Aliases for FOXB1 Gene

Aliases for FOXB1 Gene

  • Forkhead Box B1 2 3 5
  • FKH5 2 3 4
  • Transcription Factor FKH-5 3 4
  • Forkhead Box Protein B1 3 4
  • HFKH-5 2 3
  • FOXB1 5

External Ids for FOXB1 Gene

Previous GeneCards Identifiers for FOXB1 Gene

  • GC15P055855
  • GC15P053345
  • GC15P057876
  • GC15P058013
  • GC15P058084
  • GC15P060296
  • GC15P037118

Summaries for FOXB1 Gene

GeneCards Summary for FOXB1 Gene

FOXB1 (Forkhead Box B1) is a Protein Coding gene. Diseases associated with FOXB1 include Thiamine Deficiency Disease and Wernicke-Korsakoff Syndrome. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and DNA-binding transcription factor activity, RNA polymerase II-specific. An important paralog of this gene is FOXB2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXB1 Gene

Genomics for FOXB1 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for FOXB1 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J060003 Promoter/Enhancer 1.5 EPDnew Ensembl ENCODE 250.7 +1.3 1267 3.8 ZNF600 ZNF10 ZIC2 CEBPB FEZF1 ZNF341 KLF7 SIN3A ZNF513 FOXA2 FOXB1 lnc-FOXB1-6 lnc-BNIP2-4 ANXA2
GH15J060013 Enhancer 0.5 Ensembl 250.7 -1.5 -1533 0.2 CREB1 ZSCAN4 ZEB2 POLR2A ZNF501 FOXB1 lnc-FOXB1-6 lnc-BNIP2-4 lnc-BNIP2-3 BNIP2
GH15J060025 Enhancer 1 UCNEbase Ensembl ENCODE 11.8 +21.7 21667 1.8 ZNF433 ZNF843 PRDM6 ZBTB48 ZXDB GFI1B ZFHX2 FOXB1 LOC105370838 RF00017-1616 lnc-FOXB1-6 ANXA2
GH15J059917 Enhancer 1 Ensembl ENCODE 12.2 -85.4 -85372 3.2 ZNF654 ATF2 BCL11A REST ZNF341 KLF7 CTCF SIN3A RAD21 IRF4 FOXB1 HSALNG0106314 piR-43107-095 BNIP2
GH15J059886 Enhancer 1 Ensembl ENCODE 10.3 -117.9 -117934 1.8 ZNF600 ZNF580 ZNF10 ZSCAN16 ZIC2 FEZF1 ZNF639 ZNF341 KLF7 KLF9 FOXB1 DDX18P2 HSALNG0106314 BNIP2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXB1 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXB1

Top Transcription factor binding sites by QIAGEN in the FOXB1 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • HFH-1
  • Max
  • POU2F1
  • S8

Genomic Locations for FOXB1 Gene

Latest Assembly
57,497 bases
Plus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
3,134 bases
Plus strand

(GRCh37/hg19 by Ensembl)
57,509 bases
Plus strand

Genomic View for FOXB1 Gene

Genes around FOXB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXB1 Gene

Proteins for FOXB1 Gene

  • Protein details for FOXB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Forkhead box protein B1
    Protein Accession:
    Secondary Accessions:
    • O60652
    • O75917
    • Q14CL2

    Protein attributes for FOXB1 Gene

    325 amino acids
    Molecular mass:
    34978 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXB1 Gene

Post-translational modifications for FOXB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXB1 Gene

Domains & Families for FOXB1 Gene

Gene Families for FOXB1 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for FOXB1 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor FKH-5 (FOXB1_HUMAN)
genes like me logo Genes that share domains with FOXB1: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXB1 Gene

Function for FOXB1 Gene

Molecular function for FOXB1 Gene

GENATLAS Biochemistry:
transcription factor-like 5,with a Drosophila homeo forkhead DNA binding domain homolog

Phenotypes From GWAS Catalog for FOXB1 Gene

Gene Ontology (GO) - Molecular Function for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific ISA --
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with FOXB1: view
genes like me logo Genes that share phenotypes with FOXB1: view

Animal Models for FOXB1 Gene

MGI Knock Outs for FOXB1:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXB1

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXB1 Gene

Localization for FOXB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXB1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXB1 gene
Compartment Confidence
nucleus 5
plasma membrane 1
extracellular 1
cytoskeleton 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000785 chromatin ISA --
GO:0005634 nucleus ISS --
genes like me logo Genes that share ontologies with FOXB1: view

Pathways & Interactions for FOXB1 Gene

PathCards logo

SuperPathways for FOXB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development IEA --
GO:0001756 somitogenesis IEA,ISS --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007412 axon target recognition IEA,ISS --
genes like me logo Genes that share ontologies with FOXB1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXB1 Gene

Drugs & Compounds for FOXB1 Gene

No Compound Related Data Available

Transcripts for FOXB1 Gene

mRNA/cDNA for FOXB1 Gene

6 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXB1

Alternative Splicing Database (ASD) splice patterns (SP) for FOXB1 Gene

No ASD Table

Relevant External Links for FOXB1 Gene

GeneLoc Exon Structure for

Expression for FOXB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for FOXB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXB1 Gene

This gene is overexpressed in Brain - Hypothalamus (x16.0), Brain - Substantia nigra (x14.8), Testis (x8.3), and Brain - Spinal cord (cervical c-1) (x7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXB1 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXB1

SOURCE GeneReport for Unigene cluster for FOXB1 Gene:


Evidence on tissue expression from TISSUES for FOXB1 Gene

  • Lung(4.4)
  • Nervous system(3.3)
genes like me logo Genes that share expression patterns with FOXB1: view

Primer products for research

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXB1 Gene

Orthologs for FOXB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXB1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia FOXB1 29 30
  • 100 (n)
(Monodelphis domestica)
Mammalia FOXB1 30
  • 99 (a)
(Canis familiaris)
Mammalia FOXB1 29 30
  • 94.46 (n)
(Bos Taurus)
Mammalia FOXB1 29 30
  • 92.51 (n)
(Mus musculus)
Mammalia Foxb1 29 16 30
  • 92 (n)
(Gallus gallus)
Aves FOXB1 29 30
  • 89.58 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia foxb1 29
  • 76.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia fkh-5 29
(Danio rerio)
Actinopterygii foxb1b 30
  • 80 (a)
foxb1a 29 30 30
  • 79.69 (n)
foxb1.2 29
Fruit Fly
(Drosophila melanogaster)
Insecta fd64A 31
  • 60 (a)
fd96Cb 30 31
  • 39 (a)
fd96Ca 30 31
  • 34 (a)
(Caenorhabditis elegans)
Secernentea lin-31 30 31
  • 42 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 30
  • 48 (a)
-- 30
  • 30 (a)
Sea Vase
(Ciona intestinalis)
Ascidiacea Cin.376 29
Species where no ortholog for FOXB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)

Evolution for FOXB1 Gene

Gene Tree for FOXB1 (if available)
Gene Tree for FOXB1 (if available)
Evolutionary constrained regions (ECRs) for FOXB1: view image
Alliance of Genome Resources:
Additional Orthologs for FOXB1

Paralogs for FOXB1 Gene

(11) SIMAP similar genes for FOXB1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with FOXB1: view

Variants for FOXB1 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for FOXB1 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for FOXB1 Gene

Variant ID Type Subtype PubMed ID
nsv1554 CNV deletion 18451855
nsv7266 OTHER inversion 18451855
nsv833028 CNV gain 17160897
nsv951968 CNV deletion 24416366

Variation tolerance for FOXB1 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Leiden Open Variation Database (LOVD)

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXB1 Gene

Disorders for FOXB1 Gene

MalaCards: The human disease database

(4) MalaCards diseases for FOXB1 Gene - From: COP

Disorder Aliases PubMed IDs
thiamine deficiency disease
wernicke-korsakoff syndrome
  • transketolase defect
anterograde amnesia
  • amnesia, anterograde
septooptic dysplasia
  • de morsier syndrome
- elite association - COSMIC cancer census association via MalaCards
Search FOXB1 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOXB1

genes like me logo Genes that share disorders with FOXB1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXB1 Gene

Publications for FOXB1 Gene

  1. Impact of cytosine methylation on DNA binding specificities of human transcription factors. (PMID: 28473536) Yin Y … Taipale J (Science (New York, N.Y.) 2017) 3
  2. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3
  4. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3

Products for FOXB1 Gene

  • Boster Bio Antibodies for FOXB1
  • Boster Bio ELISA Kits for FOXB1

Sources for FOXB1 Gene