Aliases for FOXD4L6 Gene

Aliases for FOXD4L6 Gene

  • Forkhead Box D4 Like 6 2 3 5
  • Forkhead Box Protein D4-Like 6 3 4
  • FOXD4-Like 6 3 4
  • OTTHUMG00000066822 2
  • FOXD4L6 5

External Ids for FOXD4L6 Gene

Previous GeneCards Identifiers for FOXD4L6 Gene

  • GC09M068489
  • GC09M069199

Summaries for FOXD4L6 Gene

GeneCards Summary for FOXD4L6 Gene

FOXD4L6 (Forkhead Box D4 Like 6) is a Protein Coding gene. Diseases associated with FOXD4L6 include Miles-Carpenter Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is FOXD4L3.

Additional gene information for FOXD4L6 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXD4L6 Gene

Genomics for FOXD4L6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FOXD4L6 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J041127 Promoter 0.3 Ensembl 600.7 +1.0 962 0.2 FOXD4L6 NONHSAG052490.2-001 piR-37650-003 piR-41427-003 FRG1HP lnc-ANKRD20A2-22 BMS1P14
GH09J041073 Promoter 0.8 Ensembl 0.2 +54.8 54762 4.2 LARP7 ZSCAN4 EZH2 ZNF341 KLF9 ZBTB20 SP2 PAX8 CEBPB GATAD2B ENSG00000225655 PGM5P2 lnc-FOXD4L6-3 ENSG00000279456 FOXD4L6 lnc-ANKRD20A2-22 FRG1HP BMS1P14
GH09J040990 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 0.1 +135.6 135562 5.4 SP1 CTCF ZNF629 ZNF692 BACH1 TARDBP LARP7 ZNF143 PHF21A NR2C1 FRG1HP LOC107986997 MN298586 lnc-ANKRD20A2-22 piR-61580-646 FOXD4L6 BMS1P14
GH09J041124 Enhancer 0.3 Ensembl 0.7 +3.4 3363 0.6 EZH2 LOC440896 piR-41427-003 FOXD4L6 FRG1HP lnc-ANKRD20A2-22 BMS1P14
GH09J041094 Enhancer 0.5 Ensembl 0.3 +33.6 33560 1.6 EHMT2 DPF2 TAL1 FOXK2 PRDM10 TCF12 MTA2 CBFA2T3 ARID1B LOC105376058 piR-34099-021 FOXD4L6 lnc-ANKRD20A2-22 FRG1HP BMS1P14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXD4L6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXD4L6

Top Transcription factor binding sites by QIAGEN in the FOXD4L6 gene promoter:
  • C/EBPalpha
  • C/EBPbeta
  • CHOP-10
  • FOXD1
  • GATA-1
  • GATA-2
  • MyoD
  • RREB-1
  • STAT3
  • TBP

Genomic Locations for FOXD4L6 Gene

Genomic Locations for FOXD4L6 Gene
chr9:41,126,430-41,128,463
(GRCh38/hg38)
Size:
2,034 bases
Orientation:
Minus strand
chr9:69,199,480-69,202,204
(GRCh37/hg19)
Size:
2,725 bases
Orientation:
Minus strand

Genomic View for FOXD4L6 Gene

Genes around FOXD4L6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXD4L6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXD4L6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L6 Gene

Proteins for FOXD4L6 Gene

  • Protein details for FOXD4L6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3SYB3-FX4L6_HUMAN
    Recommended name:
    Forkhead box protein D4-like 6
    Protein Accession:
    Q3SYB3
    Secondary Accessions:
    • B2RPC4
    • Q4V336

    Protein attributes for FOXD4L6 Gene

    Size:
    417 amino acids
    Molecular mass:
    45787 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD4L6 Gene

Post-translational modifications for FOXD4L6 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXD4L6 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L6 Gene

Domains & Families for FOXD4L6 Gene

Gene Families for FOXD4L6 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXD4L6 Gene

Suggested Antigen Peptide Sequences for FOXD4L6 Gene

GenScript: Design optimal peptide antigens:
  • Forkhead box protein D4-like 6 (FX4L6_HUMAN)
genes like me logo Genes that share domains with FOXD4L6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXD4L6 Gene

Function for FOXD4L6 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD4L6: view
genes like me logo Genes that share phenotypes with FOXD4L6: view

Animal Model Products

CRISPR Products

miRNA for FOXD4L6 Gene

miRTarBase miRNAs that target FOXD4L6

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXD4L6

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXD4L6 Gene

Localization for FOXD4L6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L6 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXD4L6 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOXD4L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with FOXD4L6: view

Pathways & Interactions for FOXD4L6 Gene

PathCards logo

SuperPathways for FOXD4L6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0009653 anatomical structure morphogenesis IBA 21873635
GO:0030154 cell differentiation IBA 21873635
genes like me logo Genes that share ontologies with FOXD4L6: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD4L6 Gene

Drugs & Compounds for FOXD4L6 Gene

No Compound Related Data Available

Transcripts for FOXD4L6 Gene

mRNA/cDNA for FOXD4L6 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXD4L6

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L6 Gene

No ASD Table

Relevant External Links for FOXD4L6 Gene

GeneLoc Exon Structure for
FOXD4L6

Expression for FOXD4L6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXD4L6 Gene

mRNA differential expression in normal tissues according to GTEx for FOXD4L6 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x6.3), Brain - Cortex (x5.9), Brain - Hippocampus (x5.7), Brain - Cerebellar Hemisphere (x5.5), and Brain - Cerebellum (x4.3).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXD4L6

SOURCE GeneReport for Unigene cluster for FOXD4L6 Gene:

Hs.652377
genes like me logo Genes that share expression patterns with FOXD4L6: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXD4L6 Gene

Orthologs for FOXD4L6 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for FOXD4L6 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FOXD4L3 30
  • 99.04 (n)
Species where no ortholog for FOXD4L6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for FOXD4L6 Gene

ENSEMBL:
Gene Tree for FOXD4L6 (if available)
TreeFam:
Gene Tree for FOXD4L6 (if available)

Paralogs for FOXD4L6 Gene

(12) SIMAP similar genes for FOXD4L6 Gene using alignment to 1 proteins:

  • FX4L6_HUMAN
genes like me logo Genes that share paralogs with FOXD4L6: view

Variants for FOXD4L6 Gene

Additional dbSNP identifiers (rs#s) for FOXD4L6 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L6 Gene

Variant ID Type Subtype PubMed ID
nsv1110567 CNV duplication 24896259
nsv972389 CNV duplication 23825009

Variation tolerance for FOXD4L6 Gene

Gene Damage Index Score: 0.30; 6.57% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXD4L6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXD4L6

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXD4L6 Gene

Disorders for FOXD4L6 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXD4L6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
miles-carpenter syndrome
  • miles-carpenter x-linked mental retardation syndrome
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with FOXD4L6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXD4L6 Gene

Publications for FOXD4L6 Gene

  1. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3

Products for FOXD4L6 Gene

Sources for FOXD4L6 Gene