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This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided... See more...
Aliases for FOXA1 Gene
Aliases for FOXA1 Gene
External Ids for FOXA1 Gene
- HGNC: 5021
- Entrez Gene: 3169
- Ensembl: ENSG00000129514
- OMIM: 602294
- UniProtKB: P55317
Previous HGNC Symbols for FOXA1 Gene
- HNF3A
Previous GeneCards Identifiers for FOXA1 Gene
- GC14M035439
- GC14M031916
- GC14M036049
- GC14M037128
- GC14M038059
- GC14M018173
Summaries for FOXA1 Gene
-
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXA1 Gene
FOXA1 (Forkhead Box A1) is a Protein Coding gene. Diseases associated with FOXA1 include Estrogen-Receptor Positive Breast Cancer and Luminal Breast Carcinoma. Among its related pathways are Mesodermal Commitment Pathway and Embryonic and Induced Pluripotent Stem Cell Differentiation Pathways and Lineage-specific Markers. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOXA2.
UniProtKB/Swiss-Prot Summary for FOXA1 Gene
-
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXA1 Gene
Genomics for FOXA1 Gene
GeneHancer (GH) Regulatory Elements for FOXA1 Gene
Promoters and enhancers for FOXA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXA1 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FOXA1 gene promoter:
-
- ATF
- FOXD3
- FOXO4
- GATA-1
- HTF
- NRSF form 1
- NRSF form 2
- PPAR-alpha
- Sox9
- Sp1
Genomic Locations for FOXA1 Gene
Genomic Locations for FOXA1 Gene
- chr14:37,589,552-37,596,059
- (GRCh38/hg38)
- Size:
- 6,508 bases
- Orientation:
- Minus strand
- chr14:38,059,189-38,069,245
- (GRCh37/hg19)
- Size:
- 10,057 bases
- Orientation:
- Minus strand
Genomic View for FOXA1 Gene
Genes around FOXA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q21.1 by HGNC
- 14q21.1 by Entrez Gene
- 14q21.1 by Ensembl
FOXA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXA1 Gene
Proteins for FOXA1 Gene
-
Protein details for FOXA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55317-FOXA1_HUMAN
- Recommended name:
- Hepatocyte nuclear factor 3-alpha
- Protein Accession:
- P55317
- B2R9H6
- B7ZAP5
- Q9H2A0
Protein attributes for FOXA1 Gene
- Size:
- 472 amino acids
- Molecular mass:
- 49148 Da
- Quaternary structure:
-
- Binds DNA as a monomer (By similarity). Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 (By similarity).
Protein Expression for FOXA1 Gene
Post-translational modifications for FOXA1 Gene
Other Protein References for FOXA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FOXA1 Antibody
- NSJ Bioreagents FOXA1 Antibody (Mouse Monoclonal)
- Atlas Antibodies Anti-FOXA1 Antibody
-
Creative Diagnostics
- Anti-FOXA1 monoclonal antibody, clone 5G7
- Anti-FOXA1 monoclonal antibody, clone 3G94
- Anti-FOXA1 monoclonal antibody, clone 4D2
- Anti-FOXA1 monoclonal antibody, clone 3E8
- Rabbit Anti-FOXA1 monoclonal antibody, clone KG21-13
- Anti-FOXA1 monoclonal antibody, clone 4B9
- Anti-FOXA1 monoclonal antibody, clone FQS21992-25
- Anti-FOXA1 monoclonal antibody, clone TQ99
- Anti-FOXA1 (aa 367-472) polyclonal antibody
- Anti-FOXA1 (aa 412-422) polyclonal antibody
- Anti-FOXA1 polyclonal antibody
- Anti-FOXA1 monoclonal antibody, clone 607DU29.5.4
- Anti-FOXA1 (C-terminal) polyclonal antibody
- Anti-FOXA1 (aa 463-473) polyclonal antibody
-
Creative Biolabs
- Recombinant Anti-Human FOXA1 Antibody
- Recombinant Anti-Human FOXA1 Antibody Fab Fragment
- Mouse Anti-FOXA1 (AA 1-473) Recombinant Antibody (CBXF-3726)
- Mouse Anti-FOXA1 Recombinant Antibody (FOXA1/1512)
- Mouse Anti-FOXA1/FOXA2 Recombinant Antibody (CBFYH-0203)
- Recombinant Mouse Anti-Human FOXA1 Antibody
- Mouse Anti-FOXA1 Recombinant Antibody (CBXF-3132)
- Mouse Anti-FOXA1 Recombinant Antibody (3C1)
- Hi-Affi™ Recombinant Rabbit Anti-FOXA1 Monoclonal Antibody (DS1338AB)
- Mouse Anti-FOXA1 Recombinant Antibody (FOXA1/1241)
- Mouse Anti-FOXA1 (AA 143-171) Recombinant Antibody (CBXF-0824)
- Mouse Anti-FOXA1 Recombinant Antibody (CBXF-0822)
- Mouse Anti-FOXA1 Recombinant Antibody (CBXF-3129)
- Mouse Anti-FOXA1 (AA 372-472) Recombinant Antibody (FOXA1/1241)
- Mouse Anti-FOXA1 (AA 350-500) Recombinant Antibody (3B3NB)
- Mouse Anti-FOXA1 Recombinant Antibody (CBXF-0826)
- Mouse Anti-FOXA1 (AA 253-472) Recombinant Antibody (CBFYH-0201)
- Mouse Anti-FOXA1 Recombinant Antibody (4F6)
- Mouse Anti-FOXA1 (AA 253-472) Recombinant Antibody (CBXF-3529)
- Mouse Anti-FOXA1 Recombinant Antibody (FOXA1/1518)
- Mouse Anti-FOXA1 (AA 7-86) Recombinant Antibody (CBXF-0823)
- Mouse Anti-FOXA1 (AA 1-473) Recombinant Antibody (CBFYH-0200)
- Mouse Anti-FOXA1 (AA 367-472) Recombinant Antibody (CBXF-3131)
- Mouse Anti-FOXA1 Recombinant Antibody (CBXF-2416)
- Mouse Anti-FOXA1 Recombinant Antibody (CBFYH-0202)
- Mouse Anti-FOXA1 Recombinant Antibody (CBXF-1952)
- Mouse Anti-FOXA1 Recombinant Antibody (FOXA1/1515)
- Mouse Anti-FOXA1 (AA 287-370) Recombinant Antibody (CBXF-3130)
- Mouse Anti-FOXA1 Recombinant Antibody (CBXF-2492)
- Rabbit Anti-FOXA1 (C-term) Recombinant Antibody (SP88)
- Rabbit Anti-FOXA1 Recombinant Antibody (CBXF-1082)
- GeneTex Anti-FOXA1 antibody and Anti-FOXA1 antibody [FOXA1/1512]
-
Custom Antibody ServicesOriGene Antibodies for FOXA1
- Novus Biologicals Antibodies for FOXA1
-
Abcam antibodies for FOXA1
- Invitrogen Antibodies for FOXA1 (AFLGC-FOXA1)
- antibodies-online: Show 38 available FOXA1 Antibodies ranked by validation data
- Compare Top FOXA1 Antibodies
-
Recommended
- 297 WB Antibodies (anti-human)
- 85 IHC (p) Antibodies (anti-human)
- 63 ISt Antibodies (anti-human)
- 22 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 39 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 68 WB Antibodies (anti-rat)
- 49 IHC (p) Antibodies (anti-rat)
- 42 ISt Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for FOXA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXA1
- Sino Biological Antibodies for FOXA1
Protein Products
- Atlas Antibodies PrEST Antigen FOXA1
-
OriGene Purified Proteins for FOXA1
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXA1
- Origene Custom Protein Services for FOXA1
-
Abcam proteins for FOXA1
No data available for DME Specific Peptides for FOXA1 Gene
Domains & Families for FOXA1 Gene
Gene Families for FOXA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXA1 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXA1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ79259, highly similar to Hepatocyte nuclear factor 3-alpha (B7ZAP5_HUMAN)
- Transcription factor 3A (FOXA1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXA1 Gene
Function for FOXA1 Gene
Molecular function for FOXA1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
Phenotypes From GWAS Catalog for FOXA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IEA,ISS | -- |
| GO:0003677 | DNA binding | IEA,IDA | 9931457 |
| GO:0003700 | DNA-binding transcription factor activity | TAS | 8652662 |
| GO:0005515 | protein binding | IPI | 22722839 |
