Aliases for FOXG1 Gene
Aliases for FOXG1 Gene
- Forkhead Box G1 2 3 5
- Brain Factor 1 2 3 4
- Brain Factor 2 3 4
- FOXG1A 3 4
- FOXG1B 3 4
- FOXG1C 3 4
- HBF-2 3 4
- FKHL1 3 4
- FKHL2 3 4
- FKHL3 3 4
- FKHL4 3 4
- FKH2 3 4
- HFK1 3 4
- HFK2 3 4
- HFK3 3 4
- BF1 3 4
- BF2 3 4
- Forkhead-Related Protein FKHL1 4
- Forkhead-Related Protein FKHL2 4
- Forkhead-Related Protein FKHL3 4
- Forkhead Box Protein G1A 4
External Ids for FOXG1 Gene
- HGNC: 3811
- Entrez Gene: 2290
- Ensembl: ENSG00000176165
- OMIM: 164874
- UniProtKB: P55316
Previous HGNC Symbols for FOXG1 Gene
- FKHL2
- FOXG1B
- FKHL4
- FKH2
- FKHL1
- FOXG1C
- FKHL3
- FOXG1A
Previous GeneCards Identifiers for FOXG1 Gene
- GC14P028306
- GC14P029235
- GC14P009354
Summaries for FOXG1 Gene
-
This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012]
GeneCards Summary for FOXG1 Gene
FOXG1 (Forkhead Box G1) is a Protein Coding gene. Diseases associated with FOXG1 include Rett Syndrome, Congenital Variant and Rett Syndrome. Among its related pathways are FoxO signaling pathway and Regulation of nuclear SMAD2/3 signaling. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXD2.
UniProtKB/Swiss-Prot for FOXG1 Gene
-
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
Additional gene information for FOXG1 Gene
- Monarch Initiative
- Search for FOXG1 at DataMed
- Search for FOXG1 at HumanCyc
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXG1 Gene
Genomics for FOXG1 Gene
GeneHancer (GH) Regulatory Elements for FOXG1 Gene
Promoters and enhancers for FOXG1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH14J028759 | Enhancer | 0.8 | FANTOM5 ENCODE dbSUPER | 659.7 | -0.8 | -779 | 0.3 | MAFK EZH2 | FOXG1 FOXG1-AS1 BTF3P2 | |
| GH14J028761 | Enhancer | 0.5 | dbSUPER | 650.7 | +1.7 | 1728 | 2 | POLR2A CEBPA ATF7 EZH2 | FOXG1 FOXG1-AS1 | |
| GH14J028760 | Enhancer | 0.4 | dbSUPER | 650.7 | -0.2 | -197 | 0.2 | POLR2A SUZ12 EZH2 | FOXG1 FOXG1-AS1 BTF3P2 | |
| GH14J028762 | Enhancer | 0.3 | dbSUPER | 650.7 | -1.1 | -1143 | 0.2 | EZH2 | FOXG1 FOXG1-AS1 BTF3P2 | |
| GH14J028774 | Enhancer | 1.2 | FANTOM5 ENCODE dbSUPER | 23.8 | +14.4 | 14413 | 0.5 | CTCF SUZ12 RAD21 ZNF2 POLR2A PRDM10 ZNF600 EZH2 ZBTB20 ZNF654 | FOXG1 LINC01551 LINC02282 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXG1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FOXG1 gene promoter:
-
- FOXO4
- POU2F1
- HFH-1
- Oct-B1
- oct-B2
- oct-B3
- POU2F1a
- POU2F2
- POU2F2 (Oct-2.1)
Regulatory Element Products
Genomic Locations for FOXG1 Gene
Genomic Locations for FOXG1 Gene
- chr14:28,760,330-28,770,277
- (GRCh38/hg38)
- Size:
- 9,948 bases
- Orientation:
- Plus strand
- chr14:29,235,050-29,238,871
- (GRCh37/hg19)
- Size:
- 3,822 bases
- Orientation:
- Plus strand
Genomic View for FOXG1 Gene
Genes around FOXG1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q12 by Entrez Gene
- 14q12 by HGNC
- 14q12 by Ensembl
FOXG1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXG1 Gene
Proteins for FOXG1 Gene
-
Protein details for FOXG1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55316-FOXG1_HUMAN
- Recommended name:
- Forkhead box protein G1
- Protein Accession:
- P55316
- A6NFY2
- P55315
- Q14488
- Q86XT7
Protein attributes for FOXG1 Gene
- Size:
- 489 amino acids
- Molecular mass:
- 52352 Da
- Quaternary structure:
-
- Interacts with KDM5B.
