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Aliases for FOXD4L1 Gene

Aliases for FOXD4L1 Gene

  • Forkhead Box D4 Like 1 2 3 5
  • FOXD4-Like 1 3 4
  • Forkhead Box Protein D4-Like 1 3
  • BA395L14.1 3
  • FOXD5 3

External Ids for FOXD4L1 Gene

Previous GeneCards Identifiers for FOXD4L1 Gene

  • GC02P112177
  • GC02P114163
  • GC02P114351
  • GC02P113972
  • GC02P114256
  • GC02P113499
  • GC02P113649

Summaries for FOXD4L1 Gene

Entrez Gene Summary for FOXD4L1 Gene

  • This gene is a member of the forkhead/winged-helix (FOX) family of transcription factors with highly conserved FOX DNA-binding domains. Members of the FOX family of transcription factors are regulators of embryogenesis and may play a role in human cancer. This gene lies in a region of chromosome 2 that surrounds the site where two ancestral chromosomes fused to form human chromosome 2. This region is duplicated elsewhere in the human genome, primarily in subtelomeric and pericentromeric locations, thus mutiple copies of this gene have been found. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXD4L1 Gene

FOXD4L1 (Forkhead Box D4 Like 1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXD4.

Additional gene information for FOXD4L1 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXD4L1 Gene

Genomics for FOXD4L1 Gene

GeneHancer (GH) Regulatory Elements for FOXD4L1 Gene

Promoters and enhancers for FOXD4L1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J113430 Enhancer 0.8 Ensembl ENCODE 14.1 -66.6 -66565 3 ZNF740 CAVIN1 TEAD2 MEF2B ELF1 GTF2A2 ZNF592 MEF2D IRF9 SPI1 ENSG00000272563 FOXD4L1 IGKV1OR2-108
GH02J113501 Enhancer 0.7 Ensembl 10.3 +4.5 4454 2.8 BMI1 ZIC2 ZNF335 CTBP1 GLIS2 EGR1 SCRT2 ZNF600 PRDM10 EZH2 FOXD4L1 ENSG00000227359 PGM5P4-AS1 CBWD2 ENSG00000243389 LINC01961
GH02J113389 Enhancer 1.1 Ensembl ENCODE 6.2 -108.0 -108037 1.5 ATF1 FOXA2 ARNT ARID4B ZNF2 ZNF213 E2F8 ARID2 ZNF207 ZNF143 PAX8-AS1 PAX8 RNU6-1180P PGM5P4-AS1 CBWD2 FOXD4L1 IGKV1OR2-108 GC02P113622 LOC101927400
GH02J113602 Enhancer 1 ENCODE 4.3 +105.3 105308 2 HDGF PKNOX1 CLOCK FOXA2 SMAD1 ZFP64 ARID4B SIN3A DMAP1 ZNF2 DDX11L2 RPL23AP7 RABL2A RPS20P11 ENSG00000227359 PAX8-AS1 PSD4 FOXD4L1 ENSG00000279267
GH02J113386 Enhancer 0.5 FANTOM5 Ensembl 8.2 -111.6 -111586 0.7 IL1RN IL36B PAX8-AS1 RNU6-1180P FOXD4L1 IL36G CBWD2 IL36RN IGKV1OR2-108 GC02P113622
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXD4L1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXD4L1 gene promoter:
  • FOXO4
  • LCR-F1
  • GATA-2
  • p53
  • TBP
  • C/EBPbeta
  • Pax-3
  • STAT3
  • GATA-1
  • CP2

Genomic Locations for FOXD4L1 Gene

Genomic Locations for FOXD4L1 Gene
2,491 bases
Plus strand
2,068 bases
Plus strand

Genomic View for FOXD4L1 Gene

Genes around FOXD4L1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXD4L1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXD4L1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXD4L1 Gene

Proteins for FOXD4L1 Gene

  • Protein details for FOXD4L1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein D4-like 1
    Protein Accession:
    Secondary Accessions:
    • B3KWN1
    • B9EGF3

    Protein attributes for FOXD4L1 Gene

    408 amino acids
    Molecular mass:
    43610 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXD4L1 Gene

Post-translational modifications for FOXD4L1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXD4L1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXD4L1 Gene

Domains & Families for FOXD4L1 Gene

Gene Families for FOXD4L1 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXD4L1 Gene

Suggested Antigen Peptide Sequences for FOXD4L1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXD4L1: view

No data available for UniProtKB/Swiss-Prot for FOXD4L1 Gene

Function for FOXD4L1 Gene

Gene Ontology (GO) - Molecular Function for FOXD4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0043565 sequence-specific DNA binding IEA --
genes like me logo Genes that share ontologies with FOXD4L1: view
genes like me logo Genes that share phenotypes with FOXD4L1: view

Animal Model Products

miRNA for FOXD4L1 Gene

miRTarBase miRNAs that target FOXD4L1

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for FOXD4L1 Gene

Localization for FOXD4L1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXD4L1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXD4L1 gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOXD4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA --
genes like me logo Genes that share ontologies with FOXD4L1: view

Pathways & Interactions for FOXD4L1 Gene

SuperPathways for FOXD4L1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXD4L1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
GO:0009653 anatomical structure morphogenesis IBA --
GO:0030154 cell differentiation IBA --
genes like me logo Genes that share ontologies with FOXD4L1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXD4L1 Gene

Drugs & Compounds for FOXD4L1 Gene

No Compound Related Data Available

Transcripts for FOXD4L1 Gene

mRNA/cDNA for FOXD4L1 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(11) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXD4L1 Gene

Forkhead box D4-like 1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXD4L1 Gene

No ASD Table

Relevant External Links for FOXD4L1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for FOXD4L1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXD4L1 Gene

mRNA differential expression in normal tissues according to GTEx for FOXD4L1 Gene

This gene is overexpressed in Testis (x6.3), Brain - Cerebellar Hemisphere (x5.6), and Brain - Cerebellum (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of FOXD4L1 Gene:


SOURCE GeneReport for Unigene cluster for FOXD4L1 Gene:


Evidence on tissue expression from TISSUES for FOXD4L1 Gene

  • Heart(4.1)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with FOXD4L1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXD4L1 Gene

Orthologs for FOXD4L1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXD4L1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOXD4L1 33
  • 98.1 (n)
(Bos Taurus)
Mammalia FOXD4L1 34
  • 62 (a)
(Mus musculus)
Mammalia Foxd4 34
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 48 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 64 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia foxd4l1.1 33
  • 57.56 (n)
(Danio rerio)
Actinopterygii foxd5 34
  • 39 (a)
fruit fly
(Drosophila melanogaster)
Insecta fd59A 34
  • 25 (a)
(Caenorhabditis elegans)
Secernentea unc-130 34
  • 30 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2032 34
  • 23 (a)
-- 34
  • 22 (a)
Species where no ortholog for FOXD4L1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXD4L1 Gene

Gene Tree for FOXD4L1 (if available)
Gene Tree for FOXD4L1 (if available)
Evolutionary constrained regions (ECRs) for FOXD4L1: view image

Paralogs for FOXD4L1 Gene

(9) SIMAP similar genes for FOXD4L1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXD4L1: view

Variants for FOXD4L1 Gene

Sequence variations from dbSNP and Humsavar for FOXD4L1 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1001583647 -- 113,498,229(+) T/G upstream_transcript_variant
rs1006589313 -- 113,498,943(+) G/A upstream_transcript_variant
rs1013078439 -- 113,501,390(+) G/A/T downstream_transcript_variant
rs1013477377 -- 113,498,294(+) G/A upstream_transcript_variant
rs1013832123 -- 113,498,845(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXD4L1 Gene

Variant ID Type Subtype PubMed ID
esv2675836 CNV deletion 23128226
esv2759085 CNV gain+loss 17122850
esv28287 CNV gain 19812545
esv3592016 CNV gain 21293372
nsv834334 CNV gain 17160897
nsv979106 CNV duplication 23825009

Variation tolerance for FOXD4L1 Gene

Residual Variation Intolerance Score: 94.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 10.90; 91.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXD4L1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXD4L1 Gene

Disorders for FOXD4L1 Gene

Additional Disease Information for FOXD4L1

No disorders were found for FOXD4L1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXD4L1 Gene

Publications for FOXD4L1 Gene

  1. Diverse fates of paralogs following segmental duplication of telomeric genes. (PMID: 15233989) Wong A … Ledbetter DH (Genomics 2004) 2 3 4 58
  2. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. (PMID: 12421752) Fan Y … Trask BJ (Genome research 2002) 2 3 4 58
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for FOXD4L1 Gene

Sources for FOXD4L1 Gene

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