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The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
FOXM1 (Forkhead Box M1) is a Protein Coding gene. Diseases associated with FOXM1 include Hepatocellular Carcinoma and Cervix Carcinoma. Among its related pathways are Cyclin A/B1 associated events during G2/M transition and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein kinase binding. An important paralog of this gene is FOXO1.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 21860419 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0003677 | DNA binding | IEA | -- |
GO:0003700 | DNA-binding transcription factor activity | IEA,IBA | 21873635 |
GO:0005515 | protein binding | IPI | 16504183 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | IEA,IBA | 21873635 |
GO:0005654 | nucleoplasm | TAS | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Regulation of PLK1 Activity at G2/M Transition |
.50
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2 | Cell Cycle, Mitotic |
.83
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|
3 | DNA Damage | ||
4 | Cellular senescence (KEGG) | ||
5 | Cyclin A/B1 associated events during G2/M transition |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000086 | G2/M transition of mitotic cell cycle | IEA,IDA | 19160488 |
GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 20531406 |
GO:0001570 | vasculogenesis | IBA | 21873635 |
GO:0006281 | DNA repair | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
---|---|---|---|---|---|---|
Verteporfin | Approved, Investigational | Pharma | YAP inhibitor; disrupts YAP-TEAD interactions | 97 | ||
Thiostrepton | Vet_approved | Pharma | FOXM1 inhibitor | 0 | ||
BI 6015 | Pharma | HNF4α antagonist, Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist | 0 |
Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
---|---|---|---|---|---|---|
CID 5951923 |
|
749872-43-3 |
|
|
||
RG 102240 |
|
162326-49-0 |
|
|
||
Stauprimide |
|
154589-96-5 |
|
|
Compound | Action | Cas Number |
---|---|---|
BI 6015 | Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist | 93987-29-2 |
CID 5951923 | Kr�ppel-like factor 5 (KLF5) inhibitor | 749872-43-3 |
RG 102240 | Gene switch ligand for use in induceable gene expression systems | 162326-49-0 |
Stauprimide | Inhibits NME2 nuclear translocation; primes ESCs for differentiation | 154589-96-5 |
Verteporfin | YAP inhibitor; disrupts YAP-TEAD interactions | 129497-78-5 |
Compound | Action | Cas Number |
---|---|---|
Thiostrepton | FOXM1 inhibitor | 1393-48-2 |
ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||
SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP9: | |||||||||||||||||||||||||||||||||||||||||||
SP10: |
This gene was present in the common ancestor of animals and fungi.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FOXM1 30 |
|
||
Dog (Canis familiaris) |
Mammalia | FOXM1 30 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Foxm1 30 |
|
||
Mouse (Mus musculus) |
Mammalia | Foxm1 30 17 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FOXM1 30 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FOXM1 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FOXM1 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FOXM1 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FOXM1 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | foxm1 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | foxm1 30 31 |
|
OneToOne | |
zgc63854 30 |
|
||||
Fruit Fly (Drosophila melanogaster) |
Insecta | fd102C 31 |
|
ManyToMany | |
Worm (Caenorhabditis elegans) |
Secernentea | fkh-9 31 |
|
OneToOne | |
Baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HCM1 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
SNP ID | Clinical significance and condition | Chr 12 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
708115 | Benign: not provided | 2,858,928(-) | G/T | MISSENSE_VARIANT | |
708540 | Benign: not provided | 2,874,463(-) | G/A | MISSENSE_VARIANT | |
709111 | Benign: not provided | 2,866,516(-) | G/A | SYNONYMOUS_VARIANT | |
711070 | Benign: not provided | 2,858,924(-) | G/C | MISSENSE_VARIANT | |
734377 | Benign: not provided | 2,865,370(-) | G/A | SYNONYMOUS_VARIANT,INTRON_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
hepatocellular carcinoma |
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cervix carcinoma |
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protein c deficiency |
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meckel diverticulum |
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middle cranial fossa meningioma |
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