Aliases for FOXC2-AS1 Gene

Subcategory (RNA class) for FOXC2-AS1 Gene

lncRNA

Number of RNA Genes sources:

3 / 17

Aliases for FOXC2-AS1 Gene

  • FOXC2 Antisense RNA 1 2 3 5
  • FOXC2-AS1 2 5 165
  • Osteosarcoma Doxorubicin-Resistance Related Upregulated LncRNA 2 3
  • ODRUL 2 3
  • Osteosarcoma Doxorubicin-Resistance Related Up-Regulated LncRNA 3
  • NONHSAG020223.2 91
  • HSALNG0113319 164

External Ids for FOXC2-AS1 Gene

Summaries for FOXC2-AS1 Gene

GeneCards Summary for FOXC2-AS1 Gene

FOXC2-AS1 (FOXC2 Antisense RNA 1) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with FOXC2-AS1 include Osteogenic Sarcoma and Breast Cancer.

Additional gene information for FOXC2-AS1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXC2-AS1 Gene

Genomics for FOXC2-AS1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FOXC2-AS1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J086563 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 8.6 -5.3 -5302 20.3 CTCF PRDM10 ZNF629 KDM1A ZNF692 TARDBP JUND PRDM1 MTA2 ZNF143 MTHFSD FOXC2-AS1 ENSG00000270020 FOXC2 FOXL1 lnc-FOXL1-4
GH16J085649 Enhancer 1.3 Ensembl ENCODE CraniofacialAtlas dbSUPER 5.8 +916.3 916344 5 HNRNPL ZBTB33 JUND PKNOX1 PATZ1 ZNF600 MNT NRF1 ZBTB44 KLF9 COX4I1 EMC8 GINS2 FOXC2-AS1 RF00017-2178 RN7SL381P lnc-COX4I1-5 HQ292136 ENSG00000275393 GSE1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXC2-AS1 on the GeneHancer Hub at the UCSC Golden Path

Genomic Locations for FOXC2-AS1 Gene

Genomic Locations for FOXC2-AS1 Gene
chr16:86,564,915-86,567,845
(GRCh38/hg38)
Size:
2,931 bases
Orientation:
Minus strand
chr16:86,598,751-86,601,367
(GRCh37/hg19)
Size:
2,617 bases
Orientation:
Minus strand

Genomic View for FOXC2-AS1 Gene

Genes around FOXC2-AS1 on UCSC Golden Path with GeneCards custom track
FOXC2-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
FOXC2-AS1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXC2-AS1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXC2-AS1 Gene

Proteins for FOXC2-AS1 Gene

Post-translational modifications for FOXC2-AS1 Gene

No Post-translational modifications

No data available for DME Specific Peptides for FOXC2-AS1 Gene

Domains & Families for FOXC2-AS1 Gene

Gene Families for FOXC2-AS1 Gene

genes like me logo Genes that share domains with FOXC2-AS1: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXC2-AS1 Gene

Function for FOXC2-AS1 Gene

Phenotypes From GWAS Catalog for FOXC2-AS1 Gene

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for FOXC2-AS1 Gene

Localization for FOXC2-AS1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXC2-AS1 gene
Compartment Confidence
nucleus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for FOXC2-AS1 Gene

Pathways & Interactions for FOXC2-AS1 Gene

PathCards logo

SuperPathways for FOXC2-AS1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXC2-AS1 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for FOXC2-AS1 Gene

Drugs & Compounds for FOXC2-AS1 Gene

No Compound Related Data Available

Transcripts for FOXC2-AS1 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for FOXC2-AS1 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS000050E6E3_9606 lncRNA 319 6

