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The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014] See more...
Aliases for FOSL2 Gene
Aliases for FOSL2 Gene
External Ids for FOSL2 Gene
- HGNC: 3798
- Entrez Gene: 2355
- Ensembl: ENSG00000075426
- OMIM: 601575
- UniProtKB: P15408
Previous GeneCards Identifiers for FOSL2 Gene
- GC02P028537
- GC02P028708
- GC02P028590
- GC02P028527
- GC02P028615
- GC02P028356
Summaries for FOSL2 Gene
-
The Fos gene family consists of 4 members: FOS, FOSB, FOSL1, and FOSL2. These genes encode leucine zipper proteins that can dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators of cell proliferation, differentiation, and transformation. [provided by RefSeq, Jul 2014]
GeneCards Summary for FOSL2 Gene
FOSL2 (FOS Like 2, AP-1 Transcription Factor Subunit) is a Protein Coding gene. Diseases associated with FOSL2 include Lipodystrophy, Congenital Generalized, Type 3. Among its related pathways are IL-1 Family Signaling Pathways and Tacrolimus/Cyclosporine Pathway, Pharmacodynamics. Gene Ontology (GO) annotations related to this gene include DNA-binding transcription factor activity and RNA polymerase II regulatory region sequence-specific DNA binding. An important paralog of this gene is FOS.
UniProtKB/Swiss-Prot Summary for FOSL2 Gene
-
Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
Additional gene information for FOSL2 Gene
- Monarch Initiative
- Search for FOSL2 at DataMed
- Search for FOSL2 at HumanCyc
No data available for CIViC Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for FOSL2 Gene
Genomics for FOSL2 Gene
GeneHancer (GH) Regulatory Elements for FOSL2 Gene
Promoters and enhancers for FOSL2 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around FOSL2 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the FOSL2 gene promoter:
-
- C/EBPbeta
- E2F
- E2F-1
- E2F-2
- MyoD
- p53
Genomic Locations for FOSL2 Gene
Genomic Locations for FOSL2 Gene
- chr2:28,392,448-28,417,317
- (GRCh38/hg38)
- Size:
- 24,870 bases
- Orientation:
- Plus strand
- chr2:28,615,315-28,640,179
- (GRCh37/hg19)
- Size:
- 24,865 bases
- Orientation:
- Plus strand
Genomic View for FOSL2 Gene
Genes around FOSL2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 2p23.2 by HGNC
- 2p23.2 by Entrez Gene
- 2p23.2 by Ensembl
FOSL2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for FOSL2 Gene
Proteins for FOSL2 Gene
-
Protein details for FOSL2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- P15408-FOSL2_HUMAN
- Recommended name:
- Fos-related antigen 2
- Protein Accession:
- P15408
- B2RD58
- B3KP27
- B4DYV4
- Q6FG46
Protein attributes for FOSL2 Gene
- Size:
- 326 amino acids
- Molecular mass:
- 35193 Da
- Quaternary structure:
-
- Heterodimer.
Protein Expression for FOSL2 Gene
Post-translational modifications for FOSL2 Gene
Other Protein References for FOSL2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- G Biosciences Immunotag™ FOSL2 Antibody and Immunotag™ Fra 2 Antibody
- Atlas Antibodies Anti-FOSL2 Antibody (HPA004817) and Anti-FOSL2 Antibody (HPA061417)
-
Creative Biolabs
- Mouse Anti-FOSL2 Recombinant Antibody (CBXF-0821)
- Mouse Anti-FOSL2 (AA 207-296) Recombinant Antibody (CBXF-3125)
- Rabbit Anti-FOSL2 Recombinant Antibody (CBXF-3128)
- Mouse Anti-FOSL2 Recombinant Antibody (1B1)
- Hi-Affi™ Recombinant Rabbit Anti-FOSL2 Monoclonal Antibody (DS1337AB)
- Mouse Anti-FOSL2 Recombinant Antibody (CBXF-3126)
- Mouse Anti-FOSL2 Recombinant Antibody (CBXF-3127)
- Mouse Anti-FOSL2 Recombinant Antibody (273C4a)
- Recombinant Mouse anti-Human FOSL2 Monoclonal antibody (T68)
- Mouse Anti-FOSL2 Recombinant Antibody (CBXF-0820)
- Rabbit Anti-FOSL2 Recombinant Antibody (CBXF-1207)
-
Custom Antibody ServicesOriGene Antibodies for FOSL2
- Novus Biologicals Antibodies for FOSL2
-
Abcam antibodies for FOSL2
