Aliases for FOXJ3 Gene

Aliases for FOXJ3 Gene

  • Forkhead Box J3 2 3 5
  • Forkhead Box Protein J3 3 4
  • KIAA1041 4

External Ids for FOXJ3 Gene

Previous GeneCards Identifiers for FOXJ3 Gene

  • GC01M042056
  • GC01M042311
  • GC01M042414
  • GC01M042642
  • GC01M040761

Summaries for FOXJ3 Gene

GeneCards Summary for FOXJ3 Gene

FOXJ3 (Forkhead Box J3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is FOXJ2.

UniProtKB/Swiss-Prot Summary for FOXJ3 Gene

  • Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.

Additional gene information for FOXJ3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXJ3 Gene

Genomics for FOXJ3 Gene

GeneHancer (GH) Regulatory Elements for FOXJ3 Gene

Promoters and enhancers for FOXJ3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J042333 Promoter/Enhancer 1.8 EPDnew ENCODE CraniofacialAtlas 507.9 +0.4 411 4.5 RXRA EP300 FOXK2 HNRNPK ZBTB40 ZNF217 ZSCAN5C NRF1 TCF12 MYC FOXJ3 lnc-RIMKLA-1 CCDC30 PPIH CLDN19 GUCA2B RNU6-536P ENSG00000236180 ENSG00000228452 YBX1
GH01J042845 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 22.9 -510.9 -510896 2.7 ZBTB40 ZNF217 CTCF NRF1 MYC USF1 POLR2G SP1 SIX5 FOS ZNF691 ENSG00000228192 SVBP SZT2 P3H1 FOXJ3 YBX1 PPIH MED8 CCDC30
GH01J042923 Promoter/Enhancer 1.7 ENCODE CraniofacialAtlas dbSUPER 20.3 -588.9 -588944 3.8 HNRNPK EP300 CTCF SIN3A TCF12 NRF1 POLR2G SP1 RBAK GTF2E2 lnc-ZNF691-5 SZT2 HYI FOXJ3 KDM4A P3H1 RNU6-880P CCDC30 ENSG00000228192 ZNF691
GH01J042164 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 24.6 +169.5 169476 5.2 ZNF217 TCF12 ZNF300 ZNF354C ZIC2 ZBTB10 ZNF423 KLF4 KLF7 ZNF662 GUCA2A PPIH FOXJ3 CCDC30 P3H1 ZNF691 SCMH1 ENSG00000227527 piR-48553-003
GH01J042678 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas 11.6 -347.0 -347010 7.8 ZBTB40 ZNF217 EP300 SIN3A NRF1 TCF12 MYC USF1 POLR2G SP1 ENSG00000285728 YBX1 PPIH SZT2 SVBP P3H1 FOXJ3 CLDN19 ENSG00000234917 piR-54375-001
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXJ3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXJ3

Top Transcription factor binding sites by QIAGEN in the FOXJ3 gene promoter:
  • COUP
  • COUP-TF
  • COUP-TF1
  • FOXO1
  • FOXO1a
  • FOXO4
  • HNF-4alpha1

Genomic Locations for FOXJ3 Gene

Genomic Locations for FOXJ3 Gene
chr1:42,176,539-42,335,877
(GRCh38/hg38)
Size:
159,339 bases
Orientation:
Minus strand
chr1:42,642,210-42,801,548
(GRCh37/hg19)
Size:
159,339 bases
Orientation:
Minus strand

Genomic View for FOXJ3 Gene

Genes around FOXJ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXJ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXJ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXJ3 Gene

Proteins for FOXJ3 Gene

  • Protein details for FOXJ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UPW0-FOXJ3_HUMAN
    Recommended name:
    Forkhead box protein J3
    Protein Accession:
    Q9UPW0
    Secondary Accessions:
    • A7MBL7
    • A7MD18
    • D3DPW2
    • Q9NSS7

    Protein attributes for FOXJ3 Gene

    Size:
    622 amino acids
    Molecular mass:
    68960 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA82993.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};

    Alternative splice isoforms for FOXJ3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXJ3 Gene

Post-translational modifications for FOXJ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for FOXJ3 Gene

Domains & Families for FOXJ3 Gene

Gene Families for FOXJ3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXJ3 Gene

Suggested Antigen Peptide Sequences for FOXJ3 Gene

GenScript: Design optimal peptide antigens:
  • Forkhead box protein J3 (FOXJ3_HUMAN)
genes like me logo Genes that share domains with FOXJ3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXJ3 Gene

Function for FOXJ3 Gene

Molecular function for FOXJ3 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator of MEF2C involved in the regulation pf adult muscle fiber type identity and skeletal muscle regeneration.

Phenotypes From GWAS Catalog for FOXJ3 Gene

Gene Ontology (GO) - Molecular Function for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IC --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
genes like me logo Genes that share ontologies with FOXJ3: view
genes like me logo Genes that share phenotypes with FOXJ3: view

Animal Models for FOXJ3 Gene

MGI Knock Outs for FOXJ3:
  • Foxj3 Foxj3<tm1b(EUCOMM)Wtsi>

Animal Model Products

CRISPR Products

miRNA for FOXJ3 Gene

miRTarBase miRNAs that target FOXJ3

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXJ3

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXJ3 Gene

Localization for FOXJ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXJ3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXJ3 gene
Compartment Confidence
nucleus 4
plasma membrane 1
extracellular 1
cytoskeleton 1
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with FOXJ3: view

Pathways & Interactions for FOXJ3 Gene

PathCards logo

SuperPathways for FOXJ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXJ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0045944 positive regulation of transcription by RNA polymerase II IDA 22740631
genes like me logo Genes that share ontologies with FOXJ3: view

No data available for Pathways by source and SIGNOR curated interactions for FOXJ3 Gene

Drugs & Compounds for FOXJ3 Gene

No Compound Related Data Available

Transcripts for FOXJ3 Gene

mRNA/cDNA for FOXJ3 Gene

4 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
9 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXJ3

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXJ3 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b
SP1: - - -
SP2: - -
SP3:
SP4:

Relevant External Links for FOXJ3 Gene

GeneLoc Exon Structure for
FOXJ3

Expression for FOXJ3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXJ3 Gene

Protein differential expression in normal tissues from HIPED for FOXJ3 Gene

This gene is overexpressed in Ovary (21.1), Blymphocyte (18.7), Placenta (9.6), Testis (8.1), and NK cells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXJ3 Gene



Protein tissue co-expression partners for FOXJ3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXJ3

SOURCE GeneReport for Unigene cluster for FOXJ3 Gene:

Hs.26023

Evidence on tissue expression from TISSUES for FOXJ3 Gene

  • Nervous system(4.6)
  • Lung(4.3)
  • Liver(4.2)
genes like me logo Genes that share expression patterns with FOXJ3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXJ3 Gene

Orthologs for FOXJ3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXJ3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXJ3 31 30
  • 99.68 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FOXJ3 31 30
  • 95.23 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FOXJ3 31 30
  • 95.18 (n)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 94 (a)
OneToMany
-- 31
  • 91 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia FOXJ3 31
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Foxj3 17 31 30
  • 92.27 (n)
rat
(Rattus norvegicus)
Mammalia Foxj3 30
  • 91.84 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxj3 30
  • 75.32 (n)
zebrafish
(Danio rerio)
Actinopterygii FOXJ3 31
  • 77 (a)
OneToOne
foxj3 30
  • 71.35 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToOne
Species where no ortholog for FOXJ3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXJ3 Gene

ENSEMBL:
Gene Tree for FOXJ3 (if available)
TreeFam:
Gene Tree for FOXJ3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXJ3: view image

Paralogs for FOXJ3 Gene

(12) SIMAP similar genes for FOXJ3 Gene using alignment to 5 proteins:

  • FOXJ3_HUMAN
  • C9JVP0_HUMAN
  • C9JXI1_HUMAN
  • F6VXT0_HUMAN
  • H7C1Y6_HUMAN
genes like me logo Genes that share paralogs with FOXJ3: view

Variants for FOXJ3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXJ3 Gene

SNP ID Clinical significance and condition Chr 01 pos Variation AA Info Type
rs1139978 - p.Thr377Pro
rs343376 - p.Val162Ala

Additional dbSNP identifiers (rs#s) for FOXJ3 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXJ3 Gene

Variant ID Type Subtype PubMed ID
esv22111 CNV loss 19812545
esv24371 CNV loss 19812545
esv2539470 CNV deletion 19546169
esv2663676 CNV deletion 23128226
esv2747530 CNV deletion 23290073
esv3306125 CNV mobile element insertion 20981092
esv3375211 CNV insertion 20981092
esv3414902 CNV insertion 20981092
esv3561304 CNV deletion 23714750
esv3585840 CNV loss 21293372
esv3585842 CNV loss 21293372
nsv1133845 CNV deletion 24896259
nsv1143447 CNV deletion 24896259
nsv688 CNV insertion 18451855
nsv958710 CNV deletion 24416366

Variation tolerance for FOXJ3 Gene

Residual Variation Intolerance Score: 23.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.36% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXJ3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXJ3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXJ3 Gene

Disorders for FOXJ3 Gene

Additional Disease Information for FOXJ3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for FOXJ3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXJ3 Gene

Publications for FOXJ3 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 41 54
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  3. Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10470851) Kikuno R … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 1999) 3 4 54
  4. Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3 54
  5. Genome-wide CRISPR screen identifies HNRNPL as a prostate cancer dependency regulating RNA splicing. (PMID: 28611215) Fei T … Brown M (Proceedings of the National Academy of Sciences of the United States of America 2017) 3 54

Products for FOXJ3 Gene

Sources for FOXJ3 Gene