HGNC: 50665,

RefSeq: NR_125795,

Ensembl: ENST00000563280 (view in UCSC) ,

LncBook: HSALNT0234941,

LNCipedia: FOXC2-AS1:1,

NONCODE: NONHSAT144226.2,

URS0000D58B21_9606 lncRNA 1253 2

LncBook: HSALNT0234936,

LNCipedia: FOXC2-AS1:3,

URS0000D5DB17_9606 lncRNA 948 2

LncBook: HSALNT0234935,

LNCipedia: FOXC2-AS1:4,

URS0000D57E2F_9606 lncRNA 403 1

LNCipedia: FOXC2-AS1:2,

URS0000EC1CC3_9606 lncRNA 321 1

LncBook: HSALNT0288979,

FOXC2-AS1 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for FOXC2-AS1 Gene

1 NCBI additional mRNA sequence :

Alternative Splicing Database (ASD) splice patterns (SP) for FOXC2-AS1 Gene

No ASD Table

Relevant External Links for FOXC2-AS1 Gene

GeneLoc Exon Structure for
FOXC2-AS1

Expression for FOXC2-AS1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXC2-AS1 Gene

genes like me logo Genes that share expression patterns with FOXC2-AS1: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXC2-AS1 Gene

Orthologs for FOXC2-AS1 Gene

Evolution for FOXC2-AS1 Gene

ENSEMBL:
Gene Tree for FOXC2-AS1 (if available)
TreeFam:
Gene Tree for FOXC2-AS1 (if available)

No data available for Orthologs for FOXC2-AS1 Gene

Paralogs for FOXC2-AS1 Gene

No data available for Paralogs for FOXC2-AS1 Gene

Variants for FOXC2-AS1 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXC2-AS1 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
707267 Benign: not provided 86,567,761(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
707364 Likely Benign: not provided 86,567,605(-) G/A SYNONYMOUS_VARIANT
727342 Likely Benign: not provided 86,567,710(-) G/C NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
728445 Likely Benign: not provided 86,567,752(-) G/A NON_CODING_TRANSCRIPT_VARIANT,SYNONYMOUS_VARIANT
750253 Likely Benign: not provided 86,567,602(-) C/G SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for FOXC2-AS1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXC2-AS1 Gene

Variant ID Type Subtype PubMed ID
dgv498n67 CNV gain 20364138
esv4262 OTHER complex 18987735
nsv1065605 CNV gain 25217958
nsv483044 CNV gain 15286789
nsv525024 CNV loss 19592680

Additional Variant Information for FOXC2-AS1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXC2-AS1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for FOXC2-AS1 Gene

Disorders for FOXC2-AS1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FOXC2-AS1 Gene - From: LncRNADisease, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
osteogenic sarcoma
  • osteosarcoma; osrc
breast cancer
  • breast lobular carcinoma
distichiasis
  • eyelashes, two rows of
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for FOXC2-AS1

genes like me logo Genes that share disorders with FOXC2-AS1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXC2-AS1 Gene

Publications for FOXC2-AS1 Gene

  1. Long Noncoding RNA FOXC2-AS1 Predicts Poor Survival in Breast Cancer Patients and Promotes Cell Proliferation. (PMID: 29562954) Yang H … Zhang M (Oncology research 2019) 2 3
  2. LncRNA ODRUL Contributes to Osteosarcoma Progression through the miR-3182/MMP2 Axis. (PMID: 28750740) Zhu KP … Zhang CL (Molecular therapy : the journal of the American Society of Gene Therapy 2017) 2 3
  3. A long non-coding RNA contributes to doxorubicin resistance of osteosarcoma. (PMID: 26408180) Zhang CL … Zhu ZS (Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2016) 2 3
  4. Long noncoding RNA FOXC2-AS1 facilitates the proliferation and progression of prostate cancer via targeting miR-1253/EZH2. (PMID: 30389560) Chen Y … Wang Z (Gene 2019) 3
  5. Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells. (PMID: 28351005) Gao M … Zhang C (Biomaterials 2017) 3

Products for FOXC2-AS1 Gene

Sources for FOXC2-AS1 Gene