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The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
FOSL2 (FOS Like 2, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Among its related pathways are G-protein signaling Ras family GTPases in kinase cascades (scheme) and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOS.
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IEA,IDA | 13679379 |
GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | ISM | 19274049 |
GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 13679379 |
GO:0003677 | DNA binding | IEA | -- |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0000790 | nuclear chromatin | ISA | -- |
GO:0005634 | nucleus | TAS,IBA | 21873635 |
GO:0005654 | nucleoplasm | IDA | -- |
SuperPathway | Contained pathways | ||
---|---|---|---|
1 | Toll-Like receptor Signaling Pathways |
Mucin expression in CF via TLRs, EGFR signaling pathways
.42
Immune response IL-1 signaling pathway
.41
|
|
2 | IL-17 Family Signaling Pathways |
Mucin expression in CF via IL-6, IL-17 signaling pathways
.48
|
|
3 | Immune response IL-2 activation and signaling pathway |
Immune response IL-2 activation and signaling pathway
.41
|
Immune response IL-3 activation and signaling pathway
.41
|
4 | MAP Kinase Signaling | ||
5 | Osteoclast differentiation |
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0003334 | keratinocyte development | IEA | -- |
GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
GO:0006357 | regulation of transcription by RNA polymerase II | IEA,IBA | 21873635 |
GO:0008219 | cell death | TAS | 8954781 |
GO:0045893 | positive regulation of transcription, DNA-templated | IEA | -- |
ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | - | - | ||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||
SP3: | - | - | |||||||||||||||||||||||||
SP4: | - | - | |||||||||||||||||||||||||
SP5: | - | - | - | - |
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
Chimpanzee (Pan troglodytes) |
Mammalia | FOSL2 30 31 |
|
OneToOne | |
Dog (Canis familiaris) |
Mammalia | FOSL2 30 31 |
|
OneToOne | |
Cow (Bos Taurus) |
Mammalia | FOSL2 30 31 |
|
OneToOne | |
Mouse (Mus musculus) |
Mammalia | Fosl2 30 17 31 |
|
OneToOne | |
Rat (Rattus norvegicus) |
Mammalia | Fosl2 30 |
|
||
Oppossum (Monodelphis domestica) |
Mammalia | FOSL2 31 |
|
OneToOne | |
Platypus (Ornithorhynchus anatinus) |
Mammalia | FOSL2 31 |
|
OneToOne | |
Chicken (Gallus gallus) |
Aves | FOSL2 30 31 |
|
OneToOne | |
Lizard (Anolis carolinensis) |
Reptilia | FOSL2 31 |
|
OneToOne | |
Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | fosl2 30 |
|
||
African clawed frog (Xenopus laevis) |
Amphibia | gene 30 |
|
||
Zebrafish (Danio rerio) |
Actinopterygii | fosl2 30 31 |
|
OneToOne | |
Rainbow Trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6126 30 |
|
||
Fruit Fly (Drosophila melanogaster) |
Insecta | kay 31 |
|
OneToMany | |
Sea Squirt (Ciona savignyi) |
Ascidiacea | -- 31 |
|
OneToMany |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
nsv1006830 | CNV | gain | 25217958 |
nsv828664 | CNV | gain | 20364138 |
No disorders were found for FOSL2 Gene.