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Aliases for FOXJ2 Gene

Aliases for FOXJ2 Gene

  • Forkhead Box J2 2 3 5
  • Fork Head Homologous X 3 4
  • FHX 3 4
  • Forkhead Box Protein J2 3
  • FOXJ2 Forkhead Factor 3

External Ids for FOXJ2 Gene

Previous GeneCards Identifiers for FOXJ2 Gene

  • GC12P008078
  • GC12P008079
  • GC12P008185
  • GC12P007996

Summaries for FOXJ2 Gene

GeneCards Summary for FOXJ2 Gene

FOXJ2 (Forkhead Box J2) is a Protein Coding gene. Diseases associated with FOXJ2 include Cardiomyopathy, Familial Hypertrophic, 3. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is FOXJ3.

UniProtKB/Swiss-Prot for FOXJ2 Gene

  • Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S.

Gene Wiki entry for FOXJ2 Gene

Additional gene information for FOXJ2 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXJ2 Gene

Genomics for FOXJ2 Gene

GeneHancer (GH) Regulatory Elements for FOXJ2 Gene

Promoters and enhancers for FOXJ2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12I008031 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 550.8 +1.3 1337 4.6 ARID4B SIN3A ZNF48 YY1 ETS1 TCF12 ZNF121 GLIS2 GATA2 KLF13 FOXJ2 C3AR1 POU5F1P3 M6PR ENSG00000256967 NECAP1
GH12I008079 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 22.7 +48.9 48929 3.7 HDGF PKNOX1 SMAD1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 NECAP1 ENSG00000279865 ENSG00000284697 FOXJ2 ENSG00000256967 M6PR POU5F1P3 LINC00612 C1RL-AS1 HADHAP2
GH12I008947 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.6 +919.5 919510 8.7 CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 YBX1 ZNF2 YY1 POLR2B M6PR KLRG1 LOC642846 LINC00612 PHC1 DDX12P ENSG00000213443 FOXJ2 ENSG00000257105
GH12I007890 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE dbSUPER 10.2 -141.2 -141204 2.8 ELF3 FOXA2 ARID4B DMAP1 ZNF48 RARA ETS1 SMARCC2 FOS ATF7 SLC2A14 NANOGP1 FOXJ2 ENSG00000255356 GC12M007881
GH12I007993 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -37.5 -37518 3 HDGF PKNOX1 ARNT SIN3A ZNF2 IRF4 ARID2 ZNF207 ZNF143 ATF7 RPS20P28 FOXJ2 DPPA3 HSPD1P12 RIMKLB GC12M007989
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FOXJ2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXJ2 gene promoter:

Genomic Locations for FOXJ2 Gene

Genomic Locations for FOXJ2 Gene
chr12:8,032,703-8,055,522
(GRCh38/hg38)
Size:
22,820 bases
Orientation:
Plus strand
chr12:8,185,299-8,208,118
(GRCh37/hg19)

Genomic View for FOXJ2 Gene

Genes around FOXJ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXJ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXJ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXJ2 Gene

Proteins for FOXJ2 Gene

  • Protein details for FOXJ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P0K8-FOXJ2_HUMAN
    Recommended name:
    Forkhead box protein J2
    Protein Accession:
    Q9P0K8
    Secondary Accessions:
    • A0AVK4
    • B2RMP3
    • Q96PS9
    • Q9NSN5

    Protein attributes for FOXJ2 Gene

    Size:
    574 amino acids
    Molecular mass:
    62395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for FOXJ2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOXJ2 Gene

Post-translational modifications for FOXJ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXJ2 Gene

No data available for DME Specific Peptides for FOXJ2 Gene

Domains & Families for FOXJ2 Gene

Gene Families for FOXJ2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXJ2 Gene

Suggested Antigen Peptide Sequences for FOXJ2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXJ2: view

No data available for UniProtKB/Swiss-Prot for FOXJ2 Gene

Function for FOXJ2 Gene

Molecular function for FOXJ2 Gene

UniProtKB/Swiss-Prot Function:
Transcriptional activator. Able to bind to two different type of DNA binding sites. Isoform FOXJ2.L behaves as a more potent transactivator than FOXJ2.S.

Phenotypes From GWAS Catalog for FOXJ2 Gene

Gene Ontology (GO) - Molecular Function for FOXJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10777590
GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA 10777590
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FOXJ2: view
genes like me logo Genes that share phenotypes with FOXJ2: view

Animal Model Products

CRISPR Products

miRNA for FOXJ2 Gene

miRTarBase miRNAs that target FOXJ2

Transcription Factor Targets for FOXJ2 Gene

Selected GeneGlobe predicted Target genes for FOXJ2

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models and HOMER Transcription for FOXJ2 Gene

Localization for FOXJ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXJ2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXJ2 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli fibrillar center (3)
  • Nucleus (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001650 fibrillar center IDA --
GO:0005634 nucleus IBA,IDA --
genes like me logo Genes that share ontologies with FOXJ2: view

