Aliases for FOXA3 Gene
External Ids for FOXA3 Gene
Previous HGNC Symbols for FOXA3 Gene
Previous GeneCards Identifiers for FOXA3 Gene
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. The crystal structure of a similar protein in rat has been resolved. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXA3 Gene
FOXA3 (Forkhead Box A3) is a Protein Coding gene. Diseases associated with FOXA3 include Maturity-Onset Diabetes Of The Young and Crigler-Najjar Syndrome, Type I. Among its related pathways are FOXA1 transcription factor network and Regulation of beta-cell development. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOXA1.
UniProtKB/Swiss-Prot Summary for FOXA3 Gene
Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; binds to and activates transcription from the G6PC promoter. Binds to the CYP3A4 promoter and activates its transcription in cooperation with CEBPA. Binds to the CYP3A7 promoter together with members of the CTF/NF-I family. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis.