Aliases for FOXA1 Gene
Aliases for FOXA1 Gene
External Ids for FOXA1 Gene
- HGNC: 5021
- Entrez Gene: 3169
- Ensembl: ENSG00000129514
- OMIM: 602294
- UniProtKB: P55317
Previous HGNC Symbols for FOXA1 Gene
- HNF3A
Previous GeneCards Identifiers for FOXA1 Gene
- GC14M035439
- GC14M031916
- GC14M036049
- GC14M037128
- GC14M038059
- GC14M018173
Summaries for FOXA1 Gene
-
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXA1 Gene
FOXA1 (Forkhead Box A1) is a Protein Coding gene. Diseases associated with FOXA1 include Estrogen-Receptor Positive Breast Cancer and Luminal Breast Carcinoma. Among its related pathways are Direct p53 effectors and FOXA1 transcription factor network. Gene Ontology (GO) annotations related to this gene include DNA binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOXA2.
UniProtKB/Swiss-Prot for FOXA1 Gene
-
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3 (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at Lys-5 (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for FOXA1 Gene
Genomics for FOXA1 Gene
GeneHancer (GH) Regulatory Elements for FOXA1 Gene
Promoters and enhancers for FOXA1 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH14J037582 | Promoter/Enhancer | 2.6 | EPDnew FANTOM5 Ensembl ENCODE dbSUPER | 654.7 | +4.6 | 4608 | 18 | CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF263 | FOXA1 MIPOL1 SLC25A21-AS1 TTC6 ENSG00000259087 | |
| GH14J037566 | Enhancer | 1 | ENCODE dbSUPER | 12.2 | +29.0 | 29041 | 0.7 | FOXA2 ZBTB40 RAD21 YY1 ZNF335 FOS SMARCA5 RXRA CEBPB REST | ENSG00000259087 FOXA1 TTC6 MIPOL1 ENSG00000258414 | |
| GH14J037246 | Enhancer | 1.2 | UCNEbase ENCODE | 10 | +349.3 | 349332 | 0.5 | FOXA2 RAD21 RFX5 ZNF614 ZNF143 MIXL1 NFKBIZ ZNF654 ZBTB25 CEBPB | MIPOL1 FOXA1 GC14P037261 | |
| GH14J037622 | Enhancer | 0.8 | Ensembl ENCODE dbSUPER | 12.3 | -26.4 | -26445 | 1 | CTBP2 EZH2 | PIR51609 FOXA1 TTC6 | |
| GH14J037623 | Enhancer | 0.7 | ENCODE dbSUPER | 12.3 | -27.8 | -27757 | 1.6 | PKNOX1 RFX1 NFIB CREB1 | PIR51609 FOXA1 TTC6 ENSG00000259087 |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXA1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FOXA1 gene promoter:
-
- FOXO4
- HTF
- PPAR-alpha
- Sp1
- ATF
- FOXD3
- GATA-1
- NRSF form 1
- NRSF form 2
- Sox9
Regulatory Element Products
Genomic Locations for FOXA1 Gene
Genomic Locations for FOXA1 Gene
- chr14:37,589,552-37,596,059
- (GRCh38/hg38)
- Size:
- 6,508 bases
- Orientation:
- Minus strand
- chr14:38,059,189-38,069,245
- (GRCh37/hg19)
- Size:
- 10,057 bases
- Orientation:
- Minus strand
Genomic View for FOXA1 Gene
Genes around FOXA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q21.1 by Entrez Gene
- 14q21.1 by HGNC
- 14q21.1 by Ensembl
FOXA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXA1 Gene
Proteins for FOXA1 Gene
-
Protein details for FOXA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55317-FOXA1_HUMAN
- Recommended name:
- Hepatocyte nuclear factor 3-alpha
- Protein Accession:
- P55317
- B2R9H6
- B7ZAP5
- Q9H2A0
Protein attributes for FOXA1 Gene
- Size:
- 472 amino acids
- Molecular mass:
- 49148 Da
- Quaternary structure:
-
- Binds DNA as a monomer (By similarity). Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 (By similarity).
