The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014] See more...

Aliases for FOSL2 Gene

Aliases for FOSL2 Gene

  • FOS Like 2, AP-1 Transcription Factor Subunit 2 3 5
  • Fos-Related Antigen 2 3 4
  • FOS Like Antigen 2 2 3
  • FRA-2 3 4
  • FRA2 3 4
  • FOS Like 2, AP-1 Trancription Factor Subunit 3

External Ids for FOSL2 Gene

Previous GeneCards Identifiers for FOSL2 Gene

  • GC02P028537
  • GC02P028708
  • GC02P028590
  • GC02P028527
  • GC02P028615
  • GC02P028356

Summaries for FOSL2 Gene

Entrez Gene Summary for FOSL2 Gene

  • The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]

GeneCards Summary for FOSL2 Gene

FOSL2 (FOS Like 2, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSL2 include Lipodystrophy, Congenital Generalized, Type 3. Among its related pathways are IL-1 Family Signaling Pathways and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOS.

UniProtKB/Swiss-Prot Summary for FOSL2 Gene

  • Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.

Gene Wiki entry for FOSL2 Gene

Additional gene information for FOSL2 Gene

No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOSL2 Gene

Genomics for FOSL2 Gene

GeneHancer (GH) Regulatory Elements for FOSL2 Gene

Promoters and enhancers for FOSL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around FOSL2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the FOSL2 gene promoter:
  • C/EBPbeta
  • E2F
  • E2F-1
  • E2F-2
  • MyoD
  • p53

Genomic Locations for FOSL2 Gene

Genomic Locations for FOSL2 Gene
chr2:28,392,448-28,417,317
(GRCh38/hg38)
Size:
24,870 bases
Orientation:
Plus strand
chr2:28,615,315-28,640,179
(GRCh37/hg19)
Size:
24,865 bases
Orientation:
Plus strand

Genomic View for FOSL2 Gene

Genes around FOSL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
FOSL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for FOSL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for FOSL2 Gene

Proteins for FOSL2 Gene

  • Protein details for FOSL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P15408-FOSL2_HUMAN
    Recommended name:
    Fos-related antigen 2
    Protein Accession:
    P15408
    Secondary Accessions:
    • B2RD58
    • B3KP27
    • B4DYV4
    • Q6FG46

    Protein attributes for FOSL2 Gene

    Size:
    326 amino acids
    Molecular mass:
    35193 Da
    Quaternary structure:
    • Heterodimer.

    Alternative splice isoforms for FOSL2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for FOSL2 Gene

Post-translational modifications for FOSL2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for FOSL2 Gene

Antibody Products

  • Abcam antibodies for FOSL2
  • Boster Bio Antibodies for FOSL2

No data available for DME Specific Peptides for FOSL2 Gene

Domains & Families for FOSL2 Gene

Gene Families for FOSL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Transcription factors

Protein Domains for FOSL2 Gene

Suggested Antigen Peptide Sequences for FOSL2 Gene

GenScript: Design optimal peptide antigens:
  • cDNA FLJ54924, highly similar to Fos-related antigen 2 (B4DYV4_HUMAN)
  • Fos-related antigen 2 (FOSL2_HUMAN)

Graphical View of Domain Structure for InterPro Entry

P15408

UniProtKB/Swiss-Prot:

FOSL2_HUMAN :
  • Belongs to the bZIP family. Fos subfamily.
Family:
  • Belongs to the bZIP family. Fos subfamily.
genes like me logo Genes that share domains with FOSL2: view

Function for FOSL2 Gene

Molecular function for FOSL2 Gene

UniProtKB/Swiss-Prot Function:
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
GENATLAS Biochemistry:
fos-related antigen 2

Phenotypes From GWAS Catalog for FOSL2 Gene

Gene Ontology (GO) - Molecular Function for FOSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding IDA 13679379
GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding IBA 21873635
GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific NAS 19274049
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific IDA 13679379
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with FOSL2: view
genes like me logo Genes that share phenotypes with FOSL2: view

Animal Models for FOSL2 Gene

MGI Knock Outs for FOSL2:

Animal Model Products

CRISPR Products

miRNA for FOSL2 Gene

miRTarBase miRNAs that target FOSL2

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOSL2 Gene

Localization for FOSL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for FOSL2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for FOSL2 gene
Compartment Confidence
nucleus 5
extracellular 1
cytoskeleton 1
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for FOSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IBA,TAS 21873635
GO:0005654 nucleoplasm IDA --
genes like me logo Genes that share ontologies with FOSL2: view

Pathways & Interactions for FOSL2 Gene

genes like me logo Genes that share pathways with FOSL2: view

Pathways by source for FOSL2 Gene

6 Qiagen pathways for FOSL2 Gene
  • Ceramide Pathway
  • Epithelial Tight Junctions
  • ILK Signaling
  • iNOS Signaling
  • ITK and TCR Signaling
1 Cell Signaling Technology pathway for FOSL2 Gene