Phenotypes for FOXA1 Gene
- MGI mutant phenotypes for FOXA1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for FOXA1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for FOXA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA1
- genomics-online: gRNA clones - Search for available FOXA1 gRNA products
- Overview of 123 available FOXA1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for FOXA1 - Select products 50% OFF >
- * FOXA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FOXA1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXA1
miRNA for FOXA1 Gene
- miRTarBase miRNAs that target FOXA1
-
- hsa-let-7a-5p (MIRT002078)
- hsa-mir-215-5p (MIRT024644)
- hsa-mir-192-5p (MIRT026509)
- hsa-mir-4715-3p (MIRT548184)
- hsa-mir-3064-3p (MIRT548185)
- hsa-mir-584-5p (MIRT548186)
- hsa-mir-496 (MIRT548187)
- hsa-mir-3607-3p (MIRT548188)
- hsa-mir-758-5p (MIRT548189)
- hsa-mir-218-2-3p (MIRT548190)
- hsa-mir-30d-5p (MIRT548191)
- hsa-mir-30c-5p (MIRT548192)
- hsa-mir-30b-5p (MIRT548193)
- hsa-mir-30a-5p (MIRT548194)
- hsa-mir-30e-5p (MIRT548195)
- hsa-mir-1290 (MIRT733132)
- hsa-mir-23a-3p (MIRT733866)
- hsa-mir-93-5p (MIRT735529)
- hsa-mir-3148 (MIRT765010)
- hsa-mir-3173-3p (MIRT765222)
- hsa-mir-4278 (MIRT768280)
- hsa-mir-4428 (MIRT768890)
- hsa-mir-4668-5p (MIRT770854)
- hsa-mir-4716-3p (MIRT771420)
- hsa-mir-4779 (MIRT772243)
- hsa-mir-548e-5p (MIRT774380)
- hsa-mir-625-5p (MIRT776113)
- hsa-mir-6732-5p (MIRT778005)
- hsa-mir-6794-5p (MIRT779345)
- hsa-mir-6805-5p (MIRT779528)
- hsa-mir-6835-3p (MIRT780032)
- hsa-mir-6891-5p (MIRT781161)
Targeted motifs for FOXA1 Gene
HOMER Transcription Factor Regulatory Elements motif FOXA1
- Consensus sequence: AAAGTAAACA Submotif: canonical Cell Type: MCF7 GEO ID: GSE26831
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOXA1
- Browse OriGene Inhibitory RNA Products For FOXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXA1
- genomics-online: shRNA clones - Search for available FOXA1 shRNA products
- Overview of 123 available FOXA1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FOXA1
- Addgene plasmids for FOXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA1
- genomics-online: cdna clones - Search for available FOXA1 CDNA products
- Overview of 123 available FOXA1 gene related products
- orf clones - Search for available FOXA1 ORF products
- Overview of 123 available FOXA1 gene related products
- Applied Biological Materials (abm): Clones for FOXA1 - Select products 50% OFF >
- * FOXA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FOXA1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for FOXA1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for FOXA1 Gene
Localization for FOXA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXA1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 2 |
| extracellular | 1 |
| cytoskeleton | 1 |
| mitochondrion | 1 |
- Nucleoli fibrillar center (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IDA,IBA | 9931457 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005902 | microvillus | IEA | -- |
Pathways & Interactions for FOXA1 Gene
Pathways by source for FOXA1 Gene
6 BioSystems pathways for FOXA1 Gene
1 R&D Systems pathway for FOXA1 Gene
1 Cell Signaling Technology pathway for FOXA1 Gene
Interacting Proteins for FOXA1 Gene
Selected Interacting proteins:
P55317-FOXA1_HUMAN
ENSP00000250448
for FOXA1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FOXA1
