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This gene belongs to the forkhead family of transcription factors which is characterized by a distinct forkhead domain. The specific function of this gene has not yet been determined; however, it may play a role in the regulation of pulmonary genes as well as embryonic development. [provided by RefSeq, Jul 2008]
FOXF1 (Forkhead Box F1) is a Protein Coding gene. Diseases associated with FOXF1 include Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins and Persistent Fetal Circulation Syndrome. Among its related pathways are FOXA2 and FOXA3 transcription factor networks and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription regulatory region DNA binding. An important paralog of this gene is FOXD2.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IMP | 8626802 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IMP | 8626802 |
GO:0003677 | DNA binding | IEA,IDA | 9769171 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | TAS,IC | 9769171 |
GO:0005667 | transcription factor complex | TAS | 9722567 |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
GO:0001568 | blood vessel development | IMP | 19500772 |
GO:0001570 | vasculogenesis | IEA | -- |
GO:0001701 | in utero embryonic development | IMP | 19500772 |
GO:0001756 | somitogenesis | IEA | -- |
This gene was present in the common ancestor of chordates.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FOXF1 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FOXF1 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FOXF1 30 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FOXF1 31 |
|
OneToOne | |
Oppossum (Monodelphis domestica) |
Mammalia | FOXF1 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Foxf1 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Foxf1 30 |
|
||
Chicken (Gallus gallus) |
Aves | FOXF1 30 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | foxf1 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | Xl.182 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | foxf1 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.3557 30 |
|
||
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
SNP ID | Clinical significance and condition | Chr 16 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
666625 | Benign: not specified; not provided | 86,512,992(+) | C/T | SYNONYMOUS_VARIANT | |
692054 | Pathogenic: Persistent fetal circulation syndrome | 86,511,251(+) | TGCGGCGGC/T | FRAMESHIFT_VARIANT | |
734939 | Likely Benign: not provided | 86,511,538(+) | C/A | SYNONYMOUS_VARIANT | |
735914 | Benign: not provided | 86,511,320(+) | A/G | MISSENSE_VARIANT | |
750896 | Likely Benign: not provided | 86,510,917(+) | C/T | SYNONYMOUS_VARIANT |
Disorder | Aliases | PubMed IDs |
---|---|---|
alveolar capillary dysplasia with misalignment of pulmonary veins |
|
|
persistent fetal circulation syndrome |
|
|
idiopathic/heritable pulmonary arterial hypertension |
|
|
pyloric stenosis |
|
|
vacterl association |
|
|