Pathways & Interactions for FOXJ2 Gene

SuperPathways for FOXJ2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXJ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006366 transcription by RNA polymerase II IEA --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXJ2: view

No data available for Pathways by source and SIGNOR curated interactions for FOXJ2 Gene

Drugs & Compounds for FOXJ2 Gene

No Compound Related Data Available

Transcripts for FOXJ2 Gene

Unigene Clusters for FOXJ2 Gene

Forkhead box J2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXJ2 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1:
SP2:
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for FOXJ2 Gene

GeneLoc Exon Structure for
FOXJ2
ECgene alternative splicing isoforms for
FOXJ2

Expression for FOXJ2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXJ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FOXJ2 Gene

This gene is overexpressed in Fetal gut (16.3), Blymphocyte (12.6), Pancreas (10.8), and CD8 Tcells (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for FOXJ2 Gene



Protein tissue co-expression partners for FOXJ2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXJ2 Gene:

FOXJ2

SOURCE GeneReport for Unigene cluster for FOXJ2 Gene:

Hs.120844

mRNA Expression by UniProt/SwissProt for FOXJ2 Gene:

Q9P0K8-FOXJ2_HUMAN
Tissue specificity: Widely expressed.

Evidence on tissue expression from TISSUES for FOXJ2 Gene

  • Lung(4.2)
  • Liver(4.1)
genes like me logo Genes that share expression patterns with FOXJ2: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXJ2 Gene

Orthologs for FOXJ2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXJ2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXJ2 33 34
  • 99.3 (n)
dog
(Canis familiaris)
Mammalia FOXJ2 33 34
  • 91.83 (n)
cow
(Bos Taurus)
Mammalia FOXJ2 33 34
  • 87.2 (n)
mouse
(Mus musculus)
Mammalia Foxj2 33 16 34
  • 87.08 (n)
rat
(Rattus norvegicus)
Mammalia Foxj2 33
  • 86.51 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXJ2 34
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOXJ2 34
  • 69 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOXJ2 33 34
  • 77.78 (n)
lizard
(Anolis carolinensis)
Reptilia FOXJ2 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxj2 33
  • 63.81 (n)
zebrafish
(Danio rerio)
Actinopterygii foxj2 34
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 45 (a)
ManyToMany
Species where no ortholog for FOXJ2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXJ2 Gene

ENSEMBL:
Gene Tree for FOXJ2 (if available)
TreeFam:
Gene Tree for FOXJ2 (if available)

Paralogs for FOXJ2 Gene

(1) SIMAP similar genes for FOXJ2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXJ2: view

Variants for FOXJ2 Gene

Sequence variations from dbSNP and Humsavar for FOXJ2 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1000085491 -- 8,034,751(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000118499 -- 8,034,466(+) G/A genic_upstream_transcript_variant, intron_variant
rs1000292358 -- 8,043,715(+) A/G coding_sequence_variant, synonymous_variant
rs1000392816 -- 8,051,224(+) G/T intron_variant
rs1000445085 -- 8,050,614(+) C/A/T coding_sequence_variant, missense_variant, stop_gained

Structural Variations from Database of Genomic Variants (DGV) for FOXJ2 Gene

Variant ID Type Subtype PubMed ID
esv2751118 CNV gain 17911159
esv2759877 CNV gain+loss 17122850
esv3580549 CNV gain 25503493
esv3628444 CNV loss 21293372
esv3628445 CNV gain 21293372
esv3628457 CNV gain 21293372
nsv1045521 CNV gain 25217958
nsv428270 CNV gain 18775914

Variation tolerance for FOXJ2 Gene

Residual Variation Intolerance Score: 36.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.05; 37.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXJ2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXJ2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXJ2 Gene

Disorders for FOXJ2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXJ2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
cardiomyopathy, familial hypertrophic, 3
  • cmh3
- elite association - COSMIC cancer census association via MalaCards
Search FOXJ2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOXJ2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FOXJ2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXJ2 Gene

Publications for FOXJ2 Gene

  1. FHX.L and FHX.S, two isoforms of the human fork-head factor FHX (FOXJ2) with differential activity. (PMID: 10966786) Pérez-Sánchez C … Rey-Campos J (Journal of molecular biology 2000) 2 3 4 22 58
  2. FHX, a novel fork head factor with a dual DNA binding specificity. (PMID: 10777590) Pérez-Sánchez C … Rey-Campos J (The Journal of biological chemistry 2000) 2 3 4 58
  3. Risk of meningioma and common variation in genes related to innate immunity. (PMID: 20406964) Rajaraman P … Inskip PD (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2010) 3 44 58
  4. Polymorphisms in innate immunity genes and risk of childhood leukemia. (PMID: 20438785) Han S … Kang D (Human immunology 2010) 3 44 58
  5. Candidate gene analysis in primary lymphedema. (PMID: 18564921) Ferrell RE … Finegold DN (Lymphatic research and biology 2008) 3 44 58

Products for FOXJ2 Gene

Sources for FOXJ2 Gene

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