This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016] See more...

Aliases for FOXL2 Gene

Aliases for FOXL2 Gene

  • Forkhead Box L2 2 3 5
  • Forkhead Box Protein L2 3 4
  • BPES1 2 3
  • Forkhead Transcription Factor FOXL2 3
  • PINTO 3
  • FOXL2 5
  • BPES 3
  • PFRK 3
  • POF3 3

External Ids for FOXL2 Gene

Previous HGNC Symbols for FOXL2 Gene

  • BPES

Previous GeneCards Identifiers for FOXL2 Gene

  • GC03M135601
  • GC03M139464
  • GC03M139944
  • GC03M139983
  • GC03M140145
  • GC03M138663
  • GC03M136038

Summaries for FOXL2 Gene

Entrez Gene Summary for FOXL2 Gene

  • This gene encodes a forkhead transcription factor. The protein contains a fork-head DNA-binding domain and may play a role in ovarian development and function. Expansion of a polyalanine repeat region and other mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. [provided by RefSeq, Jul 2016]

CIViC Summary for FOXL2 Gene

GeneCards Summary for FOXL2 Gene

FOXL2 (Forkhead Box L2) is a Protein Coding gene. Diseases associated with FOXL2 include Blepharophimosis, Ptosis, And Epicanthus Inversus and Premature Ovarian Failure 3. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is FOXL1.

UniProtKB/Swiss-Prot Summary for FOXL2 Gene

  • Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.

Gene Wiki entry for FOXL2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXL2 Gene

Genomics for FOXL2 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FOXL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH03J138942 Promoter/Enhancer 1.4 Ensembl ENCODE dbSUPER 250.7 +1.8 1828 6.2 IKZF1 MYC ZNF592 NONO REST SMAD5 BHLHE40 MBD2 TBP MNT FOXL2 FOXL2NB HSALNG0029311 DBR1 DZIP1L ENSG00000272656 CEP70 ACTG1P1 COPB2 MRAS
GH03J138914 Promoter/Enhancer 1.6 FANTOM5 ENCODE CraniofacialAtlas 11.2 +31.3 31282 2.5 ZNF654 NCOR1 IKZF1 ZNF592 ZMYM3 CEBPA ATF3 NFIC POLR2A ZIC2 HSALNG0029302 lnc-FOXL2-5 CEP70 PIK3CB FAIM LINC01391 FOXL2 FOXL2NB RF00017-3720 HSALNG0029307
GH03J138923 Enhancer 0.9 Ensembl ENCODE 11.6 +23.5 23484 0.8 ZNF654 CEBPA MXD4 CTCF CEBPB REST TRIM22 HCFC1 RAD21 RFX5 FOXL2 FOXL2NB LINC01391 CEP70 FAIM HSALNG0029302 PIK3CB
GH03J138979 Enhancer 0.7 Ensembl 11.7 -32.8 -32830 0.7 IKZF1 NFIC REST CTCF FOXA2 RAD21 SMC3 FOXA1 ZNF143 HNF4A PRR23C LINC01391 FOXL2 FOXL2NB HSALNG0029314 MRPS22
GH03J139297 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 1.8 -353.9 -353882 7.6 MYC NCOR1 IKZF1 JUND ZNF592 BRCA1 NFIC NONO CEBPB REST FOXL2NB FOXL2 piR-54420 lnc-FOXL2NB-8 COPB2 PRR23C MRPS22
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXL2 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXL2

Top Transcription factor binding sites by QIAGEN in the FOXL2 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • FOXO1
  • FOXO1a
  • FOXO4

Genomic Locations for FOXL2 Gene

Latest Assembly
chr3:138,944,224-138,947,137
(GRCh38/hg38)
Size:
2,914 bases
Orientation:
Minus strand

Previous Assembly
chr3:138,663,066-138,665,979
(GRCh37/hg19 by Entrez Gene)
Size:
2,914 bases
Orientation:
Minus strand

chr3:138,663,066-138,665,982
(GRCh37/hg19 by Ensembl)
Size:
2,917 bases
Orientation:
Minus strand

Genomic View for FOXL2 Gene

Genes around FOXL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXL2 Gene

Proteins for FOXL2 Gene

  • Protein details for FOXL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P58012-FOXL2_HUMAN
    Recommended name:
    Forkhead box protein L2
    Protein Accession:
    P58012
    Secondary Accessions:
    • Q4ZGJ3

    Protein attributes for FOXL2 Gene

    Size:
    376 amino acids
    Molecular mass:
    38772 Da
    Quaternary structure:
    • Interacts with ESR1 (By similarity). Interacts with SMAD3 (By similarity). Interacts with DDX20. Interacts with UBE2I/UBC9.

neXtProt entry for FOXL2 Gene

Post-translational modifications for FOXL2 Gene

  • Sumoylated with SUMO1; sumoylation is required for transcriptional repression activity.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXL2 Gene

Domains & Families for FOXL2 Gene

Gene Families for FOXL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Cancer-related genes
  • Disease related genes
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for FOXL2 Gene

GenScript: Design optimal peptide antigens:
  • Forkhead box protein L2 (FOXL2_HUMAN)
  • FOXL2 protein (Q05CX9_HUMAN)
  • Transcription factor FOXL2 mutant 3 (Q4JHB5_HUMAN)
  • Transcription factor FOXL2 mutant 1 (Q4JHB7_HUMAN)
  • Forkhead box L2 (Q53ZD3_HUMAN)
genes like me logo Genes that share domains with FOXL2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXL2 Gene

Function for FOXL2 Gene

Molecular function for FOXL2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9 (By similarity). Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen (By similarity). Is a regulator of CYP19 expression (By similarity). Participates in SMAD3-dependent transcription of FST via the intronic SMAD-binding element (By similarity). Is a transcriptional repressor of STAR. Activates SIRT1 transcription under cellular stress conditions. Activates transcription of OSR2.
UniProtKB/Swiss-Prot Induction:
In granulosa-like cells, up-regulated at transcript and protein levels under oxidative stress and heat-shock conditions. Down-regulated by SIRT1.

Phenotypes From GWAS Catalog for FOXL2 Gene

Gene Ontology (GO) - Molecular Function for FOXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003677 DNA binding TAS 11175783
GO:0003700 DNA-binding transcription factor activity NAS 11175783
GO:0005515 protein binding IPI 16153597
genes like me logo Genes that share ontologies with FOXL2: view
genes like me logo Genes that share phenotypes with FOXL2: view

Human Phenotype Ontology for FOXL2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for FOXL2 Gene

MGI Knock Outs for FOXL2:
Targeted motifs for FOXL2 Gene
HOMER Transcription Factor Regulatory Elements motif FOXL2
  • Consensus sequence: NATGASTCABNN Submotif: canonical Cell Type: 3T3L1 GEO ID: GSE56872
  • Consensus sequence: WWTRTAAACAVG Submotif: canonical Cell Type: Ovary GEO ID: GSE60858

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXL2

No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for FOXL2 Gene

Localization for FOXL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXL2 gene
Compartment Confidence
nucleus 5
extracellular 4
cytoskeleton 2
cytosol 2
plasma membrane 1
mitochondrion 1
endoplasmic reticulum 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Midbody ring (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus IEA,IDA 12471206
GO:0005654 nucleoplasm TAS --
GO:0090543 Flemming body IDA --
genes like me logo Genes that share ontologies with FOXL2: view

Pathways & Interactions for FOXL2 Gene

PathCards logo

SuperPathways for FOXL2 Gene

No Data Available

Interacting Proteins for FOXL2 Gene

SIGNOR curated interactions for FOXL2 Gene

Activates:
Inactivates:
Is activated by:
Is inactivated by:

Gene Ontology (GO) - Biological Process for FOXL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001541 ovarian follicle development ISS --
GO:0002074 extraocular skeletal muscle development IMP 12630957
GO:0006309 apoptotic DNA fragmentation IMP 16153597
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
genes like me logo Genes that share ontologies with FOXL2: view

No data available for Pathways by source for FOXL2 Gene

Drugs & Compounds for FOXL2 Gene

(1) Drugs for FOXL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
genes like me logo Genes that share compounds with FOXL2: view

Transcripts for FOXL2 Gene

mRNA/cDNA for FOXL2 Gene

1 REFSEQ mRNAs :
11 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXL2

Alternative Splicing Database (ASD) splice patterns (SP) for FOXL2 Gene

No ASD Table

Relevant External Links for FOXL2 Gene

GeneLoc Exon Structure for
FOXL2

Expression for FOXL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXL2 Gene

This gene is overexpressed in Ovary (x23.1), Cervix - Endocervix (x6.3), Fallopian Tube (x4.9), Pituitary (x4.5), and Uterus (x4.5).

Protein differential expression in normal tissues from HIPED for FOXL2 Gene

This gene is overexpressed in Platelet (61.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXL2 Gene



Protein tissue co-expression partners for FOXL2 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXL2

SOURCE GeneReport for Unigene cluster for FOXL2 Gene:

Hs.289292

mRNA Expression by UniProt/SwissProt for FOXL2 Gene:

P58012-FOXL2_HUMAN
Tissue specificity: In addition to its expression in the developing eyelid, it is transcribed very early in somatic cells of the developing gonad (before sex determination) and its expression persists in the follicular cells of the adult ovary.

Evidence on tissue expression from TISSUES for FOXL2 Gene

  • Pancreas(4.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXL2 Gene

Germ Layers:
  • ectoderm
  • mesoderm
Systems:
  • digestive
  • endocrine
  • integumentary
  • nervous
  • reproductive
  • skeletal muscle
  • skeleton
Regions:
Head and neck:
  • brain
  • cranial nerve
  • ear
  • eye
  • eyelid
  • face
  • head
  • lacrimal apparatus
  • mouth
  • nose
  • outer ear
  • pituitary gland
  • skull
Thorax:
  • breast
Pelvis:
  • fallopian tube
  • ovary
  • penis
  • prostate
  • testicle
  • uterus
  • vagina
  • vulva
General:
  • hair
  • peripheral nervous system
  • skin
genes like me logo Genes that share expression patterns with FOXL2: view

Primer products for research

Orthologs for FOXL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXL2 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FOXL2 29 30
  • 99.47 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FOXL2 29 30
  • 90.78 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia Foxl2 29
  • 89.78 (n)
Dog
(Canis familiaris)
Mammalia FOXL2 30
  • 89 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Foxl2 29 16 30
  • 88.26 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FOXL2 30
  • 82 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia FOXL2 30
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves FOXL2 30
  • 79 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia -- 30
  • 21 (a)
ManyToMany
Zebrafish
(Danio rerio)
Actinopterygii LOC100149117 29
  • 74.36 (n)
FOXL2 30
  • 71 (a)
OneToOne
Fruit Fly
(Drosophila melanogaster)
Insecta croc 30
  • 18 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 36 (a)
OneToOne
Species where no ortholog for FOXL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for FOXL2 Gene

ENSEMBL:
Gene Tree for FOXL2 (if available)
TreeFam:
Gene Tree for FOXL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXL2: view image
Alliance of Genome Resources:
Additional Orthologs for FOXL2

Paralogs for FOXL2 Gene

(15) SIMAP similar genes for FOXL2 Gene using alignment to 6 proteins:

  • FOXL2_HUMAN
  • Q05CX9_HUMAN
  • Q4JHB5_HUMAN
  • Q4JHB6_HUMAN
  • Q4JHB7_HUMAN
  • Q53ZD3_HUMAN
genes like me logo Genes that share paralogs with FOXL2: view

Variants for FOXL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXL2 Gene

SNP ID Clinical significance and condition Chr 03 pos Variation AA Info Type
180595 Benign: Blepharophimosis, ptosis, and epicanthus inversus 138,946,021(-) CGCGGCTGCAGCCGCA
NM_023067.4(FOXL2):c.661_702= (p.Ala221_Ala234=)
NO_SEQUENCE_ALTERATION
rs104893737 Pathogenic: Blepharophimosis, ptosis, and epicanthus inversus syndrome type 1; not provided 138,946,566(-) G/A
NM_023067.4(FOXL2):c.157C>T (p.Gln53Ter)
NONSENSE
rs104893738 Pathogenic: Blepharophimosis, ptosis, and epicanthus inversus syndrome type 1; Blepharophimosis, ptosis, and epicanthus inversus syndrome type 2 138,945,901(-) G/C
NM_023067.4(FOXL2):c.822C>G (p.Tyr274Ter)
NONSENSE
rs104893739 Pathogenic: Blepharophimosis, ptosis, and epicanthus inversus 138,946,137(-) G/A
NM_023067.4(FOXL2):c.586C>T (p.Gln196Ter)
NONSENSE
rs104893741 Pathogenic: Blepharophimosis, ptosis, and epicanthus inversus; Blepharophimosis, ptosis, and epicanthus inversus syndrome type 1 138,946,068(-) G/A
NM_023067.4(FOXL2):c.655C>T (p.Gln219Ter)
NONSENSE

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FOXL2 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FOXL2 Gene

Variant ID Type Subtype PubMed ID
dgv4908n100 CNV gain 25217958
nsv591854 CNV gain 21841781

Variation tolerance for FOXL2 Gene

Gene Damage Index Score: 7.05; 80.28% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXL2 Gene

Human Gene Mutation Database (HGMD)
FOXL2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXL2
Leiden Open Variation Database (LOVD)
FOXL2

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXL2 Gene

Disorders for FOXL2 Gene

MalaCards: The human disease database

(49) MalaCards diseases for FOXL2 Gene - From: OMI, CVR, GTR, ORP, SWI, COP, and GCD

- elite association - COSMIC cancer census association via MalaCards
Search FOXL2 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

FOXL2_HUMAN
  • Blepharophimosis, ptosis, and epicanthus inversus syndrome (BPES) [MIM:110100]: A disorder characterized by eyelid dysplasia, small palpebral fissures, drooping eyelids and a skin fold curving in the mediolateral direction, inferior to the inner canthus. In type I BPSE (BPES1) eyelid abnormalities are associated with female infertility. Affected females show an ovarian deficit due to primary amenorrhea or to premature ovarian failure (POF). In type II BPSE (BPES2) affected individuals show only the eyelid defects. {ECO:0000269 PubMed:11175783, ECO:0000269 PubMed:11468277, ECO:0000269 PubMed:12400065, ECO:0000269 PubMed:12529855, ECO:0000269 PubMed:12630957, ECO:0000269 PubMed:12938087, ECO:0000269 PubMed:15257268, ECO:0000269 PubMed:16454982, ECO:0000269 PubMed:17089161, ECO:0000269 PubMed:18372316, ECO:0000269 PubMed:18484667, ECO:0000269 PubMed:18642388, ECO:0000269 Ref.2}. Note=The disease is caused by variants affecting the gene represented in this entry. There is a mutational hotspot in the region coding for the poly-Ala domain, since 30% of all mutations in the ORF lead to poly-Ala expansions, resulting mainly in BPES type II.
  • Premature ovarian failure 3 (POF3) [MIM:608996]: An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. {ECO:0000269 PubMed:12149404, ECO:0000269 PubMed:19429596}. Note=The disease is caused by variants affecting the gene represented in this entry.

Additional Disease Information for FOXL2

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with FOXL2: view

No data available for Genatlas for FOXL2 Gene

Publications for FOXL2 Gene

  1. Identification of novel mutations in FOXL2 associated with premature ovarian failure. (PMID: 12149404) Harris SE … Shelling AN (Molecular human reproduction 2002) 3 4 22 40 72
  2. Mutation of FOXL2 in granulosa-cell tumors of the ovary. (PMID: 19516027) Shah SP … Huntsman DG (The New England journal of medicine 2009) 3 4 22 72
  3. A novel polyalanine expansion in FOXL2: the first evidence for a recessive form of the blepharophimosis syndrome (BPES) associated with ovarian dysfunction. (PMID: 17089161) Nallathambi J … Veitia RA (Human genetics 2007) 3 4 22 72
  4. Comparative analysis of the FOXL2 gene and characterization of mutations in BPES patients. (PMID: 12938087) Udar N … BPES Consortium (Human mutation 2003) 3 4 22 40
  5. FOXL2 mutation screening in a large panel of POF patients and XX males. (PMID: 12161610) De Baere E … Veitia R (Journal of medical genetics 2002) 3 4 22 72

Products for FOXL2 Gene

Sources for FOXL2 Gene