Gene Ontology (GO) - Biological Process for FOSL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003334 keratinocyte development IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0006357 regulation of transcription by RNA polymerase II IEA,TAS 8954781
GO:0008219 cell death TAS 8954781
GO:0045893 positive regulation of transcription, DNA-templated IEA --
genes like me logo Genes that share ontologies with FOSL2: view

No data available for SIGNOR curated interactions for FOSL2 Gene

Drugs & Compounds for FOSL2 Gene

(3) Drugs for FOSL2 Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(2) Additional Compounds for FOSL2 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with FOSL2: view

Transcripts for FOSL2 Gene

mRNA/cDNA for FOSL2 Gene

(1) REFSEQ mRNAs :
(12) Additional mRNA sequences :
(303) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for FOSL2 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d
SP1: - - - - -
SP2: - - - -
SP3: - -
SP4: - -
SP5: - - - -

Relevant External Links for FOSL2 Gene

GeneLoc Exon Structure for
FOSL2
ECgene alternative splicing isoforms for
FOSL2

Expression for FOSL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for FOSL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for FOSL2 Gene

This gene is overexpressed in Adrenal (64.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOSL2 Gene



Protein tissue co-expression partners for FOSL2 Gene

NURSA nuclear receptor signaling pathways regulating expression of FOSL2 Gene:

FOSL2

SOURCE GeneReport for Unigene cluster for FOSL2 Gene:

Hs.220971

Evidence on tissue expression from TISSUES for FOSL2 Gene

  • Lung(4.5)
  • Heart(4.4)
  • Eye(4.1)
  • Nervous system(3.2)
  • Adrenal gland(2.7)
  • Skin(2.5)
  • Bone marrow(2.2)
  • Intestine(2)
  • Kidney(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with FOSL2: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOSL2 Gene

Orthologs for FOSL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for FOSL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia FOSL2 33 32
  • 99.59 (n)
OneToOne
dog
(Canis familiaris)
Mammalia FOSL2 33 32
  • 92.72 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FOSL2 33 32
  • 92.23 (n)
OneToOne
mouse
(Mus musculus)
Mammalia Fosl2 17 33 32
  • 89.74 (n)
rat
(Rattus norvegicus)
Mammalia Fosl2 32
  • 89.64 (n)
oppossum
(Monodelphis domestica)
Mammalia FOSL2 33
  • 88 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia FOSL2 33
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves FOSL2 33 32
  • 80.02 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FOSL2 33
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fosl2 32
  • 73.4 (n)
African clawed frog
(Xenopus laevis)
Amphibia gene 32
zebrafish
(Danio rerio)
Actinopterygii fosl2 33 32
  • 67.5 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6126 32
fruit fly
(Drosophila melanogaster)
Insecta kay 33
  • 12 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 33
  • 22 (a)
OneToMany
Species where no ortholog for FOSL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for FOSL2 Gene

ENSEMBL:
Gene Tree for FOSL2 (if available)
TreeFam:
Gene Tree for FOSL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for FOSL2: view image

Paralogs for FOSL2 Gene

Paralogs for FOSL2 Gene

(6) SIMAP similar genes for FOSL2 Gene using alignment to 2 proteins:

  • FOSL2_HUMAN
  • C9JCN8_HUMAN
genes like me logo Genes that share paralogs with FOSL2: view

Variants for FOSL2 Gene

Sequence variations from dbSNP and Humsavar for FOSL2 Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000056026 -- 28,414,267(+) C/A 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000212971 -- 28,403,096(+) G/T intron_variant
rs1000395338 -- 28,397,007(+) G/C intron_variant
rs1000414547 -- 28,403,395(+) A/G intron_variant
rs1000475229 -- 28,412,539(+) G/A 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for FOSL2 Gene

Variant ID Type Subtype PubMed ID
nsv1006830 CNV gain 25217958
nsv828664 CNV gain 20364138

Variation tolerance for FOSL2 Gene

Residual Variation Intolerance Score: 16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.60% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for FOSL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
FOSL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOSL2 Gene

Disorders for FOSL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for FOSL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
lipodystrophy, congenital generalized, type 3
  • cgl3
- elite association - COSMIC cancer census association via MalaCards
Search FOSL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for FOSL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Tumor Gene Database
(TGDB)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with FOSL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for FOSL2 Gene

Publications for FOSL2 Gene

  1. Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PMID: 2107490) Matsui M … Ishizaki R (Oncogene 1990) 3 4 23 56
  2. A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield JP … Hakonarson H (PLoS genetics 2011) 3 43 56
  3. The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis. (PMID: 20039427) Reich N … Distler JH (Arthritis and rheumatism 2010) 3 23 56
  4. Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 43 56
  5. Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis. (PMID: 19933934) Maurer B … Distler O (Circulation 2009) 3 23 56

Products for FOSL2 Gene

  • Boster Bio Antibodies for FOSL2
  • Boster Bio ELISA Kits for FOSL2

Sources for FOSL2 Gene