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The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014] See more...
Aliases for FOSL2 Gene
Aliases for FOSL2 Gene
External Ids for FOSL2 Gene
- HGNC: 3798
- Entrez Gene: 2355
- Ensembl: ENSG00000075426
- OMIM: 601575
- UniProtKB: P15408
Previous GeneCards Identifiers for FOSL2 Gene
- GC02P028537
- GC02P028708
- GC02P028590
- GC02P028527
- GC02P028615
- GC02P028356
Summaries for FOSL2 Gene
-
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
GeneCards Summary for FOSL2 Gene
FOSL2 (FOS Like 2, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOS.
UniProtKB/Swiss-Prot Summary for FOSL2 Gene
-
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
Additional gene information for FOSL2 Gene
- HGNC(3798)
- Entrez Gene(2355)
- Ensembl(ENSG00000075426)
- OMIM(601575)
- UniProtKB(P15408)
- Open Targets Platform(ENSG00000075426)
- Monarch Initiative
- Search for FOSL2 at DataMed
- Search for FOSL2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOSL2 Gene
Genomics for FOSL2 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for FOSL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOSL2 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for FOSL2
- Top Transcription factor binding sites by QIAGEN in the FOSL2 gene promoter:
-
- C/EBPbeta
- E2F
- E2F-1
- E2F-2
- MyoD
- p53
Genomic Locations for FOSL2 Gene
Genomic Locations for FOSL2 Gene
- chr2:28,392,448-28,417,317
- (GRCh38/hg38)
- Size:
- 24,870 bases
- Orientation:
- Plus strand
- chr2:28,615,315-28,640,179
- (GRCh37/hg19)
- Size:
- 24,865 bases
- Orientation:
- Plus strand
Genomic View for FOSL2 Gene
Genes around FOSL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p23.2 by HGNC
- 2p23.2 by Entrez Gene
- 2p23.2 by Ensembl
FOSL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOSL2 Gene
Proteins for FOSL2 Gene
-
Protein details for FOSL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15408-FOSL2_HUMAN
- Recommended name:
- Fos-related antigen 2
- Protein Accession:
- P15408
- B2RD58
- B3KP27
- B4DYV4
- Q6FG46
Protein attributes for FOSL2 Gene
- Size:
- 326 amino acids
- Molecular mass:
- 35193 Da
- Quaternary structure:
-
- Heterodimer.
Protein Expression for FOSL2 Gene
Post-translational modifications for FOSL2 Gene
Other Protein References for FOSL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FOSL2 Antibody and Immunotag™ Fra 2 Antibody
- Novus Biologicals Antibodies for FOSL2
-
Abcam antibodies for FOSL2
- Invitrogen Antibodies for FOSL2 (AFLGC-FOSL2)
- antibodies-online: Show 44 available FOSL2 Antibodies ranked by validation data
- Compare Top FOSL2 Antibodies
-
Recommended
- 113 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 ICC Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 35 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 38 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for FOSL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOSL2
Protein Products
- Search Origene for MassSpec and Protein Over-expression Lysates for FOSL2
- Origene Custom Protein Services for FOSL2
- ProSpec Recombinant Proteins for FOSL2
-
Abcam proteins for FOSL2
Assay Products
- antibodies-online: Show 6 available FOSL2 Elisa Kits ranked by validation data
- Compare Top FOSL2 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for FOSL2
No data available for DME Specific Peptides for FOSL2 Gene
Domains & Families for FOSL2 Gene
Gene Families for FOSL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOSL2 Gene
Suggested Antigen Peptide Sequences for FOSL2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ54924, highly similar to Fos-related antigen 2 (B4DYV4_HUMAN)
- Fos-related antigen 2 (FOSL2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15408- Family:
-
- Belongs to the bZIP family. Fos subfamily.
Function for FOSL2 Gene
Molecular function for FOSL2 Gene
- UniProtKB/Swiss-Prot Function:
- Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
- GENATLAS Biochemistry:
- fos-related antigen 2
Phenotypes From GWAS Catalog for FOSL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA,IDA | 13679379 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 13679379 |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for FOSL2 Gene
- MGI mutant phenotypes for FOSL2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FOSL2:
-
- Decreased hepcidin::fluc mRNA expression
- Increased vaccinia virus (VACV) infection
- no effect
- Increased IL-8 secretion
- Increased shRNA abundance (Z-score > 2)
- Decreased viability in glioblastoma multiforme (GBM) lineage
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Decreased shRNA abundance (Z-score < -2)
- Increased HPV18 LCR reporter activity
- Two nuclei (binuclear)
- Big cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOSL2 - Select products 50% OFF >
- * FOSL2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOSL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOSL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOSL2
miRNA for FOSL2 Gene
- miRTarBase miRNAs that target FOSL2
-
- hsa-miR-342-3p (MIRT043735)
- hsa-miR-99a-5p (MIRT048624)
- hsa-miR-6748-5p (MIRT476762)
- hsa-miR-5196-5p (MIRT476763)
- hsa-miR-4747-5p (MIRT476764)
- hsa-miR-3665 (MIRT476765)
- hsa-miR-1252-5p (MIRT476766)
- hsa-miR-550b-2-5p (MIRT523658)
- hsa-miR-7703 (MIRT523659)
- hsa-miR-6807-5p (MIRT523660)
- hsa-miR-6743-3p (MIRT523661)
- hsa-miR-4793-3p (MIRT523662)
- hsa-miR-566 (MIRT542959)
- hsa-miR-6514-3p (MIRT542960)
- hsa-miR-7977 (MIRT542961)
- hsa-miR-6811-3p (MIRT542962)
- hsa-miR-8075 (MIRT542963)
- hsa-miR-214-5p (MIRT542964)
- hsa-miR-4679 (MIRT542965)
- hsa-miR-383-3p (MIRT542966)
- mmu-miR-362-3p (MIRT590018)
- mmu-miR-329-3p (MIRT590019)
- mmu-miR-615-3p (MIRT593064)
- mmu-miR-743a-3p (MIRT594940)
- mmu-miR-743b-3p (MIRT594941)
- mmu-miR-466q (MIRT594942)
- mmu-miR-320-3p (MIRT595533)
- hsa-miR-887-5p (MIRT668272)
- hsa-miR-6780a-5p (MIRT668273)
- hsa-miR-6779-5p (MIRT668274)
- hsa-miR-3689c (MIRT668275)
- hsa-miR-3689b-3p (MIRT668276)
- hsa-miR-3689a-3p (MIRT668277)
- hsa-miR-30b-3p (MIRT668278)
- hsa-miR-1273h-5p (MIRT668279)
- hsa-miR-6788-5p (MIRT668280)
- hsa-miR-30c-2-3p (MIRT668281)
- hsa-miR-30c-1-3p (MIRT668282)
- hsa-miR-6799-5p (MIRT668283)
- hsa-miR-6883-5p (MIRT668284)
- hsa-miR-6785-5p (MIRT668285)
- hsa-miR-4728-5p (MIRT668286)
- hsa-miR-149-3p (MIRT668287)
- hsa-miR-7106-5p (MIRT668288)
- hsa-miR-7160-5p (MIRT668289)
- hsa-miR-6884-5p (MIRT668290)
- hsa-miR-485-5p (MIRT668291)
- hsa-miR-4649-3p (MIRT668292)
- hsa-miR-665 (MIRT668293)
- hsa-miR-4768-3p (MIRT668294)
- hsa-miR-4478 (MIRT668295)
- hsa-miR-4419b (MIRT668296)
- hsa-miR-3929 (MIRT668297)
- hsa-miR-940 (MIRT668298)
- hsa-miR-6893-5p (MIRT668299)
- hsa-miR-6808-5p (MIRT668300)
- hsa-miR-890 (MIRT668301)
- hsa-miR-133a-3p (MIRT668302)
- hsa-miR-4684-5p (MIRT668303)
- hsa-miR-4281 (MIRT668304)
- hsa-miR-520f-5p (MIRT668305)
- hsa-miR-4521 (MIRT668306)
- hsa-miR-6793-3p (MIRT668307)
- hsa-miR-6816-3p (MIRT668308)
- hsa-miR-5571-5p (MIRT668309)
- hsa-miR-133b (MIRT668310)
- hsa-miR-6513-5p (MIRT671565)
- hsa-miR-3913-5p (MIRT671566)
- hsa-miR-3122 (MIRT671567)
- hsa-miR-450a-1-3p (MIRT671568)
- hsa-miR-6769b-5p (MIRT671569)
- hsa-miR-6769a-5p (MIRT671570)
- hsa-miR-8085 (MIRT671571)
- hsa-miR-6731-5p (MIRT671572)
- hsa-miR-6878-5p (MIRT671573)
- hsa-miR-24-3p (MIRT671574)
- hsa-miR-4284 (MIRT671575)
- hsa-miR-6847-3p (MIRT671576)
- hsa-miR-4786-5p (MIRT671577)
- hsa-miR-4761-5p (MIRT671578)
- hsa-miR-548s (MIRT703467)
- hsa-miR-6827-3p (MIRT703468)
- hsa-miR-340-3p (MIRT703469)
- hsa-miR-6849-3p (MIRT703470)
- hsa-miR-4722-5p (MIRT717108)
- hsa-miR-1827 (MIRT717109)
- hsa-miR-590-3p (MIRT733548)
- hsa-miR-455-3p (MIRT746174)
- hsa-miR-6499-3p (MIRT752791)
- hsa-miR-6516-5p (MIRT753337)
- hsa-miR-1247-3p (MIRT761532)
- hsa-miR-1910-3p (MIRT763284)
- hsa-miR-2467-3p (MIRT764083)
- hsa-miR-3612 (MIRT765905)
- hsa-miR-377-5p (MIRT767393)
- hsa-miR-4257 (MIRT768121)
- hsa-miR-6086 (MIRT775524)
- hsa-miR-650 (MIRT776663)
- hsa-miR-6511a-5p (MIRT776782)
- hsa-miR-153-5p (MIRT783899)
- hsa-miR-7151-5p (MIRT789433)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOSL2
- Browse OriGene Inhibitory RNA Products For FOSL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOSL2
Clone Products
- Applied Biological Materials (abm): Clones for FOSL2 - Select products 50% OFF >
- * FOSL2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FOSL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOSL2
Cell Line Products
-
Horizon Cell Lines for FOSL2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOSL2 Gene
Localization for FOSL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOSL2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| plasma membrane | 2 |
| extracellular | 2 |
| cytoskeleton | 2 |
| mitochondrion | 2 |
| cytosol | 2 |
| peroxisome | 1 |
| endoplasmic reticulum | 1 |
| endosome | 1 |
| lysosome | 1 |
| golgi apparatus | 1 |
- Nucleoplasm (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000790 | nuclear chromatin | ISA | -- |
| GO:0005634 | nucleus | TAS,IBA | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for FOSL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
|
|
| 2 | IL-17 Family Signaling Pathways |
Mucin expression in CF via IL-6, IL-17 signaling pathways
.48
|
|
| 3 | Immune response IL-2 activation and signaling pathway |
Immune response IL-2 activation and signaling pathway
.41
|
Immune response IL-3 activation and signaling pathway
.41
|
| 4 | MAP Kinase Signaling | ||
| 5 | Osteoclast differentiation | ||
Pathways by source for FOSL2 Gene
1 BioSystems pathway for FOSL2 Gene
1 PharmGKB pathway for FOSL2 Gene
1 KEGG pathway for FOSL2 Gene
7 GeneGo (Thomson Reuters) pathways for FOSL2 Gene
- Immune response CD16 signaling in NK cells
- Immune response IL-1 signaling pathway
- Immune response IL-2 activation and signaling pathway
- Immune response IL-3 activation and signaling pathway
- Immune response Oncostatin M signaling via MAPK in human cells
3 R&D Systems pathways for FOSL2 Gene
6 Qiagen pathways for FOSL2 Gene
- Ceramide Pathway
- Epithelial Tight Junctions
- ILK Signaling
- iNOS Signaling
- ITK and TCR Signaling
1 Cell Signaling Technology pathway for FOSL2 Gene
Interacting Proteins for FOSL2 Gene
Selected Interacting proteins:
P15408-FOSL2_HUMAN
ENSP00000264716
for FOSL2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FOSL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003334 | keratinocyte development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
| GO:0008219 | cell death | TAS | 8954781 |
| GO:0045893 | positive regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for FOSL2 Gene
Transcripts for FOSL2 Gene
mRNA/cDNA for FOSL2 Gene
- 1 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000264716 6713 nts (view in UCSC)
- ENST00000379619 5829 nts (view in UCSC)
- ENST00000436647 889 nts (view in UCSC)
- ENST00000460736 393 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for FOSL2 - Select products 50% OFF >
- * FOSL2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for FOSL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOSL2
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOSL2
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOSL2
- Browse OriGene Inhibitory RNA Products For FOSL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOSL2
Clone Products
- Applied Biological Materials (abm): Clones for FOSL2 - Select products 50% OFF >
- * FOSL2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for FOSL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOSL2
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||
| SP5: | - | - | - | - |
Relevant External Links for FOSL2 Gene
- GeneLoc Exon Structure for
- FOSL2
Expression for FOSL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
- Dermis (Integumentary System)
- Fibroblasts
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Gall Bladder (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Adrenal (64.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOSL2 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for FOSL2
SOURCE GeneReport for Unigene cluster for FOSL2 Gene:
Hs.220971Evidence on tissue expression from TISSUES for FOSL2 Gene
- Lung(4.6)
- Heart(4.5)
- Eye(4.3)
- Nervous system(3.5)
- Kidney(3)
- Adrenal gland(2.9)
- Skin(2.9)
- Bone marrow(2.9)
- Intestine(2.7)
- Blood(2.7)
- Muscle(2.6)
- Spleen(2.5)
- Liver(2.4)
- Stomach(2.2)
- Thyroid gland(2.2)
- Lymph node(2.1)
- Bone(2)
Primer Products
-
OriGene qPCR primer pairs for FOSL2
-
OriGene qPCR primer pairs and template standards for FOSL2
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOSL2 Gene
Orthologs for FOSL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | FOSL2 30 31 |
|
OneToOne | |
| Dog (Canis familiaris) |
Mammalia | FOSL2 30 31 |
|
OneToOne | |
| Cow (Bos Taurus) |
Mammalia | FOSL2 30 31 |
|
OneToOne | |
| Mouse (Mus musculus) |
Mammalia | Fosl2 30 17 31 |
|
OneToOne | |
| Rat (Rattus norvegicus) |
Mammalia | Fosl2 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | FOSL2 31 |
|
OneToOne | |
| Platypus (Ornithorhynchus anatinus) |
Mammalia | FOSL2 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | FOSL2 30 31 |
|
OneToOne | |
| Lizard (Anolis carolinensis) |
Reptilia | FOSL2 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fosl2 30 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | gene 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | fosl2 30 31 |
|
OneToOne | |
| Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6126 30 |
|
||
| Fruit Fly (Drosophila melanogaster) |
Insecta | kay 31 |
|
OneToMany | |
| Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
- Species where no ortholog for FOSL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Evolution for FOSL2 Gene
- ENSEMBL:
- Gene Tree for FOSL2 (if available)
- TreeFam:
- Gene Tree for FOSL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOSL2: view image
Paralogs for FOSL2 Gene
Variants for FOSL2 Gene
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1006830 | CNV | gain | 25217958 |
| nsv828664 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.84;
17.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOSL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FOSL2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for FOSL2 Gene
Disorders for FOSL2 Gene
Additional Disease Information for FOSL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
- Open Targets Platform
No disorders were found for FOSL2 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for FOSL2 Gene
Publications for FOSL2 Gene
- Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PMID: 2107490) Matsui M … Ishizaki R (Oncogene 1990) 3 4 23
- A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield JP … Hakonarson H (PLoS genetics 2011) 3 41
- The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis. (PMID: 20039427) Reich N … Distler JH (Arthritis and rheumatism 2010) 3 23
- Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 41
- Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis. (PMID: 19933934) Maurer B … Distler O (Circulation 2009) 3 23
ExternalLinks
Products for FOSL2 Gene
- Custom Antibody ServicesOriGene Antibodies for FOSL2
- Browse OriGene ELISA Kits
- Custom Assay Services
- Search Origene for MassSpec and Protein Over-expression Lysates for FOSL2
- Origene Custom Protein Services for FOSL2
- Origene shrna, sirna, and RNAi products in human, mouse, rat for FOSL2
- Browse OriGene Inhibitory RNA Products For FOSL2
- OriGene qPCR primer pairs for FOSL2
- OriGene qPCR primer pairs and template standards for FOSL2
- OriGene CRISPR knockouts for FOSL2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOSL2
- Sino Biological Human cDNA Clone for FOSL2
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
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- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FOSL2
- Novus Biologicals proteins and lysates for FOSL2
- Browse Antibodies
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- Abcam antibodies for FOSL2
- Abcam proteins for FOSL2
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- Browse Primary Antibodies
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- VectorBuilder Custom and pre-made DNA vectors for FOSL2 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for FOSL2 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for FOSL2 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for FOSL2 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for FOSL2
- antibodies-online: Show 44 available FOSL2 Antibodies ranked by validation data
- Compare Top FOSL2 Antibodies
- Recommended
- 113 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 ICC Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 35 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 38 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 6 available FOSL2 Elisa Kits ranked by validation data
- Compare Top FOSL2 Elisa Kits
- Quality Products:
- antibodies-online: Show 10 available FOSL2 Proteins ranked by validation data
- Compare Top FOSL2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FOSL2
- Search Santa Cruz Biotechnology (SCBT) for FOSL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOSL2
- Horizon Cell Lines for FOSL2
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOSL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOSL2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FOSL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOSL2
- Boster Bio Antibodies for FOSL2
- Boster Bio ELISA Kits for FOSL2
Sources for FOSL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
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- (13) UniProtKB/TrEMBL
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- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
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- (109) Disease Ontology
- (110) Genetics Home Reference
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- (115) NCBI Bookshelf
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- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
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- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
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- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB