FOXM1 Gene (Protein Coding)

Forkhead Box M1

GC12M002857
GIFtS:
44
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011] See more...

Aliases for FOXM1 Gene

Aliases for FOXM1 Gene

  • Forkhead Box M1 2 3 5
  • M-Phase Phosphoprotein 2 2 3 4
  • HFH-11 2 3 4
  • MPP2 2 3 4
  • Hepatocyte Nuclear Factor 3 Forkhead Homolog 11 3 4
  • Winged-Helix Factor From INS-1 Cells 3 4
  • MPM-2 Reactive Phosphoprotein 2 3 4
  • Forkhead-Related Protein FKHL16 3 4
  • Transcription Factor Trident 3 4
  • HNF-3/Fork-Head Homolog 11 3 4
  • Forkhead Box Protein M1 3 4
  • MPHOSPH2 2 3
  • FKHL16 3 4
  • HFH11 3 4
  • HNF-3 2 3
  • INS-1 2 3
  • A Novel Forkhead Box M1 Isoform FOXM1D 3
  • Forkhead, Drosophila, Homolog-Like 16 3
  • Forkhead Box M1-D 3
  • TRIDENT 3
  • Trident 2
  • FOXM1A 3
  • FOXM1B 3
  • FOXM1C 3
  • MPP-2 3
  • PIG29 3
  • FOXM1 5
  • TGT3 2
  • WIN 4

External Ids for FOXM1 Gene

Previous HGNC Symbols for FOXM1 Gene

  • FKHL16

Previous GeneCards Identifiers for FOXM1 Gene

  • GC12M002839
  • GC12M002837
  • GC12M002966

Summaries for FOXM1 Gene

Entrez Gene Summary for FOXM1 Gene

  • The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

GeneCards Summary for FOXM1 Gene

FOXM1 (Forkhead Box M1) is a Protein Coding gene. Diseases associated with FOXM1 include Hepatocellular Carcinoma and Cervix Carcinoma. Among its related pathways are Cyclin A/B1 associated events during G2/M transition and Regulation of PLK1 Activity at G2/M Transition. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein kinase binding. An important paralog of this gene is FOXO1.

UniProtKB/Swiss-Prot Summary for FOXM1 Gene

  • Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.

Tocris Summary for FOXM1 Gene

Gene Wiki entry for FOXM1 Gene

Additional gene information for FOXM1 Gene

No data available for CIViC Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXM1 Gene

Genomics for FOXM1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for FOXM1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXM1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXM1

Top Transcription factor binding sites by QIAGEN in the FOXM1 gene promoter:
  • C/EBPalpha
  • CREB
  • deltaCREB
  • YY1

Genomic Locations for FOXM1 Gene

Genomic Locations for FOXM1 Gene
chr12:2,857,680-2,877,174
(GRCh38/hg38)
Size:
19,495 bases
Orientation:
Minus strand
chr12:2,966,847-2,986,303
(GRCh37/hg19)
Size:
19,457 bases
Orientation:
Minus strand

Genomic View for FOXM1 Gene

Genes around FOXM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXM1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for FOXM1 Gene

Proteins for FOXM1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for FOXM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q08050-FOXM1_HUMAN
    Recommended name:
    Forkhead box protein M1
    Protein Accession:
    Q08050
    Secondary Accessions:
    • O43258
    • O43259
    • O43260
    • Q4ZGG7
    • Q9BRL2

    Protein attributes for FOXM1 Gene

    Size:
    763 amino acids
    Molecular mass:
    84283 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for FOXM1 Gene

    Alternative splice isoforms for FOXM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXM1 Gene

Protein Expression for FOXM1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for FOXM1 Gene

  • Phosphorylated in M (mitotic) phase. Phosphorylation by the checkpoint kinase CHEK2 in response to DNA damage increases the FOXM1 protein stability probably stimulating the transcription of genes involved in DNA repair. Phosphorylated by CDK1 in late S and G2 phases, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates FOXM1, leading to activation of transcriptional activity and subsequent enhanced expression of key mitotic regulators.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXM1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXM1 Gene

Domains & Families for FOXM1 Gene

Gene Families for FOXM1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXM1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for FOXM1 Gene

GenScript: Design optimal peptide antigens:
  • Winged-helix factor from INS-1 cells (FOXM1_HUMAN)
  • PIG29 (Q53Y49_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q08050

UniProtKB/Swiss-Prot:

FOXM1_HUMAN :
  • Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.
Domain:
  • Within the protein there is a domain which acts as a transcriptional activator. Insertion of a splicing sequence within it inactivates this transcriptional activity, as it is the case for isoform 4.
genes like me logo Genes that share domains with FOXM1: view

Function for FOXM1 Gene

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Molecular function for FOXM1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional factor regulating the expression of cell cycle genes essential for DNA replication and mitosis. Plays a role in the control of cell proliferation. Plays also a role in DNA breaks repair participating in the DNA damage checkpoint response.
UniProtKB/Swiss-Prot Induction:
Induced during liver regeneration and oxidative stress.
GENATLAS Biochemistry:
transcription factor-like 16,with a Drosophila homeo forkhead DNA binding domain,mouse Trident homolog,expressed in cycling cells,involved in cell proliferation

Phenotypes From GWAS Catalog for FOXM1 Gene

Gene Ontology (GO) - Molecular Function for FOXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 21860419
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA,IBA 21873635
GO:0005515 protein binding IPI 16504183
genes like me logo Genes that share ontologies with FOXM1: view
genes like me logo Genes that share phenotypes with FOXM1: view

Animal Models for FOXM1 Gene

MGI Knock Outs for FOXM1:

Animal Model Products

CRISPR Products

Targeted motifs for FOXM1 Gene
HOMER Transcription Factor Regulatory Elements motif FOXM1
  • Consensus sequence: TRTTTACTTW Submotif: canonical Cell Type: MCF7 GEO ID: GSE72977

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXM1

Clone Products

  • Addgene plasmids for FOXM1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for FOXM1 Gene

Localization for FOXM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXM1 Gene

Nucleus.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXM1 gene
Compartment Confidence
nucleus 5
cytoskeleton 3
cytosol 3
plasma membrane 2
extracellular 2
mitochondrion 2
endoplasmic reticulum 2
lysosome 2
peroxisome 1
endosome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (3)
  • Nucleoplasm (3)
  • Cytosol (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA,IBA 21873635
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with FOXM1: view

Pathways & Interactions for FOXM1 Gene

genes like me logo Genes that share pathways with FOXM1: view

Pathways by source for FOXM1 Gene

1 KEGG pathway for FOXM1 Gene
1 Cell Signaling Technology pathway for FOXM1 Gene

SIGNOR curated interactions for FOXM1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for FOXM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle IEA,IDA 19160488
GO:0000122 negative regulation of transcription by RNA polymerase II IMP 20531406
GO:0001570 vasculogenesis IBA 21873635
GO:0006281 DNA repair IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FOXM1: view

Drugs & Compounds for FOXM1 Gene

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(8) Drugs for FOXM1 Gene - From: ApexBio, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Verteporfin Approved, Investigational Pharma YAP inhibitor; disrupts YAP-TEAD interactions 97
Thiostrepton Vet_approved Pharma FOXM1 inhibitor 0
BI 6015 Pharma HNF4α antagonist, Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist 0

(11) Additional Compounds for FOXM1 Gene - From: Novoseek and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
CID 5951923
749872-43-3
RG 102240
162326-49-0
Stauprimide
154589-96-5

(5) Tocris Compounds for FOXM1 Gene

Compound Action Cas Number
BI 6015 Hepatocyte nuclear factor 4alpha (HNF4alpha) antagonist 93987-29-2
CID 5951923 Kr�ppel-like factor 5 (KLF5) inhibitor 749872-43-3
RG 102240 Gene switch ligand for use in induceable gene expression systems 162326-49-0
Stauprimide Inhibits NME2 nuclear translocation; primes ESCs for differentiation 154589-96-5
Verteporfin YAP inhibitor; disrupts YAP-TEAD interactions 129497-78-5

(1) ApexBio Compounds for FOXM1 Gene

Compound Action Cas Number
Thiostrepton FOXM1 inhibitor 1393-48-2
genes like me logo Genes that share compounds with FOXM1: view

Drug Products

Transcripts for FOXM1 Gene

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  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for FOXM1 Gene

5 REFSEQ mRNAs :
21 NCBI additional mRNA sequence :
10 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXM1

Clone Products

  • Addgene plasmids for FOXM1

Alternative Splicing Database (ASD) splice patterns (SP) for FOXM1 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c · 2d · 2e ^ 3 ^ 4a · 4b · 4c · 4d ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b
SP1: -
SP2: - - - -
SP3: - - -
SP4: - - -
SP5: - -
SP6: -
SP7: - -
SP8: - - -
SP9:
SP10:

Relevant External Links for FOXM1 Gene

GeneLoc Exon Structure for
FOXM1

Expression for FOXM1 Gene

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  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXM1 Gene

mRNA expression in normal human tissues for FOXM1 Gene
mRNA expression by BioGPS for FOXM1 GenemRNA expression by GTEx for FOXM1 Gene

mRNA differential expression in normal tissues according to GTEx for FOXM1 Gene

This gene is overexpressed in Testis (x6.6) and Esophagus - Mucosa (x4.5).

Protein differential expression in normal tissues from HIPED for FOXM1 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXM1 Gene



Protein tissue co-expression partners for FOXM1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXM1

SOURCE GeneReport for Unigene cluster for FOXM1 Gene:

Hs.239

mRNA Expression by UniProt/SwissProt for FOXM1 Gene:

Q08050-FOXM1_HUMAN
Tissue specificity: Expressed in thymus, testis, small intestine, colon followed by ovary. Appears to be expressed only in adult organs containing proliferating/cycling cells or in response to growth factors. Also expressed in epithelial cell lines derived from tumors. Not expressed in resting cells. Isoform 2 is highly expressed in testis.

