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Aliases for FOXD4L5 Gene

Aliases for FOXD4L5 Gene

  • Forkhead Box D4 Like 5 2 3 5
  • FOXD4-Like 5 3 4
  • Forkhead Box Protein D4-Like 5 3
  • BA15J10.2 3

External Ids for FOXD4L5 Gene

Previous GeneCards Identifiers for FOXD4L5 Gene

  • GC09M069466
  • GC09M069467
  • GC09M070175

Summaries for FOXD4L5 Gene

GeneCards Summary for FOXD4L5 Gene

FOXD4L5 (Forkhead Box D4 Like 5) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXD4L4.

Additional gene information for FOXD4L5 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4L5 Gene

Genomics for FOXD4L5 Gene

GeneHancer (GH) Regulatory Elements for FOXD4L5 Gene

Promoters and enhancers for FOXD4L5 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09I065285 Promoter 0.5 EPDnew 550.8 0.0 -38 0.1 FOXD4L5 GC09M065283
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FOXD4L5 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXD4L5 gene promoter:

Genomic Locations for FOXD4L5 Gene

Genomic Locations for FOXD4L5 Gene
chr9:65,282,101-65,285,209
(GRCh38/hg38)
Size:
3,109 bases
Orientation:
Minus strand
chr9:70,175,707-70,178,815
(GRCh37/hg19)

Genomic View for FOXD4L5 Gene

Genes around FOXD4L5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXD4L5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXD4L5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L5 Gene

Proteins for FOXD4L5 Gene

  • Protein details for FOXD4L5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VV16-FX4L5_HUMAN
    Recommended name:
    Forkhead box protein D4-like 5
    Protein Accession:
    Q5VV16

    Protein attributes for FOXD4L5 Gene

    Size:
    416 amino acids
    Molecular mass:
    45780 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD4L5 Gene

Post-translational modifications for FOXD4L5 Gene

No Post-translational modifications

Other Protein References for FOXD4L5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L5 Gene

Domains & Families for FOXD4L5 Gene

Gene Families for FOXD4L5 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for FOXD4L5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXD4L5: view

No data available for UniProtKB/Swiss-Prot for FOXD4L5 Gene

Function for FOXD4L5 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding IBA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD4L5: view
genes like me logo Genes that share phenotypes with FOXD4L5: view

miRNA for FOXD4L5 Gene

miRTarBase miRNAs that target FOXD4L5

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXD4L5 Gene

Localization for FOXD4L5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXD4L5 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOXD4L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXD4L5: view

Pathways & Interactions for FOXD4L5 Gene

SuperPathways for FOXD4L5 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXD4L5: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD4L5 Gene

Drugs & Compounds for FOXD4L5 Gene

No Compound Related Data Available

Transcripts for FOXD4L5 Gene

mRNA/cDNA for FOXD4L5 Gene

(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L5 Gene

No ASD Table

Relevant External Links for FOXD4L5 Gene

GeneLoc Exon Structure for
FOXD4L5
ECgene alternative splicing isoforms for
FOXD4L5

Expression for FOXD4L5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXD4L5 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOXD4L5 Gene:

FOXD4L5

SOURCE GeneReport for Unigene cluster for FOXD4L5 Gene:

Hs.714683
genes like me logo Genes that share expression patterns with FOXD4L5: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXD4L5 Gene

Orthologs for FOXD4L5 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4L5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXD4L4 33
  • 98.38 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 34
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii foxd5 34
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fd59A 34
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-130 34
  • 30 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 23 (a)
ManyToMany
CSA.2032 34
  • 22 (a)
ManyToMany
Species where no ortholog for FOXD4L5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD4L5 Gene

ENSEMBL:
Gene Tree for FOXD4L5 (if available)
TreeFam:
Gene Tree for FOXD4L5 (if available)

Paralogs for FOXD4L5 Gene

(13) SIMAP similar genes for FOXD4L5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD4L5: view

Variants for FOXD4L5 Gene

Sequence variations from dbSNP and Humsavar for FOXD4L5 Gene

SNP ID Clin Chr 09 pos Variation AA Info Type
rs1000503011 -- 65,286,323(-) C/G upstream_transcript_variant
rs1001041499 -- 65,285,106(-) T/A 5_prime_UTR_variant
rs1001751773 -- 65,283,436(-) C/G coding_sequence_variant, missense_variant
rs1002076765 -- 65,282,495(-) A/G 3_prime_UTR_variant
rs1007930470 -- 65,284,803(-) C/A 5_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L5 Gene

Variant ID Type Subtype PubMed ID
dgv4425e59 CNV duplication 20981092
esv23416 CNV gain 19812545
nsv469665 CNV gain 16826518
nsv471467 CNV gain 19718026
nsv972706 CNV duplication 23825009
nsv972707 CNV duplication 23825009
nsv972750 CNV duplication 23825009
nsv973369 CNV duplication 23825009
nsv973370 CNV duplication 23825009
nsv982533 CNV duplication 23825009
nsv982534 CNV duplication 23825009

Variation tolerance for FOXD4L5 Gene

Gene Damage Index Score: 1.89; 35.29% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXD4L5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXD4L5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXD4L5 Gene

Disorders for FOXD4L5 Gene

Additional Disease Information for FOXD4L5

No disorders were found for FOXD4L5 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXD4L5 Gene

Publications for FOXD4L5 Gene

  1. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray SJ … Dunham I (Nature 2004) 3 4 58
  2. FOXD4a and FOXD4b, two new winged helix transcription factors, are expressed in human leukemia cell lines. (PMID: 12234674) Freyaldenhoven BS … Wielckens K (Gene 2002) 2 3 58
  3. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 58

Products for FOXD4L5 Gene

Sources for FOXD4L5 Gene

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