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This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has b... See more...
Aliases for FOXA2 Gene
Aliases for FOXA2 Gene
External Ids for FOXA2 Gene
- HGNC: 5022
- Entrez Gene: 3170
- Ensembl: ENSG00000125798
- OMIM: 600288
- UniProtKB: Q9Y261
Previous HGNC Symbols for FOXA2 Gene
- HNF3B
Previous GeneCards Identifiers for FOXA2 Gene
- GC20M022550
- GC20M022556
- GC20M022509
- GC20M022561
- GC20M022523
Summaries for FOXA2 Gene
-
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
GeneCards Summary for FOXA2 Gene
FOXA2 (Forkhead Box A2) is a Protein Coding gene. Diseases associated with FOXA2 include Combined Pituitary Hormone Deficiencies, Genetic Forms and Maturity-Onset Diabetes Of The Young. Among its related pathways are Regulation of beta-cell development and Hepatic ABC Transporters. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOXA1.
UniProtKB/Swiss-Prot Summary for FOXA2 Gene
-
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Additional gene information for FOXA2 Gene
- HGNC(5022)
- Entrez Gene(3170)
- Ensembl(ENSG00000125798)
- OMIM(600288)
- UniProtKB(Q9Y261)
- Open Targets Platform(ENSG00000125798)
- Monarch Initiative
- Search for FOXA2 at DataMed
- Search for FOXA2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXA2 Gene
Genomics for FOXA2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FOXA2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXA2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXA2
- Top Transcription factor binding sites by QIAGEN in the FOXA2 gene promoter:
-
- AP-2alpha
- AP-2alphaA
- ATF
- HFH-1
- S8
Genomic Locations for FOXA2 Gene
Genomic Locations for FOXA2 Gene
- chr20:22,580,998-22,585,490
- (GRCh38/hg38)
- Size:
- 4,493 bases
- Orientation:
- Minus strand
- chr20:22,561,642-22,566,101
- (GRCh37/hg19)
- Size:
- 4,460 bases
- Orientation:
- Minus strand
Genomic View for FOXA2 Gene
Genes around FOXA2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 20p11.21 by HGNC
- 20p11.21 by Entrez Gene
- 20p11.21 by Ensembl
FOXA2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXA2 Gene
Proteins for FOXA2 Gene
-
Protein details for FOXA2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9Y261-FOXA2_HUMAN
- Recommended name:
- Hepatocyte nuclear factor 3-beta
- Protein Accession:
- Q9Y261
- Q8WUW4
- Q96DF7
Protein attributes for FOXA2 Gene
- Size:
- 457 amino acids
- Molecular mass:
- 48306 Da
- Quaternary structure:
-
- Binds DNA as a monomer. Binds TLE1 (By similarity). Interacts with FOXA1 and FOXA3. Interacts with PRKDC.
- SequenceCaution:
-
- Sequence=AAH11780.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
Protein Expression for FOXA2 Gene
Post-translational modifications for FOXA2 Gene
- Phosphorylation on Thr-156 abolishes binding to target promoters and subsequent transcription activation upon insulin stimulation.
- Modification sites at PhosphoSitePlus
- Modification sites at neXtProt
Other Protein References for FOXA2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- NSJ Bioreagents FOXA2 Antibody
- BioLegend FOXA2 Antibody
- Novus Biologicals Antibodies for FOXA2
-
Abcam antibodies for FOXA2
- Invitrogen Antibodies for FOXA2 (AFLGC-FOXA2)
- antibodies-online: Show 50 available FOXA2 Antibodies ranked by validation data
- Compare Top FOXA2 Antibodies
-
Recommended
- 178 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 27 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 8 FACS Antibodies (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 8 FACS Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for FOXA2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXA2
Protein Products
-
OriGene Purified Proteins for FOXA2
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXA2
- Origene Custom Protein Services for FOXA2
-
Abcam proteins for FOXA2
Assay Products
- antibodies-online: Show 6 available FOXA2 Elisa Kits ranked by validation data
- Compare Top FOXA2 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for FOXA2 Gene
Domains & Families for FOXA2 Gene
Gene Families for FOXA2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXA2 Gene
- InterPro:
- Blocks:
-
- Fork-head N-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXA2 Gene
- GenScript: Design optimal peptide antigens:
-
- Forkhead box A2, isoform CRA_b (B0ZTD4_HUMAN)
- Transcription factor 3B (FOXA2_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXA2 Gene
Function for FOXA2 Gene
Molecular function for FOXA2 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation.
