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This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided... See more...
Aliases for FOXA1 Gene
Aliases for FOXA1 Gene
External Ids for FOXA1 Gene
- HGNC: 5021
- Entrez Gene: 3169
- Ensembl: ENSG00000129514
- OMIM: 602294
- UniProtKB: P55317
Previous HGNC Symbols for FOXA1 Gene
- HNF3A
Previous GeneCards Identifiers for FOXA1 Gene
- GC14M035439
- GC14M031916
- GC14M036049
- GC14M037128
- GC14M038059
- GC14M018173
Summaries for FOXA1 Gene
-
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]
GeneCards Summary for FOXA1 Gene
FOXA1 (Forkhead Box A1) is a Protein Coding gene. Diseases associated with FOXA1 include Estrogen-Receptor Negative Breast Cancer and Estrogen-Receptor Positive Breast Cancer. Among its related pathways are FOXA1 transcription factor network and FOXA2 and FOXA3 transcription factor networks. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and transcription factor binding. An important paralog of this gene is FOXA2.
UniProtKB/Swiss-Prot Summary for FOXA1 Gene
-
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
Additional gene information for FOXA1 Gene
- HGNC(5021)
- Entrez Gene(3169)
- Ensembl(ENSG00000129514)
- OMIM(602294)
- UniProtKB(P55317)
- Open Targets Platform(ENSG00000129514)
- Search for FOXA1 at DataMed
- Search for FOXA1 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOXA1 Gene
Genomics for FOXA1 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FOXA1 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOXA1 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOXA1
- Top Transcription factor binding sites by QIAGEN in the FOXA1 gene promoter:
-
- ATF
- FOXD3
- FOXO4
- GATA-1
- HTF
- NRSF form 1
- NRSF form 2
- PPAR-alpha
- Sox9
- Sp1
Genomic Locations for FOXA1 Gene
Genomic Locations for FOXA1 Gene
- chr14:37,589,552-37,596,059
- (GRCh38/hg38)
- Size:
- 6,508 bases
- Orientation:
- Minus strand
- chr14:38,059,189-38,069,245
- (GRCh37/hg19)
- Size:
- 10,057 bases
- Orientation:
- Minus strand
Genomic View for FOXA1 Gene
Genes around FOXA1 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 14q21.1 by HGNC
- 14q21.1 by Entrez Gene
- 14q21.1 by Ensembl
FOXA1 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOXA1 Gene
Proteins for FOXA1 Gene
-
Protein details for FOXA1 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P55317-FOXA1_HUMAN
- Recommended name:
- Hepatocyte nuclear factor 3-alpha
- Protein Accession:
- P55317
- B2R9H6
- B7ZAP5
- Q9H2A0
Protein attributes for FOXA1 Gene
- Size:
- 472 amino acids
- Molecular mass:
- 49148 Da
- Quaternary structure:
-
- Binds DNA as a monomer (By similarity). Interacts with FOXA2. Interacts with NKX2-1. Interacts with HDAC7. Interacts with the histone H3-H4 heterodimer. Associates with nucleosomes containing histone H2A. Interacts with AR. Interacts with NR0B2 (By similarity).
Protein Expression for FOXA1 Gene
Post-translational modifications for FOXA1 Gene
Other Protein References for FOXA1 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- LifeSpan BioSciences FOXA1 Antibody and FOXA1 Monoclonal Antibody
- G Biosciences Immunotag™ FOXA1 Antibody
- GeneTex Anti-FOXA1 antibody and Anti-FOXA1 antibody [FOXA1/1512]
- NSJ Bioreagents FOXA1 Antibody (Mouse Monoclonal)
- Creative Diagnostics Anti-FOXA1 monoclonal antibody, clone 3E8
-
Creative Biolabs
- Recombinant Anti-Human FOXA1 Antibody
- Mouse Anti-FOXA1 Recombinant Antibody (3C1)
- Hi-Affi™ Recombinant Rabbit Anti-FOXA1 Monoclonal Antibody (DS1338AB)
- Mouse Anti-FOXA1 (AA 253-472) Recombinant Antibody (CBFYH-0201)
- Mouse Anti-FOXA1 Recombinant Antibody (2D7)
- Recombinant Rabbit Anti-FOXA1 Monoclonal Antibody (JF10-02)
-
Custom Antibody ServicesOriGene Antibodies for FOXA1
- Novus Biologicals Antibodies for FOXA1
-
Abcam antibodies for FOXA1
- Invitrogen Antibodies for FOXA1 (AFLGC-FOXA1)
- antibodies-online: Show 38 available FOXA1 Antibodies ranked by validation data
- Compare Top FOXA1 Antibodies
-
Recommended
- 297 WB Antibodies (anti-human)
- 85 IHC (p) Antibodies (anti-human)
- 63 ISt Antibodies (anti-human)
- 22 FACS Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 7 IHC Antibodies (anti-human)
- 39 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 68 WB Antibodies (anti-rat)
- 49 IHC (p) Antibodies (anti-rat)
- 42 ISt Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- 9 FACS Antibodies (anti-rat)
- 4 IHC Antibodies (anti-rat)
-
Custom Antibody ServicesProSci Antibodies for FOXA1
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOXA1
- Sino Biological Antibodies for FOXA1
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FOXA1
- Origene Custom Protein Services for FOXA1
-
Abcam proteins for FOXA1
No data available for DME Specific Peptides for FOXA1 Gene
Domains & Families for FOXA1 Gene
Gene Families for FOXA1 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Cancer-related genes
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOXA1 Gene
- InterPro:
- Blocks:
-
- Fork-head N-terminal
- ProtoNet:
Suggested Antigen Peptide Sequences for FOXA1 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA, FLJ79259, highly similar to Hepatocyte nuclear factor 3-alpha (B7ZAP5_HUMAN)
- Transcription factor 3A (FOXA1_HUMAN)
No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for FOXA1 Gene
Function for FOXA1 Gene
Molecular function for FOXA1 Gene
- UniProtKB/Swiss-Prot Function:
- Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). Proposed to play a role in translating the epigenetic signatures into cell type-specific enhancer-driven transcriptional programs. Its differential recruitment to chromatin is dependent on distribution of histone H3 methylated at 'Lys-5' (H3K4me2) in estrogen-regulated genes. Involved in the development of multiple endoderm-derived organ systems such as liver, pancreas, lung and prostate; FOXA1 and FOXA2 seem to have at least in part redundant roles (By similarity). Modulates the transcriptional activity of nuclear hormone receptors. Is involved in ESR1-mediated transcription; required for ESR1 binding to the NKX2-1 promoter in breast cancer cells; binds to the RPRM promoter and is required for the estrogen-induced repression of RPRM. Involved in regulation of apoptosis by inhibiting the expression of BCL2. Involved in cell cycle regulation by activating expression of CDKN1B, alone or in conjunction with BRCA1. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis.