Protein Expression for FOXG1 Gene
Post-translational modifications for FOXG1 Gene
Other Protein References for FOXG1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for FOXG1
-
Abcam antibodies for FOXG1
- Invitrogen Antibodies for FOXG1 (AFLGC-FOXG1)
- GeneTex FOXG1 Antibody for FOXG1
-
Custom Antibody ServicesProSci Antibodies for FOXG1
Protein Products
-
OriGene Purified Proteins for FOXG1
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXG1
- Origene Custom Protein Services for FOXG1
- Search GeneTex for Proteins for FOXG1
-
Abcam proteins for FOXG1
Assay Products
No data available for DME Specific Peptides for FOXG1 Gene
Domains & Families for FOXG1 Gene
Gene Families for FOXG1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXG1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXG1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FOXG1 Gene
Function for FOXG1 Gene
Molecular function for FOXG1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
LifeMap Function Summary for FOXG1 Gene
FOXG1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
-
and also in
Phenotypes From GWAS Catalog for FOXG1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS,IBA | 19274049 |
| GO:0003677 | DNA binding | TAS | 7957066 |
| GO:0003700 | DNA binding transcription factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 12657635 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for FOXG1 Gene
- MGI mutant phenotypes for FOXG1:
-
inferred from 4 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- integument phenotype
- taste/olfaction phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for FOXG1:
Animal Model Products
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-
CRISPR Products
-
OriGene CRISPR knockouts for FOXG1
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- genomics-online: gRNA clones - Search results for 89 available FOXG1A gene related products
- Overview of 89 available FOXG1A gene related products
- Applied Biological Materials CRISPR for FOXG1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXG1
- GenScript: Design CRISPR guide RNA sequences for FOXG1
miRNA for FOXG1 Gene
- miRTarBase miRNAs that target FOXG1
-
- hsa-mir-590-3p (MIRT016200)
- hsa-mir-26b-5p (MIRT029405)
- hsa-mir-30a-5p (MIRT069731)
- hsa-mir-30c-5p (MIRT069733)
- hsa-mir-30d-5p (MIRT069734)
- hsa-mir-30b-5p (MIRT069735)
- hsa-mir-124-5p (MIRT069736)
- hsa-mir-153-5p (MIRT069737)
- hsa-mir-30e-5p (MIRT069738)
- hsa-mir-376a-3p (MIRT069739)
- hsa-mir-376b-3p (MIRT069740)
- hsa-mir-4504 (MIRT069744)
- hsa-mir-200b-3p (MIRT278144)
- hsa-mir-422a (MIRT341338)
- hsa-mir-6867-5p (MIRT405781)
- hsa-mir-6853-3p (MIRT557831)
- hsa-mir-1206 (MIRT557832)
- hsa-mir-4652-3p (MIRT567506)
- hsa-mir-4743-3p (MIRT567507)
- hsa-mir-654-3p (MIRT658114)
- hsa-mir-586 (MIRT658115)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXG1
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- genomics-online: shRNA clones - Search results for 89 available FOXG1A gene related products
- Overview of 89 available FOXG1A gene related products
Clone Products
- Sino Biological Human cDNA Clone for FOXG1
- Addgene plasmids for FOXG1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXG1
- Applied Biological Materials Clones for FOXG1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FOXG1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FOXG1 Gene
Localization for FOXG1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXG1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 1 |
| mitochondrion | 1 |
| cytosol | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXG1 Gene
Pathways & Interactions for FOXG1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FoxO signaling pathway | ||
| 2 | DNA Damage/Telomere Stress Induced Senescence | ||
| 3 | Regulation of nuclear SMAD2/3 signaling | ||
| 4 | Tgif disruption of Shh signaling | ||
Pathways by source for FOXG1 Gene
2 BioSystems pathways for FOXG1 Gene
1 KEGG pathway for FOXG1 Gene
1 GeneGo (Thomson Reuters) pathway for FOXG1 Gene
Interacting Proteins for FOXG1 Gene
GPS-Prot Interaction Network for FOXG1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0002052 | positive regulation of neuroblast proliferation | IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IBA,IEA | -- |
Transcripts for FOXG1 Gene
mRNA/cDNA for FOXG1 Gene
- (1) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (9) Selected AceView cDNA sequences:
- (8) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000636604 100 bps
- ENST00000637220 147 bps
- ENST00000636893 166 bps
- ENST00000637351 100 bps
- ENST00000637817 172 bps
Unigene Clusters for FOXG1 Gene
CRISPR Products
-
OriGene CRISPR knockouts for FOXG1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXG1
- genomics-online: gRNA clones - Search results for 89 available FOXG1A gene related products
- Overview of 89 available FOXG1A gene related products
- Applied Biological Materials CRISPR for FOXG1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXG1