Phenotypes From GWAS Catalog for FOXA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IMP | 15737987 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IDA | 12642491 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0003677 | DNA binding | IEA,IDA | 9931457 |
| GO:0003700 | DNA-binding transcription factor activity | IDA | 9931457 |
Phenotypes for FOXA2 Gene
- MGI mutant phenotypes for FOXA2:
-
inferred from 12 alleles
- nervous system phenotype
- immune system phenotype
- respiratory system phenotype
- normal phenotype
- cardiovascular system phenotype
- cellular phenotype
- behavior/neurological phenotype
- mortality/aging
- homeostasis/metabolism phenotype
- growth/size/body region phenotype
- liver/biliary system phenotype
- neoplasm
- digestive/alimentary phenotype
- endocrine/exocrine gland phenotype
- reproductive system phenotype
- vision/eye phenotype
- skeleton phenotype
- hematopoietic system phenotype
- integument phenotype
- embryo phenotype
- craniofacial phenotype
- adipose tissue phenotype
- GenomeRNAi human phenotypes for FOXA2:
-
- Increased vaccinia virus (VACV) infection
- no effect
- Decreased viability
- Synthetic lethal with Ras
- Decreased shRNA abundance
- Decreased nuclei size in G2M
- Decreased Sindbis virus (SINV) infection
- Inconclusive
- Increased HPV18 LCR reporter activity
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased viability in ovarian lineage
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Increased CDKN1A mRNA expression
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
- Increased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased TP53 mRNA expression
Animal Models for FOXA2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXA2 - Select products 50% OFF >
- * FOXA2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXA2
miRNA for FOXA2 Gene
- miRTarBase miRNAs that target FOXA2
-
- mmu-miR-124-3p (MIRT002332)
- hsa-miR-335-5p (MIRT017120)
- hsa-miR-1185-2-3p (MIRT440616)
- hsa-miR-1185-1-3p (MIRT440617)
- hsa-miR-187-3p (MIRT733743)
- hsa-miR-124-3p (MIRT734258)
- hsa-miR-200a-3p (MIRT735206)
- hsa-miR-199a-3p (MIRT735287)
- hsa-miR-1290 (MIRT762282)
- hsa-miR-3167 (MIRT765207)
- hsa-miR-450a-1-3p (MIRT769842)
- hsa-miR-5096 (MIRT773306)
- hsa-miR-6716-5p (MIRT777704)
- hsa-miR-876-5p (MIRT782531)
Targeted motifs for FOXA2 Gene
HOMER Transcription Factor Regulatory Elements motif FOXA2
- Consensus sequence: CTTGTTTACATA Submotif: canonical Cell Type: Liver GEO ID: GSE25694
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXA2
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Clone Products
- Applied Biological Materials (abm): Clones for FOXA2 - Select products 50% OFF >
- * FOXA2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227354
- MR227354
- MR227354L3
- MR227354L4
- MR229860
- MR230052
- RC204066
- RC204066L1
- RC204066L2
- RC204066L3
- RC204066L4
- RC211408
- RC211408L1
- RC211408L2
- RC211408L3
- RC211408L4
- RG204066
- RG211408
- RR214378
- RR214378L3
- RR214378L4
- MR227354L3V
- MR227354L4V
- RC204066L1V
- RC204066L2V
- RC204066L3V
- RC204066L4V
- RC211408L1V
- RC211408L2V
- RC211408L3V
- RC211408L4V
- RR214378L3V
- RR214378L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FOXA2
- Addgene plasmids for FOXA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA2
Cell Line Products
-
Horizon Cell Lines for FOXA2
No data available for Enzyme Numbers (IUBMB) and Transcription Factor Targets for FOXA2 Gene
Localization for FOXA2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXA2 Gene
- Nucleus. Cytoplasm. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner. in response to insulin signaling via AKT1 is exported from the nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 3 |
| cytosol | 3 |
| plasma membrane | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| endoplasmic reticulum | 2 |
| peroxisome | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (3)
- Cell Junctions (2)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | IBA,IDA | 9931457 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005737 | cytoplasm | IEA | -- |
| GO:0030054 | cell junction | IDA | -- |
Pathways & Interactions for FOXA2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Regulation of beta-cell development | ||
| 2 | Mesodermal Commitment Pathway | ||
| 3 | FOXA1 transcription factor network | ||
| 4 | Glucose / Energy Metabolism | ||
| 5 | PI3K / Akt Signaling | ||
Pathways by source for FOXA2 Gene
10 BioSystems pathways for FOXA2 Gene
3 Reactome pathways for FOXA2 Gene
2 KEGG pathways for FOXA2 Gene
1 R&D Systems pathway for FOXA2 Gene
1 Qiagen pathway for FOXA2 Gene
- MODY (Maturity-Onset Diabetes of Young)
2 Cell Signaling Technology pathways for FOXA2 Gene
Interacting Proteins for FOXA2 Gene
Selected Interacting proteins:
Q9Y261-FOXA2_HUMAN
ENSP00000400341
for FOXA2 Gene via
MINT
STRING
IID
GPS-Prot Interaction Network for FOXA2
SIGNOR curated interactions for FOXA2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000432 | positive regulation of transcription from RNA polymerase II promoter by glucose | ISS | -- |
| GO:0001708 | cell fate specification | ISS | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IDA | 12911579 |
Transcripts for FOXA2 Gene
mRNA/cDNA for FOXA2 Gene
- 2 REFSEQ mRNAs :
- 10 NCBI additional mRNA sequence :
- 2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000377115 2401 nts (view in UCSC)
- ENST00000419308 2422 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXA2 - Select products 50% OFF >
- * FOXA2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXA2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXA2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXA2
- Browse OriGene Inhibitory RNA Products For FOXA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXA2
Clone Products
- Applied Biological Materials (abm): Clones for FOXA2 - Select products 50% OFF >
- * FOXA2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
- MG227354
- MR227354
- MR227354L3
- MR227354L4
- MR229860
- MR230052
- RC204066
- RC204066L1
- RC204066L2
- RC204066L3
- RC204066L4
- RC211408
- RC211408L1
- RC211408L2
- RC211408L3
- RC211408L4
- RG204066
- RG211408
- RR214378
- RR214378L3
- RR214378L4
- MR227354L3V
- MR227354L4V
- RC204066L1V
- RC204066L2V
- RC204066L3V
- RC204066L4V
- RC211408L1V
- RC211408L2V
- RC211408L3V
- RC211408L4V
- RR214378L3V
- RR214378L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FOXA2
- Addgene plasmids for FOXA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA2
Relevant External Links for FOXA2 Gene
- GeneLoc Exon Structure for
- FOXA2
Expression for FOXA2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Acinar Progenitor Cells Dorsal Pancreatic Bud
- Alpha Progenitor Cells Dorsal Pancreatic Bud
- Prepancreatic Foregut Endoderm Cells Prepancreatic Ventral Foregut Endoderm
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
-
Endoderm (Gastrulation Derivatives)
- Definitive Endoderm Cells Definitive Endoderm
- Endoderm Progenitor Cells Anterior Primitive Streak
- Mesendoderm Cells Anterior Primitive Streak
- Endoderm-like cells(Hannan NR et. al. 2013)
- Definitive endoderm-like cells(Si-Tayeb K et. al. 2010)
-
Epithelial Cells
- Acinar Progenitor Cells Dorsal Pancreatic Bud
- Alveolar Epithelial Type 2 Cells Alveoli
- Prepancreatic Foregut Endoderm Cells Prepancreatic Ventral Foregut Endoderm
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Bipotent Endocrine/Duct Progenitor Cells Dorsal Pancreatic Bud
-
Brain (Nervous System)
- Early Caudal Floor Plate Cells Diencephalic Floor Plate
- Early Floor Plate Cells Mesencephalic Floor Plate
- Meso-diencephalic Dopaminergic Precursor Cells Diencephalic Ventricular Zone
- Meso-diencephalic Dopaminergic Precursor Cells Mesencephalic Ventricular Zone
- Hypothalamus
- NULL (Uncategorized)
-
Neural Tube (Nervous System)
- Floor Plate Cells Spinal Floor Plate
- Late Caudal Floor Plate Cells Diencephalic Floor Plate
- Early Caudal Floor Plate Cells Diencephalic Floor Plate
- Early Floor Plate Cells Mesencephalic Floor Plate
- Meso-diencephalic Dopaminergic Precursor Cells Diencephalic Ventricular Zone
-
Primitive Streak (Early Embryonic Tissues)
- Primitive Streak Cells Anterior Primitive Streak
- Endoderm Progenitor Cells Anterior Primitive Streak
- Primitive Streak Cells Primitive Streak
- Prechordal Plate Cells Prechordal Plate
- Notochord Cells Notochord
-
Gut Tube (Gastrointestinal Tract)
- Foregut Endoderm Cells Foregut
- Prepancreatic Foregut Endoderm Cells Prepancreatic Ventral Foregut Endoderm
- Multipotent Lung Progenitor Cells Ventral Foregut Endoderm
- Hindgut Endoderm Cells Hindgut
- Primitive Gut Endoderm Cells Gut Tube
-
Epiblast (Early Embryonic Tissues)
- Epiblast Cells Epiblast
- Primitive Streak Cells Anterior Primitive Streak
- Early-Gastrula Organizer Epiblast
- Prechordal Plate Cells Prechordal Plate
- Primitive Streak Cells Posterior Primitive Streak
-
Lung (Respiratory System)
- Trachea Progenitor Cells Trachea
- Alveolar Epithelial Type 2 Cells Alveoli
- Clara Cells Respiratory Bronchioles
- Multipotent Lung Progenitor Cells Ventral Foregut Endoderm
- Clara Cells Trachea
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Hepatic Endoderm Cells Ventral Foregut Endoderm
- Hepatoblasts Liver Bud
- Hepatocyte-like cells(Si-Tayeb K et. al. 2010)
-
Neurons
- Ventral midbrain dopaminergic-like neurons(Cooper O et. al. 2010)
- Dopaminergic neuron-like cells(Yoshikawa T et. al. 2013)
- Dopaminergic neuron-like cells (Sundberg M et. al. 2013)
- Ventral midbrain dopaminergic neurons-like cells(Sundberg M et. al. 2013)
- Midbrain dopaminergic-like neurons (Ganat YM et. al. 2012)
-
Dopaminergic Neurons (Nervous System)
- Ventral midbrain dopaminergic-like neurons(Cooper O et. al. 2010)
- Dopaminergic neuron-like cells(Yoshikawa T et. al. 2013)
- Dopaminergic neuron-like cells (Sundberg M et. al. 2013)
- Ventral midbrain dopaminergic neurons-like cells(Sundberg M et. al. 2013)
- Midbrain dopaminergic-like neurons (Ganat YM et. al. 2012)
- Bone (Muscoskeletal System)
-
Neural Ectoderm (Nervous System)
- Cranial Neural Plate Cells Neural Plate
- Spinal Neural Plate Cells Neural Plate
- Cartilage (Muscoskeletal System)
-
Mesoderm (Gastrulation Derivatives)
- Mesendoderm Cells Anterior Primitive Streak
- Mesoderm-like cells(Oldershaw RA et. al. 2010)
- Mesenchymal Stem Cells
-
Eye (Sensory Organs)
- Limbal Basal Epithelial Cells Limbus Epithelium
-
Hypoblast (Extraembryonic Tissues)
- Extraembryonic Endoderm Cells Extraembryonic Endoderm
-
Yolk Sac (Extraembryonic Tissues)
- Extraembryonic Endoderm Cells Extraembryonic Endoderm
- Ovary (Reproductive System)
- Inner Cell Mass (Early Embryonic Tissues)
- Extraembryonic Tissues (Extraembryonic Tissues)
- Uncategorized
mRNA differential expression in normal tissues according to GTEx for FOXA2 Gene
This gene is overexpressed in Liver (x15.7), Pancreas (x12.5), Stomach (x10.2), and Lung (x4.3).