Phenotypes From GWAS Catalog for FOXA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000976 | transcription regulatory region sequence-specific DNA binding | IDA | 16087863 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IEA | -- |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | ISS | -- |
| GO:0003677 | DNA binding | IEA,IDA | 9931457 |
Phenotypes for FOXA1 Gene
- MGI mutant phenotypes for FOXA1:
- inferred from 4 alleles
- GenomeRNAi human phenotypes for FOXA1:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXA1 - Select products 50% OFF >
- * FOXA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXA1
miRNA for FOXA1 Gene
- miRTarBase miRNAs that target FOXA1
-
- hsa-let-7a-5p (MIRT002078)
- hsa-miR-215-5p (MIRT024644)
- hsa-miR-192-5p (MIRT026509)
- hsa-miR-4715-3p (MIRT548184)
- hsa-miR-3064-3p (MIRT548185)
- hsa-miR-584-5p (MIRT548186)
- hsa-miR-496 (MIRT548187)
- hsa-miR-3607-3p (MIRT548188)
- hsa-miR-758-5p (MIRT548189)
- hsa-miR-218-2-3p (MIRT548190)
- hsa-miR-30d-5p (MIRT548191)
- hsa-miR-30c-5p (MIRT548192)
- hsa-miR-30b-5p (MIRT548193)
- hsa-miR-30a-5p (MIRT548194)
- hsa-miR-30e-5p (MIRT548195)
- mmu-miR-3065-5p (MIRT590017)
- hsa-miR-1290 (MIRT733132)
- hsa-miR-23a-3p (MIRT733866)
- hsa-miR-93-5p (MIRT735529)
- hsa-miR-3148 (MIRT765010)
- hsa-miR-3173-3p (MIRT765222)
- hsa-miR-4278 (MIRT768280)
- hsa-miR-4428 (MIRT768890)
- hsa-miR-4668-5p (MIRT770854)
- hsa-miR-4716-3p (MIRT771420)
- hsa-miR-4779 (MIRT772243)
- hsa-miR-548e-5p (MIRT774380)
- hsa-miR-625-5p (MIRT776113)
- hsa-miR-6732-5p (MIRT778005)
- hsa-miR-6794-5p (MIRT779345)
- hsa-miR-6805-5p (MIRT779528)
- hsa-miR-6835-3p (MIRT780032)
- hsa-miR-6891-5p (MIRT781161)
Targeted motifs for FOXA1 Gene
HOMER Transcription Factor Regulatory Elements motif FOXA1
- Consensus sequence: AAAGTAAACA Submotif: canonical Cell Type: MCF7 GEO ID: GSE26831
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXA1
- Browse OriGene Inhibitory RNA Products For FOXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXA1
Clone Products
- Applied Biological Materials (abm): Clones for FOXA1 - Select products 50% OFF >
- * FOXA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FOXA1
- Addgene plasmids for FOXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA1
Cell Line Products
-
Horizon Cell Lines for FOXA1
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology and Transcription Factor Targets for FOXA1 Gene
Localization for FOXA1 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOXA1 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| cytosol | 3 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoli fibrillar center (3)
- Nucleoplasm (3)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0001650 | fibrillar center | IDA | -- |
| GO:0005634 | nucleus | IBA,IDA | 9931457 |
| GO:0005654 | nucleoplasm | TAS | -- |
| GO:0005902 | microvillus | IEA | -- |
Pathways & Interactions for FOXA1 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Mesodermal Commitment Pathway | ||
| 2 | FOXA1 transcription factor network | ||
| 3 | Glucose / Energy Metabolism | ||
| 4 | Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers | ||
| 5 | Direct p53 effectors | ||
Pathways by source for FOXA1 Gene
6 BioSystems pathways for FOXA1 Gene
1 R&D Systems pathway for FOXA1 Gene
1 Cell Signaling Technology pathway for FOXA1 Gene
Interacting Proteins for FOXA1 Gene
Selected Interacting proteins:
P55317-FOXA1_HUMAN
ENSP00000250448
for FOXA1 Gene via
UniProtKB
MINT
STRING
IID
GPS-Prot Interaction Network for FOXA1
SIGNOR curated interactions for FOXA1 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000122 | negative regulation of transcription by RNA polymerase II | IEA | -- |
| GO:0006325 | chromatin organization | IEA | -- |
| GO:0006338 | chromatin remodeling | IEA,ISS | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
Transcripts for FOXA1 Gene
mRNA/cDNA for FOXA1 Gene
- 1 REFSEQ mRNAs :
- 8 NCBI additional mRNA sequence :
- 5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000250448 3509 nts (view in UCSC)
- ENST00000545425 1806 nts (view in UCSC)
- ENST00000553751 507 nts (view in UCSC)
- ENST00000554607 789 nts (view in UCSC)
- ENST00000557418 392 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOXA1 - Select products 50% OFF >
- * FOXA1 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOXA1
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOXA1
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOXA1
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOXA1
- Browse OriGene Inhibitory RNA Products For FOXA1
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOXA1
Clone Products
- Applied Biological Materials (abm): Clones for FOXA1 - Select products 50% OFF >
- * FOXA1 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FOXA1
- Addgene plasmids for FOXA1
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOXA1
Relevant External Links for FOXA1 Gene
- GeneLoc Exon Structure for
- FOXA1
Expression for FOXA1 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
-
Gut Tube (Gastrointestinal Tract)
- Foregut Endoderm Cells Foregut
- Multipotent Lung Progenitor Cells Ventral Foregut Endoderm
- Primitive Gut Endoderm Cells Gut Tube
- Hepatic Endoderm Cells Ventral Foregut Endoderm
- Ventral Foregut Endoderm Cells Ventral Foregut Endoderm
-
Liver (Hepatobiliary System)
- Mature Hepatocytes Liver Lobule
- Hepatocytes Liver Lobule
- Hepatic Endoderm Cells Ventral Foregut Endoderm
- Hepatoblasts Liver Bud
- NULL (Uncategorized)
-
Lung (Respiratory System)
- Multipotent Lung Progenitor Cells Ventral Foregut Endoderm
- Stem Bronchi
- Trachea
-
Epithelial Cells
- Hepatic Endoderm Cells Ventral Foregut Endoderm
- Ventral Foregut Endoderm Cells Ventral Foregut Endoderm
- Hepatoblasts Liver Bud
- Kidney (Urinary System)
- Pancreas (Endocrine System)
-
Endoderm (Gastrulation Derivatives)
- Definitive Endoderm Cells Definitive Endoderm
-
Inner Cell Mass (Early Embryonic Tissues)
- Inner Cell Mass Cells Inner Cell Mass
-
Hypoblast (Extraembryonic Tissues)
- Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
-
Yolk Sac (Extraembryonic Tissues)
- Anterior Visceral Endoderm Cells Extraembryonic Visceral Endoderm
-
Primitive Streak (Early Embryonic Tissues)
- Notochord Cells Notochord
-
Cartilage (Muscoskeletal System)
- Notochord Cells Notochord
- Neural Tube (Nervous System)
- Lower Urinary Tract (Urinary System)
- Bone (Muscoskeletal System)
- Epiblast (Early Embryonic Tissues)
- Neurons
-
Prostate (Endocrine System)
mRNA differential expression in normal tissues according to GTEx for FOXA1 Gene
This gene is overexpressed in Prostate (x12.2), Liver (x7.9), Stomach (x6.3), Bladder (x5.5), and Colon - Transverse (x4.0).
This gene is overexpressed in Brain (64.3).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOXA1 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOXA1
SOURCE GeneReport for Unigene cluster for FOXA1 Gene:
Hs.163484mRNA Expression by UniProt/SwissProt for FOXA1 Gene:
P55317-FOXA1_HUMAN
Tissue specificity:
Highly expressed in prostate and ESR1-positive breast tumors. Overexpressed in esophageal and lung adenocarcinomas.
Evidence on tissue expression from TISSUES for FOXA1 Gene
- Liver(4.7)
- Lung(4.6)
- Intestine(2.6)
- Stomach(2.5)
- Skin(2.4)
- Kidney(2.3)
- Pancreas(2.2)
- Nervous system(2.2)
- Blood(2.2)
Primer Products
-
OriGene qPCR primer pairs for FOXA1
-
OriGene qPCR primer pairs and template standards for FOXA1
Gene Expression Assay Products
No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for FOXA1 Gene
Orthologs for FOXA1 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FOXA1 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Foxa1 30 17 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FOXA1 30 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Foxa1 30 |
|
||
| Cow (Bos Taurus) |
Mammalia | FOXA1 30 31 |
|
OneToOne | |
| Oppossum (Monodelphis domestica) |
Mammalia | FOXA1 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FOXA1 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | foxa1 30 |
|
||
| Hnf3a 30 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | foxa1-prov 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | foxa1 30 31 |
|
OneToOne | |
| Fruit Fly (Drosophila melanogaster) |
Insecta | fkh 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
ManyToMany | |
| CSA.7421 31 |
|
ManyToMany |
- Species where no ortholog for FOXA1 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FOXA1 Gene
- ENSEMBL:
- Gene Tree for FOXA1 (if available)
- TreeFam:
- Gene Tree for FOXA1 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOXA1: view image
Paralogs for FOXA1 Gene
Paralogs for FOXA1 Gene
- FOXA2 5
- FOXA3 5
- FOXC1 5
- FOXC2 5
- FOXD2 5
- FOXD3 5
- FOXB1 5
- FOXD1 5
- FOXI3 5
- FOXD4L6 5
- FOXK1 5
- FOXD4L5 5
- FOXD4L1 5
- FOXD4L4 5
- FOXD4 5
- FOXD4L3 5
- FOXB2 5
- FOXL1 5
- FOXQ1 5
- FOXJ3 5
- FOXE3 5
- FOXK2 5
- FOXS1 5
- FOXI2 5
- FOXE1 5
- FOXL2 5
- FOXJ2 5
- FOXM1 5
- FOXF1 5
- FOXL3 5
- FOXH1 5
- FOXO3 5
- FOXJ1 5
- FOXO1 5
- ENSG00000285708 5
- FOXN1 5
- FOXO4 5
- FOXO6 5
- FOXP1 5
- FOXR2 5
- FOXP3 5
- FOXR1 5
- FOXO3B 5
(7) SIMAP similar genes for FOXA1 Gene using alignment to 3 proteins:
- FOXA1_HUMAN
- B7ZAP5_HUMAN
- G3V4B9_HUMAN
Pseudogenes.org Pseudogenes for FOXA1 Gene
Variants for FOXA1 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOXA1 Gene
| SNP ID | Clinical significance and condition | Chr 14 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| 727186 | Benign: not provided | 37,591,563(-) | G/A | SYNONYMOUS_VARIANT | |
| 728193 | Likely Benign: not provided | 37,592,034(-) | G/A | SYNONYMOUS_VARIANT | |
| 790373 | Benign: not provided | 37,591,452(-) | C/T | SYNONYMOUS_VARIANT | |
| rs33984772 | - | p.Ser448Asn | |||
| rs35220193 | - | p.Gly87Glu |
Residual Variation Intolerance Score:
34.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.99;
60.12% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOXA1 Gene
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOXA1 Gene
Disorders for FOXA1 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| estrogen-receptor negative breast cancer |
|
|
| estrogen-receptor positive breast cancer |
|
|
| miliaria profunda |
|
|
| miliaria crystallina |
|
|
| luminal breast carcinoma a |
|
|
Search FOXA1 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FOXA1
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No data available for UniProtKB/Swiss-Prot and Genatlas for FOXA1 Gene
Publications for FOXA1 Gene
- Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq. (PMID: 19919681) Motallebipour M … Wadelius C (Genome biology 2009) 3 4 23
- The hepatocyte nuclear factor 3 alpha gene, HNF3alpha (FOXA1), on chromosome band 14q13 is amplified and overexpressed in esophageal and lung adenocarcinomas. (PMID: 12234996) Lin L … Beer DG (Cancer research 2002) 3 4 23
- Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4. (PMID: 9119385) Mincheva A … Kaestner KH (Genomics 1997) 2 3 23
- Molecular cloning of the forkhead transcription factor HNF-3 alpha from a human pulmonary adenocarcinoma cell line. (PMID: 8652662) Bingle CD … Gowan S (Biochimica et biophysica acta 1996) 2 3 4
- Overexpression of hepatocyte nuclear factor-3alpha induces apoptosis through the upregulation and accumulation of cytoplasmic p53 in prostate cancer cells. (PMID: 19866472) Lee HJ … Lee K (The Prostate 2010) 3 23
ExternalLinks
Products for FOXA1 Gene
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- antibodies-online: Show 38 available FOXA1 Antibodies ranked by validation data
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