- GenScript: Design CRISPR guide RNA sequences for FOXG1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXG1
- Browse OriGene Inhibitory RNA Products For FOXG1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXG1
- genomics-online: shRNA clones - Search results for 89 available FOXG1A gene related products
- Overview of 89 available FOXG1A gene related products
Clone Products
- Sino Biological Human cDNA Clone for FOXG1
- Addgene plasmids for FOXG1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXG1
- Applied Biological Materials Clones for FOXG1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FOXG1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Myoblasts Mandibular Arch Muscles
- Muscle Progenitor Cells Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
-
Neural Tube (Nervous System)
- Ventral Telencephalic Progenitor Cells Ventral Telencephalon
- Dorsal Telencephalic Progenitor Cells Dorsal Telencephalon
- Telencephalon
- Floating neuronal aggregates(Watanabe M et. al. 2012)
-
Ectoderm (Gastrulation Derivatives)
- Surface Ectoderm Cells Surface Ectoderm
- Ectoderm
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Neural Ectoderm (Nervous System)
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
-
Surface Ectoderm (Integumentary System)
- Surface Ectoderm Cells Surface Ectoderm
-
Epidermis (Integumentary System)
- Surface Ectoderm Cells Surface Ectoderm
-
Limb (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
- Head Mesenchyme (Muscoskeletal System)
- Gut Tube (Gastrointestinal Tract)
- NULL (Uncategorized)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for FOXG1 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.5), Brain - Cortex (x6.5), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Nucleus accumbens (basal ganglia) (x6.1), Brain - Putamen (basal ganglia) (x5.8), Brain - Caudate (basal ganglia) (x5.7), Brain - Hippocampus (x5.6), and Brain - Amygdala (x5.2).
This gene is overexpressed in Fetal Brain (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXG1 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of FOXG1 Gene:
FOXG1SOURCE GeneReport for Unigene cluster for FOXG1 Gene:
Hs.632336mRNA Expression by UniProt/SwissProt for FOXG1 Gene:
P55316-FOXG1_HUMAN
Tissue specificity:
Expression is restricted to the neurons of the developing telencephalon.
Evidence on tissue expression from TISSUES for FOXG1 Gene
- Nervous system(4.8)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXG1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- pharynx
- salivary gland
- skull
- tongue
- tooth
- vocal cord
Thorax:
- diaphragm
- esophagus
- heart
- heart valve
- lung
- rib
- rib cage
Abdomen:
- intestine
- large intestine
- stomach
Pelvis:
- pelvis
- rectum
Limb:
- arm
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
General:
- blood vessel
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for FOXG1
-
OriGene qPCR primer pairs and template standards for FOXG1
- genomics-online: primer clones - Search results for 89 available FOXG1A gene related products
- Overview of 89 available FOXG1A gene related products
Gene Expression Assay Products
Orthologs for FOXG1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | FOXG1 34 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | FOXG1 34 33 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FOXG1 33 |
|
||
| mouse (Mus musculus) |
Mammalia | Foxg1 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Foxg1 33 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FOXG1 34 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FOXG1 34 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FOXG1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FOXG1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | foxg1 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | foxg1b-A-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | foxg1a 34 33 |
|
OneToOne | |
| foxg1 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | slp1 34 |
|
OneToMany | |
| slp2 34 |
|
OneToMany | |||
| fd19B 34 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | fkh-2 34 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for FOXG1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for FOXG1 Gene
- ENSEMBL:
- Gene Tree for FOXG1 (if available)
- TreeFam:
- Gene Tree for FOXG1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXG1: view image
Paralogs for FOXG1 Gene
Paralogs for FOXG1 Gene
(1) SIMAP similar genes for FOXG1 Gene using alignment to 1 proteins:
- FOXG1_HUMAN
Variants for FOXG1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1057516138 | likely-pathogenic, Rett syndrome, congenital variant | 28,767,833(+) | G/T | coding_sequence_variant, missense_variant | |
| rs1057524328 | likely-benign, not specified, Rett syndrome, congenital variant | 28,768,599(+) | C/G | coding_sequence_variant, synonymous_variant | |
| rs1064797186 | uncertain-significance, likely-pathogenic, not provided, Rett syndrome, congenital variant | 28,767,964(+) | A/C | coding_sequence_variant, missense_variant | |
