Aliases for FOXB1 Gene

Aliases for FOXB1 Gene

  • Forkhead Box B1 2 3 5
  • FKH5 2 3 4
  • Transcription Factor FKH-5 3 4
  • Forkhead Box Protein B1 3 4
  • HFKH-5 2 3
  • FOXB1 5

External Ids for FOXB1 Gene

Previous GeneCards Identifiers for FOXB1 Gene

  • GC15P055855
  • GC15P053345
  • GC15P057876
  • GC15P058013
  • GC15P058084
  • GC15P060296
  • GC15P037118

Summaries for FOXB1 Gene

GeneCards Summary for FOXB1 Gene

FOXB1 (Forkhead Box B1) is a Protein Coding gene. Diseases associated with FOXB1 include Thiamine Deficiency Disease and Wernicke-Korsakoff Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is FOXB2.

Additional gene information for FOXB1 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXB1 Gene

Genomics for FOXB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FOXB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J060003 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE 600.7 +0.2 223 1.4 TEAD4 PRDM10 ZIC2 POLR2A PATZ1 EZH2 ZNF600 ZNF341 ZNF561 ZBTB20 FOXB1 lnc-FOXB1-6 lnc-BNIP2-4 ANXA2
GH15J060007 Promoter/Enhancer 1.2 Ensembl ENCODE 600.7 +2.0 1967 2 PRDM10 ZNF629 FOXA1 PRDM1 POLR2A PATZ1 ZNF740 EZH2 ZNF600 ZNF341 FOXB1 lnc-FOXB1-6 lnc-BNIP2-4 ANXA2
GH15J060025 Enhancer 1 UCNEbase Ensembl ENCODE 11.8 +21.7 21667 1.8 ZXDB ZBTB48 ZFHX2 ZNF843 VEZF1 PRDM6 ZNF433 GFI1B FOXB1 LOC105370838 RF00017-1803 lnc-FOXB1-6 ANXA2
GH15J059917 Enhancer 1 Ensembl ENCODE 12.2 -85.4 -85372 3.2 CTCF TEAD4 PRDM10 ZNF629 ZNF692 JUND PRDM1 PATZ1 REST RAD21 FOXB1 HSALNG0106314 piR-43107-095 BNIP2
GH15J059886 Enhancer 1 Ensembl ENCODE 10.3 -117.8 -117833 1.6 ZNF629 PRDM1 ZIC2 PATZ1 ZNF501 ZNF600 ZNF341 ZNF561 ZBTB44 KLF9 FOXB1 DDX18P2 HSALNG0106314 BNIP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXB1

Top Transcription factor binding sites by QIAGEN in the FOXB1 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • HFH-1
  • Max
  • POU2F1
  • S8

Genomic Locations for FOXB1 Gene

Genomic Locations for FOXB1 Gene
chr15:60,004,234-60,061,730
(GRCh38/hg38)
Size:
57,497 bases
Orientation:
Plus strand
chr15:60,296,421-60,353,929
(GRCh37/hg19)
Size:
57,509 bases
Orientation:
Plus strand

Genomic View for FOXB1 Gene

Genes around FOXB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXB1 Gene

Proteins for FOXB1 Gene

  • Protein details for FOXB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99853-FOXB1_HUMAN
    Recommended name:
    Forkhead box protein B1
    Protein Accession:
    Q99853
    Secondary Accessions:
    • O60652
    • O75917
    • Q14CL2

    Protein attributes for FOXB1 Gene

    Size:
    325 amino acids
    Molecular mass:
    34978 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXB1 Gene

Post-translational modifications for FOXB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXB1 Gene

Domains & Families for FOXB1 Gene

Gene Families for FOXB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXB1 Gene

Suggested Antigen Peptide Sequences for FOXB1 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor FKH-5 (FOXB1_HUMAN)
genes like me logo Genes that share domains with FOXB1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXB1 Gene

Function for FOXB1 Gene

Molecular function for FOXB1 Gene

GENATLAS Biochemistry:
transcription factor-like 5,with a Drosophila homeo forkhead DNA binding domain homolog

Phenotypes From GWAS Catalog for FOXB1 Gene

Gene Ontology (GO) - Molecular Function for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISM 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding ISS --
genes like me logo Genes that share ontologies with FOXB1: view
genes like me logo Genes that share phenotypes with FOXB1: view

