Aliases for FOSL2 Gene
External Ids for FOSL2 Gene
Previous GeneCards Identifiers for FOSL2 Gene
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
GeneCards Summary for FOSL2 Gene
FOSL2 (FOS Like 2, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSL2 include Lipodystrophy, Congenital Generalized, Type 3. Among its related pathways are IL-1 Family Signaling Pathways and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOS.
UniProtKB/Swiss-Prot Summary for FOSL2 Gene
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.