This gene is overexpressed in Islet of Langerhans (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXA2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXA2
SOURCE GeneReport for Unigene cluster for FOXA2 Gene:
Hs.155651Evidence on tissue expression from TISSUES for FOXA2 Gene
- Lung(4.7)
- Liver(4.6)
- Pancreas(3.1)
- Intestine(2.8)
- Stomach(2.6)
- Skin(2.6)
- Nervous system(2.5)
- Muscle(2.3)
- Blood(2.3)
- Heart(2.2)
- Kidney(2)
Primer Products
-
OriGene qPCR primer pairs for FOXA2
-
OriGene qPCR primer pairs and template standards for FOXA2
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXA2 Gene
Orthologs for FOXA2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Dog (Canis familiaris) |
Mammalia | FOXA2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FOXA2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Foxa2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Foxa2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | FOXA2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FOXA2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FOXA2 30 |
|
||
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | foxa2 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | foxa2 30 31 |
|
OneToOne | |
| -- 30 |
|
||||
| Fruit Fly (Drosophila melanogaster) |
Insecta | fkh 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| CSA.7421 31 |
|
ManyToMany |
- Species where no ortholog for FOXA2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chimpanzee (Pan troglodytes)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FOXA2 Gene
- ENSEMBL:
- Gene Tree for FOXA2 (if available)
- TreeFam:
- Gene Tree for FOXA2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXA2: view image
Paralogs for FOXA2 Gene
Paralogs for FOXA2 Gene
- FOXA1 5
- FOXA3 5
- FOXC1 5
- FOXC2 5
- FOXD3 5
- FOXK1 5
- FOXI3 5
- FOXD4L6 5
- FOXB1 5
- FOXD2 5
- FOXD1 5
- FOXK2 5
- FOXB2 5
- FOXJ3 5
- FOXI2 5
- FOXD4L5 5
- FOXE3 5
- FOXD4L1 5
- FOXD4L4 5
- FOXD4 5
- FOXE1 5
- FOXO1 5
- FOXD4L3 5
- FOXL1 5
- FOXS1 5
- FOXQ1 5
- FOXL2 5
- FOXJ2 5
- FOXO3 5
- FOXM1 5
- FOXJ1 5
- FOXF1 5
- FOXL3 5
- FOXO4 5
- FOXH1 5
- FOXN1 5
- FOXO6 5
- FOXP1 5
- ENSG00000285708 5
- FOXR2 5
- FOXR1 5
- FOXP3 5
- FOXO3B 5
(9) SIMAP similar genes for FOXA2 Gene using alignment to 2 proteins:
- FOXA2_HUMAN
- B0ZTD4_HUMAN
Variants for FOXA2 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXA2 Gene
| SNP ID | Clinical significance and condition | Chr 20 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 769996 | Benign: not provided | 22,581,969(-) | G/T | MISSENSE_VARIANT | |
| rs1555809148 | Uncertain Significance: not provided | 22,582,382(-) | TG/T | FRAMESHIFT_VARIANT | |
| rs199796119 | - | p.Ala328Val |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1073050 | CNV | deletion | 25765185 |
| nsv1136325 | CNV | deletion | 24896259 |
| nsv953003 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
22.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
2.93;
49.04% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXA2 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXA2 Gene
Disorders for FOXA2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| combined pituitary hormone deficiencies, genetic forms |
|
|
| maturity-onset diabetes of the young |
|
|
| meckel diverticulum |
|
|
| hyperinsulinemic hypoglycemia |
|
|
| hepatitis c virus |
|
|
Search FOXA2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FOXA2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FOXA2 Gene
Publications for FOXA2 Gene
- Genetic predictors of interindividual variability in hepatic CYP3A4 expression. (PMID: 19934400) Lamba V … Schuetz EG (The Journal of pharmacology and experimental therapeutics 2010) 3 23 41
- Insulin regulates the activity of forkhead transcription factor Hnf-3beta/Foxa-2 by Akt-mediated phosphorylation and nuclear/cytosolic localization. (PMID: 14500912) Wolfrum C … Stoffel M (Proceedings of the National Academy of Sciences of the United States of America 2003) 3 4 23
- Foxa2 (HNF3beta ) controls multiple genes implicated in metabolism-secretion coupling of glucose-induced insulin release. (PMID: 11875061) Wang H … Wollheim CB (The Journal of biological chemistry 2002) 2 3 23
- Beta-cell transcription factors and diabetes: no evidence for diabetes-associated mutations in the hepatocyte nuclear factor-3beta gene (HNF3B) in Japanese patients with maturity-onset diabetes of the young. (PMID: 10868948) Hinokio Y … Bell GI (Diabetes 2000) 3 23 41
- Foxa2 (HNF-3beta) regulates expression of hepatotrophic factor ALR in liver cells. (PMID: 20382118) Dayoub R … Weiss TS (Biochemical and biophysical research communications 2010) 3 23
ExternalLinks
Products for FOXA2 Gene
- View all 13 R&D Systems FOXA2 (HNF-3 beta/FoxA2) Products
- View all 11 R&D Systems FOXA2 (HNF-3 beta/FoxA2) Primary Antibodies
- View all 2 R&D Systems FOXA2 (HNF-3 beta/FoxA2) Proteome Profiler Antibody Arrays
- Learn more about R&D Systems custom FOXA2 antibody, protein, and immunoassay development services
- Custom Antibody ServicesOriGene Antibodies for FOXA2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FOXA2
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXA2
- Origene Custom Protein Services for FOXA2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXA2
- Browse OriGene Inhibitory RNA Products For FOXA2
- OriGene qPCR primer pairs for FOXA2
- OriGene qPCR primer pairs and template standards for FOXA2
- OriGene CRISPR knockouts for FOXA2
- MG227354
- MR227354
- MR227354L3
- MR227354L4
- MR229860
- MR230052
- RC204066
- RC204066L1
- RC204066L2
- RC204066L3
- RC204066L4
- RC211408
- RC211408L1
- RC211408L2
- RC211408L3
- RC211408L4
- RG204066
- RG211408
- RR214378
- RR214378L3
- RR214378L4
- MR227354L3V
- MR227354L4V
- RC204066L1V
- RC204066L2V
- RC204066L3V
- RC204066L4V
- RC211408L1V
- RC211408L2V
- RC211408L3V
- RC211408L4V
- RR214378L3V
- RR214378L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOXA2
- Sino Biological Human cDNA Clone for FOXA2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FOXA2
- Novus Biologicals proteins and lysates for FOXA2
- Browse Antibodies
- Browse Peptides and Proteins
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- Abcam antibodies for FOXA2
- Abcam proteins for FOXA2
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- Browse Primary Antibodies
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- Invitrogen Antibodies for FOXA2 (AFLGC-FOXA2)
- VectorBuilder Custom and pre-made DNA vectors for FOXA2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FOXA2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FOXA2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FOXA2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FOXA2
- Addgene plasmids for FOXA2
- antibodies-online: Show 50 available FOXA2 Antibodies ranked by validation data
- Compare Top FOXA2 Antibodies
- Recommended
- 178 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 FACS Antibodies (anti-human)
- 1 ICC Antibody (anti-human)
- 1 IF Antibody (anti-human)
- 27 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 8 FACS Antibodies (anti-mouse)
- 37 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 8 FACS Antibodies (anti-rat)
- antibodies-online: Show 6 available FOXA2 Elisa Kits ranked by validation data
- Compare Top FOXA2 Elisa Kits
- Quality Products:
- antibodies-online: Show 9 available FOXA2 Proteins ranked by validation data
- Compare Top FOXA2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FOXA2
- Search Santa Cruz Biotechnology (SCBT) for FOXA2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOXA2
- Custom Antibody ServicesProSci Antibodies for FOXA2
- Search for FOXA2 Proteins at ProSci
- Horizon Cell Lines for FOXA2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FOXA2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXA2
Sources for FOXA2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB