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Aliases for FOXI3 Gene

Aliases for FOXI3 Gene

  • Forkhead Box I3 2 3 5

External Ids for FOXI3 Gene

Previous GeneCards Identifiers for FOXI3 Gene

  • GC02M088520
  • GC02M088747
  • GC02M087669

Summaries for FOXI3 Gene

GeneCards Summary for FOXI3 Gene

FOXI3 (Forkhead Box I3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXI1.

UniProtKB/Swiss-Prot for FOXI3 Gene

  • Possible transcriptional factor.

Additional gene information for FOXI3 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXI3 Gene

Genomics for FOXI3 Gene

GeneHancer (GH) Regulatory Elements for FOXI3 Gene

Promoters and enhancers for FOXI3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I088452 Promoter 1.4 EPDnew Ensembl 550.8 +0.1 55 0.8 ZNF777 ZNF449 ZBTB8A ZNF335 E2F1 CBX8 HDAC2 POLR2A ZFX ZBTB26 FOXI3 RNU6-1007P ENSG00000224291
GH02I088503 Enhancer 0.5 FANTOM5 3.2 -51.1 -51100 0.4 CTCF PKNOX1 MTA3 NFATC3 GTF2A2 TEX37 EIF2AK3 FOXI3 PIR49195 GC02M088487
GH02I088442 Enhancer 0.6 ENCODE 0.4 +9.1 9103 2.3 BACH1 MAFG ZNF316 MAFF POU5F1 NFE2 EMSY MAFK TEX37 RNU6-1007P LOC101928403 FOXI3 ENSG00000224291
GH02I088471 Enhancer 0.3 ENCODE 0.4 -19.1 -19105 0.6 SIN3A RPIA FOXI3 GC02M088487
GH02I088443 Enhancer 0.2 ENCODE 0.4 +10.4 10379 0.2 RNU6-1007P FOXI3 ENSG00000224291
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FOXI3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXI3 gene promoter:

Genomic Locations for FOXI3 Gene

Genomic Locations for FOXI3 Gene
chr2:88,446,787-88,452,656
(GRCh38/hg38)
Size:
5,870 bases
Orientation:
Minus strand
chr2:88,747,726-88,752,131
(GRCh37/hg19)

Genomic View for FOXI3 Gene

Genes around FOXI3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXI3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXI3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXI3 Gene

Proteins for FOXI3 Gene

  • Protein details for FOXI3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MTJ6-FOXI3_HUMAN
    Recommended name:
    Forkhead box protein I3
    Protein Accession:
    A8MTJ6
    Secondary Accessions:
    • B5RI09

    Protein attributes for FOXI3 Gene

    Size:
    420 amino acids
    Molecular mass:
    43326 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXI3 Gene

Post-translational modifications for FOXI3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXI3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXI3 Gene

Domains & Families for FOXI3 Gene

Gene Families for FOXI3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for FOXI3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXI3: view

No data available for UniProtKB/Swiss-Prot for FOXI3 Gene

Function for FOXI3 Gene

Molecular function for FOXI3 Gene

UniProtKB/Swiss-Prot Function:
Possible transcriptional factor.

Gene Ontology (GO) - Molecular Function for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXI3: view
genes like me logo Genes that share phenotypes with FOXI3: view

Animal Models for FOXI3 Gene

MGI Knock Outs for FOXI3:

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for FOXI3 Gene

Localization for FOXI3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXI3 Gene

Gene Ontology (GO) - Cellular Components for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXI3: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for FOXI3 Gene

Pathways & Interactions for FOXI3 Gene

SuperPathways for FOXI3 Gene

No Data Available

Interacting Proteins for FOXI3 Gene

Selected Interacting proteins: A8MTJ6-FOXI3_HUMAN for FOXI3 Gene via IID

Symbol External ID(s) Details
CREBBP
EP300

Gene Ontology (GO) - Biological Process for FOXI3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXI3: view

No data available for Pathways by source and SIGNOR curated interactions for FOXI3 Gene

Drugs & Compounds for FOXI3 Gene

No Compound Related Data Available

Transcripts for FOXI3 Gene

mRNA/cDNA for FOXI3 Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXI3 Gene

Forkhead box I3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXI3 Gene

No ASD Table

Relevant External Links for FOXI3 Gene

GeneLoc Exon Structure for
FOXI3
ECgene alternative splicing isoforms for
FOXI3

Expression for FOXI3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXI3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXI3 Gene

This gene is overexpressed in Testis (x21.8), Skin - Not Sun Exposed (Suprapubic) (x9.2), Pituitary (x6.2), and Skin - Sun Exposed (Lower leg) (x5.7).

NURSA nuclear receptor signaling pathways regulating expression of FOXI3 Gene:

FOXI3

SOURCE GeneReport for Unigene cluster for FOXI3 Gene:

Hs.716722
genes like me logo Genes that share expression patterns with FOXI3: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXI3 Gene

Orthologs for FOXI3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for FOXI3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXI3 33
  • 98.56 (n)
cow
(Bos Taurus)
Mammalia FOXI3 33
  • 85.71 (n)
dog
(Canis familiaris)
Mammalia FOXI3 33
  • 83.97 (n)
mouse
(Mus musculus)
Mammalia Foxi3 33 16
  • 79.55 (n)
rat
(Rattus norvegicus)
Mammalia Foxi3 33
  • 78.39 (n)
chicken
(Gallus gallus)
Aves FOXI3 33
  • 65.84 (n)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxi4.1 33
  • 61.17 (n)
zebrafish
(Danio rerio)
Actinopterygii foxi2 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.11012 33
Species where no ortholog for FOXI3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXI3 Gene

ENSEMBL:
Gene Tree for FOXI3 (if available)
TreeFam:
Gene Tree for FOXI3 (if available)

Paralogs for FOXI3 Gene

(6) SIMAP similar genes for FOXI3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXI3: view

Variants for FOXI3 Gene

Sequence variations from dbSNP and Humsavar for FOXI3 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000990640 -- 88,449,183(-) T/C intron_variant
rs1001058870 -- 88,452,228(-) C/A coding_sequence_variant, missense_variant
rs1001093258 -- 88,451,757(-) A/G intron_variant
rs1002036825 -- 88,449,580(-) G/A intron_variant
rs1003043119 -- 88,451,039(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXI3 Gene

Variant ID Type Subtype PubMed ID
dgv1950n106 CNV deletion 24896259
dgv61n16 CNV deletion 17901297
dgv6947n54 CNV gain 21841781
nsv1072005 CNV deletion 25765185
nsv1130752 CNV deletion 24896259
nsv1148611 CNV deletion 26484159
nsv458596 CNV gain 19166990
nsv470476 CNV gain 18288195
nsv582383 CNV gain 21841781
nsv582384 CNV loss 21841781
nsv582386 CNV loss 21841781
nsv582387 CNV gain 21841781

Additional Variant Information for FOXI3 Gene

Human Gene Mutation Database (HGMD)
FOXI3
SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXI3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FOXI3 Gene

Disorders for FOXI3 Gene

Additional Disease Information for FOXI3

No disorders were found for FOXI3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXI3 Gene

Publications for FOXI3 Gene

  1. A mutation in hairless dogs implicates FOXI3 in ectodermal development. (PMID: 18787161) Drögemüller C … Leeb T (Science (New York, N.Y.) 2008) 2 3 4 58
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  3. Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. (PMID: 7566098) Adams MD … White O (Nature 1995) 3 58
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3

Products for FOXI3 Gene

Sources for FOXI3 Gene

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