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Aliases for FOXJ3 Gene

Aliases for FOXJ3 Gene

  • Forkhead Box J3 2 3 5
  • Forkhead Box Protein J3 3 4
  • KIAA1041 4

External Ids for FOXJ3 Gene

Previous GeneCards Identifiers for FOXJ3 Gene

  • GC01M042056
  • GC01M042311
  • GC01M042414
  • GC01M042642
  • GC01M040761

Summaries for FOXJ3 Gene

GeneCards Summary for FOXJ3 Gene

FOXJ3 (Forkhead Box J3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is FOXJ2.

UniProtKB/Swiss-Prot for FOXJ3 Gene

  • Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.

Additional gene information for FOXJ3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXJ3 Gene

Genomics for FOXJ3 Gene

GeneHancer (GH) Regulatory Elements for FOXJ3 Gene

Promoters and enhancers for FOXJ3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J042333 Promoter/Enhancer 1.6 EPDnew ENCODE 618.2 +0.4 411 4.5 SP1 ZFX ELF3 MNT SIX5 ZNF148 NKRF POLR2A MLLT1 ZNF121 FOXJ3 GC01P042336 GC01P042337 CCDC30 P3H1 PPIH CLDN19 GUCA2B RNU6-536P ENSG00000236180
GH01J042923 Enhancer 1.3 ENCODE dbSUPER 41.5 -588.9 -588944 3.8 SP1 ELF3 CC2D1A ZFX CTCF CBFA2T2 ZNF148 NKRF POLR2A MLLT1 FOXJ3 SZT2 HYI PPIH P3H1 RNU6-880P CCDC30 ENSG00000228192 ZNF691 KDM4A
GH01J041493 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 28.3 +837.3 837340 12.7 ZFX CTCF ZKSCAN8 CBFA2T2 MLLT1 ZNF687 ZSCAN21 MAFK ZBTB7A YY1 EXO5 FOXJ3 EDN2 ENSG00000230881 ENSG00000230638 SCMH1 RIMS3 ENSG00000229901 NFYC GC01M041492
GH01J042164 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 24.4 +170.3 170315 2.5 ZNF473 ELF3 ZNF121 NFIB ZSCAN21 ZBTB7A SP7 SP5 ZNF548 KLF14 GC01P042164 GUCA2A PPIH FOXJ3 P3H1 CCDC30 ZNF691 ENSG00000227527 GC01M042279 PIR49391
GH01J042845 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 22.9 -510.9 -510896 2.7 SP1 ZFX SIX5 ZNF148 NKRF POLR2A MLLT1 FOS ZBTB7A YY1 ZNF691 ENSG00000228192 SVBP SZT2 FOXJ3 YBX1 CCDC30 PPIH ERMAP PIR46792
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXJ3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXJ3 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • FOXO1
  • FOXO1a
  • FOXO4
  • HNF-4alpha1

Genomic Locations for FOXJ3 Gene

Genomic Locations for FOXJ3 Gene
chr1:42,176,539-42,335,877
(GRCh38/hg38)
Size:
159,339 bases
Orientation:
Minus strand
chr1:42,642,210-42,801,548
(GRCh37/hg19)
Size:
159,339 bases
Orientation:
Minus strand

Genomic View for FOXJ3 Gene

Genes around FOXJ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXJ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXJ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXJ3 Gene

Proteins for FOXJ3 Gene

  • Protein details for FOXJ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPW0-FOXJ3_HUMAN
    Recommended name:
    Forkhead box protein J3
    Protein Accession:
    Q9UPW0
    Secondary Accessions:
    • A7MBL7
    • A7MD18
    • D3DPW2
    • Q9NSS7

    Protein attributes for FOXJ3 Gene

    Size:
    622 amino acids
    Molecular mass:
    68960 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA82993.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for FOXJ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXJ3 Gene

Post-translational modifications for FOXJ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOXJ3 Gene

Domains & Families for FOXJ3 Gene

Gene Families for FOXJ3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXJ3 Gene

Suggested Antigen Peptide Sequences for FOXJ3 Gene

GenScript: Design optimal peptide antigens:
  • Forkhead box protein J3 (FOXJ3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXJ3: view

No data available for UniProtKB/Swiss-Prot for FOXJ3 Gene

Function for FOXJ3 Gene

Molecular function for FOXJ3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.

Phenotypes From GWAS Catalog for FOXJ3 Gene

Gene Ontology (GO) - Molecular Function for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IC --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IDA 23332764
genes like me logo Genes that share ontologies with FOXJ3: view
genes like me logo Genes that share phenotypes with FOXJ3: view

Animal Models for FOXJ3 Gene

MGI Knock Outs for FOXJ3:
  • Foxj3 Foxj3<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for FOXJ3 Gene

miRTarBase miRNAs that target FOXJ3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXJ3

Clone Products

  • Applied Biological Materials (abm): Clones for FOXJ3 - Now 50% OFF >
  • * FOXJ3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FOXJ3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXJ3 Gene

Localization for FOXJ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXJ3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXJ3 gene
Compartment Confidence
nucleus 4

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FOXJ3: view

Pathways & Interactions for FOXJ3 Gene

PathCards logo

SuperPathways for FOXJ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 22740631
genes like me logo Genes that share ontologies with FOXJ3: view

No data available for Pathways by source and SIGNOR curated interactions for FOXJ3 Gene

Drugs & Compounds for FOXJ3 Gene

No Compound Related Data Available

Transcripts for FOXJ3 Gene

Unigene Clusters for FOXJ3 Gene

Forkhead box J3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXJ3

Clone Products

  • Applied Biological Materials (abm): Clones for FOXJ3 - Now 50% OFF >
  • * FOXJ3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FOXJ3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FOXJ3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for FOXJ3 Gene

GeneLoc Exon Structure for
FOXJ3
ECgene alternative splicing isoforms for
FOXJ3

Expression for FOXJ3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXJ3 Gene

Protein differential expression in normal tissues from HIPED for FOXJ3 Gene

This gene is overexpressed in Ovary (21.1), Blymphocyte (18.7), Placenta (9.6), Testis (8.1), and NK cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXJ3 Gene



Protein tissue co-expression partners for FOXJ3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of FOXJ3 Gene:

FOXJ3

SOURCE GeneReport for Unigene cluster for FOXJ3 Gene:

Hs.26023

Evidence on tissue expression from TISSUES for FOXJ3 Gene

  • Nervous system(4.6)
  • Lung(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with FOXJ3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXJ3 Gene

Orthologs for FOXJ3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXJ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXJ3 35 34
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FOXJ3 35 34
  • 95.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FOXJ3 35 34
  • 95.18 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 94 (a)
OneToMany
-- 35
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FOXJ3 35
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxj3 17 35 34
  • 92.27 (n)
rat
(Rattus norvegicus)
Mammalia Foxj3 34
  • 91.84 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxj3 34
  • 75.32 (n)
zebrafish
(Danio rerio)
Actinopterygii FOXJ3 35
  • 77 (a)
OneToOne
foxj3 34
  • 71.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 37 (a)
OneToOne
Species where no ortholog for FOXJ3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXJ3 Gene

ENSEMBL:
Gene Tree for FOXJ3 (if available)
TreeFam:
Gene Tree for FOXJ3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXJ3: view image

Paralogs for FOXJ3 Gene

(12) SIMAP similar genes for FOXJ3 Gene using alignment to 5 proteins:

  • FOXJ3_HUMAN
  • C9JVP0_HUMAN
  • C9JXI1_HUMAN
  • F6VXT0_HUMAN
  • H7C1Y6_HUMAN
genes like me logo Genes that share paralogs with FOXJ3: view

Variants for FOXJ3 Gene

Sequence variations from dbSNP and Humsavar for FOXJ3 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000000261 -- 42,265,511(-) G/C intron_variant
rs1000005230 -- 42,263,492(-) T/C intron_variant
rs1000006415 -- 42,290,127(-) T/C genic_upstream_transcript_variant, intron_variant
rs1000071445 -- 42,218,778(-) C/A intron_variant
rs1000072289 -- 42,313,369(-) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXJ3 Gene

Variant ID Type Subtype PubMed ID
esv22111 CNV loss 19812545
esv24371 CNV loss 19812545
esv2539470 CNV deletion 19546169
esv2663676 CNV deletion 23128226
esv2747530 CNV deletion 23290073
esv3306125 CNV mobile element insertion 20981092
esv3375211 CNV insertion 20981092
esv3414902 CNV insertion 20981092
esv3561304 CNV deletion 23714750
esv3585840 CNV loss 21293372
esv3585842 CNV loss 21293372
nsv1133845 CNV deletion 24896259
nsv1143447 CNV deletion 24896259
nsv688 CNV insertion 18451855
nsv958710 CNV deletion 24416366

Variation tolerance for FOXJ3 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXJ3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXJ3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXJ3 Gene

Disorders for FOXJ3 Gene

Additional Disease Information for FOXJ3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FOXJ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXJ3 Gene

Publications for FOXJ3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 45 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 58
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 58
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 58

Products for FOXJ3 Gene

Sources for FOXJ3 Gene

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