Aliases for FOXD4L3 Gene

Aliases for FOXD4L3 Gene

  • Forkhead Box D4 Like 3 2 3 5
  • Forkhead Box Protein D4-Like 3 3 3 4
  • FOXD4-Like 3 3 4
  • Forkhead Box Protein D4-Like 4 3
  • Forkhead Box Protein D4-Like 2 3
  • Forkhead Box Protein D4B 3
  • Myeloid Factor-Gamma 3
  • FOXD4-Like 2 3
  • FOXD4-Like 4 3
  • FOXD4L2 3
  • FOXD4L4 3
  • FOXD4B 3
  • FOXD6 3

External Ids for FOXD4L3 Gene

Previous GeneCards Identifiers for FOXD4L3 Gene

  • GC09U900383
  • GC09P066375
  • GC09M067936
  • GC09P068148
  • GC09P070107
  • GC09P070917

Summaries for FOXD4L3 Gene

GeneCards Summary for FOXD4L3 Gene

FOXD4L3 (Forkhead Box D4 Like 3) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is FOXD4L6.

Additional gene information for FOXD4L3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXD4L3 Gene

Genomics for FOXD4L3 Gene

GeneHancer (GH) Regulatory Elements for FOXD4L3 Gene

Promoters and enhancers for FOXD4L3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH09J068303 Promoter 0.3 Ensembl 500.7 +0.6 634 0.2 FOXD4L3 NONHSAG052490.2-002 piR-37650-006 piR-41427-004
GH09J068289 Enhancer 0.2 Ensembl 0.4 -13.1 -13066 0.8 piR-57133-614 FOXD4L3 CBWD3
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXD4L3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXD4L3

Top Transcription factor binding sites by QIAGEN in the FOXD4L3 gene promoter:
  • aMEF-2
  • C/EBPbeta
  • FOXD1
  • GATA-1
  • GATA-2
  • MyoD
  • p53
  • RREB-1
  • STAT3
  • TBP

Genomic Locations for FOXD4L3 Gene

Genomic Locations for FOXD4L3 Gene
chr9:68,302,867-68,305,084
(GRCh38/hg38)
Size:
2,218 bases
Orientation:
Plus strand
chr9:70,917,276-70,920,000
(GRCh37/hg19)
Size:
2,725 bases
Orientation:
Plus strand

Genomic View for FOXD4L3 Gene

Genes around FOXD4L3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXD4L3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXD4L3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L3 Gene

Proteins for FOXD4L3 Gene

  • Protein details for FOXD4L3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6VB84-FX4L3_HUMAN
    Recommended name:
    Forkhead box protein D4-like 3
    Protein Accession:
    Q6VB84
    Secondary Accessions:
    • Q5JTX9

    Protein attributes for FOXD4L3 Gene

    Size:
    417 amino acids
    Molecular mass:
    45820 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD4L3 Gene

Post-translational modifications for FOXD4L3 Gene

No Post-translational modifications

Other Protein References for FOXD4L3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L3 Gene

Domains & Families for FOXD4L3 Gene

Gene Families for FOXD4L3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXD4L3 Gene

Suggested Antigen Peptide Sequences for FOXD4L3 Gene

GenScript: Design optimal peptide antigens:
  • Forkhead box protein D4-like 3 (FX4L3_HUMAN)
genes like me logo Genes that share domains with FOXD4L3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXD4L3 Gene

Function for FOXD4L3 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD4L3: view
genes like me logo Genes that share phenotypes with FOXD4L3: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOXD4L3 Gene

Localization for FOXD4L3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXD4L3 gene
Compartment Confidence
nucleus 4
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOXD4L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA 21873635
genes like me logo Genes that share ontologies with FOXD4L3: view

Pathways & Interactions for FOXD4L3 Gene

PathCards logo

SuperPathways for FOXD4L3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0009653 anatomical structure morphogenesis IBA 21873635
GO:0030154 cell differentiation IBA 21873635
genes like me logo Genes that share ontologies with FOXD4L3: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD4L3 Gene

Drugs & Compounds for FOXD4L3 Gene

No Compound Related Data Available

Transcripts for FOXD4L3 Gene

mRNA/cDNA for FOXD4L3 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L3 Gene

No ASD Table

Relevant External Links for FOXD4L3 Gene

GeneLoc Exon Structure for
FOXD4L3

Expression for FOXD4L3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXD4L3 Gene

mRNA differential expression in normal tissues according to GTEx for FOXD4L3 Gene

This gene is overexpressed in Brain - Hippocampus (x6.0), Brain - Cortex (x5.7), and Brain - Frontal Cortex (BA9) (x5.3).

Protein differential expression in normal tissues from HIPED for FOXD4L3 Gene

This gene is overexpressed in Liver, secretome (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXD4L3 Gene



Protein tissue co-expression partners for FOXD4L3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXD4L3

SOURCE GeneReport for Unigene cluster for FOXD4L3 Gene:

Hs.449471
genes like me logo Genes that share expression patterns with FOXD4L3: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXD4L3 Gene

Orthologs for FOXD4L3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4L3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXD4L3 30
  • 99.04 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 50 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 65 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii foxd5 31
  • 38 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta fd59A 31
  • 26 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea unc-130 31
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 23 (a)
ManyToMany
CSA.2032 31
  • 22 (a)
ManyToMany
Species where no ortholog for FOXD4L3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for FOXD4L3 Gene

ENSEMBL:
Gene Tree for FOXD4L3 (if available)
TreeFam:
Gene Tree for FOXD4L3 (if available)

Paralogs for FOXD4L3 Gene

(13) SIMAP similar genes for FOXD4L3 Gene using alignment to 1 proteins:

  • FX4L3_HUMAN
genes like me logo Genes that share paralogs with FOXD4L3: view

Variants for FOXD4L3 Gene

Additional dbSNP identifiers (rs#s) for FOXD4L3 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L3 Gene

Variant ID Type Subtype PubMed ID
esv3380501 CNV duplication 20981092
esv3411607 CNV duplication 20981092
nsv1115839 CNV duplication 24896259
nsv1146589 CNV duplication 26484159
nsv428218 CNV loss 18775914
nsv831609 CNV gain 17160897
nsv951521 CNV duplication 24416366
nsv972754 CNV duplication 23825009

Variation tolerance for FOXD4L3 Gene

Gene Damage Index Score: 3.89; 59.21% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXD4L3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXD4L3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXD4L3 Gene

Disorders for FOXD4L3 Gene

Additional Disease Information for FOXD4L3

No disorders were found for FOXD4L3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXD4L3 Gene

Publications for FOXD4L3 Gene

  1. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A … Ledbetter DH (Genomics 2004) 3 4 54
  2. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y … Trask BJ (Genome research 2002) 2 3 54
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 54
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 54
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L … Andersson-Svahn H (Molecular & cellular proteomics : MCP 2008) 3 54

Products for FOXD4L3 Gene

Sources for FOXD4L3 Gene