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The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] See more...
Aliases for FOXM1 Gene
Aliases for FOXM1 Gene
- Forkhead Box M1 2 3 5
- M-Phase Phosphoprotein 2 2 3 4
- Hepatocyte Nuclear Factor 3 Forkhead Homolog 11 3 4
- Winged-Helix Factor From INS-1 Cells 3 4
- Forkhead-Related Protein FKHL16 3 4
- MPM-2 Reactive Phosphoprotein 2 3 4
- Transcription Factor Trident 3 4
- HNF-3/Fork-Head Homolog 11 3 4
- Forkhead Box Protein M1 3 4
- FKHL16 3 4
- HFH-11 3 4
- HFH11 3 4
- MPP2 3 4
External Ids for FOXM1 Gene
- HGNC: 3818
- Entrez Gene: 2305
- Ensembl: ENSG00000111206
- OMIM: 602341
- UniProtKB: Q08050
Previous HGNC Symbols for FOXM1 Gene
- FKHL16
Previous GeneCards Identifiers for FOXM1 Gene
- GC12M002839
- GC12M002837
- GC12M002966
Summaries for FOXM1 Gene
-
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]
GeneCards Summary for FOXM1 Gene
FOXM1 (Forkhead Box M1) is a Protein Coding gene. Diseases associated with FOXM1 include Hepatocellular Carcinoma and Meckel Diverticulum. Among its related pathways are Cell Cycle, Mitotic and Cellular senescence (KEGG). Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein kinase binding. An important paralog of this gene is FOXJ3.
UniProtKB/Swiss-Prot Summary for FOXM1 Gene
-
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.
Additional gene information for FOXM1 Gene
- Monarch Initiative
- Search for FOXM1 at DataMed
- Search for FOXM1 at HumanCyc
No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXM1 Gene
Genomics for FOXM1 Gene
GeneHancer (GH) Regulatory Elements for FOXM1 Gene
Promoters and enhancers for FOXM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXM1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FOXM1 gene promoter:
-
- C/EBPalpha
- CREB
- deltaCREB
- YY1
Genomic Locations for FOXM1 Gene
Genomic Locations for FOXM1 Gene
- chr12:2,857,681-2,877,155
- (GRCh38/hg38)
- Size:
- 19,475 bases
- Orientation:
- Minus strand
- chr12:2,966,847-2,986,303
- (GRCh37/hg19)
- Size:
- 19,457 bases
- Orientation:
- Minus strand
Genomic View for FOXM1 Gene
Genes around FOXM1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12p13.33 by HGNC
- 12p13.33 by Entrez Gene
- 12p13.33 by Ensembl
FOXM1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXM1 Gene
Proteins for FOXM1 Gene
-
Protein details for FOXM1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q08050-FOXM1_HUMAN
- Recommended name:
- Forkhead box protein M1
- Protein Accession:
- Q08050
- O43258
- O43259
- O43260
- Q4ZGG7
- Q9BRL2
Protein attributes for FOXM1 Gene
- Size:
- 763 amino acids
- Molecular mass:
- 84283 Da
- Quaternary structure:
- No Data Available
Protein Expression for FOXM1 Gene
Post-translational modifications for FOXM1 Gene
- Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FOXM1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FOXM1 Antibody and Immunotag™ FOXM1 Polyclonal Antibody
- Atlas Antibodies Anti-FOXM1 Antibody
-
Creative Biolabs
- Recombinant Anti-Human FOXM1 Antibody
- Recombinant Anti-Human FOXM1 Antibody Fab Fragment
- Mouse Anti-FOXM1 Recombinant Antibody (CBXF-2356)
- Mouse Anti-FOXM1 Recombinant Antibody (CBXF-0850)
- Mouse Anti-FOXM1 Recombinant Antibody (CBXF-2029)
- Mouse Anti-FOXM1 Recombinant Antibody (CBXF-0849)
- Mouse Anti-FOXM1 (AA 702-801) Recombinant Antibody (CBXF-3168)
- Mouse Anti-FOXM1 Recombinant Antibody (CBXF-2357)
- Mouse Anti-FOXM1 (AA 22-110) Recombinant Antibody (CBXF-3167)
- Rabbit Anti-FOXM1 Recombinant Antibody (CBXF-1509)
- Mouse Anti-FOXM1 Recombinant Antibody (CBXF-0847)
- Mouse Anti-FOXM1 Recombinant Antibody (1H4)
- Mouse Anti-FOXM1 Recombinant Antibody (2E6)
- Mouse Anti-FOXM1 Recombinant Antibody (CBXF-1300)
- Mouse Anti-FOXM1 Recombinant Antibody (263C2a)
- Recombinant Mouse Anti-Human FOXM1 Antibody (clone 0.U.277), FITC-Conjugated
- GeneTex Anti-FOXM1 antibody [C3], C-term and Anti-FOXM1 antibody
- Novus Biologicals Antibodies for FOXM1
-
Abcam antibodies for FOXM1
- Invitrogen Antibodies for FOXM1 (AFLGC-FOXM1)
-
Boster Bio Antibodies for FOXM1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXM1
Protein Products
- Atlas Antibodies PrEST Antigen FOXM1
- Creative Diagnostics Human FOXM1 peptide
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXM1
- Origene Custom Protein Services for FOXM1
-
Abcam proteins for FOXM1
Assay Products
- RayBiotech Custom Human FoxM1/FKHL16 ELISA
- antibodies-online: Show 8 available FOXM1 Elisa Kits ranked by validation data
- Compare Top FOXM1 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for FOXM1 Gene
Domains & Families for FOXM1 Gene
Gene Families for FOXM1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXM1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXM1 Gene
- GenScript: Design optimal peptide antigens:
-
- Winged-helix factor from INS-1 cells (FOXM1_HUMAN)
- PIG29 (Q53Y49_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q08050UniProtKB/Swiss-Prot:
FOXM1_HUMAN :- Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.
- Domain:
-
- Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.
Function for FOXM1 Gene
Molecular function for FOXM1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.
- UniProtKB/Swiss-Prot Induction:
- Induced during liver regeneration and oxidative stress.
- GENATLAS Biochemistry:
- transcription factor-like 16,with a Drosophila homeo forkhead DNA binding domain,mouse Trident homolog,expressed in cycling cells,involved in cell proliferation
Phenotypes From GWAS Catalog for FOXM1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 21860419 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific | IC | -- |
| GO:0003677 | DNA binding | IEA | -- |
| GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
Phenotypes for FOXM1 Gene
- MGI mutant phenotypes for FOXM1:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FOXM1:
-
- Increased shRNA abundance (Z-score > 2)
- Decreased shRNA abundance (Z-score < -2)
- Reduced mammosphere formation
- Decreased number of cells in monopolar arrest with EMD534085 (a Kinesin-5 inhibitor)
- Decreased viability with TRAIL
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased NF-kappaB reporter expression
- shRNA abundance <= 50%
- Synthetic lethal with vaccinia virus (VACV) infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for FOXM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXM1
- genomics-online: gRNA clones - Search for available FOXM1 gRNA products
- Overview of 181 available FOXM1 gene related products
-
Recommended
- Applied Biological Materials (abm): CRISPR Clones for FOXM1 - Select products 50% OFF >
- * FOXM1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FOXM1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXM1
miRNA for FOXM1 Gene
- miRTarBase miRNAs that target FOXM1
-
- hsa-mir-134-5p (MIRT006979)
- hsa-mir-26b-5p (MIRT030070)
- hsa-mir-186-5p (MIRT045084)
- hsa-mir-149-5p (MIRT052645)
- hsa-mir-370-3p (MIRT053073)
- hsa-mir-194-5p (MIRT053766)
- hsa-mir-24-1-5p (MIRT438246)
- hsa-mir-509-3-5p (MIRT731505)
- hsa-mir-320a (MIRT731927)
- hsa-mir-23a-3p (MIRT732488)
- hsa-mir-671-5p (MIRT733656)
- hsa-mir-216b-5p (MIRT734484)
- hsa-mir-204-5p (MIRT734849)
- hsa-mir-630 (MIRT735380)
Targeted motifs for FOXM1 Gene
HOMER Transcription Factor Regulatory Elements motif FOXM1
- Consensus sequence: TRTTTACTTW Submotif: canonical Cell Type: MCF7 GEO ID: GSE72977
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOXM1
- Browse OriGene Inhibitory RNA Products For FOXM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXM1
- genomics-online: shRNA clones - Search for available FOXM1 shRNA products
- Overview of 181 available FOXM1 gene related products
-
Recommended
Clone Products
-
- MG210493
- MR210493
- MR210493L3
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- MR210493L4
- MR210493L4V
- RC202246
- RC202246L1
- RC202246L1V
- RC202246L2
- RC202246L2V
- RC202246L3
- RC202246L3V
- RC202246L4
- RC202246L4V
- RC202540
- RC202540L1
- RC202540L1V
- RC202540L2
- RC202540L2V
- RC202540L3
- RC202540L3V
- RC202540L4
- RC202540L4V
- RC211450
- RC211450L1
- RC211450L1V
- RC211450L2
- RC211450L2V
- RC211450L3
- RC211450L3V
- RC211450L4
- RC211450L4V
- RC233117
- RC233119
- RG202246
- RG202540
- RG211450
- RG233117
- RG233119
- RR203894
- RR203894L3
- RR203894L3V
- RR203894L4
- RR203894L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FOXM1
- Addgene plasmids for FOXM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXM1
- genomics-online: cdna clones - Search for available FOXM1 CDNA products
- Overview of 181 available FOXM1 gene related products
-
Recommended
- orf clones - Search for available FOXM1 ORF products
- Overview of 181 available FOXM1 gene related products
-
Recommended
- Applied Biological Materials (abm): Clones for FOXM1 - Select products 50% OFF >
- * FOXM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FOXM1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for FOXM1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for FOXM1 Gene
Localization for FOXM1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXM1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| plasma membrane | 1 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
| endoplasmic reticulum | 1 |
- Nucleoli (3)
- Nucleus (3)
- Cytosol (1)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
Pathways & Interactions for FOXM1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of PLK1 Activity at G2/M Transition |
.49
|
|
| 2 | Cell Cycle, Mitotic |
.83
|
|
| 3 | DNA Damage | ||
| 4 | Cellular senescence (KEGG) | ||
| 5 | Cyclin A/B1 associated events during G2/M transition | ||
Pathways by source for FOXM1 Gene
2 BioSystems pathways for FOXM1 Gene
6 Reactome pathways for FOXM1 Gene
1 KEGG pathway for FOXM1 Gene
1 Cell Signaling Technology pathway for FOXM1 Gene
Interacting Proteins for FOXM1 Gene
Selected Interacting proteins:
Q08050-FOXM1_HUMAN
ENSP00000342307
for FOXM1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FOXM1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000086 | G2/M transition of mitotic cell cycle | IDA | 19160488 |
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IMP | 20531406 |
| GO:0006281 | DNA repair | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006974 | cellular response to DNA damage stimulus | IEA | -- |
Drugs & Compounds for FOXM1 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Verteporfin | Approved, Investigational | Pharma | YAP inhibitor; disrupts YAP-TEAD interactions | 95 | ||
| Thiostrepton | Vet_approved | Pharma | FOXM1 inhibitor | 0 | ||
| BI 6015 | Pharma | HNF4α antagonist, Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| CID 5951923 |
|
749872-43-3 |
|
|
||
| RG 102240 |
|
162326-49-0 |
|
|
||
| Stauprimide |
|
154589-96-5 |
|
|
(5) Tocris Compounds for FOXM1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| BI 6015 | Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist | 93987-29-2 |
| CID 5951923 | Kr�ppel-like factor 5 (KLF5) inhibitor | 749872-43-3 |
| RG 102240 | Gene switch ligand for use in induceable gene expression systems | 162326-49-0 |
| Stauprimide | Inhibits NME2 nuclear translocation; primes ESCs for differentiation | 154589-96-5 |
| Verteporfin | YAP inhibitor; disrupts YAP-TEAD interactions | 129497-78-5 |
(1) ApexBio Compounds for FOXM1 Gene
| Compound | Action | Cas Number |
|---|---|---|
| Thiostrepton | FOXM1 inhibitor | 1393-48-2 |
Drug Products
- Atlas Antibodies PrEST Antigen FOXM1
- Creative Diagnostics Human FOXM1 peptide
- ApexBio compounds for FOXM1
Transcripts for FOXM1 Gene
mRNA/cDNA for FOXM1 Gene
- (5) REFSEQ mRNAs :
- (21) Additional mRNA sequences :
- (283) Selected AceView cDNA sequences:
- (10) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000536066 2518 bps (ENST00000536066.1)
- ENST00000342628 3475 bps (ENST00000342628.6)
- ENST00000361953 3370 bps (ENST00000361953.7)
- ENST00000359843 3315 bps (ENST00000359843.7)
- ENST00000535350 618 bps (ENST00000535350.1)
CRISPR Products
-
OriGene CRISPR knockouts for FOXM1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXM1
- genomics-online: gRNA clones - Search for available FOXM1 gRNA products
- Overview of 181 available FOXM1 gene related products
-
Recommended
- Applied Biological Materials (abm): CRISPR Clones for FOXM1 - Select products 50% OFF >
- * FOXM1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FOXM1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXM1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOXM1
- Browse OriGene Inhibitory RNA Products For FOXM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXM1
- genomics-online: shRNA clones - Search for available FOXM1 shRNA products
- Overview of 181 available FOXM1 gene related products
-
Recommended
Clone Products
-
- MG210493
- MR210493
- MR210493L3
- MR210493L3V
- MR210493L4
- MR210493L4V
- RC202246
- RC202246L1
- RC202246L1V
- RC202246L2
- RC202246L2V
- RC202246L3
- RC202246L3V
- RC202246L4
- RC202246L4V
- RC202540
- RC202540L1
- RC202540L1V
- RC202540L2
- RC202540L2V
- RC202540L3
- RC202540L3V
- RC202540L4
- RC202540L4V
- RC211450
- RC211450L1
- RC211450L1V
- RC211450L2
- RC211450L2V
- RC211450L3
- RC211450L3V
- RC211450L4
- RC211450L4V
- RC233117
- RC233119
- RG202246
- RG202540
- RG211450
- RG233117
- RG233119
- RR203894
- RR203894L3
- RR203894L3V
- RR203894L4
- RR203894L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FOXM1
- Addgene plasmids for FOXM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXM1
- genomics-online: cdna clones - Search for available FOXM1 CDNA products
- Overview of 181 available FOXM1 gene related products
-
Recommended
- orf clones - Search for available FOXM1 ORF products
- Overview of 181 available FOXM1 gene related products
-
Recommended
- Applied Biological Materials (abm): Clones for FOXM1 - Select products 50% OFF >
- * FOXM1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FOXM1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | · | 2d | · | 2e | ^ | 3 | ^ | 4a | · | 4b | · | 4c | · | 4d | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8a | · | 8b | · | 8c | ^ | 9a | · | 9b | ^ | 10a | · | 10b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP4: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP5: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP6: | - | ||||||||||||||||||||||||||||||||||||||||||
| SP7: | - | - | |||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
| SP9: | |||||||||||||||||||||||||||||||||||||||||||
| SP10: |
Expression for FOXM1 Gene
mRNA differential expression in normal tissues according to GTEx for FOXM1 Gene
This gene is overexpressed in Testis (x6.6) and Esophagus - Mucosa (x4.5).
This gene is overexpressed in Liver, secretome (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXM1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FOXM1 Gene:
FOXM1SOURCE GeneReport for Unigene cluster for FOXM1 Gene:
Hs.239mRNA Expression by UniProt/SwissProt for FOXM1 Gene:
Q08050-FOXM1_HUMAN
Tissue specificity:
Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.
Evidence on tissue expression from TISSUES for FOXM1 Gene
- Lung(4.4)
- Skin(4.4)
- Blood(4.3)
- Pancreas(3.5)
- Liver(2.5)
- Intestine(2.4)
Primer Products
-
OriGene qPCR primer pairs for FOXM1
-
OriGene qPCR primer pairs and template standards for FOXM1
- genomics-online: primer clones - Search for available FOXM1 Primer products
- Overview of 181 available FOXM1 gene related products
-
Recommended
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXM1 Gene
Orthologs for FOXM1 Gene
This gene was present in the common ancestor of animals and fungi.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FOXM1 32 |
|
||
| dog (Canis familiaris) |
Mammalia | FOXM1 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Foxm1 32 |
|
||
| mouse (Mus musculus) |
Mammalia | Foxm1 17 33 32 |
|
||
| cow (Bos Taurus) |
Mammalia | FOXM1 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FOXM1 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FOXM1 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FOXM1 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FOXM1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | foxm1 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | foxm1 33 32 |
|
OneToOne | |
| zgc63854 32 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | fd102C 33 |
|
ManyToMany | |
| worm (Caenorhabditis elegans) |
Secernentea | fkh-9 33 |
|
OneToOne | |
| baker's yeast (Saccharomyces cerevisiae) |
Saccharomycetes | HCM1 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToOne |
- Species where no ortholog for FOXM1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for FOXM1 Gene
- ENSEMBL:
- Gene Tree for FOXM1 (if available)
- TreeFam:
- Gene Tree for FOXM1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXM1: view image
Paralogs for FOXM1 Gene
Paralogs for FOXM1 Gene
- FOXJ3 5
- FOXK2 5
- FOXJ2 5
- FOXI3 5
- FOXK1 5
- FOXN1 5
- FOXO3 5
- FOXD3 5
- FOXQ1 5
- FOXO1 5
- FOXC1 5
- FOXD2 5
- FOXB2 5
- FOXA2 5
- FOXP1 5
- FOXL2 5
- FOXD4L1 5
- FOXE3 5
- FOXB1 5
- FOXD4L5 5
- FOXA1 5
- FOXC2 5
- ENSG00000285708 5
- FOXJ1 5
- FOXO4 5
- FOXD4L4 5
- FOXD4 5
- FOXL1 5
- FOXD1 5
- FOXI2 5
- FOXF1 5
- FOXD4L6 5
- FOXE1 5
- FOXD4L3 5
- FOXS1 5
- FOXH1 5
- FOXA3 5
- FOXO6 5
- WI2-2373I1.2 5
- FOXP3 5
- FOXR1 5
- FOXR2 5
- FOXO3B 5
Variants for FOXM1 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000087903 | -- | 2,860,557(-) | G/T | intron_variant | |
| rs1000266917 | -- | 2,877,271(-) | C/A | upstream_transcript_variant | |
| rs1000319560 | -- | 2,877,170(-) | G/T | 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant | |
| rs1000449104 | -- | 2,871,406(-) | G/C | intron_variant | |
| rs1000517837 | -- | 2,864,523(-) | C/G | intron_variant |
Residual Variation Intolerance Score:
88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
8.16;
84.73% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXM1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXM1 Gene
Disorders for FOXM1 Gene
(13) MalaCards diseases for FOXM1 Gene - From: HGMD, LncRNADisease, DISEASES, Novoseek, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| hepatocellular carcinoma |
|
|
| meckel diverticulum |
|
|
| central pontine myelinolysis |
|
|
| balanoposthitis |
|
|
| maturity-onset diabetes of the young, type 10 |
|
|
Search FOXM1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FOXM1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FOXM1 Gene
Publications for FOXM1 Gene
- Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. (PMID: 9032290) Ye H … Costa RH (Molecular and cellular biology 1997) 2 3 4 23 56
- Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. (PMID: 9242644) Yao KM … Wong GG (The Journal of biological chemistry 1997) 3 4 23 56
- The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. (PMID: 9441747) Korver W … Clevers H (Genomics 1997) 2 3 23 56
- Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 43 56
- Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. (PMID: 19351851) Li Q … Xie K (Cancer research 2009) 3 23 56
ExternalLinks
Products for FOXM1 Gene
- Custom Antibody Services
- Browse OriGene ELISA Kits
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- Browse OriGene Inhibitory RNA Products For FOXM1
- OriGene qPCR primer pairs for FOXM1
- OriGene qPCR primer pairs and template standards for FOXM1
- OriGene CRISPR knockouts for FOXM1
- MG210493
- MR210493
- MR210493L3
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- MR210493L4
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- RC202246
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- RC202540
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- RC211450
- RC211450L1
- RC211450L1V
- RC211450L2
- RC211450L2V
- RC211450L3
- RC211450L3V
- RC211450L4
- RC211450L4V
- RC233117
- RC233119
- RG202246
- RG202540
- RG211450
- RG233117
- RG233119
- RR203894
- RR203894L3
- RR203894L3V
- RR203894L4
- RR203894L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOXM1
- Sino Biological Human cDNA Clone for FOXM1
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- High-throughput Antibody Production Service
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- Novus Biologicals proteins and lysates for FOXM1
- Browse Antibodies
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- antibodies-online: Show 28 available FOXM1 Antibodies ranked by validation data
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- Quality Products:
- antibodies-online: Show 7 available FOXM1 Proteins ranked by validation data
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- Santa Cruz Biotechnology (SCBT) Antibodies for FOXM1
- Search Santa Cruz Biotechnology (SCBT) for FOXM1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOXM1
- Horizon Cell Lines for FOXM1
- genomics-online: cdna clones - Search for available FOXM1 CDNA products
- Overview of 181 available FOXM1 gene related products
- Recommended
- orf clones - Search for available FOXM1 ORF products
- Overview of 181 available FOXM1 gene related products
- Recommended
- genomics-online: gRNA clones - Search for available FOXM1 gRNA products
- Overview of 181 available FOXM1 gene related products
- Recommended
- genomics-online: primer clones - Search for available FOXM1 Primer products
- Overview of 181 available FOXM1 gene related products
- Recommended
- genomics-online: shRNA clones - Search for available FOXM1 shRNA products
- Overview of 181 available FOXM1 gene related products
- Recommended
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXM1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXM1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FOXM1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXM1
- Boster Bio Antibodies for FOXM1
- Browse Boster Bio ELISA Kits
Sources for FOXM1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource