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Aliases for FOXN2 Gene

Aliases for FOXN2 Gene

  • Forkhead Box N2 2 3 5
  • Human T-Cell Leukemia Virus Enhancer Factor 2 3 4
  • Forkhead Box Protein N2 3 4
  • HTLF 3 4

External Ids for FOXN2 Gene

Previous HGNC Symbols for FOXN2 Gene

  • HTLF

Previous GeneCards Identifiers for FOXN2 Gene

  • GC02P048395
  • GC02P048541
  • GC02P048277

Summaries for FOXN2 Gene

Entrez Gene Summary for FOXN2 Gene

  • This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXN2 Gene

FOXN2 (Forkhead Box N2) is a Protein Coding gene. Diseases associated with FOXN2 include T-Cell Leukemia. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXN3.

UniProtKB/Swiss-Prot for FOXN2 Gene

Additional gene information for FOXN2 Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXN2 Gene

Genomics for FOXN2 Gene

GeneHancer (GH) Regulatory Elements for FOXN2 Gene

Promoters and enhancers for FOXN2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J048311 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 604.8 +0.1 119 6.2 ZNF652 ZFX SP1 ELF3 MNT ZNF148 NKRF POLR2A MLLT1 ZNF121 FOXN2 LOC105374593 ENSG00000230773 PPP1R21 FBXO11 MSH6 STON1-GTF2A1L GTF2A1L GC02P048318
GH02J048342 Promoter/Enhancer 1.7 Ensembl ENCODE dbSUPER 47.4 +30.2 30237 4.4 CC2D1A ELF3 MNT CEBPG RERE ZNF384 MAFK SP1 HNF1A PPARG FOXN2 PPP1R21 MSH6 RPL36AP15 GTF2A1L GC02M048341 RNU4-49P GC02M048365
GH02J048165 Enhancer 1.1 FANTOM5 Ensembl 46.7 -145.6 -145636 15.6 ELF3 CEBPG BACH1 TRIM24 SP1 SP5 ZNF644 RXRA RFX1 CEBPA FOXN2 PPP1R21 MSH6 FBXO11 RNU6-282P GTF2A1L STON1-GTF2A1L GC02P048218 GC02P048073 LOC105374593
GH02J047902 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 12.4 -409.5 -409523 5.8 SP1 CC2D1A ZFX CTCF ZKSCAN8 ZNF148 NKRF POLR2A MLLT1 CEBPG ENSG00000233230 LOC100506235 FBXO11 FOXN2 MSH6 GC02P047883
GH02J048405 Enhancer 0.5 Ensembl ENCODE 53.8 +92.1 92092 1.5 RUNX3 FOXN2 PPP1R21 GTF2A1L GC02M048388 ENSG00000272663 GC02P048370
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXN2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXN2 gene promoter:
  • AP-4
  • E47
  • FOXO1
  • FOXO1a
  • FOXO4
  • Lmo2

Genomic Locations for FOXN2 Gene

Genomic Locations for FOXN2 Gene
chr2:48,314,637-48,379,295
(GRCh38/hg38)
Size:
64,659 bases
Orientation:
Plus strand
chr2:48,541,776-48,606,434
(GRCh37/hg19)
Size:
64,659 bases
Orientation:
Plus strand

Genomic View for FOXN2 Gene

Genes around FOXN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXN2 Gene

Proteins for FOXN2 Gene

  • Protein details for FOXN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P32314-FOXN2_HUMAN
    Recommended name:
    Forkhead box protein N2
    Protein Accession:
    P32314
    Secondary Accessions:
    • Q15769
    • Q6P4Q2

    Protein attributes for FOXN2 Gene

    Size:
    431 amino acids
    Molecular mass:
    47161 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXN2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXN2 Gene

Post-translational modifications for FOXN2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOXN2 Gene

Domains & Families for FOXN2 Gene

Gene Families for FOXN2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXN2 Gene

Suggested Antigen Peptide Sequences for FOXN2 Gene

GenScript: Design optimal peptide antigens:
  • Human T-cell leukemia virus enhancer factor (FOXN2_HUMAN)
  • FOXN2 protein (Q6IS90_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXN2: view

No data available for UniProtKB/Swiss-Prot for FOXN2 Gene

Function for FOXN2 Gene

Molecular function for FOXN2 Gene

UniProtKB/Swiss-Prot Function:
Binds to the purine-rich region in HTLV-I LTR.

Phenotypes From GWAS Catalog for FOXN2 Gene

Gene Ontology (GO) - Molecular Function for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS,IEA 1639393
GO:0005515 protein binding IPI 25609649
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXN2: view
genes like me logo Genes that share phenotypes with FOXN2: view

Animal Model Products

CRISPR Products

miRNA for FOXN2 Gene

miRTarBase miRNAs that target FOXN2

Clone Products

  • Applied Biological Materials (abm): Clones for FOXN2 - Now 50% OFF >
  • * FOXN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FOXN2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXN2 Gene

Localization for FOXN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXN2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXN2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (3)
  • Vesicles (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with FOXN2: view

Pathways & Interactions for FOXN2 Gene

PathCards logo

SuperPathways for FOXN2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0035914 skeletal muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with FOXN2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXN2 Gene

Drugs & Compounds for FOXN2 Gene

No Compound Related Data Available

Transcripts for FOXN2 Gene

mRNA/cDNA for FOXN2 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(80) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for FOXN2 Gene

Forkhead box N2:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for FOXN2 - Now 50% OFF >
  • * FOXN2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FOXN2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FOXN2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7
SP1:
SP2: -

Relevant External Links for FOXN2 Gene

GeneLoc Exon Structure for
FOXN2
ECgene alternative splicing isoforms for
FOXN2

Expression for FOXN2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXN2 Gene

Protein differential expression in normal tissues from HIPED for FOXN2 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXN2 Gene



Protein tissue co-expression partners for FOXN2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXN2 Gene:

FOXN2

SOURCE GeneReport for Unigene cluster for FOXN2 Gene:

Hs.468478
genes like me logo Genes that share expression patterns with FOXN2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXN2 Gene

Orthologs for FOXN2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXN2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXN2 35 34
  • 99.77 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FOXN2 35 34
  • 93.97 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FOXN2 35 34
  • 93.12 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXN2 35
  • 86 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxn2 34
  • 84.58 (n)
mouse
(Mus musculus)
Mammalia Foxn2 35 17 34
  • 84.46 (n)
OneToOne
chicken
(Gallus gallus)
Aves FOXN2 35 34
  • 81.71 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXN2 35
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxn2 34
  • 74.97 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34746 34
zebrafish
(Danio rerio)
Actinopterygii LOC100330010 34
  • 62.83 (n)
CABZ01056728.1 35
  • 53 (a)
OneToMany
foxn2b 35
  • 51 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CHES-1-like 35
  • 11 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5413 35
  • 20 (a)
OneToMany
Species where no ortholog for FOXN2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXN2 Gene

ENSEMBL:
Gene Tree for FOXN2 (if available)
TreeFam:
Gene Tree for FOXN2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXN2: view image

Paralogs for FOXN2 Gene

Paralogs for FOXN2 Gene

(3) SIMAP similar genes for FOXN2 Gene using alignment to 3 proteins:

  • FOXN2_HUMAN
  • C9JTA7_HUMAN
  • Q6IS90_HUMAN
genes like me logo Genes that share paralogs with FOXN2: view

Variants for FOXN2 Gene

Sequence variations from dbSNP and Humsavar for FOXN2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000083464 -- 48,359,370(+) T/C intron_variant
rs1000149699 -- 48,345,584(+) A/G intron_variant
rs1000199145 -- 48,356,264(+) A/G intron_variant
rs1000203022 -- 48,370,251(+) G/A/C intron_variant
rs1000223434 -- 48,365,011(+) C/A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXN2 Gene

Variant ID Type Subtype PubMed ID
esv2762252 CNV gain 21179565
nsv519831 CNV gain 19592680
nsv953781 CNV duplication 24416366

Variation tolerance for FOXN2 Gene

Residual Variation Intolerance Score: 12.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.69; 14.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXN2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXN2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXN2 Gene

Disorders for FOXN2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXN2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
t-cell leukemia
  • leukemia t-cell
- elite association - COSMIC cancer census association via MalaCards
Search FOXN2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOXN2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FOXN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXN2 Gene

Publications for FOXN2 Gene

  1. Characterization and chromosomal mapping of the gene encoding the cellular DNA binding protein HTLF. (PMID: 1639393) Li C … Gaynor R (Genomics 1992) 2 3 4 23 58
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  3. β-Trcp ubiquitin ligase and RSK2 kinase-mediated degradation of FOXN2 promotes tumorigenesis and radioresistance in lung cancer. (PMID: 29396548) Ma J … Xu S (Cell death and differentiation 2018) 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma. (PMID: 28963376) Zhang MP … Cai J (Bioscience reports 2017) 3 58

Products for FOXN2 Gene

Sources for FOXN2 Gene

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