylated. Interacts with WDFY2. Forms a complex with WDFY2 and AKT1 (By similarity). Interacts with CRY1 (By similarity).

    Three dimensional structures from OCA and Proteopedia for FOXO1 Gene

neXtProt entry for FOXO1 Gene

Post-translational modifications for FOXO1 Gene

  • Phosphorylation by NLK promotes nuclear export and inhibits the transcriptional activity. In response to growth factors, phosphorylation on Thr-24, Ser-256 and Ser-322 by PKB/AKT1 promotes nuclear export and inactivation of transactivational activity. Phosphorylation on Thr-24 is required for binding 14-3-3 proteins. Phosphorylation of Ser-256 decreases DNA-binding activity and promotes the phosphorylation of Thr-24 and Ser-319, permitting phosphorylation of Ser-322 and Ser-325, probably by CDK1, leading to nuclear exclusion and loss of function. Stress signals, such as response to oxygen or nitric oxide, attenuate the PKB/AKT1-mediated phosphorylation leading to nuclear retention. Phosphorylation of Ser-329 is independent of IGF1 and leads to reduced function. Dephosphorylated on Thr-24 and Ser-256 by PP2A in beta-cells under oxidative stress leading to nuclear retention (By similarity). Phosphorylation of Ser-249 by CDK1 disrupts binding of 14-3-3 proteins leading to nuclear accumulation and has no effect on DNA-binding nor transcriptional activity. Phosphorylation by STK4/MST1 on Ser-212, upon oxidative stress, inhibits binding to 14-3-3 proteins and nuclear export.
  • Acetylated. Acetylation at Lys-262, Lys-265 and Lys-274 are necessary for autophagic cell death induction. Deacetylated by SIRT2 in response to oxidative stress or serum deprivation, thereby negatively regulating FOXO1-mediated autophagic cell death.
  • Ubiquitinated by SKP2. Ubiquitination leads to proteasomal degradation.
  • Methylation inhibits AKT1-mediated phosphorylation at Ser-256 and is increased by oxidative stress.
  • Once in the nucleus, acetylated by CREBBP/EP300. Acetylation diminishes the interaction with target DNA and attenuates the transcriptional activity. It increases the phosphorylation at Ser-256. Deacetylation by SIRT1 results in reactivation of the transcriptional activity. Oxidative stress by hydrogen peroxide treatment appears to promote deacetylation and uncoupling of insulin-induced phosphorylation. By contrast, resveratrol acts independently of acetylation.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXO1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for FOXO1

No data available for DME Specific Peptides for FOXO1 Gene

Domains & Families for FOXO1 Gene

Gene Families for FOXO1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXO1 Gene

Suggested Antigen Peptide Sequences for FOXO1 Gene

GenScript: Design optimal peptide antigens:
  • Forkhead in rhabdomyosarcoma (FOXO1_HUMAN)
genes like me logo Genes that share domains with FOXO1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXO1 Gene

Function for FOXO1 Gene

Molecular function for FOXO1 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress (PubMed:10358076, PubMed:12228231, PubMed:15220471, PubMed:15890677, PubMed:18356527, PubMed:19221179, PubMed:20543840, PubMed:21245099). Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3' (PubMed:10358076). Activity suppressed by insulin (PubMed:10358076). Main regulator of redox balance and osteoblast numbers and controls bone mass (By similarity). Orchestrates the endocrine function of the skeleton in regulating glucose metabolism (By similarity). lso acts as a key regulator of chondrogenic commitment of skeletal progenitor cells in response to lipid availability: when lipids levels are low, translocates to the nucleus and promotes expression of SOX9, which induces chondrogenic commitment and suppresses fatty acid oxidation (By similarity). Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity (By similarity). Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP (By similarity). In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1 (By similarity). Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and STK4/MST1 (PubMed:18356527, PubMed:19221179). Promotes neural cell death (PubMed:18356527). Mediates insulin action on adipose tissue (By similarity). Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake (By similarity). Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells (By similarity). Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner (PubMed:20543840). Mediates the function of MLIP in cardiomyocytes hypertrophy and cardiac remodeling (By similarity).
UniProtKB/Swiss-Prot Induction:
Expression is regulated by KRIT1. Levels of expression also regulated by FOXC1 which binds to a conserved element in the FOXO1 promoter.

Phenotypes From GWAS Catalog for FOXO1 Gene

Gene Ontology (GO) - Molecular Function for FOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001223 transcription coactivator binding IEA --
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IEA --
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific ISS --
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with FOXO1: view
genes like me logo Genes that share phenotypes with FOXO1: view

Human Phenotype Ontology for FOXO1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FOXO1 Gene

MGI Knock Outs for FOXO1:

Animal Model Products

CRISPR Products

miRNA for FOXO1 Gene

miRTarBase miRNAs that target FOXO1

Transcription Factor Targets for FOXO1 Gene

Selected GeneGlobe predicted Target genes for FOXO1
Targeted motifs for FOXO1 Gene
HOMER Transcription Factor Regulatory Elements motif FOXO1
  • Consensus sequence: CTGTTTAC Submotif: canonical Cell Type: RAW

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO1

No data available for Enzyme Numbers (IUBMB) for FOXO1 Gene

Localization for FOXO1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXO1 Gene

Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and nucleus. Largely nuclear in unstimulated cells (PubMed:11311120, PubMed:12228231, PubMed:19221179, PubMed:21245099, PubMed:20543840). In osteoblasts, colocalizes with ATF4 and RUNX2 in the nucleus (By similarity). Serum deprivation increases localization to the nucleus, leading to activate expression of SOX9 and subsequent chondrogenesis (By similarity). Insulin-induced phosphorylation at Ser-256 by PKB/AKT1 leads, via stimulation of Thr-24 phosphorylation, to binding of 14-3-3 proteins and nuclear export to the cytoplasm where it is degraded by the ubiquitin-proteosomal pathway (PubMed:11237865, PubMed:12228231). Phosphorylation at Ser-249 by CDK1 disrupts binding of 14-3-3 proteins and promotes nuclear accumulation (PubMed:18356527). Phosphorylation by NLK results in nuclear export (By similarity). Translocates to the nucleus upon oxidative stress-induced phosphorylation at Ser-212 by STK4/MST1 (PubMed:19221179, PubMed:21245099). SGK1-mediated phosphorylation also results in nuclear translocation (By similarity). Retained in the nucleus under stress stimuli including oxidative stress, nutrient deprivation or nitric oxide (By similarity). Retained in the nucleus on methylation (By similarity). {ECO:0000250 UniProtKB:Q9R1E0, ECO:0000269 PubMed:11237865, ECO:0000269 PubMed:11311120, ECO:0000269 PubMed:12228231, ECO:0000269 PubMed:18356527, ECO:0000269 PubMed:19221179, ECO:0000269 PubMed:20543840, ECO:0000269 PubMed:21245099}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXO1 gene
Compartment Confidence
mitochondrion 5
nucleus 5
cytosol 5
plasma membrane 3
extracellular 3
cytoskeleton 3
peroxisome 2
endoplasmic reticulum 2
endosome 2
lysosome 2
golgi apparatus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005623 cell IEA --
GO:0005634 nucleus IBA,IDA 11311120
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IBA,IDA 11237865
genes like me logo Genes that share ontologies with FOXO1: view

Pathways & Interactions for FOXO1 Gene

genes like me logo Genes that share pathways with FOXO1: view

Pathways by source for FOXO1 Gene

2 GeneGo (Thomson Reuters) pathways for FOXO1 Gene
  • Development Angiopoietin - Tie2 signaling
  • Development Thrombopoietin-regulated cell processes
6 Qiagen pathways for FOXO1 Gene
  • Akt Signaling
  • Angiopoietin-TIE2 Signaling
  • DHA Signaling
  • ErbB Family Pathway
  • Glioblastoma Multiforme
1 Cell Signaling Technology pathway for FOXO1 Gene