Evidence on tissue expression from TISSUES for FOXM1 Gene

  • Skin(4.6)
  • Lung(4.5)
  • Blood(4.5)
  • Intestine(3.1)
  • Pancreas(3)
  • Liver(2.8)
  • Lymph node(2.7)
  • Nervous system(2.6)
  • Bone marrow(2.6)
  • Kidney(2.4)
  • Muscle(2.4)
  • Heart(2.4)
  • Stomach(2.4)
  • Bone(2.1)
genes like me logo Genes that share expression patterns with FOXM1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXM1 Gene

Orthologs for FOXM1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXM1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia FOXM1 30
  • 98.75 (n)
Dog
(Canis familiaris)
 Mammalia FOXM1 30 31
  • 87.24 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia Foxm1 30
  • 82.87 (n)
Mouse
(Mus musculus)
 Mammalia Foxm1 30 17 31
  • 82.5 (n)
 OneToOne
Cow
(Bos Taurus)
 Mammalia FOXM1 30 31
  • 82.34 (n)
 OneToOne
Oppossum
(Monodelphis domestica)
 Mammalia FOXM1 31
  • 77 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia FOXM1 31
  • 74 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves FOXM1 30 31
  • 60.66 (n)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia FOXM1 31
  • 47 (a)
 OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
 Amphibia foxm1 30
  • 56.02 (n)
Zebrafish
(Danio rerio)
 Actinopterygii foxm1 30 31
  • 57.62 (n)
 OneToOne
zgc63854 30
Fruit Fly
(Drosophila melanogaster)
 Insecta fd102C 31
  • 11 (a)
 ManyToMany
Worm
(Caenorhabditis elegans)
 Secernentea fkh-9 31
  • 24 (a)
 OneToOne
Baker's yeast
(Saccharomyces cerevisiae)
 Saccharomycetes HCM1 31
  • 14 (a)
 OneToMany
Sea Squirt
(Ciona savignyi)
 Ascidiacea -- 31
  • 19 (a)
 OneToOne
Species where no ortholog for FOXM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FOXM1 Gene

ENSEMBL:
Gene Tree for FOXM1 (if available)
TreeFam:
Gene Tree for FOXM1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXM1: view image

Paralogs for FOXM1 Gene

Variants for FOXM1 Gene

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  1. SNP Genotyping and Copy Number Assay

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXM1 Gene

SNP ID Clinical significance and condition Chr 12 pos Variation AA Info Type
708115 Benign: not provided 2,858,928(-) G/T MISSENSE_VARIANT
708540 Benign: not provided 2,874,463(-) G/A MISSENSE_VARIANT
709111 Benign: not provided 2,866,516(-) G/A SYNONYMOUS_VARIANT
711070 Benign: not provided 2,858,924(-) G/C MISSENSE_VARIANT
734377 Benign: not provided 2,865,370(-) G/A SYNONYMOUS_VARIANT,INTRON_VARIANT

Additional dbSNP identifiers (rs#s) for FOXM1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXM1 Gene

Variant ID Type Subtype PubMed ID
dgv19n68 CNV loss 17160897
esv3628321 CNV gain 21293372
nsv832311 CNV loss 17160897

Variation tolerance for FOXM1 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.16; 84.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXM1 Gene

Human Gene Mutation Database (HGMD)
FOXM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXM1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXM1 Gene

Disorders for FOXM1 Gene

MalaCards: The human disease database

(29) MalaCards diseases for FOXM1 Gene - From: LncRNADisease, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hepatocellular carcinoma
  • hcc
cervix carcinoma
  • cancer of cervix
protein c deficiency
  • autosomal recessive thrombophilia due to congenital protein c deficiency
meckel diverticulum
  • meckel's diverticulum
middle cranial fossa meningioma
  • meningioma of the middle cranial fossa
- elite association - COSMIC cancer census association via MalaCards
Search FOXM1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOXM1

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with FOXM1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXM1 Gene

Publications for FOXM1 Gene

  1. Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. (PMID: 9032290) Ye H … Costa RH (Molecular and cellular biology 1997) 2 3 4 23
  2. The human TRIDENT/HFH-11/FKHL16 gene: structure, localization, and promoter characterization. (PMID: 9441747) Korver W … Clevers H (Genomics 1997) 2 3 23
  3. Molecular analysis of a novel winged helix protein, WIN. Expression pattern, DNA binding property, and alternative splicing within the DNA binding domain. (PMID: 9242644) Yao KM … Wong GG (The Journal of biological chemistry 1997) 3 4 23
  4. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F … Nebel A (Mutation research 2010) 3 41
  5. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. (PMID: 19351851) Li Q … Xie K (Cancer research 2009) 3 23

ExternalLinks

View latest publications for FOXM1 gene in Mastermind

Products for FOXM1 Gene

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Sources for FOXM1 Gene