Aliases for FOXH1 Gene
External Ids for FOXH1 Gene
Previous GeneCards Identifiers for FOXH1 Gene
FOXH1 encodes a human homolog of Xenopus forkhead activin signal transducer-1. FOXH1 protein binds SMAD2 and activates an activin response element via binding the DNA motif TGT(G/T)(T/G)ATT. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXH1 Gene
FOXH1 (Forkhead Box H1) is a Protein Coding gene. Diseases associated with FOXH1 include Septopreoptic Holoprosencephaly and Midline Interhemispheric Variant Of Holoprosencephaly. Among its related pathways are TGF-Beta Pathway and Heart Development. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and protein domain specific binding. An important paralog of this gene is FOXD2.
UniProtKB/Swiss-Prot Summary for FOXH1 Gene
Transcriptional activator. Recognizes and binds to the DNA sequence 5'-TGT[GT][GT]ATT-3'. Required for induction of the goosecoid (GSC) promoter by TGF-beta or activin signaling. Forms a transcriptionally active complex containing FOXH1/SMAD2/SMAD4 on a site on the GSC promoter called TARE (TGF-beta/activin response element).