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Aliases for FOXB1 Gene

Aliases for FOXB1 Gene

  • Forkhead Box B1 2 3 5
  • Transcription Factor FKH-5 3 4
  • FKH5 3 4
  • Forkhead Box Protein B1 3
  • HFKH-5 3

External Ids for FOXB1 Gene

Previous GeneCards Identifiers for FOXB1 Gene

  • GC15P055855
  • GC15P053345
  • GC15P057876
  • GC15P058013
  • GC15P058084
  • GC15P060296
  • GC15P037118

Summaries for FOXB1 Gene

GeneCards Summary for FOXB1 Gene

FOXB1 (Forkhead Box B1) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and RNA polymerase II transcription factor activity, sequence-specific DNA binding. An important paralog of this gene is FOXB2.

Additional gene information for FOXB1 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXB1 Gene

Genomics for FOXB1 Gene

GeneHancer (GH) Regulatory Elements for FOXB1 Gene

Promoters and enhancers for FOXB1 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J060003 Promoter/Enhancer 1.3 EPDnew ENCODE 650.7 +0.0 25 1 PKNOX1 INSM2 SIN3A FEZF1 YY1 EGR2 SP3 ZBTB11 ZNF398 ZNF843 FOXB1 LOC105370838 GC15M059893
GH15J060006 Enhancer 0.6 ENCODE 650.7 +1.6 1583 0.1 CTCF L3MBTL2 YY2 SIN3A ZBTB8A HIC1 ZFHX2 KLF9 KLF8 ZBTB26 FOXB1 LOC105370838 GC15M059893
GH15J060004 Enhancer 0.5 ENCODE 650.7 +0.8 845 0.2 ZBTB11 ZNF10 ZNF600 ZBTB26 EZH2 FOXB1 LOC105370838 GC15M059893
GH15J060007 Enhancer 0.5 ENCODE 650.7 +1.1 1125 0.1 L3MBTL2 SUZ12 ZNF10 ZNF600 ZBTB26 EZH2 FOXB1 LOC105370838 GC15M059893
GH15J059976 Enhancer 0.7 Ensembl ENCODE 12.2 -27.5 -27538 0.6 POLR2A MAX CEBPG MYC GABPA FOXB1 NMNAT1P5 GC15M059893
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around FOXB1 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXB1 gene promoter:

Genomic Locations for FOXB1 Gene

Genomic Locations for FOXB1 Gene
chr15:60,004,222-60,061,730
(GRCh38/hg38)
Size:
57,509 bases
Orientation:
Plus strand
chr15:60,296,421-60,353,929
(GRCh37/hg19)

Genomic View for FOXB1 Gene

Genes around FOXB1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXB1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXB1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXB1 Gene

Proteins for FOXB1 Gene

  • Protein details for FOXB1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99853-FOXB1_HUMAN
    Recommended name:
    Forkhead box protein B1
    Protein Accession:
    Q99853
    Secondary Accessions:
    • O60652
    • O75917
    • Q14CL2

    Protein attributes for FOXB1 Gene

    Size:
    325 amino acids
    Molecular mass:
    34978 Da
    Quaternary structure:
    No Data Available

neXtProt entry for FOXB1 Gene

Post-translational modifications for FOXB1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXB1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXB1 Gene

Domains & Families for FOXB1 Gene

Gene Families for FOXB1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOXB1 Gene

Suggested Antigen Peptide Sequences for FOXB1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXB1: view

No data available for UniProtKB/Swiss-Prot for FOXB1 Gene

Function for FOXB1 Gene

Molecular function for FOXB1 Gene

GENATLAS Biochemistry:
transcription factor-like 5,with a Drosophila homeo forkhead DNA binding domain homolog

Phenotypes From GWAS Catalog for FOXB1 Gene

Gene Ontology (GO) - Molecular Function for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA binding transcription factor activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0043565 sequence-specific DNA binding ISS --
genes like me logo Genes that share ontologies with FOXB1: view
genes like me logo Genes that share phenotypes with FOXB1: view

Animal Models for FOXB1 Gene

MGI Knock Outs for FOXB1:

Animal Model Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXB1 Gene

Localization for FOXB1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXB1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXB1 gene
Compartment Confidence
nucleus 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,ISS --
genes like me logo Genes that share ontologies with FOXB1: view

Pathways & Interactions for FOXB1 Gene

SuperPathways for FOXB1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for FOXB1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001655 urogenital system development IEA --
GO:0001756 somitogenesis ISS,IEA --
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA --
genes like me logo Genes that share ontologies with FOXB1: view

No data available for Pathways by source and SIGNOR curated interactions for FOXB1 Gene

Drugs & Compounds for FOXB1 Gene

No Compound Related Data Available

Transcripts for FOXB1 Gene

mRNA/cDNA for FOXB1 Gene

(3) Selected AceView cDNA sequences:
(6) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for FOXB1 Gene

Forkhead box B1:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOXB1 Gene

No ASD Table

Relevant External Links for FOXB1 Gene

GeneLoc Exon Structure for
FOXB1
ECgene alternative splicing isoforms for
FOXB1

Expression for FOXB1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXB1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXB1 Gene

This gene is overexpressed in Brain - Hypothalamus (x16.0), Brain - Substantia nigra (x14.8), Testis (x8.3), and Brain - Spinal cord (cervical c-1) (x7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXB1 Gene



NURSA nuclear receptor signaling pathways regulating expression of FOXB1 Gene:

FOXB1

SOURCE GeneReport for Unigene cluster for FOXB1 Gene:

Hs.734475

Evidence on tissue expression from TISSUES for FOXB1 Gene

  • Lung(4.4)
  • Nervous system(3.1)
genes like me logo Genes that share expression patterns with FOXB1: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXB1 Gene

Orthologs for FOXB1 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXB1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXB1 34 33
  • 100 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia FOXB1 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia FOXB1 34 33
  • 94.46 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FOXB1 34 33
  • 92.51 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Foxb1 16 34 33
  • 92 (n)
chicken
(Gallus gallus)
Aves FOXB1 34 33
  • 89.58 (n)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia foxb1 33
  • 76.98 (n)
African clawed frog
(Xenopus laevis)
Amphibia fkh-5 33
zebrafish
(Danio rerio)
Actinopterygii foxb1a 34 34
  • 88 (a)
OneToMany
foxb1b 34
  • 80 (a)
OneToMany
LOC100535158 33
  • 79.69 (n)
foxb1.2 33
fruit fly
(Drosophila melanogaster)
Insecta fd64A 35
  • 60 (a)
fd96Cb 34 35
  • 39 (a)
ManyToMany
fd96Ca 34 35
  • 34 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea lin-31 34 35
  • 42 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 48 (a)
ManyToMany
-- 34
  • 30 (a)
ManyToMany
Cin.376 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.376 33
Species where no ortholog for FOXB1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for FOXB1 Gene

ENSEMBL:
Gene Tree for FOXB1 (if available)
TreeFam:
Gene Tree for FOXB1 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXB1: view image

Paralogs for FOXB1 Gene

Paralogs for FOXB1 Gene

(11) SIMAP similar genes for FOXB1 Gene using alignment to 1 proteins:

  • FOXB1_HUMAN
genes like me logo Genes that share paralogs with FOXB1: view

Variants for FOXB1 Gene

Sequence variations from dbSNP and Humsavar for FOXB1 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000437452 -- 60,004,590(+) G/T 5_prime_UTR_variant
rs1000888710 -- 60,006,155(+) T/C downstream_transcript_variant
rs1001502824 -- 60,003,940(+) G/T upstream_transcript_variant
rs1002710625 -- 60,006,429(+) A/G downstream_transcript_variant
rs1002856261 -- 60,003,313(+) G/A upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXB1 Gene

Variant ID Type Subtype PubMed ID
nsv1554 CNV deletion 18451855
nsv7266 OTHER inversion 18451855
nsv833028 CNV gain 17160897
nsv951968 CNV deletion 24416366

Variation tolerance for FOXB1 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.13; 22.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXB1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXB1

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXB1 Gene

Disorders for FOXB1 Gene

Additional Disease Information for FOXB1

No disorders were found for FOXB1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOXB1 Gene

Publications for FOXB1 Gene

  1. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. (PMID: 25609649) Li X … Chen J (Molecular systems biology 2015) 3 58
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  3. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J … Yang X (Molecular systems biology 2011) 3 58
  4. A census of human transcription factors: function, expression and evolution. (PMID: 19274049) Vaquerizas JM … Luscombe NM (Nature reviews. Genetics 2009) 3 58
  5. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang SJ … Fox CS (BMC medical genetics 2007) 44 58

Products for FOXB1 Gene

Sources for FOXB1 Gene

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