Protein Expression for FOXA1 Gene
Post-translational modifications for FOXA1 Gene
Other Protein References for FOXA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for FOXA1 (HNF-3 alpha/FoxA1)
- Novus Biologicals Antibodies for FOXA1
-
Abcam antibodies for FOXA1
- Invitrogen Antibodies for FOXA1
- antibodies-online: Search results for 367 available FOXA1 Antibodies ranked by validation data
- Compare Top FOXA1 Antibodies
-
Recommended
- 237 WB Antibodies (anti-human)
- 83 IHC (p) Antibodies (anti-human)
- 22 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 33 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 46 WB Antibodies (anti-rat)
- 39 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 6 IHC Antibodies (anti-rat)
- GeneTex FOXA1 Antibody for FOXA1
-
Custom Antibody ServicesProSci Antibodies for FOXA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXA1
- Sino Biological Antibodies for FOXA1
Protein Products
-
OriGene Purified Proteins for FOXA1
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXA1
- Origene Custom Protein Services for FOXA1
- Search GeneTex for Proteins for FOXA1
-
Abcam proteins for FOXA1
Assay Products
No data available for DME Specific Peptides for FOXA1 Gene
Domains & Families for FOXA1 Gene
Gene Families for FOXA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXA1 Gene
- InterPro:
- Blocks:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXA1 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for FOXA1 Gene
Function for FOXA1 Gene
Molecular function for FOXA1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a pioneer factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3 (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at Lys-5 (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
Phenotypes From GWAS Catalog for FOXA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding | NAS,IBA | 19274049 |
| GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | ISS | -- |
| GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | IEA | -- |
| GO:0003677 | DNA binding | IDA,IEA | 9931457 |
| GO:0003700 | DNA binding transcription factor activity | TAS | 8652662 |
Phenotypes for FOXA1 Gene
- MGI mutant phenotypes for FOXA1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for FOXA1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for FOXA1
-
CRISPR Products
-
OriGene CRISPR knockouts for FOXA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA1
- genomics-online: gRNA clones - Search results for 109 available FOXA1 gene related products
- Overview of 109 available FOXA1 gene related products
- Applied Biological Materials CRISPR for FOXA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXA1
- GenScript: Design CRISPR guide RNA sequences for FOXA1
miRNA for FOXA1 Gene
- miRTarBase miRNAs that target FOXA1
-
- hsa-let-7a-5p (MIRT002078)
- hsa-mir-215-5p (MIRT024644)
- hsa-mir-192-5p (MIRT026509)
- hsa-mir-4715-3p (MIRT548184)
- hsa-mir-3064-3p (MIRT548185)
- hsa-mir-584-5p (MIRT548186)
- hsa-mir-496 (MIRT548187)
- hsa-mir-3607-3p (MIRT548188)
- hsa-mir-758-5p (MIRT548189)
- hsa-mir-218-2-3p (MIRT548190)
- hsa-mir-30d-5p (MIRT548191)
- hsa-mir-30c-5p (MIRT548192)
- hsa-mir-30b-5p (MIRT548193)
- hsa-mir-30a-5p (MIRT548194)
- hsa-mir-30e-5p (MIRT548195)
- hsa-mir-1290 (MIRT733132)
- hsa-mir-23a-3p (MIRT733866)
- hsa-mir-93-5p (MIRT735529)
- hsa-mir-3148 (MIRT765010)
- hsa-mir-3173-3p (MIRT765222)
- hsa-mir-4278 (MIRT768280)
- hsa-mir-4428 (MIRT768890)
- hsa-mir-4668-5p (MIRT770854)
- hsa-mir-4716-3p (MIRT771420)
- hsa-mir-4779 (MIRT772243)
- hsa-mir-548e-5p (MIRT774380)
- hsa-mir-625-5p (MIRT776113)
- hsa-mir-6732-5p (MIRT778005)
- hsa-mir-6794-5p (MIRT779345)
- hsa-mir-6805-5p (MIRT779528)
- hsa-mir-6835-3p (MIRT780032)
- hsa-mir-6891-5p (MIRT781161)
Targeted motifs for FOXA1 Gene
HOMER Transcription Factor Regulatory Elements motif FOXA1
- Consensus sequence: AAAGTAAACA Submotif: canonical Cell Type: MCF7 GEO ID: GSE26831
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOXA1
- Browse OriGene Inhibitory RNA Products For FOXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXA1
- genomics-online: shRNA clones - Search results for 109 available FOXA1 gene related products
- Overview of 109 available FOXA1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FOXA1
- VectorBuilder custom plasmid, inducible vectors for FOXA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FOXA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FOXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA1
- Applied Biological Materials Clones for FOXA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for FOXA1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for FOXA1 Gene
Localization for FOXA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXA1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| extracellular | 1 |
| mitochondrion | 1 |
- Nucleoli fibrillar center (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IEA,IDA | 9931457 |
| GO:0005654 | nucleoplasm | IDA | -- |
| GO:0005902 | microvillus | IEA | -- |
Pathways & Interactions for FOXA1 Gene
Pathways by source for FOXA1 Gene
6 BioSystems pathways for FOXA1 Gene
1 R&D Systems pathway for FOXA1 Gene
1 Cell Signaling Technology pathway for FOXA1 Gene
Interacting Proteins for FOXA1 Gene
Selected Interacting proteins:
ENSP00000250448
P55317-FOXA1_HUMAN
for FOXA1 Gene via
STRING
UniProtKB
IID
MINT
GPS-Prot Interaction Network for FOXA1
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006338 | chromatin remodeling | ISS,IEA | -- |
| GO:0006351 | transcription, DNA-templated | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
Transcripts for FOXA1 Gene
mRNA/cDNA for FOXA1 Gene
- (2) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (95) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000250448 2862 bps (uc001wuf.5)
- ENST00000545425 1806 bps (uc059aym.1)
- ENST00000553751 507 bps (uc059ayn.1)
- ENST00000554607 789 bps (uc059ayo.1)
- ENST00000557418 392 bps (uc059ayp.1)
CRISPR Products
-
OriGene CRISPR knockouts for FOXA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA1
- genomics-online: gRNA clones - Search results for 109 available FOXA1 gene related products
- Overview of 109 available FOXA1 gene related products
- Applied Biological Materials CRISPR for FOXA1
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXA1
- GenScript: Design CRISPR guide RNA sequences for FOXA1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOXA1
- Browse OriGene Inhibitory RNA Products For FOXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXA1
- genomics-online: shRNA clones - Search results for 109 available FOXA1 gene related products
- Overview of 109 available FOXA1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FOXA1
- VectorBuilder custom plasmid, inducible vectors for FOXA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FOXA1
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FOXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA1
- Applied Biological Materials Clones for FOXA1
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for FOXA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Gut Tube (Gastrointestinal Tract)
- Foregut Endoderm Cells Foregut
- Multipotent Lung Progenitor Cells Ventral Foregut Endoderm
- Primitive Gut Endoderm Cells Gut Tube
- Hepatic Endoderm Cells Ventral Foregut Endoderm
- Ventral Foregut Endoderm Cells Ventral Foregut Endoderm
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Hepatic Endoderm Cells Ventral Foregut Endoderm
- Hepatoblasts Liver Bud
- NULL (Uncategorized)
-
Lung (Respiratory System)
- Multipotent Lung Progenitor Cells Ventral Foregut Endoderm
- Stem Bronchi
- Trachea
-
Epithelial Cells
- Hepatic Endoderm Cells Ventral Foregut Endoderm
- Ventral Foregut Endoderm Cells Ventral Foregut Endoderm
- Hepatoblasts Liver Bud
- Kidney (Urinary System)
- Pancreas (Endocrine System)
-
Endoderm (Gastrulation Derivatives)
- Definitive Endoderm Cells Definitive Endoderm
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Hypoblast (Extraembryonic Tissues)
- Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
-
Yolk Sac (Extraembryonic Tissues)
- Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
- Neural Tube (Nervous System)
- Lower Urinary Tract (Urinary System)
- Bone (Muscoskeletal System)
- Epiblast (Early Embryonic Tissues)
- Neurons
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for FOXA1 Gene
This gene is overexpressed in Prostate (x12.2), Liver (x7.9), Stomach (x6.3), Bladder (x5.5), and Colon - Transverse (x4.0).
This gene is overexpressed in Brain (64.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FOXA1 Gene:
FOXA1SOURCE GeneReport for Unigene cluster for FOXA1 Gene:
Hs.163484mRNA Expression by UniProt/SwissProt for FOXA1 Gene:
P55317-FOXA1_HUMAN
Tissue specificity:
Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
Evidence on tissue expression from TISSUES for FOXA1 Gene
- Liver(4.6)
- Lung(4.5)
Primer Products
-
OriGene qPCR primer pairs and template standards for FOXA1
-
OriGene qPCR primer pairs for FOXA1
- genomics-online: primer clones - Search results for 109 available FOXA1 gene related products
- Overview of 109 available FOXA1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXA1 Gene
Orthologs for FOXA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FOXA1 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Foxa1 16 34 33 |
|
||
| dog (Canis familiaris) |
Mammalia | FOXA1 34 33 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Foxa1 33 |
|
||
| cow (Bos Taurus) |
Mammalia | FOXA1 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FOXA1 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FOXA1 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | foxa1 33 |
|
||
| Hnf3a 33 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | foxa1-prov 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | foxa1 34 33 33 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | fkh 34 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
ManyToMany | |
| CSA.7421 34 |
|
ManyToMany |
- Species where no ortholog for FOXA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for FOXA1 Gene
- ENSEMBL:
- Gene Tree for FOXA1 (if available)
- TreeFam:
- Gene Tree for FOXA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXA1: view image
Paralogs for FOXA1 Gene
Paralogs for FOXA1 Gene
(7) SIMAP similar genes for FOXA1 Gene using alignment to 3 proteins:
- FOXA1_HUMAN
- B7ZAP5_HUMAN
- G3V4B9_HUMAN
Pseudogenes.org Pseudogenes for FOXA1 Gene
Variants for FOXA1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000211851 | -- | 37,595,824(-) | A/G | upstream_transcript_variant | |
| rs1000306350 | -- | 37,589,181(-) | C/G | downstream_transcript_variant | |
| rs1000358414 | -- | 37,589,651(-) | TAGTTA/TA | 3_prime_UTR_variant | |
| rs1000412963 | -- | 37,594,280(-) | C/T | 5_prime_UTR_variant, intron_variant | |
| rs1000603594 | -- | 37,595,572(-) | A/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.99;
60.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXA1 Gene
Disorders for FOXA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| estrogen-receptor positive breast cancer |
|
|
| luminal breast carcinoma |
|
|
| estrogen-receptor negative breast cancer |
|
|
| breast cancer |
|
|
Search FOXA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FOXA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FOXA1 Gene
Publications for FOXA1 Gene
- Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. (PMID: 19919681) Motallebipour M … Wadelius C (Genome biology 2009) 3 4 22 58
- The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas. (PMID: 12234996) Lin L … Beer DG (Cancer research 2002) 3 4 22 58
- Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4. (PMID: 9119385) Mincheva A … Kaestner KH (Genomics 1997) 2 3 22 58
- Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line. (PMID: 8652662) Bingle CD … Gowan S (Biochimica et biophysica acta 1996) 2 3 4 58
- Overexpression of hepatocyte nuclear factor-3alpha induces apoptosis through the upregulation and accumulation of cytoplasmic p53 in prostate cancer cells. (PMID: 19866472) Lee HJ … Lee K (The Prostate 2010) 3 22 58
Products for FOXA1 Gene
- R&D Systems Antibodies for FOXA1 (HNF-3 alpha/FoxA1)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Human Proteins and Enzymes
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody ServicesOriGene Antibodies for FOXA1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FOXA1
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXA1
- Origene Custom Protein Services for FOXA1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOXA1
- Browse OriGene Inhibitory RNA Products For FOXA1
- OriGene qPCR primer pairs and template standards for FOXA1
- OriGene qPCR primer pairs for FOXA1
- OriGene CRISPR knockouts for FOXA1
- OriGene ORF clones in human for FOXA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOXA1
- GenScript: Next-day shipping of latest version cDNA ORF clones for FOXA1 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for FOXA1
- GenScript Custom Assay Services for FOXA1
- GenScript Custom overexpressing Cell Line Services for FOXA1
- GenScript: Design CRISPR guide RNA sequences for FOXA1
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for FOXA1
- Sino Biological Human cDNA Clone for FOXA1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for FOXA1
- Browse Sino Biological Assays
- Browse Antibodies
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FOXA1
- Novus Biologicals proteins and lysates for FOXA1
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for FOXA1
- Abcam proteins for FOXA1
- Find your target
- Browse Primary Antibodies
- Browse Conjugated Primary Antibodies
- Browse Secondary Antibodies
- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- Cyagen custom Knockout/knockin (KOKI) mouse models for FOXA1
- VectorBuilder custom plasmid, inducible vectors for FOXA1
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for FOXA1
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Addgene plasmids for FOXA1
- antibodies-online: Search results for 367 available FOXA1 Antibodies ranked by validation data
- Compare Top FOXA1 Antibodies
- Recommended
- 237 WB Antibodies (anti-human)
- 83 IHC (p) Antibodies (anti-human)
- 22 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 8 IHC Antibodies (anti-human)
- 33 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 46 WB Antibodies (anti-rat)
- 39 IHC (p) Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 6 IHC Antibodies (anti-rat)
- antibodies-online: Search results for available FOXA1 related products ranked by validation data
- antibodies-online: Search results for 9 available FOXA1 Proteins ranked by validation data
- Compare Top FOXA1 Proteins
- GeneTex FOXA1 Antibody for FOXA1
- Search GeneTex for Proteins for FOXA1
- Santa Cruz Biotechnology (SCBT) Antibodies for FOXA1
- Search Santa Cruz Biotechnology (SCBT) for FOXA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOXA1
- Custom Antibody ServicesProSci Antibodies for FOXA1
- Search for FOXA1 Proteins at ProSci
- Horizon Cell Lines for FOXA1
- genomics-online: cdna clones - Search results for 109 available FOXA1 gene related products
- Overview of 109 available FOXA1 gene related products
- orf clones - Search results for 109 available FOXA1 gene related products
- Overview of 109 available FOXA1 gene related products
- genomics-online: gRNA clones - Search results for 109 available FOXA1 gene related products
- Overview of 109 available FOXA1 gene related products
- genomics-online: primer clones - Search results for 109 available FOXA1 gene related products
- Overview of 109 available FOXA1 gene related products
- genomics-online: shRNA clones - Search results for 109 available FOXA1 gene related products
- Overview of 109 available FOXA1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA1
- GeneCopoeia miRNA 3'UTR Target clone products for FOXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXA1
Sources for FOXA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt