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This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012] See more...
Aliases for FOXG1 Gene
Aliases for FOXG1 Gene
- Forkhead-Related Protein FKHL3 4
- Forkhead Box Protein G1A 4
- Forkhead Box Protein G1B 4
- Forkhead Box Protein G1C 4
- Forkhead Box G1B 2
- Forkhead Box G1C 2
- Forkhead Box G1A 2
- Forkhead-Like 1 3
- Forkhead-Like 2 3
- Forkhead-Like 3 3
- Forkhead-Like 4 3
- Oncogene QIN 3
- HBF-G2 3
- FHKL3 3
- HBF-1 3
- HBF-3 3
- HBF2 3
- KHL2 3
- BF-1 4
- BF-2 4
- QIN 3
External Ids for FOXG1 Gene
- HGNC: 3811
- Entrez Gene: 2290
- Ensembl: ENSG00000176165
- OMIM: 164874
- UniProtKB: P55316
Previous HGNC Symbols for FOXG1 Gene
- FKHL2
- FOXG1B
- FKHL4
- FKH2
- FKHL1
- FOXG1C
- FKHL3
- FOXG1A
Previous GeneCards Identifiers for FOXG1 Gene
- GC14P028306
- GC14P029235
- GC14P009354
Summaries for FOXG1 Gene
-
This locus encodes a member of the forked-head transcription factor family. The encoded protein, which functions as a repressor, may play a role in brain development. Mutations at this locus have been associated with Rett syndrome. [provided by RefSeq, Feb 2012]
GeneCards Summary for FOXG1 Gene
FOXG1 (Forkhead Box G1) is a Protein Coding gene. Diseases associated with FOXG1 include Rett Syndrome, Congenital Variant and Rett Syndrome. Among its related pathways are DNA Damage/Telomere Stress Induced Senescence and Regulation of nuclear SMAD2/3 signaling. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and sequence-specific DNA binding. An important paralog of this gene is FOXF2.
UniProtKB/Swiss-Prot Summary for FOXG1 Gene
-
Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
Additional gene information for FOXG1 Gene
- Monarch Initiative
- Search for FOXG1 at DataMed
- Search for FOXG1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXG1 Gene
Genomics for FOXG1 Gene
GeneHancer (GH) Regulatory Elements for FOXG1 Gene
Promoters and enhancers for FOXG1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH14J028756 | Promoter/Enhancer | 2.4 | VISTA UCNEbase FANTOM5 Ensembl ENCODE dbSUPER | 509.6 | +1.7 | 1655 | 13.6 | HNRNPK EP300 CTCF ZSCAN5C NONO ZNF639 ZBTB10 TCF7 ZNF423 ZNF623 | FOXG1 LINC02282 FOXG1-AS1 | |
| GH14J028775 | Enhancer | 1.3 | VISTA FANTOM5 ENCODE dbSUPER | 23.8 | +14.5 | 14461 | 2.4 | CTCF ZNF10 ZBTB26 RAD21 EZH2 SRSF1 SMC3 ZNF263 POU2F2 ZNF189 | FOXG1 LINC01551 LINC02282 | |
| GH14J028876 | Enhancer | 1 | UCNEbase FANTOM5 Ensembl | 6.4 | +116.2 | 116171 | 1 | EP300 ZSCAN5C ZNF10 PRDM6 TCF7L2 TRIM28 PKNOX1 ZBTB20 POLR2A | FOXG1 lnc-FOXG1-8 lnc-FOXG1-12 LINC02327 LINC02326 | |
| GH14J028377 | Enhancer | 0.2 | FANTOM5 | 2.5 | -382.4 | -382421 | 0.3 | FOXG1 piR-39858-171 piR-41525-177 ENSG00000257869 | ||
| GH14J028769 | Enhancer | 0.7 | UCNEbase dbSUPER | 0.4 | +9.2 | 9186 | 0.3 | FOXA2 CBX8 EZH2 | FOXG1-AS1 LINC01551 FOXG1 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXG1 on UCSC Golden Path with GeneCards custom track
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXG1
- Top Transcription factor binding sites by QIAGEN in the FOXG1 gene promoter:
-
- FOXO4
- HFH-1
- Oct-B1
- oct-B2
- oct-B3
- POU2F1
- POU2F1a
- POU2F2
- POU2F2 (Oct-2.1)
Genomic Locations for FOXG1 Gene
Genomic Locations for FOXG1 Gene
- chr14:28,760,330-28,770,277
- (GRCh38/hg38)
- Size:
- 9,948 bases
- Orientation:
- Plus strand
- chr14:29,235,050-29,238,871
- (GRCh37/hg19)
- Size:
- 3,822 bases
- Orientation:
- Plus strand
Genomic View for FOXG1 Gene
Genes around FOXG1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q12 by HGNC
- 14q12 by Entrez Gene
- 14q12 by Ensembl
FOXG1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXG1 Gene
Proteins for FOXG1 Gene
-
Protein details for FOXG1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55316-FOXG1_HUMAN
- Recommended name:
- Forkhead box protein G1
- Protein Accession:
- P55316
- A6NFY2
- P55315
- Q14488
- Q86XT7
Protein attributes for FOXG1 Gene
- Size:
- 489 amino acids
- Molecular mass:
- 52352 Da
- Quaternary structure:
-
- Interacts with KDM5B.
Protein Expression for FOXG1 Gene
Post-translational modifications for FOXG1 Gene
Other Protein References for FOXG1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents FOXG1 Antibody
- Creative Diagnostics Anti-FOXG1 monoclonal antibody, clone nBcdbn 62885 [FITC]
- Creative Biolabs Recombinant Mouse Anti-Human FOXG1 Antibody (clone nBcdbn 62885)
- Novus Biologicals Antibodies for FOXG1
-
Abcam antibodies for FOXG1
- Invitrogen Antibodies for FOXG1 (AFLGC-FOXG1)
-
Custom Antibody ServicesProSci Antibodies for FOXG1
Protein Products
- Creative Biomart Recombinant Human FOXG1
-
OriGene Purified Proteins for FOXG1
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXG1
- Origene Custom Protein Services for FOXG1
- antibodies-online: Show 8 available FOXG1 Proteins ranked by validation data
- Compare Top FOXG1 Proteins
-
Quality Products:
-
Abcam proteins for FOXG1
No data available for DME Specific Peptides for FOXG1 Gene
Domains & Families for FOXG1 Gene
Gene Families for FOXG1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Disease related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXG1 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXG1 Gene
- GenScript: Design optimal peptide antigens:
-
- Forkhead-related protein FKHL3 (FOXG1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXG1 Gene
Function for FOXG1 Gene
Molecular function for FOXG1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
LifeMap Function Summary for FOXG1 Gene
FOXG1 as growth factor is involved in stem cell differentiation protocols towards the derivation of the following cells:
-
and also in
Phenotypes From GWAS Catalog for FOXG1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0003677 | DNA binding | TAS | 7957066 |
| GO:0003700 | DNA-binding transcription factor activity | IEA | -- |
| GO:0005515 | protein binding | IPI | 12657635 |
| GO:0043565 | sequence-specific DNA binding | IEA | -- |
Phenotypes for FOXG1 Gene
- MGI mutant phenotypes for FOXG1:
-
inferred from 4 alleles
- cardiovascular system phenotype
- respiratory system phenotype
- pigmentation phenotype
- vision/eye phenotype
- digestive/alimentary phenotype
- homeostasis/metabolism phenotype
- nervous system phenotype
- behavior/neurological phenotype
- integument phenotype
- taste/olfaction phenotype
- endocrine/exocrine gland phenotype
- mortality/aging
- cellular phenotype
- muscle phenotype
- craniofacial phenotype
- skeleton phenotype
- embryo phenotype
- normal phenotype
- hearing/vestibular/ear phenotype
- hematopoietic system phenotype
- immune system phenotype
- growth/size/body region phenotype
- GenomeRNAi human phenotypes for FOXG1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXG1 - Select products 50% OFF >
- * FOXG1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXG1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXG1
- genomics-online: gRNA clones - Search for available FOXG1 gRNA products
- Overview of 108 available FOXG1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXG1
miRNA for FOXG1 Gene
- miRTarBase miRNAs that target FOXG1
-
- hsa-mir-590-3p (MIRT016200)
- hsa-mir-26b-5p (MIRT029405)
- hsa-mir-30a-5p (MIRT069731)
- hsa-mir-30c-5p (MIRT069733)
- hsa-mir-30d-5p (MIRT069734)
- hsa-mir-30b-5p (MIRT069735)
- hsa-mir-124-5p (MIRT069736)
- hsa-mir-153-5p (MIRT069737)
- hsa-mir-30e-5p (MIRT069738)
- hsa-mir-376a-3p (MIRT069739)
- hsa-mir-376b-3p (MIRT069740)
- hsa-mir-4504 (MIRT069744)
- hsa-mir-200b-3p (MIRT278144)
- hsa-mir-422a (MIRT341338)
- hsa-mir-6867-5p (MIRT405781)
- hsa-mir-6853-3p (MIRT557831)
- hsa-mir-1206 (MIRT557832)
- hsa-mir-4652-3p (MIRT567506)
- hsa-mir-4743-3p (MIRT567507)
- hsa-mir-654-3p (MIRT658114)
- hsa-mir-586 (MIRT658115)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXG1
- Browse OriGene Inhibitory RNA Products For FOXG1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXG1
- genomics-online: shRNA clones - Search for available FOXG1 shRNA products
- Overview of 108 available FOXG1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for FOXG1 - Select products 50% OFF >
- * FOXG1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FOXG1
- Addgene plasmids for FOXG1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXG1
- genomics-online: cdna clones - Search for available FOXG1 CDNA products
- Overview of 108 available FOXG1 gene related products
- orf clones - Search for available FOXG1 ORF products
- Overview of 108 available FOXG1 gene related products
Cell Line Products
-
Horizon Cell Lines for FOXG1
No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for FOXG1 Gene
Localization for FOXG1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXG1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IEA | -- |
| GO:0005654 | nucleoplasm | TAS | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for FOXG1 Gene
Pathways & Interactions for FOXG1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | FoxO signaling pathway | ||
| 2 | DNA Damage/Telomere Stress Induced Senescence |
Signal transduction Activin A signaling regulation
.38
|
|
| 3 | Regulation of nuclear SMAD2/3 signaling | ||
| 4 | Tgif disruption of Shh signaling | ||
Pathways by source for FOXG1 Gene
2 BioSystems pathways for FOXG1 Gene
1 KEGG pathway for FOXG1 Gene
1 GeneGo (Thomson Reuters) pathway for FOXG1 Gene
- Signal transduction Activin A signaling regulation
Interacting Proteins for FOXG1 Gene
GPS-Prot Interaction Network for FOXG1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0002052 | positive regulation of neuroblast proliferation | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0007275 | multicellular organism development | IEA | -- |
Drugs & Compounds for FOXG1 Gene
No Compound Related Data Available
Drug Products
- Creative Biomart Recombinant Human FOXG1
Transcripts for FOXG1 Gene
mRNA/cDNA for FOXG1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000313071 3491 bps (ENST00000313071.7)
- ENST00000636346 111 bps (ENST00000636346.1)
- ENST00000636353 158 bps (ENST00000636353.1)
- ENST00000636604 100 bps (ENST00000636604.1)
- ENST00000636893 166 bps (ENST00000636893.1)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXG1 - Select products 50% OFF >
- * FOXG1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXG1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXG1
- genomics-online: gRNA clones - Search for available FOXG1 gRNA products
- Overview of 108 available FOXG1 gene related products
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXG1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXG1
- Browse OriGene Inhibitory RNA Products For FOXG1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXG1
- genomics-online: shRNA clones - Search for available FOXG1 shRNA products
- Overview of 108 available FOXG1 gene related products
Clone Products
- Applied Biological Materials (abm): Clones for FOXG1 - Select products 50% OFF >
- * FOXG1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FOXG1
- Addgene plasmids for FOXG1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXG1
- genomics-online: cdna clones - Search for available FOXG1 CDNA products
- Overview of 108 available FOXG1 gene related products
- orf clones - Search for available FOXG1 ORF products
- Overview of 108 available FOXG1 gene related products
Relevant External Links for FOXG1 Gene
- GeneLoc Exon Structure for
- FOXG1
Expression for FOXG1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Skeletal Muscle (Muscoskeletal System)
- Mononuclear Myocytes Hyoid Arch Muscles
- Mononuclear Myocytes Mandibular Arch Muscles
- Myoblasts Mandibular Arch Muscles
- Muscle Progenitor Cells Mandibular Arch Muscles
- Myoblasts Hyoid Arch Muscles
-
Neural Tube (Nervous System)
- Ventral Telencephalic Progenitor Cells Ventral Telencephalon
- Dorsal Telencephalic Progenitor Cells Dorsal Telencephalon
- Telencephalon
- Floating neuronal aggregates(Watanabe M et. al. 2012)
-
Ectoderm (Gastrulation Derivatives)
- Surface Ectoderm Cells Surface Ectoderm
- Ectoderm
-
Brain (Nervous System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
-
Endothelium (Cardiovascular System)
- Mature Endothelial Cells Blood Brain Barrier
- Endothelial Cells Blood Brain Barrier
- Neural Ectoderm (Nervous System)
-
Ovary (Reproductive System)
- Cumulus Cells Antral Follicle
-
Surface Ectoderm (Integumentary System)
- Surface Ectoderm Cells Surface Ectoderm
-
Epidermis (Integumentary System)
- Surface Ectoderm Cells Surface Ectoderm
-
Limb (Muscoskeletal System)
- Limb Muscle Progenitor Cells Forelimb Myotome
- Head Mesenchyme (Muscoskeletal System)
- Gut Tube (Gastrointestinal Tract)
- NULL (Uncategorized)
-
Placenta (Extraembryonic Tissues)
mRNA differential expression in normal tissues according to GTEx for FOXG1 Gene
This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.5), Brain - Cortex (x6.5), Brain - Anterior cingulate cortex (BA24) (x6.4), Brain - Nucleus accumbens (basal ganglia) (x6.1), Brain - Putamen (basal ganglia) (x5.8), Brain - Caudate (basal ganglia) (x5.7), Brain - Hippocampus (x5.6), and Brain - Amygdala (x5.2).
This gene is overexpressed in Fetal Brain (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXG1 Gene
- Elite partner
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXG1
SOURCE GeneReport for Unigene cluster for FOXG1 Gene:
Hs.632336mRNA Expression by UniProt/SwissProt for FOXG1 Gene:
P55316-FOXG1_HUMAN
Tissue specificity:
Expression is restricted to the neurons of the developing telencephalon.
Evidence on tissue expression from TISSUES for FOXG1 Gene
- Nervous system(4.8)
Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXG1 Gene
Germ Layers:
- ectoderm
- endoderm
- mesoderm
Systems:
- cardiovascular
- digestive
- integumentary
- nervous
- respiratory
- skeletal muscle
- skeleton
Regions:
Head and neck:
- brain
- cerebellum
- ear
- eye
- eyelid
- face
- forehead
- head
- jaw
- larynx
- lip
- mandible
- maxilla
- mouth
- neck
- nose
- outer ear
- pharynx
- salivary gland
- skull
- tongue
- tooth
- vocal cord
Thorax:
- diaphragm
- esophagus
- heart
- heart valve
- lung
- rib
- rib cage
Abdomen:
- intestine
- large intestine
- stomach
Pelvis:
- pelvis
- rectum
Limb:
- arm
- digit
- finger
- foot
- hand
- lower limb
- toe
- upper limb
General:
- blood vessel
- hair
- peripheral nerve
- peripheral nervous system
- skin
- spinal column
- spinal cord
- vertebrae
Primer Products
-
OriGene qPCR primer pairs for FOXG1
-
OriGene qPCR primer pairs and template standards for FOXG1
- genomics-online: primer clones - Search for available FOXG1 Primer products
- Overview of 108 available FOXG1 gene related products
Gene Expression Assay Products
Orthologs for FOXG1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| dog (Canis familiaris) |
Mammalia | FOXG1 31 |
|
OneToOne | |
| chimpanzee (Pan troglodytes) |
Mammalia | FOXG1 31 30 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FOXG1 30 |
|
||
| mouse (Mus musculus) |
Mammalia | Foxg1 17 31 30 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Foxg1 30 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | FOXG1 31 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FOXG1 31 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FOXG1 31 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FOXG1 31 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | foxg1 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | foxg1b-A-prov 30 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | foxg1a 31 30 |
|
OneToOne | |
| foxg1 30 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | slp1 31 |
|
OneToMany | |
| slp2 31 |
|
OneToMany | |||
| fd19B 31 |
|
OneToMany | |||
| worm (Caenorhabditis elegans) |
Secernentea | fkh-2 31 |
|
OneToOne | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToOne |
- Species where no ortholog for FOXG1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
Evolution for FOXG1 Gene
- ENSEMBL:
- Gene Tree for FOXG1 (if available)
- TreeFam:
- Gene Tree for FOXG1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXG1: view image
Paralogs for FOXG1 Gene
Variants for FOXG1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXG1 Gene
| SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 639140 | Uncertain Significance: Rett syndrome, congenital variant | 28,767,708(+) | C/CGAGAAG | INFRAME_INSERTION | |
| 650501 | Uncertain Significance: Rett syndrome, congenital variant | 28,767,626(+) | T/C | MISSENSE_VARIANT | |
| 650891 | Uncertain Significance: Rett syndrome, congenital variant | 28,767,426(+) | CCACCACCACCACCAT | INFRAME_DELETION | |
| 651047 | Uncertain Significance: Rett syndrome, congenital variant | 28,767,593(+) | CGCCG/AGCCGCCGCC | INFRAME_INSERTION | |
| 651666 | Pathogenic: Rett syndrome, congenital variant | 28,768,041(+) | C/A | NONSENSE |
Residual Variation Intolerance Score:
31.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.55;
11.86% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXG1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXG1 Gene
Disorders for FOXG1 Gene
(35) MalaCards diseases for FOXG1 Gene - From: UniProtKB/Swiss-Prot, OMIM, ClinVar, GTR, Orphanet, DISEASES, and GeneCards
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| rett syndrome, congenital variant |
|
|
| rett syndrome |
|
|
| 14q12 microdeletion syndrome |
|
|
| 14q11.2 microduplication syndrome |
|
|
| foxg1 syndrome |
|
|
Search FOXG1 in MalaCards
View complete list of genes associated with diseases
UniProtKB/Swiss-Prot
FOXG1_HUMAN- Rett syndrome congenital variant (RTTCV) [MIM:613454]: A severe neurodevelopmental disorder with features of classic Rett syndrome but earlier onset in the first months of life. Clinical features include progressive microcephaly, hypotonia, irresponsiveness and irritability in the neonatal period, mental retardation, psychomotor regression and stereotypical movements. {ECO:0000269 PubMed:19578037, ECO:0000269 PubMed:21280142, ECO:0000269 PubMed:26993267}. Note=The disease is caused by mutations affecting the gene represented in this entry.
Additional Disease Information for FOXG1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for Genatlas for FOXG1 Gene
Publications for FOXG1 Gene
- Human brain factor 1, a new member of the fork head gene family. (PMID: 7959731) Murphy DB … Thies U (Genomics 1994) 2 3 4 23 54
- Comparative evolutionary analysis of the FoxG1 transcription factor from diverse vertebrates identifies conserved recognition sites for microRNA regulation. (PMID: 17260156) Bredenkamp N … Illing N (Development genes and evolution 2007) 2 3 4 54
- Human PLU-1 Has transcriptional repression properties and interacts with the developmental transcription factors BF-1 and PAX9. (PMID: 12657635) Tan K … Freemont PS (The Journal of biological chemistry 2003) 3 4 23 54
- The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q. (PMID: 7599184) Wiese S … Thies U (Biochimica et biophysica acta 1995) 3 4 23 54
- A missense mutation within the fork-head domain of the forkhead box G1 Gene (FOXG1) affects its nuclear localization. (PMID: 21280142) Le Guen T … Bienvenu T (Human mutation 2011) 3 4 54
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