Animal Models for FOXB1 Gene

MGI Knock Outs for FOXB1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXB1 Gene

Localization for FOXB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXB1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin ISA --
GO:0005634 nucleus IBA,ISS --
genes like me logo Genes that share ontologies with FOXB1: view

Pathways & Interactions for FOXB1 Gene

PathCards logo

SuperPathways for FOXB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development IEA --
GO:0001756 somitogenesis IEA,ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007412 axon target recognition IEA,ISS --
genes like me logo Genes that share ontologies with FOXB1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXB1 Gene

Drugs & Compounds for FOXB1 Gene

No Compound Related Data Available

Transcripts for FOXB1 Gene

mRNA/cDNA for FOXB1 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXB1

Alternative Splicing Database (ASD) splice patterns (SP) for FOXB1 Gene

No ASD Table

Relevant External Links for FOXB1 Gene

GeneLoc Exon Structure for
FOXB1

Expression for FOXB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXB1 Gene

This gene is overexpressed in Brain - Hypothalamus (x16.0), Brain - Substantia nigra (x14.8), Testis (x8.3), and Brain - Spinal cord (cervical c-1) (x7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXB1 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXB1

SOURCE GeneReport for Unigene cluster for FOXB1 Gene:

Hs.734475

Evidence on tissue expression from TISSUES for FOXB1 Gene

  • Lung(4.4)
  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with FOXB1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXB1 Gene

Orthologs for FOXB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXB1 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia FOXB1 30 31
  • 100 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia FOXB1 31
  • 99 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia FOXB1 30 31
  • 94.46 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia FOXB1 30 31
  • 92.51 (n)
OneToOne
Mouse
(Mus musculus)
Mammalia Foxb1 30 17 31
  • 92 (n)
OneToOne
Chicken
(Gallus gallus)
Aves FOXB1 30 31
  • 89.58 (n)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia foxb1 30
  • 76.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia fkh-5 30
Zebrafish
(Danio rerio)
Actinopterygii foxb1b 31
  • 80 (a)
OneToMany
foxb1a 30 31 31
  • 79.69 (n)
OneToMany
foxb1.2 30
Fruit Fly
(Drosophila melanogaster)
Insecta fd64A 32
  • 60 (a)
fd96Cb 31 32
  • 39 (a)
ManyToMany
fd96Ca 31 32
  • 34 (a)
ManyToMany
Worm
(Caenorhabditis elegans)
Secernentea lin-31 31 32
  • 42 (a)
OneToMany
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 48 (a)
ManyToMany
-- 31
  • 30 (a)
ManyToMany
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.376 30
Species where no ortholog for FOXB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FOXB1 Gene

ENSEMBL:
Gene Tree for FOXB1 (if available)
TreeFam:
Gene Tree for FOXB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXB1: view image

Paralogs for FOXB1 Gene

(11) SIMAP similar genes for FOXB1 Gene using alignment to 1 proteins:

  • FOXB1_HUMAN
genes like me logo Genes that share paralogs with FOXB1: view

Variants for FOXB1 Gene

Additional dbSNP identifiers (rs#s) for FOXB1 Gene

Structural Variations from Database of Genomic Variants (DGV) for FOXB1 Gene

Variant ID Type Subtype PubMed ID
nsv1554 CNV deletion 18451855
nsv7266 OTHER inversion 18451855
nsv833028 CNV gain 17160897
nsv951968 CNV deletion 24416366

Variation tolerance for FOXB1 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXB1 Gene

Disorders for FOXB1 Gene

MalaCards: The human disease database

(3) MalaCards diseases for FOXB1 Gene - From: DISEASES

Disorder Aliases PubMed IDs
thiamine deficiency disease
wernicke-korsakoff syndrome
  • transketolase defect
septooptic dysplasia
  • de morsier syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FOXB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOXB1

genes like me logo Genes that share disorders with FOXB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXB1 Gene

Publications for FOXB1 Gene

  1. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3

Products for FOXB1 Gene

  • Boster Bio Antibodies for FOXB1
  • Boster Bio ELISA Kits for FOXB1

Sources for FOXB1 Gene