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Aliases for FOXC2-AS1 Gene

Subcategory (RNA class) for FOXC2-AS1 Gene

non-coding RNA

Quality Score for this RNA gene is

13

Aliases for FOXC2-AS1 Gene

  • FOXC2 Antisense RNA 1 2 3 5
  • Osteosarcoma Doxorubicin-Resistance Related Upregulated LncRNA 2 3
  • Osteosarcoma Doxorubicin-Resistance Related Up-Regulated LncRNA 3
  • ODRUL 3

External Ids for FOXC2-AS1 Gene

Summaries for FOXC2-AS1 Gene

GeneCards Summary for FOXC2-AS1 Gene

FOXC2-AS1 (FOXC2 Antisense RNA 1) is an RNA Gene, and is affiliated with the non-coding RNA class. Diseases associated with FOXC2-AS1 include Osteogenic Sarcoma and Breast Cancer.

Additional gene information for FOXC2-AS1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXC2-AS1 Gene

Genomics for FOXC2-AS1 Gene

GeneHancer (GH) Regulatory Elements for FOXC2-AS1 Gene

Promoters and enhancers for FOXC2-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J086563 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 8.6 -5.5 -5454 20.2 PKNOX1 ARNT ARID4B SIN3A ZNF2 YY1 ZNF213 ZNF207 ZNF143 FOS MTHFSD FOXC2-AS1 ENSG00000270020 FOXC2 FOXL1 GC16P086582
GH16J085650 Enhancer 1.2 Ensembl ENCODE dbSUPER 5.8 +915.4 915383 3.2 PKNOX1 ATF1 NFIB RCOR1 CREM ZNF263 SMAD5 RXRA ZNF398 ZNF148 ENSG00000270184 MTHFSD RNU1-103P ZDHHC7 RN7SL381P COX4I1 EMC8 GINS2 FOXC2-AS1 GC16P085659
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXC2-AS1 on UCSC Golden Path with GeneCards custom track

Genomic Locations for FOXC2-AS1 Gene

Genomic Locations for FOXC2-AS1 Gene
chr16:86,565,145-86,567,761
(GRCh38/hg38)
Size:
2,617 bases
Orientation:
Minus strand
chr16:86,598,751-86,601,367
(GRCh37/hg19)
Size:
2,617 bases
Orientation:
Minus strand

Genomic View for FOXC2-AS1 Gene

Genes around FOXC2-AS1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXC2-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXC2-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXC2-AS1 Gene

Proteins for FOXC2-AS1 Gene

Post-translational modifications for FOXC2-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FOXC2-AS1 Gene

Domains & Families for FOXC2-AS1 Gene

Graphical View of Domain Structure for InterPro Entry

No data available for Gene Families , Protein Domains , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for FOXC2-AS1 Gene

Function for FOXC2-AS1 Gene

Phenotypes From GWAS Catalog for FOXC2-AS1 Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOXC2-AS1 Gene

Localization for FOXC2-AS1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FOXC2-AS1 Gene

Pathways & Interactions for FOXC2-AS1 Gene

SuperPathways for FOXC2-AS1 Gene

No Data Available

Interacting Proteins for FOXC2-AS1 Gene

Gene Ontology (GO) - Biological Process for FOXC2-AS1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for FOXC2-AS1 Gene

Drugs & Compounds for FOXC2-AS1 Gene

No Compound Related Data Available

Transcripts for FOXC2-AS1 Gene

mRNA/cDNA for FOXC2-AS1 Gene

(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(1) RNA Central transcripts :

Alternative Splicing Database (ASD) splice patterns (SP) for FOXC2-AS1 Gene

No ASD Table

Relevant External Links for FOXC2-AS1 Gene

GeneLoc Exon Structure for
FOXC2-AS1
ECgene alternative splicing isoforms for
FOXC2-AS1

Expression for FOXC2-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXC2-AS1 Gene

genes like me logo Genes that share expression patterns with FOXC2-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXC2-AS1 Gene

Orthologs for FOXC2-AS1 Gene

Evolution for FOXC2-AS1 Gene

ENSEMBL:
Gene Tree for FOXC2-AS1 (if available)
TreeFam:
Gene Tree for FOXC2-AS1 (if available)

No data available for Orthologs for FOXC2-AS1 Gene

Paralogs for FOXC2-AS1 Gene

No data available for Paralogs for FOXC2-AS1 Gene

Variants for FOXC2-AS1 Gene

Sequence variations from dbSNP and Humsavar for FOXC2-AS1 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs104894516 pathogenic, Distichiasis-lymphedema syndrome 86,567,632(-) C/G non_coding_transcript_variant
rs121909106 pathogenic, Distichiasis-lymphedema syndrome 86,567,709(-) C/T non_coding_transcript_variant
rs121909107 pathogenic, Distichiasis-lymphedema syndrome 86,567,697(-) G/A non_coding_transcript_variant
rs886041497 pathogenic, not provided 86,568,322(-) CC/CCC upstream_transcript_variant
rs145346124 likely-benign, not specified 86,568,643(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXC2-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv498n67 CNV gain 20364138
esv4262 OTHER complex 18987735
nsv1065605 CNV gain 25217958
nsv483044 CNV gain 15286789
nsv525024 CNV loss 19592680

Additional Variant Information for FOXC2-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXC2-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FOXC2-AS1 Gene

Disorders for FOXC2-AS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FOXC2-AS1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
osteogenic sarcoma
  • osteosarcoma; osrc
breast cancer
  • breast cancer, familial
distichiasis
  • eyelashes, two rows of
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FOXC2-AS1

genes like me logo Genes that share disorders with FOXC2-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXC2-AS1 Gene

Publications for FOXC2-AS1 Gene

  1. LncRNA ODRUL Contributes to Osteosarcoma Progression through the miR-3182/MMP2 Axis. (PMID: 28750740) Zhu KP … Zhang CL (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 2 3 58
  2. A long non-coding RNA contributes to doxorubicin resistance of osteosarcoma. (PMID: 26408180) Zhang CL … Zhu ZS (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 2 3 58
  3. Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells. (PMID: 28351005) Gao M … Zhang C (Biomaterials 2017) 3 58
  4. Long non-coding RNA FOXC2-AS1 predicts poor survival in breast cancer patients and promotes cell proliferation. (PMID: 29562954) Yang H … Zhang M (Oncology research 2018) 3

Products for FOXC2-AS1 Gene

Sources for FOXC2-AS1 Gene

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