SIGNOR curated interactions for FOXO1 Gene

Gene Ontology (GO) - Biological Process for FOXO1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IBA 21873635
GO:0001568 blood vessel development IEA --
GO:0001659 temperature homeostasis ISS 22510882
GO:0001678 cellular glucose homeostasis ISS 22510882
GO:0006111 regulation of gluconeogenesis IEA --
genes like me logo Genes that share ontologies with FOXO1: view

Drugs & Compounds for FOXO1 Gene

(15) Drugs for FOXO1 Gene - From: PharmGKB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 3670
Epirubicin Approved Pharma 483
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 2338

(9) Additional Compounds for FOXO1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOXO1: view

Transcripts for FOXO1 Gene

mRNA/cDNA for FOXO1 Gene

1 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXO1

Alternative Splicing Database (ASD) splice patterns (SP) for FOXO1 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6
SP1: - - -
SP2: -
SP3: - -
SP4: -

Relevant External Links for FOXO1 Gene

GeneLoc Exon Structure for
FOXO1

Expression for FOXO1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXO1 Gene

mRNA differential expression in normal tissues according to GTEx for FOXO1 Gene

This gene is overexpressed in Muscle - Skeletal (x7.4).

Protein differential expression in normal tissues from HIPED for FOXO1 Gene

This gene is overexpressed in Blymphocyte (20.0), CD4 Tcells (19.0), CD8 Tcells (12.0), and Peripheral blood mononuclear cells (9.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXO1 Gene



Protein tissue co-expression partners for FOXO1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXO1

SOURCE GeneReport for Unigene cluster for FOXO1 Gene:

Hs.370666

mRNA Expression by UniProt/SwissProt for FOXO1 Gene:

Q12778-FOXO1_HUMAN
Tissue specificity: Ubiquitous.

Evidence on tissue expression from TISSUES for FOXO1 Gene

  • Muscle(3.8)
  • Liver(3.8)
  • Nervous system(3.5)
  • Heart(3.3)
  • Blood(3.2)
  • Pancreas(3.2)
  • Kidney(3.1)
  • Intestine(3.1)
  • Lymph node(3)
  • Spleen(3)
  • Skin(2.9)
  • Bone marrow(2.8)
  • Lung(2.8)
  • Thyroid gland(2.7)
  • Adrenal gland(2.5)
  • Eye(2.4)
  • Bone(2.4)
  • Stomach(2.4)
  • Gall bladder(2.1)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXO1 Gene

Germ Layers:
  • ectoderm
  • endoderm
Systems:
  • respiratory
Regions:
Thorax:
  • lung
genes like me logo Genes that share expression patterns with FOXO1: view

Orthologs for FOXO1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXO1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FOXO1 30 31
  • 99.75 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia FOXO1 30 31
  • 92.62 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FOXO1 30 31
  • 90.22 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Foxo1 30 17 31
  • 89.21 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Foxo1 30
  • 88.85 (n)
Oppossum
(Monodelphis domestica)
Mammalia FOXO1 31
  • 83 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FOXO1 31
  • 81 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FKHR 31
  • 80 (a)
OneToOne
FOXO1 30
  • 77.85 (n)
Lizard
(Anolis carolinensis)
Reptilia FOXO1 31
  • 69 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia foxo1 30
  • 72.43 (n)
Str.14625 30
Zebrafish
(Danio rerio)
Actinopterygii FOXO1 (3 of 3) 31
  • 73 (a)
OneToMany
foxo1a 30 31
  • 64.67 (n)
OneToMany
foxo1b 31
  • 54 (a)
OneToMany
Fruit Fly
(Drosophila melanogaster)
Insecta foxo 31
  • 30 (a)
OneToMany
Worm
(Caenorhabditis elegans)
Secernentea daf-16 31
  • 30 (a)
OneToMany
Baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes HCM1 31
  • 16 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea CSA.3143 31
  • 25 (a)
OneToMany
Species where no ortholog for FOXO1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FOXO1 Gene

ENSEMBL:
Gene Tree for FOXO1 (if available)
TreeFam:
Gene Tree for FOXO1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXO1: view image

Paralogs for FOXO1 Gene

(3) SIMAP similar genes for FOXO1 Gene using alignment to 2 proteins:

  • FOXO1_HUMAN
  • L8E9Y8_HUMAN

Pseudogenes.org Pseudogenes for FOXO1 Gene

genes like me logo Genes that share paralogs with FOXO1: view

Variants for FOXO1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXO1 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
708958 Benign: not provided 40,560,570(-) A/G SYNONYMOUS_VARIANT
786748 Benign: not provided 40,559,985(-) C/T SYNONYMOUS_VARIANT
791400 Benign: not provided 40,560,492(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for FOXO1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXO1 Gene

Variant ID Type Subtype PubMed ID
esv2747290 CNV deletion 23290073
esv3352453 CNV duplication 20981092
esv3892332 CNV gain 25118596
nsv525547 CNV loss 19592680

Variation tolerance for FOXO1 Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.86; 58.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXO1 Gene

Human Gene Mutation Database (HGMD)
FOXO1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXO1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXO1 Gene

Disorders for FOXO1 Gene

MalaCards: The human disease database

(37) MalaCards diseases for FOXO1 Gene - From: LncRNADisease, OMIM, GTR, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
rhabdomyosarcoma 2
  • rms2
glioma
rhabdomyosarcoma
muscle cancer
  • malignant neoplasm of muscle
patau syndrome
  • d1 trisomy
- elite association - COSMIC cancer census association via MalaCards
Search FOXO1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FOXO1_HUMAN
  • Rhabdomyosarcoma 2 (RMS2) [MIM:268220]: A form of rhabdomyosarcoma, a highly malignant tumor of striated muscle derived from primitive mesenchymal cells and exhibiting differentiation along rhabdomyoblastic lines. Rhabdomyosarcoma is one of the most frequently occurring soft tissue sarcomas and the most common in children. It occurs in four forms: alveolar, pleomorphic, embryonal and botryoidal rhabdomyosarcomas. Note=The gene represented in this entry may be involved in disease pathogenesis. Chromosomal aberrations involving FOXO1 are found in rhabdomyosarcoma. Translocation (2;13)(q35;q14) with PAX3 and translocation t(1;13)(p36;q14) with PAX7. The resulting protein is a transcriptional activator.

Additional Disease Information for FOXO1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FOXO1: view

No data available for Genatlas for FOXO1 Gene

Publications for FOXO1 Gene

  1. Association of common genetic variation in the FOXO1 gene with beta-cell dysfunction, impaired glucose tolerance, and type 2 diabetes. (PMID: 19141580) Müssig K … Häring HU (The Journal of clinical endocrinology and metabolism 2009) 3 23 41
  2. Structural basis for DNA recognition by FoxO1 and its regulation by posttranslational modification. (PMID: 18786403) Brent MM … Marmorstein R (Structure (London, England : 1993) 2008) 3 4 23
  3. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. (PMID: 18951090) Yamagata K … Fukamizu A (Molecular cell 2008) 3 4 23
  4. Analysis of FOXO1A as a candidate gene for type 2 diabetes. (PMID: 16497530) Karim MA … Elbein SC (Molecular genetics and metabolism 2006) 3 23 41
  5. Polymorphisms in FOXO gene family and association analysis with BMI. (PMID: 16571842) Kim JR … Shin HD (Obesity (Silver Spring, Md.) 2006) 3 23 41

Products for FOXO1 Gene

  • Addgene plasmids for FOXO1