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Aliases for FOXA3 Gene

Aliases for FOXA3 Gene

  • Forkhead Box A3 2 3 5
  • Hepatocyte Nuclear Factor 3-Gamma 3 4
  • Fork Head-Related Protein FKH H3 3 4
  • Forkhead Box Protein A3 3 4
  • Transcription Factor 3G 3 4
  • HNF-3-Gamma 3 4
  • HNF-3G 3 4
  • TCF-3G 3 4
  • HNF3G 3 4
  • TCF3G 3 4
  • Hepatocyte Nuclear Factor 3, Gamma 2
  • FKHH3 3

External Ids for FOXA3 Gene

Previous HGNC Symbols for FOXA3 Gene

  • HNF3G

Previous GeneCards Identifiers for FOXA3 Gene

  • GC19P047011
  • GC19P046758
  • GC19P051043
  • GC19P051059
  • GC19P046368
  • GC19P042796

Summaries for FOXA3 Gene

Entrez Gene Summary for FOXA3 Gene

  • This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]

GeneCards Summary for FOXA3 Gene

FOXA3 (Forkhead Box A3) is a Protein Coding gene. Diseases associated with FOXA3 include Maturity-Onset Diabetes Of The Young. Among its related pathways are Regulation of beta-cell development and FOXA1 transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOXA1.

UniProtKB/Swiss-Prot for FOXA3 Gene

  • Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.

Gene Wiki entry for FOXA3 Gene

Additional gene information for FOXA3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXA3 Gene

Genomics for FOXA3 Gene

GeneHancer (GH) Regulatory Elements for FOXA3 Gene

Promoters and enhancers for FOXA3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J045861 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 600.7 +0.7 684 5.9 HDGF ZNF652 SP1 ZFX CTCF CC2D1A ELF3 MNT SIX5 ZNF148 SYMPK FOXA3 ENSG00000268810 CCDC61 CLASRP DMWD ENSG00000267114 SLC1A5 FBXO46 IRF2BP1
GH19J045763 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 -95.1 -95147 10.2 HDGF ZFX SP1 CTCF MNT CBFA2T2 ZNF148 NKRF POLR2A MLLT1 DM1-AS SIX5 CCDC61 SYMPK CLASRP ENSG00000268810 FBXO46 ENSG00000267114 ENSG00000269148 DMPK
GH19J045790 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11.3 -71.6 -71588 3.6 HDGF SP1 ZFX NKRF POLR2A CSDE1 ZNF384 ZNF687 MCM2 ELF1 DMWD SYMPK CCDC61 DMPK SIX5 FOXA3 ENSG00000259605 GC19M045789
GH19J045994 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 11 +131.1 131112 3 ZNF652 SP1 MNT NKRF POLR2A MLLT1 GTF2F1 ZSCAN21 FOS MYC CCDC61 ENSG00000268810 SYMPK CLASRP FOXA3 QPCTL CD3EAP NOVA2
GH19J045690 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 10.1 -171.6 -171644 3.5 HDGF CC2D1A ZFX SP1 CTCF MNT NKRF POLR2A MLLT1 CEBPG QPCTL SNRPD2 CCDC61 ENSG00000268810 SYMPK FBXO46 CLASRP ENSG00000269148 ENSG00000267114 IRF2BP1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOXA3 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOXA3 gene promoter:
  • E2F
  • E2F-1
  • Ik-3
  • NF-1
  • NF-1/L
  • Olf-1
  • USF-1
  • USF1
  • ZID

Genomic Locations for FOXA3 Gene

Genomic Locations for FOXA3 Gene
chr19:45,863,989-45,873,797
(GRCh38/hg38)
Size:
9,809 bases
Orientation:
Plus strand
chr19:46,367,247-46,377,055
(GRCh37/hg19)
Size:
9,809 bases
Orientation:
Plus strand

Genomic View for FOXA3 Gene

Genes around FOXA3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOXA3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOXA3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOXA3 Gene

Proteins for FOXA3 Gene

  • Protein details for FOXA3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P55318-FOXA3_HUMAN
    Recommended name:
    Hepatocyte nuclear factor 3-gamma
    Protein Accession:
    P55318
    Secondary Accessions:
    • A9LYI5
    • Q53F16
    • Q9UMW9

    Protein attributes for FOXA3 Gene

    Size:
    350 amino acids
    Molecular mass:
    37140 Da
    Quaternary structure:
    • Interacts with FOXA2.

    Three dimensional structures from OCA and Proteopedia for FOXA3 Gene

neXtProt entry for FOXA3 Gene

Post-translational modifications for FOXA3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOXA3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for FOXA3 Gene

Domains & Families for FOXA3 Gene

Gene Families for FOXA3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Suggested Antigen Peptide Sequences for FOXA3 Gene

GenScript: Design optimal peptide antigens:
  • Transcription factor 3G (FOXA3_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with FOXA3: view

No data available for UniProtKB/Swiss-Prot for FOXA3 Gene

Function for FOXA3 Gene

Molecular function for FOXA3 Gene

UniProtKB/Swiss-Prot Function:
Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.

Phenotypes From GWAS Catalog for FOXA3 Gene

Gene Ontology (GO) - Molecular Function for FOXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0003677 DNA binding IEA --
GO:0003700 DNA-binding transcription factor activity TAS 9369482
GO:0008134 transcription factor binding IEA --
GO:0019904 protein domain specific binding IEA --
genes like me logo Genes that share ontologies with FOXA3: view
genes like me logo Genes that share phenotypes with FOXA3: view

Animal Models for FOXA3 Gene

MGI Knock Outs for FOXA3:

Animal Model Products

CRISPR Products

miRNA for FOXA3 Gene

miRTarBase miRNAs that target FOXA3

Clone Products

  • Addgene plasmids for FOXA3
  • Applied Biological Materials (abm): Clones for FOXA3 - Now 50% OFF >
  • * FOXA3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FOXA3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOXA3 Gene

Localization for FOXA3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOXA3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOXA3 gene
Compartment Confidence
nucleus 5
cytoskeleton 4
cytosol 2
extracellular 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS 21873635
GO:0005654 nucleoplasm IDA --
GO:0015629 actin cytoskeleton IDA --
genes like me logo Genes that share ontologies with FOXA3: view

Pathways & Interactions for FOXA3 Gene

genes like me logo Genes that share pathways with FOXA3: view

Gene Ontology (GO) - Biological Process for FOXA3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001678 cellular glucose homeostasis TAS 9369482
GO:0006325 chromatin organization IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IBA 21873635
GO:0007275 multicellular organism development IEA --
genes like me logo Genes that share ontologies with FOXA3: view

No data available for SIGNOR curated interactions for FOXA3 Gene

Drugs & Compounds for FOXA3 Gene

No Compound Related Data Available

Transcripts for FOXA3 Gene

mRNA/cDNA for FOXA3 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(41) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for FOXA3 Gene

Forkhead box A3:
Representative Sequences:

CRISPR Products

Clone Products

  • Addgene plasmids for FOXA3
  • Applied Biological Materials (abm): Clones for FOXA3 - Now 50% OFF >
  • * FOXA3 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * FOXA3 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for FOXA3 Gene

No ASD Table

Relevant External Links for FOXA3 Gene

GeneLoc Exon Structure for
FOXA3
ECgene alternative splicing isoforms for
FOXA3

Expression for FOXA3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOXA3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for FOXA3 Gene

This gene is overexpressed in Liver (x20.2), Pancreas (x12.7), Stomach (x8.3), and Colon - Transverse (x5.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for FOXA3 Gene



NURSA nuclear receptor signaling pathways regulating expression of FOXA3 Gene:

FOXA3

SOURCE GeneReport for Unigene cluster for FOXA3 Gene:

Hs.36137

mRNA Expression by UniProt/SwissProt for FOXA3 Gene:

P55318-FOXA3_HUMAN
Tissue specificity: Expressed in erythroleukemia and hepatoma cell lines and in liver and pancreas. Not expressed in any other cell lines or tissues examined.

Evidence on tissue expression from TISSUES for FOXA3 Gene

  • Liver(4.5)
  • Stomach(4.4)
genes like me logo Genes that share expression patterns with FOXA3: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXA3 Gene

Orthologs for FOXA3 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOXA3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOXA3 35 34
  • 99.05 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FOXA3 34 35
  • 88.54 (n)
cow
(Bos Taurus)
Mammalia FOXA3 35 34
  • 87.11 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Foxa3 34
  • 83.09 (n)
mouse
(Mus musculus)
Mammalia Foxa3 17 35 34
  • 81.95 (n)
oppossum
(Monodelphis domestica)
Mammalia FOXA3 35
  • 74 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOXA3 35
  • 48 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii foxa3 34 34 35
  • 59.81 (n)
fruit fly
(Drosophila melanogaster)
Insecta fkh 35
  • 28 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 47 (a)
ManyToMany
CSA.7421 35
  • 23 (a)
ManyToMany
Species where no ortholog for FOXA3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOXA3 Gene

ENSEMBL:
Gene Tree for FOXA3 (if available)
TreeFam:
Gene Tree for FOXA3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOXA3: view image

Paralogs for FOXA3 Gene

(9) SIMAP similar genes for FOXA3 Gene using alignment to 2 proteins:

  • FOXA3_HUMAN
  • M0QZW5_HUMAN
genes like me logo Genes that share paralogs with FOXA3: view

Variants for FOXA3 Gene

Sequence variations from dbSNP and Humsavar for FOXA3 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000520326 -- 45,869,147(+) G/A intron_variant
rs1000572163 -- 45,866,643(+) C/A intron_variant
rs1000692608 -- 45,863,567(+) TTTCTTTCTTTCTTT/TTTCTTTCTTT/TTTCTTTCTTTCTTTCTTT upstream_transcript_variant
rs1000822757 -- 45,866,305(+) G/A intron_variant
rs1001059435 -- 45,868,840(+) TGTT/TGTTGTT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for FOXA3 Gene

Variant ID Type Subtype PubMed ID
nsv510770 CNV deletion 20534489
nsv523029 CNV loss 19592680

Variation tolerance for FOXA3 Gene

Residual Variation Intolerance Score: 33.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.06; 21.68% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOXA3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOXA3
Human Gene Mutation Database (HGMD)
FOXA3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXA3 Gene

Disorders for FOXA3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOXA3 Gene - From: GeneCards

Disorder Aliases PubMed IDs
maturity-onset diabetes of the young
  • mody
- elite association - COSMIC cancer census association via MalaCards
Search FOXA3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOXA3

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FOXA3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOXA3 Gene

Publications for FOXA3 Gene

  1. Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. (PMID: 19919681) Motallebipour M … Wadelius C (Genome biology 2009) 3 4 23 58
  2. Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma. (PMID: 12695546) Rodríguez-Antona C … Castell JV (Molecular pharmacology 2003) 3 4 23 58
  3. Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PMID: 19934400) Lamba V … Schuetz EG (The Journal of pharmacology and experimental therapeutics 2010) 3 45 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis. (PMID: 10899756) Navas MA … Stoffel M (Human heredity 2000) 3 4 58

Products for FOXA3 Gene

Sources for FOXA3 Gene

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