SIGNOR curated interactions for FOXA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006338 | chromatin remodeling | ISS,IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
Transcripts for FOXA1 Gene
mRNA/cDNA for FOXA1 Gene
- (1) REFSEQ mRNAs :
- (8) Additional mRNA sequences :
- (95) Selected AceView cDNA sequences:
- (5) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000250448 3373 bps (ENST00000250448.2)
- ENST00000545425 1806 bps (ENST00000545425.2)
- ENST00000553751 507 bps (ENST00000553751.1)
- ENST00000554607 789 bps (ENST00000554607.1)
- ENST00000557418 392 bps (ENST00000557418.1)
CRISPR Products
-
OriGene CRISPR knockouts for FOXA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA1
- genomics-online: gRNA clones - Search for available FOXA1 gRNA products
- Overview of 123 available FOXA1 gene related products
- Applied Biological Materials (abm): CRISPR Clones for FOXA1 - Select products 50% OFF >
- * FOXA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FOXA1 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXA1
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOXA1
- Browse OriGene Inhibitory RNA Products For FOXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXA1
- genomics-online: shRNA clones - Search for available FOXA1 shRNA products
- Overview of 123 available FOXA1 gene related products
Clone Products
- Sino Biological Human cDNA Clone for FOXA1
- Addgene plasmids for FOXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA1
- genomics-online: cdna clones - Search for available FOXA1 CDNA products
- Overview of 123 available FOXA1 gene related products
- orf clones - Search for available FOXA1 ORF products
- Overview of 123 available FOXA1 gene related products
- Applied Biological Materials (abm): Clones for FOXA1 - Select products 50% OFF >
- * FOXA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FOXA1 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Expression for FOXA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Gut Tube (Gastrointestinal Tract)
- Foregut Endoderm Cells Foregut
- Multipotent Lung Progenitor Cells Ventral Foregut Endoderm
- Primitive Gut Endoderm Cells Gut Tube
- Hepatic Endoderm Cells Ventral Foregut Endoderm
- Ventral Foregut Endoderm Cells Ventral Foregut Endoderm
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Hepatic Endoderm Cells Ventral Foregut Endoderm
- Hepatoblasts Liver Bud
- NULL (Uncategorized)
-
Lung (Respiratory System)
- Multipotent Lung Progenitor Cells Ventral Foregut Endoderm
- Stem Bronchi
- Trachea
-
Epithelial Cells
- Hepatic Endoderm Cells Ventral Foregut Endoderm
- Ventral Foregut Endoderm Cells Ventral Foregut Endoderm
- Hepatoblasts Liver Bud
- Kidney (Urinary System)
- Pancreas (Endocrine System)
-
Endoderm (Gastrulation Derivatives)
- Definitive Endoderm Cells Definitive Endoderm
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Hypoblast (Extraembryonic Tissues)
- Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
-
Yolk Sac (Extraembryonic Tissues)
- Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
- Neural Tube (Nervous System)
- Lower Urinary Tract (Urinary System)
- Bone (Muscoskeletal System)
- Epiblast (Early Embryonic Tissues)
- Neurons
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for FOXA1 Gene
This gene is overexpressed in Prostate (x12.2), Liver (x7.9), Stomach (x6.3), Bladder (x5.5), and Colon - Transverse (x4.0).
This gene is overexpressed in Brain (64.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXA1 Gene
NURSA nuclear receptor signaling pathways regulating expression of FOXA1 Gene:
FOXA1SOURCE GeneReport for Unigene cluster for FOXA1 Gene:
Hs.163484mRNA Expression by UniProt/SwissProt for FOXA1 Gene:
P55317-FOXA1_HUMAN
Tissue specificity:
Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
Evidence on tissue expression from TISSUES for FOXA1 Gene
- Liver(4.6)
- Lung(4.5)
Primer Products
-
OriGene qPCR primer pairs for FOXA1
-
OriGene qPCR primer pairs and template standards for FOXA1
- genomics-online: primer clones - Search for available FOXA1 Primer products
- Overview of 123 available FOXA1 gene related products
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXA1 Gene
Orthologs for FOXA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FOXA1 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Foxa1 17 33 32 |
|
||
| dog (Canis familiaris) |
Mammalia | FOXA1 33 32 |
|
OneToOne | |
| rat (Rattus norvegicus) |
Mammalia | Foxa1 32 |
|
||
| cow (Bos Taurus) |
Mammalia | FOXA1 33 32 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | FOXA1 33 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FOXA1 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | foxa1 32 |
|
||
| Hnf3a 32 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | foxa1-prov 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | foxa1 33 32 32 |
|
OneToOne | |
| fruit fly (Drosophila melanogaster) |
Insecta | fkh 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
ManyToMany | |
| CSA.7421 33 |
|
ManyToMany |
- Species where no ortholog for FOXA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for FOXA1 Gene
- ENSEMBL:
- Gene Tree for FOXA1 (if available)
- TreeFam:
- Gene Tree for FOXA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXA1: view image
Paralogs for FOXA1 Gene
Paralogs for FOXA1 Gene
- FOXA2 5
- FOXA3 5
- FOXC1 5
- FOXC2 5
- FOXB1 5
- FOXD3 5
- FOXB2 5
- FOXI3 5
- FOXD2 5
- FOXD1 5
- FOXD4L3 5
- FOXD4L6 5
- FOXD4 5
- FOXD4L4 5
- FOXD4L1 5
- FOXJ3 5
- FOXD4L5 5
- FOXL1 5
- FOXK1 5
- FOXK2 5
- FOXS1 5
- FOXI2 5
- FOXN1 5
- FOXQ1 5
- FOXE3 5
- FOXE1 5
- FOXJ2 5
- FOXM1 5
- FOXF1 5
- WI2-2373I1.2 5
- FOXL2 5
- FOXO3 5
- ENSG00000285708 5
- FOXO1 5
- FOXP1 5
- FOXO4 5
- FOXJ1 5
- FOXO6 5
- FOXH1 5
- FOXP3 5
- FOXR2 5
- FOXR1 5
- FOXO3B 5
(7) SIMAP similar genes for FOXA1 Gene using alignment to 3 proteins:
- FOXA1_HUMAN
- B7ZAP5_HUMAN
- G3V4B9_HUMAN
Pseudogenes.org Pseudogenes for FOXA1 Gene
Variants for FOXA1 Gene
| SNP ID | Clin | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000211851 | -- | 37,595,824(-) | A/G | upstream_transcript_variant | |
| rs1000306350 | -- | 37,589,181(-) | C/G | downstream_transcript_variant | |
| rs1000358414 | -- | 37,589,651(-) | TAGTTA/TA | 3_prime_UTR_variant | |
| rs1000412963 | -- | 37,594,280(-) | C/T | 5_prime_UTR_variant, intron_variant | |
| rs1000603594 | -- | 37,595,572(-) | A/G | upstream_transcript_variant |
Residual Variation Intolerance Score:
34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.99;
60.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXA1 Gene
Disorders for FOXA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| estrogen-receptor positive breast cancer |
|
|
| luminal breast carcinoma |
|
|
| breast cancer |
|
|
| maturity-onset diabetes of the young |
|
|
Search FOXA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FOXA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FOXA1 Gene
Publications for FOXA1 Gene
- Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. (PMID: 19919681) Motallebipour M … Wadelius C (Genome biology 2009) 3 4 23 56
- The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas. (PMID: 12234996) Lin L … Beer DG (Cancer research 2002) 3 4 23 56
- Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4. (PMID: 9119385) Mincheva A … Kaestner KH (Genomics 1997) 2 3 23 56
- Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line. (PMID: 8652662) Bingle CD … Gowan S (Biochimica et biophysica acta 1996) 2 3 4 56
- Histone deacetylase 7 and FoxA1 in estrogen-mediated repression of RPRM. (PMID: 19917725) Malik S … Oesterreich S (Molecular and cellular biology 2010) 3 4 56
ExternalLinks
Products for FOXA1 Gene
- Custom Antibody ServicesOriGene Antibodies for FOXA1
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FOXA1
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXA1
- Origene Custom Protein Services for FOXA1
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOXA1
- Browse OriGene Inhibitory RNA Products For FOXA1
- OriGene qPCR primer pairs for FOXA1
- OriGene qPCR primer pairs and template standards for FOXA1
- OriGene CRISPR knockouts for FOXA1
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOXA1
- Sino Biological Human cDNA Clone for FOXA1
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Sino Biological Antibodies for FOXA1
- Browse Sino Biological Assays
- Browse ELISA Kits
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- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FOXA1
- Novus Biologicals proteins and lysates for FOXA1
- Browse Antibodies
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- Abcam antibodies for FOXA1
- Abcam proteins for FOXA1
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- antibodies-online: Show 38 available FOXA1 Antibodies ranked by validation data
- Compare Top FOXA1 Antibodies
- Recommended
- 297 WB Antibodies (anti-human)
- 85 IHC (p) Antibodies (anti-human)
- 63 ISt Antibodies (anti-human)
- 22 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 39 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 68 WB Antibodies (anti-rat)
- 49 IHC (p) Antibodies (anti-rat)
- 42 ISt Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
- antibodies-online: Search results for available FOXA1 related products ranked by validation data
- antibodies-online: Show 10 available FOXA1 Proteins ranked by validation data
- Compare Top FOXA1 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FOXA1
- Search Santa Cruz Biotechnology (SCBT) for FOXA1 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOXA1
- Custom Antibody ServicesProSci Antibodies for FOXA1
- Search for FOXA1 Proteins at ProSci
- Horizon Cell Lines for FOXA1
- genomics-online: cdna clones - Search for available FOXA1 CDNA products
- Overview of 123 available FOXA1 gene related products
- orf clones - Search for available FOXA1 ORF products
- Overview of 123 available FOXA1 gene related products
- genomics-online: gRNA clones - Search for available FOXA1 gRNA products
- Overview of 123 available FOXA1 gene related products
- genomics-online: primer clones - Search for available FOXA1 Primer products
- Overview of 123 available FOXA1 gene related products
- genomics-online: shRNA clones - Search for available FOXA1 shRNA products
- Overview of 123 available FOXA1 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA1
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FOXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXA1
Sources for FOXA1 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141) Monarch Initiative
- (142) DataMed
- (143) HumanCyc
- (144) genomics-online
- (145) UCNEbase
- (146) EPDnew
- (147) Applied Biosystems
- (148) GlyConnect
- (149) Aminode
- (150) GeneCopoeia
- (151) GPS-Prot
- (152) RNACentral
- (153) LncRNADisease
- (154) LOVD
- (155) miR2Disease
- (156) DiseaseEnhancer
- (157) Boster Bio
- (158) Biorbyt
- (159) Biocompare
- (160) Mastermind
- (161) CTD^2 Dashboard
- (162) CraniofacialAtlas
- (163) GeneImprint
- (164) Synthego
- (165) Bio Basic
- (166) ENA
- (167) GtRNAdb
- (168) LncBase
- (169) LncBook
- (170) LNCipedia
- (171) LncRNAdb
- (172) Modomics
- (173) PDBe
- (174) Rfam
- (175) SILVA
- (176) snOPY
- (177) SRPDB
- (178) GENCODE
- (179) TarBase
- (180) MyBioSource