Aliases for FOXK1 Gene

Aliases for FOXK1 Gene

  • Forkhead Box K1 2 3 5
  • Forkhead Box Protein K1 3 4
  • Myocyte Nuclear Factor 3 4
  • MNF 3 4
  • FOXK1L 3

External Ids for FOXK1 Gene

Previous GeneCards Identifiers for FOXK1 Gene

  • GC07U901483
  • GC07P004588
  • GC07P004496
  • GC07P004683

Summaries for FOXK1 Gene

GeneCards Summary for FOXK1 Gene

FOXK1 (Forkhead Box K1) is a Protein Coding gene. Diseases associated with FOXK1 include Central Nervous System Fibrosarcoma and Thyroid Angiosarcoma. Among its related pathways are Metabolism of proteins and Deubiquitination. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is FOXK2.

UniProtKB/Swiss-Prot Summary for FOXK1 Gene

  • Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164).

Gene Wiki entry for FOXK1 Gene

Additional gene information for FOXK1 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXK1 Gene

Genomics for FOXK1 Gene

GeneHancer (GH) Regulatory Elements for FOXK1 Gene

Promoters and enhancers for FOXK1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXK1 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXK1

Top Transcription factor binding sites by QIAGEN in the FOXK1 gene promoter:
  • ATF
  • C/EBPalpha
  • FOXO1
  • FOXO1a
  • Ik-3
  • NF-E2
  • NF-E2 p45
  • NF-kappaB
  • NF-kappaB1
  • RelA

Genomic Locations for FOXK1 Gene

Genomic Locations for FOXK1 Gene
chr7:4,644,691-4,771,443
(GRCh38/hg38)
Size:
126,753 bases
Orientation:
Plus strand
chr7:4,683,388-4,811,074
(GRCh37/hg19)
Size:
127,687 bases
Orientation:
Plus strand

Genomic View for FOXK1 Gene

Genes around FOXK1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXK1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXK1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXK1 Gene

Proteins for FOXK1 Gene

  • Protein details for FOXK1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P85037-FOXK1_HUMAN
    Recommended name:
    Forkhead box protein K1
    Protein Accession:
    P85037

    Protein attributes for FOXK1 Gene

    Size:
    733 amino acids
    Molecular mass:
    75457 Da
    Quaternary structure:
    • Interacts with SIN3A and SIN3B (via PAH2) to form a complex which represses transcription (By similarity). Component of SIN3A-, but not SIN3B-, containing multiprotein complexes (By similarity). Interacts with FOXO4 and MEF2C; both interactions inhibit FOXO4 and MEF2C transactivation activity (By similarity). Interacts (when phosphorylated) with YWHAE/14-3-3-epsilon; promotes sequestration in the cytoplasm and leads to impaired ability to bind DNA (By similarity). Interacts with FHL2 (By similarity). Interacts with SRF (PubMed:17670796). Interacts with DVL2 and DVL3; the interaction induces DVL2 nuclear translocation (PubMed:25805136). Interacts with BAP1 (when phosphorylated) (PubMed:25451922).

    Alternative splice isoforms for FOXK1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXK1 Gene

Post-translational modifications for FOXK1 Gene

  • Phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with YWHAE/14-3-3-epsilon and retention in the cytoplasm. In response to mTORC1 signaling, phosphorylation by GSK3 is prevented, leading to translocation to the nucleus.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXK1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Boster Bio Antibodies for FOXK1

No data available for DME Specific Peptides for FOXK1 Gene

Domains & Families for FOXK1 Gene

Gene Families for FOXK1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for FOXK1 Gene

GenScript: Design optimal peptide antigens:
  • Myocyte nuclear factor (FOXK1_HUMAN)
genes like me logo Genes that share domains with FOXK1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXK1 Gene