- Invitrogen Antibodies for FOSL2 (AFLGC-FOSL2)
- antibodies-online: Show 44 available FOSL2 Antibodies ranked by validation data
- Compare Top FOSL2 Antibodies
-
Recommended
- 113 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 ICC Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 35 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 38 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
-
Boster Bio Antibodies for FOSL2
-
Santa Cruz Biotechnology (SCBT) Antibodies for FOSL2
Protein Products
- Creative Biomart Recombinant Human FOSL2 293 Cell Lysate and Recombinant Human FOSL2 Protein, His-tagged
-
OriGene Purified Proteins for FOSL2
- Search Origene for MassSpec and Protein Over-expression Lysates for FOSL2
- Origene Custom Protein Services for FOSL2
- ProSpec Recombinant Proteins for FOSL2
-
Abcam proteins for FOSL2
Assay Products
- antibodies-online: Show 6 available FOSL2 Elisa Kits ranked by validation data
- Compare Top FOSL2 Elisa Kits
-
Quality Products:
-
Boster Bio ELISA Kits for FOSL2
No data available for DME Specific Peptides for FOSL2 Gene
Domains & Families for FOSL2 Gene
Gene Families for FOSL2 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
- Transcription factors
Protein Domains for FOSL2 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for FOSL2 Gene
- GenScript: Design optimal peptide antigens:
-
- cDNA FLJ54924, highly similar to Fos-related antigen 2 (B4DYV4_HUMAN)
- Fos-related antigen 2 (FOSL2_HUMAN)
Graphical View of Domain Structure for InterPro Entry
P15408- Family:
-
- Belongs to the bZIP family. Fos subfamily.
Function for FOSL2 Gene
Molecular function for FOSL2 Gene
- UniProtKB/Swiss-Prot Function:
- Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts.
- GENATLAS Biochemistry:
- fos-related antigen 2
Phenotypes From GWAS Catalog for FOSL2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding | IDA | 13679379 |
| GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding | IBA | 21873635 |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | NAS | 19274049 |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | IDA | 13679379 |
| GO:0003677 | DNA binding | IEA | -- |
Phenotypes for FOSL2 Gene
- MGI mutant phenotypes for FOSL2:
- inferred from 3 alleles
- GenomeRNAi human phenotypes for FOSL2:
-
- Increased HPV18 LCR reporter activity
- Decreased shRNA abundance (Z-score < -2)
- Increased shRNA abundance (Z-score > 2)
- Effect on mitosis
- Dynamic nuclei (hole, folded or small irregular)
- Decreased viability in esophageal squamous lineage
- Decreased viability
- no effect
- Increased vaccinia virus (VACV) infection
- Decreased hepcidin::fluc mRNA expression
- Decreased IL-8 secretion
- Synthetic lethal with MLN4924 (a NAE inhibitor)
- Lamellipodia cells
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
-
OriGene CRISPR knockouts for FOSL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOSL2
- genomics-online: gRNA clones - Search for available FOSL2 gRNA products
- Overview of 134 available FOSL2 gene related products
- Applied Biological Materials (abm): CRISPR Clones for FOSL2 - Select products 50% OFF >
- * FOSL2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FOSL2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOSL2
miRNA for FOSL2 Gene
- miRTarBase miRNAs that target FOSL2
-
- hsa-mir-342-3p (MIRT043735)
- hsa-mir-99a-5p (MIRT048624)
- hsa-mir-6748-5p (MIRT476762)
- hsa-mir-5196-5p (MIRT476763)
- hsa-mir-4747-5p (MIRT476764)
- hsa-mir-3665 (MIRT476765)
- hsa-mir-1252-5p (MIRT476766)
- hsa-mir-550b-2-5p (MIRT523658)
- hsa-mir-7703 (MIRT523659)
- hsa-mir-6807-5p (MIRT523660)
- hsa-mir-6743-3p (MIRT523661)
- hsa-mir-4793-3p (MIRT523662)
- hsa-mir-566 (MIRT542959)
- hsa-mir-6514-3p (MIRT542960)
- hsa-mir-7977 (MIRT542961)
- hsa-mir-6811-3p (MIRT542962)
- hsa-mir-8075 (MIRT542963)
- hsa-mir-214-5p (MIRT542964)
- hsa-mir-4679 (MIRT542965)
- hsa-mir-383-3p (MIRT542966)
- hsa-mir-887-5p (MIRT668272)
- hsa-mir-6780a-5p (MIRT668273)
- hsa-mir-6779-5p (MIRT668274)
- hsa-mir-3689c (MIRT668275)
- hsa-mir-3689b-3p (MIRT668276)
- hsa-mir-3689a-3p (MIRT668277)
- hsa-mir-30b-3p (MIRT668278)
- hsa-mir-1273h-5p (MIRT668279)
- hsa-mir-6788-5p (MIRT668280)
- hsa-mir-30c-2-3p (MIRT668281)
- hsa-mir-30c-1-3p (MIRT668282)
- hsa-mir-6799-5p (MIRT668283)
- hsa-mir-6883-5p (MIRT668284)
- hsa-mir-6785-5p (MIRT668285)
- hsa-mir-4728-5p (MIRT668286)
- hsa-mir-149-3p (MIRT668287)
- hsa-mir-7106-5p (MIRT668288)
- hsa-mir-7160-5p (MIRT668289)
- hsa-mir-6884-5p (MIRT668290)
- hsa-mir-485-5p (MIRT668291)
- hsa-mir-4649-3p (MIRT668292)
- hsa-mir-665 (MIRT668293)
- hsa-mir-4768-3p (MIRT668294)
- hsa-mir-4478 (MIRT668295)
- hsa-mir-4419b (MIRT668296)
- hsa-mir-3929 (MIRT668297)
- hsa-mir-940 (MIRT668298)
- hsa-mir-6893-5p (MIRT668299)
- hsa-mir-6808-5p (MIRT668300)
- hsa-mir-890 (MIRT668301)
- hsa-mir-133a-3p (MIRT668302)
- hsa-mir-4684-5p (MIRT668303)
- hsa-mir-4281 (MIRT668304)
- hsa-mir-520f-5p (MIRT668305)
- hsa-mir-4521 (MIRT668306)
- hsa-mir-6793-3p (MIRT668307)
- hsa-mir-6816-3p (MIRT668308)
- hsa-mir-5571-5p (MIRT668309)
- hsa-mir-133b (MIRT668310)
- hsa-mir-6513-5p (MIRT671565)
- hsa-mir-3913-5p (MIRT671566)
- hsa-mir-3122 (MIRT671567)
- hsa-mir-450a-1-3p (MIRT671568)
- hsa-mir-6769b-5p (MIRT671569)
- hsa-mir-6769a-5p (MIRT671570)
- hsa-mir-8085 (MIRT671571)
- hsa-mir-6731-5p (MIRT671572)
- hsa-mir-6878-5p (MIRT671573)
- hsa-mir-24-3p (MIRT671574)
- hsa-mir-4284 (MIRT671575)
- hsa-mir-6847-3p (MIRT671576)
- hsa-mir-4786-5p (MIRT671577)
- hsa-mir-4761-5p (MIRT671578)
- hsa-mir-548s (MIRT703467)
- hsa-mir-6827-3p (MIRT703468)
- hsa-mir-340-3p (MIRT703469)
- hsa-mir-6849-3p (MIRT703470)
- hsa-mir-4722-5p (MIRT717108)
- hsa-mir-1827 (MIRT717109)
- hsa-mir-590-3p (MIRT733548)
- hsa-mir-455-3p (MIRT746174)
- hsa-mir-6499-3p (MIRT752791)
- hsa-mir-6516-5p (MIRT753337)
- hsa-mir-1247-3p (MIRT761532)
- hsa-mir-1910-3p (MIRT763284)
- hsa-mir-2467-3p (MIRT764083)
- hsa-mir-3612 (MIRT765905)
- hsa-mir-377-5p (MIRT767393)
- hsa-mir-4257 (MIRT768121)
- hsa-mir-6086 (MIRT775524)
- hsa-mir-650 (MIRT776663)
- hsa-mir-6511a-5p (MIRT776782)
- hsa-mir-153-5p (MIRT783899)
- hsa-mir-7151-5p (MIRT789433)
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOSL2
- Browse OriGene Inhibitory RNA Products For FOSL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOSL2
- genomics-online: shRNA clones - Search for available FOSL2 shRNA products
- Overview of 134 available FOSL2 gene related products
Clone Products
-
- MG204779
- MR204779
- MR204779L3
- MR204779L3V
- MR204779L4
- MR204779L4V
- RC204146
- RC204146L1
- RC204146L1V
- RC204146L2
- RC204146L2V
- RC204146L3
- RC204146L3V
- RC204146L4
- RC204146L4V
- RG204146
- RR204984
- RR204984L3
- RR204984L3V
- RR204984L4
- RR204984L4V
- RR209188
- RR209188L1
- RR209188L1V
- RR209188L2
- RR209188L2V
- RR209188L3
- RR209188L3V
- RR209188L4
- RR209188L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FOSL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOSL2
- genomics-online: cdna clones - Search for available FOSL2 CDNA products
- Overview of 134 available FOSL2 gene related products
- orf clones - Search for available FOSL2 ORF products
- Overview of 134 available FOSL2 gene related products
- Applied Biological Materials (abm): Clones for FOSL2 - Select products 50% OFF >
- * FOSL2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FOSL2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
Cell Line Products
-
Horizon Cell Lines for FOSL2
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for FOSL2 Gene
Localization for FOSL2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for FOSL2 Gene
- Nucleus.
| Compartment | Confidence |
|---|---|
| nucleus | 5 |
| extracellular | 1 |
| cytoskeleton | 1 |
| cytosol | 1 |
- Nucleus (4)
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005634 | nucleus | IBA,TAS | 21873635 |
| GO:0005654 | nucleoplasm | IDA | -- |
Pathways & Interactions for FOSL2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | IL-1 Family Signaling Pathways | ||
| 2 | IL-17 Family Signaling Pathways | ||
| 3 | Immune response IL-2 activation and signaling pathway | ||
| 4 | MAP Kinase Signaling | ||
| 5 | Osteoclast differentiation | ||
Pathways by source for FOSL2 Gene
1 BioSystems pathway for FOSL2 Gene
1 PharmGKB pathway for FOSL2 Gene
1 KEGG pathway for FOSL2 Gene
7 GeneGo (Thomson Reuters) pathways for FOSL2 Gene
3 R&D Systems pathways for FOSL2 Gene
6 Qiagen pathways for FOSL2 Gene
- Ceramide Pathway
- Epithelial Tight Junctions
- ILK Signaling
- iNOS Signaling
- ITK and TCR Signaling
1 Cell Signaling Technology pathway for FOSL2 Gene
Interacting Proteins for FOSL2 Gene
Selected Interacting proteins:
P15408-FOSL2_HUMAN
ENSP00000264716
for FOSL2 Gene via
UniProtKB
STRING
IID
GPS-Prot Interaction Network for FOSL2
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0003334 | keratinocyte development | IEA | -- |
| GO:0006355 | regulation of transcription, DNA-templated | IEA | -- |
| GO:0006357 | regulation of transcription by RNA polymerase II | IEA,TAS | 8954781 |
| GO:0008219 | cell death | TAS | 8954781 |
| GO:0045893 | positive regulation of transcription, DNA-templated | IEA | -- |
No data available for SIGNOR curated interactions for FOSL2 Gene
Drugs & Compounds for FOSL2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs |
|---|
Drug Products
- Creative Biomart Recombinant Human FOSL2 293 Cell Lysate and Recombinant Human FOSL2 Protein, His-tagged
Transcripts for FOSL2 Gene
mRNA/cDNA for FOSL2 Gene
- (1) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (303) Selected AceView cDNA sequences:
- (4) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000460736 393 bps (ENST00000460736.1)
- ENST00000379619 5829 bps (ENST00000379619.5)
- ENST00000264716 6713 bps (ENST00000264716.8)
- ENST00000436647 889 bps (ENST00000436647.1)
CRISPR Products
-
OriGene CRISPR knockouts for FOSL2
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOSL2
- genomics-online: gRNA clones - Search for available FOSL2 gRNA products
- Overview of 134 available FOSL2 gene related products
- Applied Biological Materials (abm): CRISPR Clones for FOSL2 - Select products 50% OFF >
- * FOSL2 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * FOSL2 CRISPR applications: KO, Activation, Repression, and more - Browse All
-
Santa Cruz Biotechnology (SCBT) CRISPR for FOSL2
miRNA Products
Inhibitory RNA Products
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOSL2
- Browse OriGene Inhibitory RNA Products For FOSL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOSL2
- genomics-online: shRNA clones - Search for available FOSL2 shRNA products
- Overview of 134 available FOSL2 gene related products
Clone Products
-
- MG204779
- MR204779
- MR204779L3
- MR204779L3V
- MR204779L4
- MR204779L4V
- RC204146
- RC204146L1
- RC204146L1V
- RC204146L2
- RC204146L2V
- RC204146L3
- RC204146L3V
- RC204146L4
- RC204146L4V
- RG204146
- RR204984
- RR204984L3
- RR204984L3V
- RR204984L4
- RR204984L4V
- RR209188
- RR209188L1
- RR209188L1V
- RR209188L2
- RR209188L2V
- RR209188L3
- RR209188L3V
- RR209188L4
- RR209188L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Sino Biological Human cDNA Clone for FOSL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOSL2
- genomics-online: cdna clones - Search for available FOSL2 CDNA products
- Overview of 134 available FOSL2 gene related products
- orf clones - Search for available FOSL2 ORF products
- Overview of 134 available FOSL2 gene related products
- Applied Biological Materials (abm): Clones for FOSL2 - Select products 50% OFF >
- * FOSL2 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * FOSL2 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All
| ExUns: | 1 | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | · | 7d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | - | ||||||||||||||||||||||
| SP2: | - | - | - | - | |||||||||||||||||||||||
| SP3: | - | - | |||||||||||||||||||||||||
| SP4: | - | - | |||||||||||||||||||||||||
| SP5: | - | - | - | - |
Expression for FOSL2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Kidney (Urinary System)
- Ureteric Bud Cells Ureteric Bud
- Ureteric Bud Tip Cells Ureteric Bud
-
Eye (Sensory Organs)
- Glycinergic Amacrine Cells Inner Nuclear Layer
-
Neurons
- Glycinergic Amacrine Cells Inner Nuclear Layer
- Brain (Nervous System)
- Gut Tube (Gastrointestinal Tract)
- Neural Tube (Nervous System)
- Intestine (Gastrointestinal Tract)
- Bone (Muscoskeletal System)
- Ovary (Reproductive System)
- Blood (Hematopoietic System)
- Dermis (Integumentary System)
- Fibroblasts
-
Uterus (Reproductive System)
-
Colon (Gastrointestinal Tract)
-
Gall Bladder (Hepatobiliary System)
-
Esophagus (Gastrointestinal Tract)
-
Stomach (Gastrointestinal Tract)
This gene is overexpressed in Adrenal (64.7).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for FOSL2 Gene
NURSA nuclear receptor signaling pathways regulating expression of FOSL2 Gene:
FOSL2SOURCE GeneReport for Unigene cluster for FOSL2 Gene:
Hs.220971Evidence on tissue expression from TISSUES for FOSL2 Gene
- Lung(4.5)
- Heart(4.4)
- Eye(4.1)
- Nervous system(3.2)
- Adrenal gland(2.7)
- Skin(2.5)
- Bone marrow(2.2)
- Intestine(2)
- Kidney(2)
- Muscle(2)
Primer Products
-
OriGene qPCR primer pairs for FOSL2
-
OriGene qPCR primer pairs and template standards for FOSL2
- genomics-online: primer clones - Search for available FOSL2 Primer products
- Overview of 134 available FOSL2 gene related products
Gene Expression Assay Products
No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for FOSL2 Gene
Orthologs for FOSL2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | FOSL2 33 32 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | FOSL2 33 32 |
|
OneToOne | |
| cow (Bos Taurus) |
Mammalia | FOSL2 33 32 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | Fosl2 17 33 32 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Fosl2 32 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | FOSL2 33 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | FOSL2 33 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | FOSL2 33 32 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | FOSL2 33 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | fosl2 32 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | gene 32 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | fosl2 33 32 |
|
OneToOne | |
| rainbow trout (Oncorhynchus mykiss) |
Actinopterygii | Omy.6126 32 |
|
||
| fruit fly (Drosophila melanogaster) |
Insecta | kay 33 |
|
OneToMany | |
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 33 |
|
OneToMany |
- Species where no ortholog for FOSL2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for FOSL2 Gene
- ENSEMBL:
- Gene Tree for FOSL2 (if available)
- TreeFam:
- Gene Tree for FOSL2 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for FOSL2: view image
Paralogs for FOSL2 Gene
Variants for FOSL2 Gene
| SNP ID | Clin | Chr 02 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000056026 | -- | 28,414,267(+) | C/A | 3_prime_UTR_variant, genic_downstream_transcript_variant | |
| rs1000212971 | -- | 28,403,096(+) | G/T | intron_variant | |
| rs1000395338 | -- | 28,397,007(+) | G/C | intron_variant | |
| rs1000414547 | -- | 28,403,395(+) | A/G | intron_variant | |
| rs1000475229 | -- | 28,412,539(+) | G/A | 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1006830 | CNV | gain | 25217958 |
| nsv828664 | CNV | gain | 20364138 |
Residual Variation Intolerance Score:
16.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
0.84;
17.60% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for FOSL2 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- FOSL2
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for FOSL2 Gene
Disorders for FOSL2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| lipodystrophy, congenital generalized, type 3 |
|
|
Search FOSL2 in MalaCards
View complete list of genes associated with diseases
Additional Disease Information for FOSL2
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- Tumor Gene Database
- (TGDB)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No data available for UniProtKB/Swiss-Prot and Genatlas for FOSL2 Gene
Publications for FOSL2 Gene
- Isolation of human fos-related genes and their expression during monocyte-macrophage differentiation. (PMID: 2107490) Matsui M … Ishizaki R (Oncogene 1990) 3 4 23 56
- A genome-wide meta-analysis of six type 1 diabetes cohorts identifies multiple associated loci. (PMID: 21980299) Bradfield JP … Hakonarson H (PLoS genetics 2011) 3 43 56
- The transcription factor Fra-2 regulates the production of extracellular matrix in systemic sclerosis. (PMID: 20039427) Reich N … Distler JH (Arthritis and rheumatism 2010) 3 23 56
- Genetical genomic determinants of alcohol consumption in rats and humans. (PMID: 19874574) Tabakoff B … WHO/ISBRA Study on State and Trait Markers of Alcoholism (BMC biology 2009) 3 43 56
- Transcription factor fos-related antigen-2 induces progressive peripheral vasculopathy in mice closely resembling human systemic sclerosis. (PMID: 19933934) Maurer B … Distler O (Circulation 2009) 3 23 56
ExternalLinks
Products for FOSL2 Gene
- Custom Antibody ServicesOriGene Antibodies for FOSL2
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for FOSL2
- Search Origene for MassSpec and Protein Over-expression Lysates for FOSL2
- Origene Custom Protein Services for FOSL2
- Origene sirna, shrna, and RNAi products in human, mouse, rat for FOSL2
- Browse OriGene Inhibitory RNA Products For FOSL2
- OriGene qPCR primer pairs for FOSL2
- OriGene qPCR primer pairs and template standards for FOSL2
- OriGene CRISPR knockouts for FOSL2
- MG204779
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- MR204779L3
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- MR204779L4
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- RC204146L2V
- RC204146L3
- RC204146L3V
- RC204146L4
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- RG204146
- RR204984
- RR204984L3
- RR204984L3V
- RR204984L4
- RR204984L4V
- RR209188
- RR209188L1
- RR209188L1V
- RR209188L2
- RR209188L2V
- RR209188L3
- RR209188L3V
- RR209188L4
- RR209188L4V
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For FOSL2
- Sino Biological Human cDNA Clone for FOSL2
- Browse Sino Biological Recombinant Proteins
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- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for FOSL2
- Novus Biologicals proteins and lysates for FOSL2
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Abcam antibodies for FOSL2
- Abcam proteins for FOSL2
- Find your target
- Browse Primary Antibodies
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- Browse ELISA Kits
- Browse Matched Antibody Pairs
- Browse Proteins and Peptides
- Search Knockout (KO) Validated Antibodies
- Browse Monoclonal Antibodies
- Browse Recombinant Antibodies
- antibodies-online: Show 44 available FOSL2 Antibodies ranked by validation data
- Compare Top FOSL2 Antibodies
- Recommended
- 113 WB Antibodies (anti-human)
- 12 IF (p) Antibodies (anti-human)
- 3 IP Antibodies (anti-human)
- 2 ICC Antibodies (anti-human)
- 2 IHC Antibodies (anti-human)
- 1 IHC (p) Antibody (anti-human)
- 35 WB Antibodies (anti-mouse)
- 12 IF (p) Antibodies (anti-mouse)
- 38 WB Antibodies (anti-rat)
- 12 IF (p) Antibodies (anti-rat)
- antibodies-online: Show 6 available FOSL2 Elisa Kits ranked by validation data
- Compare Top FOSL2 Elisa Kits
- Quality Products:
- antibodies-online: Show 10 available FOSL2 Proteins ranked by validation data
- Compare Top FOSL2 Proteins
- Santa Cruz Biotechnology (SCBT) Antibodies for FOSL2
- Search Santa Cruz Biotechnology (SCBT) for FOSL2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for FOSL2
- Horizon Cell Lines for FOSL2
- genomics-online: cdna clones - Search for available FOSL2 CDNA products
- Overview of 134 available FOSL2 gene related products
- orf clones - Search for available FOSL2 ORF products
- Overview of 134 available FOSL2 gene related products
- genomics-online: gRNA clones - Search for available FOSL2 gRNA products
- Overview of 134 available FOSL2 gene related products
- genomics-online: primer clones - Search for available FOSL2 Primer products
- Overview of 134 available FOSL2 gene related products
- genomics-online: shRNA clones - Search for available FOSL2 shRNA products
- Overview of 134 available FOSL2 gene related products
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for FOSL2
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for FOSL2
- Search GeneCopoeia for miRNA 3'UTR Target clone products for FOSL2
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for FOSL2
Sources for FOSL2 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) CGAP SAGE
- (31) SOURCE
- (32) HomoloGene
- (33) PanEnsembl
- (34) euGenes
- (35) SGD
- (36) FlyBase
- (37) WormBase
- (38) Pseudogene
- (39) DGV
- (40) dbSNP
- (41) GenAtlas
- (42) HGMD
- (43) GAD
- (44) BGMUT
- (45) HuGE
- (46) Atlas
- (47) GenBank
- (48) H-invDB
- (49) HORDE
- (50) HUGE
- (51) IMGT
- (52) Leiden
- (53) miRBase
- (54) DME
- (55) OriGene
- (56) PubMed
- (57) R&D Systems
- (58) TGDB
- (59) Tocris
- (60) Abcam
- (61) Novus Biologicals
- (62) ProSpec
- (63) Sino Biological
- (64) GenScript
- (65) Qiagen
- (66) OCA
- (67) Proteopedia
- (68) MOPED
- (69) neXtProt
- (70) Reactome
- (71) GeneGo (Thomson Reuters)
- (72) DISEASES
- (73) SIMAP
- (74) GenomeRNAi
- (75) LifeMap
- (76) miRTarBase
- (77) MalaCards
- (78) Invitrogen
- (79) BitterDB
- (80) ESI-BIO
- (81) RefSeq
- (82) BioSystems
- (83) MaxQB
- (84) IUPHAR
- (85) BioGPS
- (86) Illumina
- (87) COMPARTMENTS
- (88) HOMER
- (89) PaxDb
- (90) ApexBio
- (91) Addgene
- (92) antibodies-online
- (93) CYP
- (94) NONCODE
- (95) TreeFam
- (96) PathCards
- (97) GeneReviews
- (98) GeneTex
- (99) Taconic Biosciences
- (100) GTEx
- (101) ProteomicsDB
- (102) SCBT
- (103) DGIdb
- (104) ClinicalTrials
- (105) RVIS
- (106) SIGNOR
- (107) diseasecard
- (108) NIH Rare Diseases
- (109) Orphanet
- (110) UMLS
- (111) GTR
- (112) Disease Ontology
- (113) Genetics Home Reference
- (114) MeSH
- (115) MedlinePlus
- (116) CDC
- (117) NINDS
- (118) NCBI Bookshelf
- (119) ClinVar
- (120) Gene Damage Index
- (121) HPO
- (122) UDN
- (123) VISTA
- (124) FANTOM5
- (125) ENCODE
- (126) ProSci
- (127) Horizon
- (128) NURSA
- (129) IID
- (130) VectorBuilder
- (131) SNPedia
- (132) BRCA Exchange
- (133) CIViC
- (134) ProteoGenix
- (135) dbSUPER
- (136) TISSUES
- (137) Gene ORGANizer
- (138) abm
- (139) Human Protein Atlas
- (140) GWAS Catalog
- (141)