Aliases for FOXD1 Gene
External Ids for FOXD1 Gene
Previous HGNC Symbols for FOXD1 Gene
Previous GeneCards Identifiers for FOXD1 Gene
This gene belongs to the forkhead family of transcription factors which are characterized by a distinct forkhead domain. Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity. [provided by RefSeq, Apr 2014]
GeneCards Summary for FOXD1 Gene
FOXD1 (Forkhead Box D1) is a Protein Coding gene. Diseases associated with FOXD1 include Hypertrichosis Universalis Congenita, Ambras Type and Blepharophimosis, Ptosis, And Epicanthus Inversus. Among its related pathways are Preimplantation Embryo. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding. An important paralog of this gene is FOXD2.
UniProtKB/Swiss-Prot Summary for FOXD1 Gene
Transcription factor involved in regulation of gene expression in a variety of processes, including formation of positional identity in the developing retina, regionalization of the optic chiasm, morphogenesis of the kidney, and neuralization of ectodermal cells (By similarity). Involved in transcriptional activation of PGF and C3 genes (PubMed:27805902).