Function for FOXK1 Gene

Molecular function for FOXK1 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional regulator involved in different processes such as glucose metabolism, aerobic glycolysis, muscle cell differentiation and autophagy (By similarity). Recognizes and binds the forkhead DNA sequence motif (5'-GTAAACA-3') and can both act as a transcription activator or repressor, depending on the context (PubMed:17670796). Together with FOXK2, acts as a key regulator of metabolic reprogramming towards aerobic glycolysis, a process in which glucose is converted to lactate in the presence of oxygen (By similarity). Acts by promoting expression of enzymes for glycolysis (such as hexokinase-2 (HK2), phosphofructokinase, pyruvate kinase (PKLR) and lactate dehydrogenase), while suppressing further oxidation of pyruvate in the mitochondria by up-regulating pyruvate dehydrogenase kinases PDK1 and PDK4 (By similarity). Probably plays a role in gluconeogenesis during overnight fasting, when lactate from white adipose tissue and muscle is the main substrate (By similarity). Involved in mTORC1-mediated metabolic reprogramming: in response to mTORC1 signaling, translocates into the nucleus and regulates the expression of genes associated with glycolysis and downstream anabolic pathways, such as HIF1A, thereby regulating glucose metabolism (By similarity). Together with FOXK2, acts as a negative regulator of autophagy in skeletal muscle: in response to starvation, enters the nucleus, binds the promoters of autophagy genes and represses their expression, preventing proteolysis of skeletal muscle proteins (By similarity). Acts as a transcriptional regulator of the myogenic progenitor cell population in skeletal muscle (By similarity). Binds to the upstream enhancer region (CCAC box) of myoglobin (MB) gene, regulating the myogenic progenitor cell population (By similarity). Promotes muscle progenitor cell proliferation by repressing the transcriptional activity of FOXO4, thereby inhibiting myogenic differentiation (By similarity). Involved in remodeling processes of adult muscles that occur in response to physiological stimuli (By similarity). Required to correct temporal orchestration of molecular and cellular events necessary for muscle repair (By similarity). Represses myogenic differentiation by inhibiting MEFC activity (By similarity). Positively regulates Wnt/beta-catenin signaling by translocating DVL into the nucleus (PubMed:25805136). Reduces virus replication, probably by binding the interferon stimulated response element (ISRE) to promote antiviral gene expression (PubMed:25852164).

Phenotypes From GWAS Catalog for FOXK1 Gene

Gene Ontology (GO) - Molecular Function for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000976 transcription regulatory region sequence-specific DNA binding IDA 17670796
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IEA --
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific IEA,ISM 19274049
GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific IDA 17670796
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with FOXK1: view
genes like me logo Genes that share phenotypes with FOXK1: view

Animal Models for FOXK1 Gene

MGI Knock Outs for FOXK1:

Animal Model Products

miRNA for FOXK1 Gene

miRTarBase miRNAs that target FOXK1

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXK1 Gene

Localization for FOXK1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXK1 Gene

Nucleus. Cytoplasm. Note=Translocation to the nucleus is regulated by phosphorylation: phosphorylation by GSK3 (GSK3A or GSK3B) promotes interaction with 14-3-3 proteins and sequestration in the cytoplasm. Dephosphorylation promotes translocation to the nucleus (By similarity). Accumulates in the nucleus upon viral infection (PubMed:25852164). {ECO:0000250 UniProtKB:P42128, ECO:0000269 PubMed:25852164}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXK1 gene
Compartment Confidence
nucleus 5
extracellular 2
cytoskeleton 2
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1
endosome 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Nucleoli fibrillar center (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005623 cell IEA --
GO:0005634 nucleus IDA,IBA 25402684
GO:0005654 nucleoplasm TAS --
GO:0005737 cytoplasm IEA,IDA 25402684
genes like me logo Genes that share ontologies with FOXK1: view

Pathways & Interactions for FOXK1 Gene

genes like me logo Genes that share pathways with FOXK1: view

Pathways by source for FOXK1 Gene

Gene Ontology (GO) - Biological Process for FOXK1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription by RNA polymerase II IEA --
GO:0001678 cellular glucose homeostasis IDA 29861159
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with FOXK1: view

No data available for SIGNOR curated interactions for FOXK1 Gene

Drugs & Compounds for FOXK1 Gene

No Compound Related Data Available

Transcripts for FOXK1 Gene

mRNA/cDNA for FOXK1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXK1 Gene

No ASD Table

Relevant External Links for FOXK1 Gene

GeneLoc Exon Structure for
FOXK1

Expression for FOXK1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXK1 Gene

Protein differential expression in normal tissues from HIPED for FOXK1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXK1 Gene



Protein tissue co-expression partners for FOXK1 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXK1

SOURCE GeneReport for Unigene cluster for FOXK1 Gene:

Hs.487393

mRNA Expression by UniProt/SwissProt for FOXK1 Gene:

P85037-FOXK1_HUMAN
Tissue specificity: Expressed both developing and adult tissues (PubMed:15289879). In adults, significant expression is seen in tumors of the brain, colon and lymph node (PubMed:15289879).

Evidence on tissue expression from TISSUES for FOXK1 Gene

  • Liver(4.2)
  • Lung(4.2)
  • Muscle(2.5)
genes like me logo Genes that share expression patterns with FOXK1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXK1 Gene

Orthologs for FOXK1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for FOXK1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXK1 31 30
  • 99.32 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXK1 31
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXK1 31 30
  • 88.11 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FOXK1 31 30
  • 87.45 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Foxk1 17 31 30
  • 85.77 (n)
rat
(Rattus norvegicus)
Mammalia Foxk1 30
  • 85.62 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXK1 31
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXK1 31 30
  • 76.24 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXK1 31
  • 82 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxk1 31 30
  • 71.29 (n)
OneToOne
wufi75f05 30
fruit fly
(Drosophila melanogaster)
Insecta fd68A 31
  • 29 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes FKH1 31
  • 14 (a)
ManyToMany
FKH2 31
  • 11 (a)
ManyToMany
FHL1 33
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9506 31
  • 37 (a)
OneToMany
Species where no ortholog for FOXK1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXK1 Gene

ENSEMBL:
Gene Tree for FOXK1 (if available)
TreeFam:
Gene Tree for FOXK1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXK1: view image

Paralogs for FOXK1 Gene

(2) SIMAP similar genes for FOXK1 Gene using alignment to 2 proteins:

  • FOXK1_HUMAN
  • U3KQ26_HUMAN
genes like me logo Genes that share paralogs with FOXK1: view

Variants for FOXK1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXK1 Gene

SNP ID Clinical significance and condition Chr 07 pos Variation AA Info Type
742980 Benign: not provided 4,762,230(+) C/T SYNONYMOUS_VARIANT
750543 Benign: not provided 4,755,368(+) C/T SYNONYMOUS_VARIANT
773475 Benign: not provided 4,762,434(+) C/T SYNONYMOUS_VARIANT
776196 Benign: not provided 4,682,510(+) G/A MISSENSE_VARIANT
776197 Benign: not provided 4,759,099(+) C/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for FOXK1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXK1 Gene

Variant ID Type Subtype PubMed ID
esv2157596 CNV deletion 18987734
esv2380266 CNV deletion 18987734
esv2664593 CNV deletion 23128226
esv2678462 CNV deletion 23128226
esv2759503 CNV gain 17122850
esv3541087 CNV deletion 23714750
esv3571581 CNV loss 25503493
esv3611947 CNV loss 21293372
esv3611948 CNV loss 21293372
nsv1019692 CNV loss 25217958
nsv1074064 CNV deletion 25765185
nsv1124164 CNV deletion 24896259
nsv1133647 CNV deletion 24896259
nsv1145124 CNV deletion 24896259
nsv366495 CNV deletion 16902084
nsv471293 CNV loss 18288195
nsv508442 CNV deletion 20534489
nsv8033 CNV loss 18304495
nsv823994 CNV gain 20364138
nsv950797 CNV deletion 24416366

Variation tolerance for FOXK1 Gene

Residual Variation Intolerance Score: 6.33% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.80; 73.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXK1 Gene

Human Gene Mutation Database (HGMD)
FOXK1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXK1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXK1 Gene

Disorders for FOXK1 Gene

MalaCards: The human disease database

(9) MalaCards diseases for FOXK1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
central nervous system fibrosarcoma
  • fibrosarcoma of the cns
thyroid angiosarcoma
  • hemangiosarcoma of the thyroid
proliferative type fibrocystic change of breast
  • fibrocystic change, proliferative type with atypia
thyroid sarcoma
  • sarcoma of the thyroid gland
contagious pustular dermatitis
  • ecthyma contagiosum
- elite association - COSMIC cancer census association via MalaCards
Search FOXK1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOXK1

genes like me logo Genes that share disorders with FOXK1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXK1 Gene

Publications for FOXK1 Gene

  1. Identification and characterization of a novel human FOXK1 gene in silico. (PMID: 15289879) Huang JT … Lee V (International journal of oncology 2004) 3 4 23 54
  2. Identification and characterization of human FOXK1 gene in silico. (PMID: 15202027) Katoh M … Katoh M (International journal of molecular medicine 2004) 2 3 4 54
  3. BRCA1-associated protein 1 (BAP1) deubiquitinase antagonizes the ubiquitin-mediated activation of FoxK2 target genes. (PMID: 25451922) Okino Y … Machida YJ (The Journal of biological chemistry 2015) 3 4 54
  4. FOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus. (PMID: 25805136) Wang W … Chen J (Developmental cell 2015) 3 4 54
  5. The transcription factor FoxK participates with Nup98 to regulate antiviral gene expression. (PMID: 25852164) Panda D … Cherry S (mBio 2015) 3 4 54

Products for FOXK1 Gene

Sources for FOXK1 Gene