| rs112803404 | conflicting-interpretations-of-pathogenicity, uncertain-significance, likely-benign, not specified, not provided, Rett syndrome, congenital variant | 28,767,726(+) | C/G/T | coding_sequence_variant, synonymous_variant | |
| rs121913678 | pathogenic, Rett syndrome, congenital variant | 28,768,044(+) | G/A/T | coding_sequence_variant, missense_variant, stop_gained |
Residual Variation Intolerance Score:
31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXG1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXG1 Gene
Disorders for FOXG1 Gene
(15) MalaCards diseases for FOXG1 Gene - From: HGMD, OMIM, ClinVar, GTR, Orphanet, Swiss-Prot, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rett syndrome, congenital variant |
|
|
| rett syndrome |
|
|
| 14q12 microdeletion syndrome |
|
|
| 14q11.2 microduplication syndrome |
|
|
| foxg1 syndrome |
|
|
Search FOXG1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FOXG1_HUMAN- Rett syndrome congenital variant (RTTCV) [MIM:613454]: A severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements. {ECO:0000269 PubMed:19578037, ECO:0000269 PubMed:21280142, ECO:0000269 PubMed:26993267}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for FOXG1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for FOXG1 Gene
Publications for FOXG1 Gene
- Human brain factor 1, a new member of the fork head gene family. (PMID: 7959731) Murphy DB … Thies U (Genomics 1994) 2 3 4 22 58
- Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation. (PMID: 17260156) Bredenkamp N … Illing N (Development genes and evolution 2007) 2 3 4 58
- Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. (PMID: 12657635) Tan K … Freemont PS (The Journal of biological chemistry 2003) 3 4 22 58
- The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q. (PMID: 7599184) Wiese S … Thies U (Biochimica et biophysica acta 1995) 3 4 22 58
- A missense mutation within the fork-head domain of the forkhead box G1 Gene (FOXG1) affects its nuclear localization. (PMID: 21280142) Le Guen T … Bienvenu T (Human mutation 2011) 3 4 58
Products for FOXG1 Gene
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- OriGene qPCR primer pairs for FOXG1
- OriGene qPCR primer pairs and template standards for FOXG1
- OriGene CRISPR knockouts for FOXG1
- OriGene ORF clones in human for FOXG1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOXG1
- GenScript: Next-day shipping of latest version cDNA ORF clones for FOXG1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FOXG1
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- GenScript Custom overexpressing Cell Line Services for FOXG1
- GenScript: Design CRISPR guide RNA sequences for FOXG1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
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- Sino Biological Human cDNA Clone for FOXG1
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FOXG1
- Novus Biologicals lysates and proteins for FOXG1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for FOXG1
- Abcam proteins for FOXG1
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
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- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Invitrogen Antibodies for FOXG1 (AFLGC-FOXG1)
- Cyagen custom Knockout/knockin (KOKI) mouse models for FOXG1
- Addgene plasmids for FOXG1
- antibodies-online: Search results for 88 available FOXG1A Antibodies ranked by validation data
- Compare Top FOXG1A Antibodies
- antibodies-online: Search results for available FOXG1A related products ranked by validation data
- antibodies-online: Search results for 8 available FOXG1A Proteins ranked by validation data
- Compare Top FOXG1A Proteins
- GeneTex FOXG1 Antibody for FOXG1
- Search GeneTex for Proteins for FOXG1
- Custom Antibody ServicesProSci Antibodies for FOXG1
- Search for FOXG1 Proteins at ProSci
- Horizon Cell Lines for FOXG1
- genomics-online: cdna clones - Search results for 89 available FOXG1A gene related products
- Overview of 89 available FOXG1A gene related products
- orf clones - Search results for 89 available FOXG1A gene related products
- Overview of 89 available FOXG1A gene related products
- genomics-online: gRNA clones - Search results for 89 available FOXG1A gene related products
- Overview of 89 available FOXG1A gene related products
- genomics-online: primer clones - Search results for 89 available FOXG1A gene related products
- Overview of 89 available FOXG1A gene related products
- genomics-online: shRNA clones - Search results for 89 available FOXG1A gene related products
- Overview of 89 available FOXG1A gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXG1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXG1
- GeneCopoeia miRNA 3'UTR Target clone products for FOXG1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXG1
Sources for FOXG1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt